JP2010506203A - 並行化された顕微鏡イメージングのための方法および装置 - Google Patents

並行化された顕微鏡イメージングのための方法および装置 Download PDF

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JP2010506203A
JP2010506203A JP2009530795A JP2009530795A JP2010506203A JP 2010506203 A JP2010506203 A JP 2010506203A JP 2009530795 A JP2009530795 A JP 2009530795A JP 2009530795 A JP2009530795 A JP 2009530795A JP 2010506203 A JP2010506203 A JP 2010506203A
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illumination
fluorescence
sample
region
detector
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JP2010506203A5 (enExample
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カンペ、ミカエル
クラムペルト、ゲルハルト
ヴァルト、マティアス
ヴォレシェンスキー、ラルフ
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Carl Zeiss Microscopy GmbH
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Carl Zeiss MicroImaging GmbH
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0072—Optical details of the image generation details concerning resolution or correction, including general design of CSOM objectives
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
JP2009530795A 2006-10-06 2007-10-02 並行化された顕微鏡イメージングのための方法および装置 Pending JP2010506203A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006047912A DE102006047912A1 (de) 2006-10-06 2006-10-06 Verfahren und Anordnung zur parallelisierten mikroskopischen Bildgebung
PCT/EP2007/008556 WO2008043460A1 (de) 2006-10-06 2007-10-02 Verfahren und anordnung zur parallelisierten mikroskopischen bildgebung

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JP2010506203A true JP2010506203A (ja) 2010-02-25
JP2010506203A5 JP2010506203A5 (enExample) 2011-08-18

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US (2) US20090250632A1 (enExample)
EP (1) EP2102695B1 (enExample)
JP (1) JP2010506203A (enExample)
DE (1) DE102006047912A1 (enExample)
WO (1) WO2008043460A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515249A (ja) * 2009-12-22 2013-05-02 カール ツァイス マイクロスコピー ゲーエムベーハー 物体の２次元または３次元の位置調整のための高解像度顕微鏡および方法
JP2013114265A (ja) * 2011-11-28 2013-06-10 Leica Microsystems Cms Gmbh 顕微鏡照明系および方法
WO2015162921A1 (ja) * 2014-04-25 2015-10-29 株式会社ニコン 構造化照明顕微鏡装置及び構造化照明観察方法
JP2016503892A (ja) * 2013-01-09 2016-02-08 マックス−プランク−ゲゼルシャフト ツア フェーデルンク デア ヴィッセンシャフテン エー．ファオ． 発光団を有する試料構造の高空間分解イメージング方法
US9335181B2 (en) 2010-11-10 2016-05-10 Qualcomm Incorporated Haptic based personal navigation
JP2019211788A (ja) * 2013-09-19 2019-12-12 カール ツァイス マイクロスコピー ゲーエムベーハーＣａｒｌ Ｚｅｉｓｓ Ｍｉｃｒｏｓｃｏｐｙ Ｇｍｂｈ 高分解能走査顕微鏡

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DE102008024954A1 (de) * 2008-05-23 2009-11-26 Carl Zeiss Microlmaging Gmbh Mikroskop mit einer optischen Anordnung zur Strukturierung des Beleuchtungslichtes
DE102008049886B4 (de) 2008-09-30 2021-11-04 Carl Zeiss Microscopy Gmbh Vorrichtung, insbesondere ein Mikroskop, zur Untersuchung von Proben
WO2010045949A2 (en) 2008-10-21 2010-04-29 Chemometec A/S A method and apparatus for analysis of a particle
DE102008054317A1 (de) 2008-11-03 2010-05-06 Carl Zeiss Microlmaging Gmbh Kombinationsmikroskopie
JP2012515930A (ja) * 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
DE102010028138A1 (de) * 2010-04-22 2011-10-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Bestimmen der Verteilung einer Substanz durch Abtasten mit einer Messfront
US8711211B2 (en) 2010-06-14 2014-04-29 Howard Hughes Medical Institute Bessel beam plane illumination microscope
US10051240B2 (en) 2010-06-14 2018-08-14 Howard Hughes Medical Institute Structured plane illumination microscopy
DE102011013614A1 (de) * 2011-03-08 2012-09-13 Carl Zeiss Microimaging Gmbh Laser-Scanning-Mikroskop und Verfahren zu seinem Betrieb
DE102011100507B4 (de) * 2011-04-29 2020-05-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Tragbares optisches Analysegerät
US9664614B2 (en) 2011-07-11 2017-05-30 University Of Limerick Method for high resolution sum-frequency generation and infrared microscopy
WO2013108626A1 (ja) * 2012-01-18 2013-07-25 株式会社ニコン 構造化照明装置、構造化照明顕微鏡装置、構造化照明方法
US20130250088A1 (en) * 2012-03-22 2013-09-26 Molecular Devices, Llc Multi-color confocal microscope and imaging methods
DE102012017922B4 (de) 2012-09-11 2024-03-14 Carl Zeiss Microscopy Gmbh Optikanordnung und Lichtmikroskop
EP2898312B1 (en) * 2012-09-24 2021-03-24 Global Life Sciences Solutions USA LLC Methods for resolving positions in fluorescence stochastic microscopy using three-dimensional structured illumination.
US9897536B2 (en) 2013-01-04 2018-02-20 University Of Limerick Differential infra red nanoscopy system and method
EP2801854B1 (en) 2013-05-10 2017-07-19 Ruprecht-Karls-Universität Heidelberg Method and apparatus for combination of localization microscopy and structured illumination microscopy
DE102013227107A1 (de) * 2013-09-03 2015-03-05 Leica Microsystems Cms Gmbh Mikroskop mit einem Element zum Verändern der Form des Beleuchtungslichtfokus
US10656401B2 (en) * 2013-12-09 2020-05-19 Nikon Corporation Optical apparatus, measuring apparatus, measuring method, screening apparatus, and screening method
DE102013114860B3 (de) 2013-12-23 2015-05-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zur Bestimmung der Orte einzelner Moleküle einer Substanz in einer Probe
WO2016054118A1 (en) * 2014-09-29 2016-04-07 Howard Hughes Medical Institute Non-linear structured illumination microscopy
US10795144B2 (en) 2014-12-06 2020-10-06 Howard Hughes Medical Institute Microscopy with structured plane illumination and point accumulation for imaging and nanoscale topography
EP3465319A4 (en) 2016-05-30 2020-02-19 The Trustees of Columbia University in the City of New York SCAPE MICROSCOPY WITH PHASE MODULATION ELEMENT AND IMAGE RECONSTRUCTION
LU93117B1 (de) * 2016-06-23 2018-01-24 Leica Microsystems Beleuchtungsvorrichtung für ein Mikroskop
US10955652B2 (en) * 2016-09-30 2021-03-23 The Trustees Of Columbia University In The City Of New York Three-dimensional imaging using swept, confocally aligned planar excitation with a Powell lens and/or deliberate misalignment
JP6673497B2 (ja) * 2016-11-02 2020-03-25 株式会社ニコン 蛍光観察装置
DE102017011843A1 (de) 2017-12-21 2019-06-27 Horst Wochnowski Initialisierung von chemischen, physikalisch-chemischen und/oder physikalischen Reaktionen mittels eines angefangenen und nicht zu Ende geführten STED-Prozesses mit einer örtlichen Auflösung unterhalb des klassischen optischen Auflösungsgrenze mit Anwendungen aus der Biochemie
AU2019205496B2 (en) 2018-01-08 2021-08-19 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
NL2020621B1 (en) 2018-01-08 2019-07-15 Illumina Inc Multiplexing of an active sensor detector using structured illumination
TWI725875B (zh) 2018-01-16 2021-04-21 美商伊路米納有限公司 結構照明成像系統和使用結構化光來創建高解析度圖像的方法
NL2020620B1 (en) 2018-01-16 2019-07-25 Illumina Inc Pattern angle spatial selection structured illumination imaging
NL2020619B1 (en) 2018-01-16 2019-07-25 Illumina Inc Dual optical grating slide structured illumination imaging
NL2020623B1 (en) 2018-01-24 2019-07-30 Illumina Inc Structured illumination microscopy with line scanning
NL2020622B1 (en) 2018-01-24 2019-07-30 Lllumina Cambridge Ltd Reduced dimensionality structured illumination microscopy with patterned arrays of nanowells
NL2021258B1 (en) 2018-06-14 2019-12-20 Illumina Inc Device for luminescent imaging
TWI718557B (zh) 2018-06-29 2021-02-11 美商伊路米納有限公司 用於預測結構照明參數之方法、系統和非暫時性電腦可讀取媒體
US10901202B2 (en) 2018-09-19 2021-01-26 Illumina, Inc. Structured illumination of a sample
CN109375358B (zh) * 2018-11-28 2020-07-24 南京理工大学 一种基于最优照明模式设计下的差分相衬定量相位显微成像方法
DE102019110160B4 (de) 2019-04-17 2023-07-27 Leica Microsystems Cms Gmbh Fluoreszenzmikroskop und Verfahren zur Abbildung einer Probe
DE102020113998A1 (de) * 2020-05-26 2021-12-02 Abberior Instruments Gmbh Verfahren, Computerprogramm und Vorrichtung zum Bestimmen von Positionen von Molekülen in einer Probe
CN112260053B (zh) * 2020-10-23 2023-01-03 长春理工大学 高效率的叠阵型半导体激光器
CN112649405B (zh) * 2020-11-27 2022-04-19 浙江大学 基于共路并行荧光辐射差分的超分辨显微成像方法和装置
DE102021005684A1 (de) 2021-11-16 2023-05-17 Jörn Volkher Wochnowski STED-Verfahren mit Hohllichtwellenleitern
US20230314327A1 (en) * 2022-04-04 2023-10-05 10X Genomics, Inc. Systems and methods for nearly isotropic optical resolution using tilted structured illumination microscopy
CN115291406B (zh) * 2022-07-20 2024-12-27 中国航空工业集团公司济南特种结构研究所 一种基于激光准直的光轴校准装置

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013515249A (ja) * 2009-12-22 2013-05-02 カール ツァイス マイクロスコピー ゲーエムベーハー 物体の２次元または３次元の位置調整のための高解像度顕微鏡および方法
JP2015187745A (ja) * 2009-12-22 2015-10-29 カール ツァイス マイクロスコピー ゲーエムベーハーＣａｒｌ Ｚｅｉｓｓ Ｍｉｃｒｏｓｃｏｐｙ Ｇｍｂｈ 物体の２次元または３次元の位置調整のための高解像度顕微鏡および方法
US9335181B2 (en) 2010-11-10 2016-05-10 Qualcomm Incorporated Haptic based personal navigation
US9733086B2 (en) 2010-11-10 2017-08-15 Qualcomm Incorporated Haptic based personal navigation
JP2013114265A (ja) * 2011-11-28 2013-06-10 Leica Microsystems Cms Gmbh 顕微鏡照明系および方法
JP2016503892A (ja) * 2013-01-09 2016-02-08 マックス−プランク−ゲゼルシャフト ツア フェーデルンク デア ヴィッセンシャフテン エー．ファオ． 発光団を有する試料構造の高空間分解イメージング方法
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WO2015162921A1 (ja) * 2014-04-25 2015-10-29 株式会社ニコン 構造化照明顕微鏡装置及び構造化照明観察方法
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EP2102695A1 (de) 2009-09-23
DE102006047912A1 (de) 2008-04-10
EP2102695B1 (de) 2013-03-27
US8207510B2 (en) 2012-06-26
US20110215258A1 (en) 2011-09-08
WO2008043460A1 (de) 2008-04-17
US20090250632A1 (en) 2009-10-08

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