JP2010505937A5 - - Google Patents
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- Publication number
- JP2010505937A5 JP2010505937A5 JP2009531932A JP2009531932A JP2010505937A5 JP 2010505937 A5 JP2010505937 A5 JP 2010505937A5 JP 2009531932 A JP2009531932 A JP 2009531932A JP 2009531932 A JP2009531932 A JP 2009531932A JP 2010505937 A5 JP2010505937 A5 JP 2010505937A5
- Authority
- JP
- Japan
- Prior art keywords
- surfactant
- analog
- native
- reconstituted
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004094 surface-active agent Substances 0.000 claims 29
- 229920001184 polypeptide Chemical class 0.000 claims 11
- 108090000765 processed proteins & peptides Chemical class 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 claims 9
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 7
- 108010007131 Pulmonary Surfactant-Associated Protein B Proteins 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- 201000005085 Meconium Aspiration Syndrome Diseases 0.000 claims 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- -1 palmitoyl oleoyl phospholipid Chemical class 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- PAZGBAOHGQRCBP-ZCXUNETKSA-N 1-Palmitoyl-2-oleoylglycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-ZCXUNETKSA-N 0.000 claims 1
- 244000137850 Marrubium vulgare Species 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 238000011268 retreatment Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06021521 | 2006-10-13 | ||
| EP06021521.7 | 2006-10-13 | ||
| PCT/IB2007/002841 WO2008044109A1 (en) | 2006-10-13 | 2007-09-28 | Reconstituted surfactants having improved properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161238A Division JP2013241449A (ja) | 2006-10-13 | 2013-08-02 | 改善された性質を有する再構成サーファクタント |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010505937A JP2010505937A (ja) | 2010-02-25 |
| JP2010505937A5 true JP2010505937A5 (enExample) | 2010-09-24 |
| JP5405307B2 JP5405307B2 (ja) | 2014-02-05 |
Family
ID=39079026
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009531932A Active JP5405307B2 (ja) | 2006-10-13 | 2007-09-28 | 改善された性質を有する再構成サーファクタント |
| JP2013161238A Pending JP2013241449A (ja) | 2006-10-13 | 2013-08-02 | 改善された性質を有する再構成サーファクタント |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161238A Pending JP2013241449A (ja) | 2006-10-13 | 2013-08-02 | 改善された性質を有する再構成サーファクタント |
Country Status (35)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008011559A2 (en) | 2006-07-20 | 2008-01-24 | University Of Rochester | Synthetic lung surfactant and use thereof |
| EP1997502A1 (en) * | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| US8399406B2 (en) * | 2009-06-05 | 2013-03-19 | Chiesi Farmaceutici S.P.A. | Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C) |
| CN101948526B (zh) * | 2010-09-02 | 2012-12-05 | 华东理工大学 | 一种肺泡表面活性蛋白质(sp-b和sp-c)的分离纯化方法 |
| US9815869B2 (en) | 2012-02-09 | 2017-11-14 | University Of Rochester | SP-B and SP-C peptides, synthetic lung surfactants, and use thereof |
| US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
| BR112015009486B1 (pt) | 2012-11-21 | 2022-06-14 | Chiesi Farmaceutici S.P.A | Surfactante reconstituído, formulação farmacêutica, kit e uso de surfactante reconstituído |
| EP3393489B1 (en) * | 2015-12-17 | 2021-09-01 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Synthetic lung surfactant with enhanced stability and effectiveness |
| CA3016810C (en) | 2016-03-07 | 2024-04-02 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Compositions and methods for administering ppar.gamma. agonists, surfactant peptides and phospholipids |
| CN109562139A (zh) | 2016-08-24 | 2019-04-02 | 奇斯药制品公司 | 包含重构肺表面活性物质组合物的稳定药物制剂 |
| US20230257446A1 (en) | 2020-01-28 | 2023-08-17 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
| EP4228691A4 (en) * | 2020-10-16 | 2025-01-01 | Biosuperior Technology, Inc. | PULMONARY TREATMENT COMPOSITIONS |
| WO2025024609A1 (en) * | 2023-07-25 | 2025-01-30 | Biosuperior Technology, Inc. | Polypeptides for lung surfactant compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0706374B1 (en) * | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Method for preparing liposomes |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| US7065342B1 (en) * | 1999-11-23 | 2006-06-20 | Gofigure, L.L.C. | System and mobile cellular telephone device for playing recorded music |
| ITMI20021058A1 (it) | 2002-05-17 | 2003-11-17 | Chiesi Farma Spa | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| EP1481665A1 (en) * | 2003-05-30 | 2004-12-01 | CHIESI FARMACEUTICI S.p.A. | Novel lipid mixtures for synthetic surfactants |
| WO2008011559A2 (en) * | 2006-07-20 | 2008-01-24 | University Of Rochester | Synthetic lung surfactant and use thereof |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| EP2022798A1 (en) | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetic pulmonary surfactant peptides |
-
2007
- 2007-09-28 BR BRPI0715317-1A patent/BRPI0715317B1/pt active IP Right Grant
- 2007-09-28 ME MEP-2016-20A patent/ME02326B/me unknown
- 2007-09-28 CA CA2666344A patent/CA2666344C/en active Active
- 2007-09-28 PL PL07825212T patent/PL2078038T3/pl unknown
- 2007-09-28 AU AU2007306075A patent/AU2007306075B2/en active Active
- 2007-09-28 MX MX2009003638A patent/MX343064B/es active IP Right Grant
- 2007-09-28 GE GEAP200711224A patent/GEP20125531B/en unknown
- 2007-09-28 RS RS20140037A patent/RS53172B/sr unknown
- 2007-09-28 UA UAA200903082A patent/UA94477C2/ru unknown
- 2007-09-28 ZA ZA200902481A patent/ZA200902481B/xx unknown
- 2007-09-28 EA EA200900373A patent/EA015802B1/ru unknown
- 2007-09-28 MY MYPI20091454A patent/MY148127A/en unknown
- 2007-09-28 WO PCT/IB2007/002841 patent/WO2008044109A1/en not_active Ceased
- 2007-09-28 DK DK07825212.9T patent/DK2078038T3/da active
- 2007-09-28 CN CN201310053516.8A patent/CN103169947B/zh active Active
- 2007-09-28 JP JP2009531932A patent/JP5405307B2/ja active Active
- 2007-09-28 SI SI200731393T patent/SI2078038T1/sl unknown
- 2007-09-28 ME MEP-121/09A patent/MEP12109A/xx unknown
- 2007-09-28 ES ES07825212.9T patent/ES2438727T3/es active Active
- 2007-09-28 PT PT78252129T patent/PT2078038E/pt unknown
- 2007-09-28 EP EP07825212.9A patent/EP2078038B1/en active Active
- 2007-09-28 NZ NZ576189A patent/NZ576189A/en unknown
- 2007-09-28 HR HRP20140052TT patent/HRP20140052T1/hr unknown
- 2007-09-28 KR KR1020097007008A patent/KR101328851B1/ko active Active
- 2007-09-28 CN CN2007800382767A patent/CN101522711B/zh active Active
- 2007-10-11 TW TW096137965A patent/TWI388333B/zh active
- 2007-10-11 AR ARP070104520A patent/AR063263A1/es not_active Application Discontinuation
- 2007-10-11 CL CL200702931A patent/CL2007002931A1/es unknown
- 2007-10-11 JO JO2007436A patent/JO2963B1/en active
- 2007-10-11 PE PE2007001375A patent/PE20081184A1/es active IP Right Grant
-
2009
- 2009-03-25 TN TN2009000099A patent/TN2009000099A1/fr unknown
- 2009-04-07 IL IL198075A patent/IL198075A/en active IP Right Grant
- 2009-04-08 CO CO09036247A patent/CO6400235A2/es not_active Application Discontinuation
- 2009-04-13 US US12/422,581 patent/US8183210B2/en active Active
- 2009-04-14 NO NO20091441A patent/NO342038B1/no unknown
- 2009-05-08 MA MA31854A patent/MA31062B1/fr unknown
-
2012
- 2012-04-10 US US13/443,164 patent/US9238058B2/en active Active
-
2013
- 2013-08-02 JP JP2013161238A patent/JP2013241449A/ja active Pending
- 2013-12-11 CY CY20131101121T patent/CY1114716T1/el unknown
-
2018
- 2018-11-05 AR ARP180103211A patent/AR113422A2/es not_active Application Discontinuation
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