JP2010507567A5 - - Google Patents
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- Publication number
- JP2010507567A5 JP2010507567A5 JP2009523960A JP2009523960A JP2010507567A5 JP 2010507567 A5 JP2010507567 A5 JP 2010507567A5 JP 2009523960 A JP2009523960 A JP 2009523960A JP 2009523960 A JP2009523960 A JP 2009523960A JP 2010507567 A5 JP2010507567 A5 JP 2010507567A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- pharmaceutically acceptable
- cxcr4 inhibitor
- acceptable salt
- cxcr2 agonist
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 10
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 10
- 239000003112 inhibitor Substances 0.000 claims 10
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 8
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 8
- 239000000556 agonist Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 102100039398 C-X-C motif chemokine 2 Human genes 0.000 claims 5
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 5
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 5
- 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical group C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims 5
- 229960002169 plerixafor Drugs 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000001483 mobilizing effect Effects 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83640906P | 2006-08-07 | 2006-08-07 | |
| PCT/US2007/075376 WO2008019371A1 (en) | 2006-08-07 | 2007-08-07 | Combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507567A JP2010507567A (ja) | 2010-03-11 |
| JP2010507567A5 true JP2010507567A5 (https=) | 2010-09-30 |
Family
ID=39033325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523960A Withdrawn JP2010507567A (ja) | 2006-08-07 | 2007-08-07 | 併用療法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20100178271A1 (https=) |
| EP (1) | EP2056853A1 (https=) |
| JP (1) | JP2010507567A (https=) |
| CN (1) | CN101500595A (https=) |
| AR (1) | AR062271A1 (https=) |
| AU (1) | AU2007281677A1 (https=) |
| BR (1) | BRPI0715393A2 (https=) |
| CA (1) | CA2659337A1 (https=) |
| IL (1) | IL196559A0 (https=) |
| MX (1) | MX2009001445A (https=) |
| RU (1) | RU2009108289A (https=) |
| WO (1) | WO2008019371A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008086426A2 (en) * | 2007-01-09 | 2008-07-17 | Cleveland Biolabs, Inc. | Methods for increasing and mobilizing hematopoietic stem cells |
| EP2262494A2 (en) * | 2008-02-29 | 2010-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of post-radiation tumor growth by an inhibitor of vasculogenesis |
| US10813917B2 (en) * | 2009-12-11 | 2020-10-27 | Medregen, Llc | Treatment methods utilizing stem cell mobilizers and immunosuppressive agents |
| WO2011119738A2 (en) | 2010-03-23 | 2011-09-29 | The Johns Hopkins University | Methods of treatment using stem cell mobilizers |
| US8546353B2 (en) | 2010-05-06 | 2013-10-01 | Glykos Finland Oy | Compounds and combinations |
| EP2384759A1 (en) | 2010-05-06 | 2011-11-09 | Suomen Punainen Risti Veripalvelu | Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells |
| ES2370986B1 (es) * | 2010-06-08 | 2012-11-16 | Institut Quimic De Sarria Cets | Nuevos inhibidores de cxcr4 como agentes anti-vih |
| WO2012047339A2 (en) | 2010-06-28 | 2012-04-12 | The General Hospital Corporation | Anti-cxcr4 as a sensitizer to cancer therapeutics |
| WO2012019168A2 (en) * | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012129073A2 (en) * | 2011-03-18 | 2012-09-27 | University Of Virginia Patent Foundation | Compositions and methods for tissue engineering and cell based therapies |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| KR20140045411A (ko) | 2011-05-16 | 2014-04-16 | 젠자임 코포레이션 | Cxcr4 길항제의 용도 |
| EP2720690A4 (en) | 2011-06-16 | 2014-12-31 | Childrens Medical Center | COMBINED CHEMICAL MODIFICATION OF SPHINGOSIN-1-PHOSPHATE (S1P) AND CXCR4 SIGNALING PATHWAYS FOR HEMATOPOIETIC STEM CELL (HSC) MOBILIZATION AND TRANSPLANT |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| KR102503695B1 (ko) * | 2013-02-28 | 2023-02-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 줄기세포를 동원하기 위한 방법 및 조성물 |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| EP3302710A4 (en) * | 2015-06-03 | 2019-02-20 | The University of Queensland | MOBILIZERS AND USE THEREOF |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| CN110035702A (zh) * | 2016-10-24 | 2019-07-19 | 耶鲁大学 | 穿刺装置 |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| AU2018358012A1 (en) | 2017-11-03 | 2020-04-02 | Roemer & Heigl Gmbh | Extraction of stem cells from bone marrow niches |
| CN111712262A (zh) * | 2017-12-06 | 2020-09-25 | 美真达治疗公司 | 用于动员造血干细胞和祖细胞的给药方案 |
| US10058573B1 (en) | 2017-12-06 | 2018-08-28 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem cells |
| US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
| WO2022101359A1 (en) | 2020-11-12 | 2022-05-19 | Roemer & Heigl Gmbh | Reversible release of stem cells from bone marrow niches |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US5194596A (en) * | 1989-07-27 | 1993-03-16 | California Biotechnology Inc. | Production of vascular endothelial cell growth factor |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US6001826A (en) * | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| US6447766B1 (en) * | 1993-06-08 | 2002-09-10 | Smithkline Beecham Corporation | Method of mobilizing hematopoietic stem cells |
| ES2210255T3 (es) * | 1993-06-08 | 2004-07-01 | Smithkline Beecham Corporation | Metodos para mejorar la actividad biologica de quimiocinas. |
| DE4320478B4 (de) * | 1993-06-21 | 2007-11-15 | Robert Bosch Gmbh | Fahrstabilitätsregler |
| GB9400411D0 (en) * | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US6506770B1 (en) * | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| GB9511357D0 (en) * | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| US6713052B1 (en) * | 1995-10-24 | 2004-03-30 | Human Genome Sciences, Inc. | Method of mobilizing stem cells with chemokine β-8 |
| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| US6750348B1 (en) * | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| AU2334301A (en) * | 1999-12-17 | 2001-06-25 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds |
| US6734191B2 (en) * | 2000-09-15 | 2004-05-11 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| HK1052011A1 (zh) * | 2000-09-15 | 2003-08-29 | Anormed Inc. | 趋化因子受体结合杂环化合物 |
| DE60136476D1 (de) * | 2000-09-29 | 2008-12-18 | Anormed Inc | -stickstoffhaltigen zyklischen polyaminen und deren verbindungen |
| US6853731B1 (en) * | 2000-09-30 | 2005-02-08 | Keen Personal Technologies, Inc. | Digital video recorder employing a unique ID to interlock with encrypted video programs stored on a storage device |
| WO2002081727A2 (en) * | 2001-04-03 | 2002-10-17 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| DK1411918T3 (da) * | 2001-07-31 | 2012-04-23 | Genzyme Global S A R L | Fremgangsmåder til at mobilisere progenitor/stamceller |
| CN100463962C (zh) * | 2001-12-07 | 2009-02-25 | 图尔金株式会社 | 嵌合蛋白质的表型筛选 |
| WO2004091518A2 (en) * | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
| JP4778420B2 (ja) * | 2003-04-22 | 2011-09-21 | アノーメッド インコーポレイティド | 増強された有効性を有するケモカインレセプタ結合複素環式化合物 |
| EP1708703A4 (en) * | 2003-12-11 | 2008-04-09 | Anormed Inc | CHEMOKIN RECEPTOR BINDING COMPOUNDS |
-
2007
- 2007-08-07 CN CNA2007800295078A patent/CN101500595A/zh active Pending
- 2007-08-07 AR ARP070103484A patent/AR062271A1/es unknown
- 2007-08-07 BR BRPI0715393-7A patent/BRPI0715393A2/pt not_active Application Discontinuation
- 2007-08-07 JP JP2009523960A patent/JP2010507567A/ja not_active Withdrawn
- 2007-08-07 AU AU2007281677A patent/AU2007281677A1/en not_active Abandoned
- 2007-08-07 RU RU2009108289/15A patent/RU2009108289A/ru not_active Application Discontinuation
- 2007-08-07 US US12/376,591 patent/US20100178271A1/en not_active Abandoned
- 2007-08-07 EP EP07813853A patent/EP2056853A1/en active Pending
- 2007-08-07 MX MX2009001445A patent/MX2009001445A/es unknown
- 2007-08-07 WO PCT/US2007/075376 patent/WO2008019371A1/en not_active Ceased
- 2007-08-07 CA CA002659337A patent/CA2659337A1/en not_active Abandoned
-
2009
- 2009-01-15 IL IL196559A patent/IL196559A0/en unknown
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