HRP20140052T1 - Rekonstituirani surfakanti koji imaju poboljšana svojstva - Google Patents
Rekonstituirani surfakanti koji imaju poboljšana svojstva Download PDFInfo
- Publication number
- HRP20140052T1 HRP20140052T1 HRP20140052TT HRP20140052T HRP20140052T1 HR P20140052 T1 HRP20140052 T1 HR P20140052T1 HR P20140052T T HRP20140052T T HR P20140052TT HR P20140052 T HRP20140052 T HR P20140052T HR P20140052 T1 HRP20140052 T1 HR P20140052T1
- Authority
- HR
- Croatia
- Prior art keywords
- surfactant
- protein
- reconstituted
- analog
- natural
- Prior art date
Links
- 239000004094 surface-active agent Substances 0.000 title claims 32
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 claims 9
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108010007131 Pulmonary Surfactant-Associated Protein B Proteins 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 3
- 150000003904 phospholipids Chemical class 0.000 claims 3
- PAZGBAOHGQRCBP-DDDNOICHSA-N 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-DDDNOICHSA-N 0.000 claims 2
- 201000005085 Meconium Aspiration Syndrome Diseases 0.000 claims 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 2
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- PAZGBAOHGQRCBP-ZCXUNETKSA-N 1-Palmitoyl-2-oleoylglycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-ZCXUNETKSA-N 0.000 claims 1
- 244000137850 Marrubium vulgare Species 0.000 claims 1
- 102100032617 Pulmonary surfactant-associated protein B Human genes 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Claims (20)
1. Rekonstituirani surfakant koji sadržava smjesu fosfolipida i kombinaciju polipeptidnog analoga proteina SP-C, prirodnog surfakanta, s polpepdidnim analogom proteina SP-B, prirodnog surfakanta, naznačen time da rečeni polipepdini analog prirodnog surfakanta, proteina SP-C, sadržava najmanje 20 aminokiselinskih ostataka a ne više od 40 aminokiselinskih ostataka, a koji imaju sekvenciju predstavljenu općem formulom (I)
FeGeIfPfSgSPVHLKRXaBXb(BXc)nGALL�pGpLp (I)
u kojoj:
X jest aminokiselinski ostatak neovisno odabran iz skupine koju čine I, L, i nL,
B jest aminokiselinski ostatak neovisno odabran iz skupine koju čine K, W, F, Y te Orn,
S može biti supstituiran acilnim skupinama koje sadrže 12-22 ugljikovih atoma, preferirano 16 ugljikovih atoma, vezanih za bočni lanac esterskom vezom,
Ω jest aminokiselinski ostatak neovisno odabran iz skupine koju čine M ili njegovi analozi I, L, i nL koji su oksidirani na sumporovom atomu,
a je cijeli broj čija se vrijednost kreće od 1 do 8,
b je cijeli broj čija se vrijednost kreće od 1 do 19,
c je cijeli broj koji je neovisno odabran u rasponu od 3 do 8,
e, f, g i p jesu cijeli brojevi čija je vrijednost 0 ili 1,
N je cijeli broj čija se vrijednost kreće od 0 do 3,
uz uvjet da XaBXb(BXc)n jest sekvencija koja ima najviše 22 aminokiseline, te da rečeni polipepdini analog prirodnog surfakanta proteina SP-B jest polipeptid opće formule (II):
CfΔLCRALIKRIQAΩIPKGGRΩLPQLVCRLVLΦCSf (II)
u kojoj
Δ jest aminokiselinski ostatak neovisno odabran iz skupine koju čine W i L,
Ω jest aminokiselinski ostatak neovisno odabran iz skupine koju čine M I, L, i nL,
Φ jest aminokiselinski ostatak odabran iz skupine koju čine R i T, te
f je cijeli broj vrijednosti 0 ili 1.
2. Rekonstituirani surfakant prema patentnom zahtjevu 1, naznačen time da Φ jest R.
3. Rekonstituirani surfakant prema patentnom zahtjevu 1 ili 2, naznačen time da su analog proteina SP-C, prirodnog surfakanta, i analog proteina SP-B, prirodnog surfakanta, prisutni u određenoj kombinaciji.
4. Pripravak rekonstituiranog surfakanta prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time da je polipeptid (II) u obliku disulfidom vezane molekule koja ima intramolekulske disulfidne veze između dvaju Cys ostataka u položajima 1 i 33 i/ili između dvaju Cys ostataka u položajima 4 i 27.
5. Pripravak rekonstituiranog surfakanta prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time da je analog prirodnog surfakanta proteina SP-B predstavljen općom formulom (IIa)
CWLCRALIKRIQAMIPKGGRMLPQLVCRLVLRCS (IIa)
6. Rekonstituirani surfakant prema patentnom zahtjevu 5, naznačen time da je analog prirodnog surfakanta proteina SP-C predstavljen općom formulom (Ia)
IfPfSSPVHLKRXaBXbGALLΩpGpLp (Ia)
u kojoj
X, B i Ω jesu kao što je gore definirano,
a je od 1 do 8, preferirano od 1 do 3, preferiranije 1,
b je od 1 do 19, preferirano od 5 do 15, preferiranije 14, te
f i p jesu 0 ili 1.
7. Pripravak rekonstituiranog surfakanta prema patentnom zahtjevu 6, naznačen time da je analog prirodnog surfakanta proteina SP-C predstavljen općom formulom (Ib)
IPSSPVHLKRXaBXbGALLΩpGpLp (Ib)
u kojoj:
X, B, Ω, a i b jesu kao što je gore definirano, te
p jest 0 ili 1.
8. Pripravak rekonstituiranog surfakanta prema patentnom zahtjevu 7, naznačen time da je analog prirodnog surfakanta proteina SP-C predstavljen općom formulom (Ic)
IPSSPVHLKRLKLLLLLLLLILLLILGALLΩpGpLp (Ic)
u kojoj:
Ω jest kao što je gore definirano, te
p jest 0 ili 1.
9. Pripravak rekonstituiranog surfakanta prema patentnom zahtjevu 8, naznačen time da je analog prirodnog surfakanta proteina SP-C odabran iz sljedeće skupine:
IPSSPVHLKRLKLLLLLLLLILLLILGALLMGL (Id)
IPSSPVHLKRLKLLLLLLLLILLLILGALLIGL (Ie)
IPSSPVHLKRLKLLLLLLLLILLLILGALLLGL (If)
IPSSPVHLKRLKLLLLLLLLILLLILGALLnLGL (Ig)
IPSSPVHLKRLKLLLLLLLLILLLILGALL (Ih)
10. Rekonstituirani surfakant prema patentnom zahtjevu 1, naznačen time da analog prirodnog surfakanta proteina SP-C jest
IPSSPVHLKRLKLLLLLLLLILLLILGALLLGL (If),
a analog prirodnog surfakanta proteina SP-B jest
CWLCRALIKRIQAMIPKGGRMLPQLVCRLVLRCS (IIa)
11. Rekonstituirani surfakant prema patentnom zahtjevu 1, naznačen time da polipeptidni analog prirodnog surfakanta proteina SP-C jest
IPSSPVHLKRLKLLLLLLLLILLLILGALLLGL (If),
a polipeptidni analog prirodnog surfakanta proteina SP-B jest
CWLCRALIKRIQALIPKGGRLLPQLVCRLVLRCS (IIc)
12. Rekonstituirani surfakant prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time da se fosfolipidna smjesa sastoji od dipalmitoil-fosfatidilkolina (DPPC) i palmitoil-oleoil-fosfolipida odabranih od palmitoil-oleoil-fosfatidilglicerola (POPG) ili njegove smjese s palmitoil-oleoil-fosfatidilkolinom (POPC) masenih omjera u rasponu od 95:5 do 50:50.
13. Rekonstituirani surfakant prema patentnom zahtjevu 12, naznačen time da omjer masa komponenata fosfolipidne smjese koja sadrži DPPC i POPG iznosi 68:31.
14. Farmaceutski pripravak, naznačen time da sadrži rekonstituirani surfakant prema bilo kojem od patentnih zahtjeva 1 to 13.
15. Farmaceutski pripravak prema patentnom zahtjevu 14, naznačen time da je u obliku otopine, disperzije, suspenzije ili suhog praška.
16. Farmaceutski pripravak prema patentnom zahtjevu 15, naznačen time da je u obliku vodene suspenzije.
17. Farmaceutski pripravak prema patentnom zahtjevu 16, naznačen time da sadrži rekonstituirani surfakant čija je koncentracija u rasponu između 2 i 160 mg/mL.
18. Farmaceutski pripravak prema patentnom zahtjevu 17, naznačen time da je koncentracija rekonstituiranog surfakanta u rasponu između 20 i 80 mg/mL.
19. Rekonstituirani surfakant prema bilo kojem od patentnih zahtjeva 1 do 13, naznačen time da se koristi za liječenje i profilaksu respiratornog distresnog sindroma kod prerano rođene djece ili za liječenje i profilaksu drugih bolesti povezanih s nedostatkom surfakanta ili disfunkcijom.
20. Rekonstituirani surfakant za upotrebu u patentnom zahtjevu 19, naznačen time da je bolest povezana s deficijencijom ili disfunkcijom surfakanta uključujući RDS kod odraslih (ARDS) sidrom aspracije mekonija (MAS), te bronhopulmonarna displazija (BPD).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06021521 | 2006-10-13 | ||
| PCT/IB2007/002841 WO2008044109A1 (en) | 2006-10-13 | 2007-09-28 | Reconstituted surfactants having improved properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140052T1 true HRP20140052T1 (hr) | 2014-02-28 |
Family
ID=39079026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140052TT HRP20140052T1 (hr) | 2006-10-13 | 2014-01-17 | Rekonstituirani surfakanti koji imaju poboljšana svojstva |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US8183210B2 (hr) |
| EP (1) | EP2078038B1 (hr) |
| JP (2) | JP5405307B2 (hr) |
| KR (1) | KR101328851B1 (hr) |
| CN (2) | CN103169947B (hr) |
| AR (2) | AR063263A1 (hr) |
| AU (1) | AU2007306075B2 (hr) |
| BR (1) | BRPI0715317B1 (hr) |
| CA (1) | CA2666344C (hr) |
| CL (1) | CL2007002931A1 (hr) |
| CO (1) | CO6400235A2 (hr) |
| CY (1) | CY1114716T1 (hr) |
| DK (1) | DK2078038T3 (hr) |
| EA (1) | EA015802B1 (hr) |
| ES (1) | ES2438727T3 (hr) |
| GE (1) | GEP20125531B (hr) |
| HK (2) | HK1134497A1 (hr) |
| HR (1) | HRP20140052T1 (hr) |
| IL (1) | IL198075A (hr) |
| JO (1) | JO2963B1 (hr) |
| MA (1) | MA31062B1 (hr) |
| ME (2) | MEP12109A (hr) |
| MX (1) | MX343064B (hr) |
| MY (1) | MY148127A (hr) |
| NO (1) | NO342038B1 (hr) |
| NZ (1) | NZ576189A (hr) |
| PE (1) | PE20081184A1 (hr) |
| PL (1) | PL2078038T3 (hr) |
| PT (1) | PT2078038E (hr) |
| RS (1) | RS53172B (hr) |
| SI (1) | SI2078038T1 (hr) |
| TN (1) | TN2009000099A1 (hr) |
| TW (1) | TWI388333B (hr) |
| UA (1) | UA94477C2 (hr) |
| WO (1) | WO2008044109A1 (hr) |
| ZA (1) | ZA200902481B (hr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008011559A2 (en) | 2006-07-20 | 2008-01-24 | University Of Rochester | Synthetic lung surfactant and use thereof |
| EP1997502A1 (en) * | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| US8399406B2 (en) * | 2009-06-05 | 2013-03-19 | Chiesi Farmaceutici S.P.A. | Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C) |
| CN101948526B (zh) * | 2010-09-02 | 2012-12-05 | 华东理工大学 | 一种肺泡表面活性蛋白质(sp-b和sp-c)的分离纯化方法 |
| EP2812018B1 (en) | 2012-02-09 | 2018-12-05 | University Of Rochester | Novel sp-b&sp-c peptides, synthetic lung surfactants, and use thereof |
| US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
| ES2644317T3 (es) * | 2012-11-21 | 2017-11-28 | Chiesi Farmaceutici S.P.A. | Tensioactivos pulmonares reconstituidos |
| EP3393489B1 (en) * | 2015-12-17 | 2021-09-01 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Synthetic lung surfactant with enhanced stability and effectiveness |
| EP3452041A4 (en) | 2016-03-07 | 2020-11-11 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | COMPOSITIONS AND METHOD OF ADMINISTRATION OF PPAR AGONISTS, SURFACTANT PEPTIDES AND PHOSPHOLIPIDS |
| KR102395835B1 (ko) * | 2016-08-24 | 2022-05-10 | 키에시 파르마슈티시 엣스. 피. 에이. | 재구성된 폐 계면활성제 조성물을 포함하는 안정한 약제학적 제제 |
| US20230257446A1 (en) | 2020-01-28 | 2023-08-17 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08512056A (ja) * | 1993-06-30 | 1996-12-17 | ジェネンテク・インコーポレイテッド | リポソームの製造法 |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| US7065342B1 (en) * | 1999-11-23 | 2006-06-20 | Gofigure, L.L.C. | System and mobile cellular telephone device for playing recorded music |
| ITMI20021058A1 (it) * | 2002-05-17 | 2003-11-17 | Chiesi Farma Spa | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| EP1481665A1 (en) * | 2003-05-30 | 2004-12-01 | CHIESI FARMACEUTICI S.p.A. | Novel lipid mixtures for synthetic surfactants |
| WO2008011559A2 (en) * | 2006-07-20 | 2008-01-24 | University Of Rochester | Synthetic lung surfactant and use thereof |
| EP1997502A1 (en) * | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| EP2022798A1 (en) | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetic pulmonary surfactant peptides |
-
2007
- 2007-09-28 DK DK07825212.9T patent/DK2078038T3/da active
- 2007-09-28 EP EP07825212.9A patent/EP2078038B1/en active Active
- 2007-09-28 WO PCT/IB2007/002841 patent/WO2008044109A1/en active Application Filing
- 2007-09-28 SI SI200731393T patent/SI2078038T1/sl unknown
- 2007-09-28 CN CN201310053516.8A patent/CN103169947B/zh active Active
- 2007-09-28 BR BRPI0715317-1A patent/BRPI0715317B1/pt active IP Right Grant
- 2007-09-28 PL PL07825212T patent/PL2078038T3/pl unknown
- 2007-09-28 NZ NZ576189A patent/NZ576189A/en unknown
- 2007-09-28 CA CA2666344A patent/CA2666344C/en active Active
- 2007-09-28 MY MYPI20091454A patent/MY148127A/en unknown
- 2007-09-28 ME MEP-121/09A patent/MEP12109A/xx unknown
- 2007-09-28 ZA ZA200902481A patent/ZA200902481B/xx unknown
- 2007-09-28 PT PT78252129T patent/PT2078038E/pt unknown
- 2007-09-28 ES ES07825212.9T patent/ES2438727T3/es active Active
- 2007-09-28 UA UAA200903082A patent/UA94477C2/ru unknown
- 2007-09-28 JP JP2009531932A patent/JP5405307B2/ja active Active
- 2007-09-28 KR KR1020097007008A patent/KR101328851B1/ko active IP Right Grant
- 2007-09-28 EA EA200900373A patent/EA015802B1/ru unknown
- 2007-09-28 RS RS20140037A patent/RS53172B/en unknown
- 2007-09-28 CN CN2007800382767A patent/CN101522711B/zh active Active
- 2007-09-28 MX MX2009003638A patent/MX343064B/es active IP Right Grant
- 2007-09-28 GE GEAP200711224A patent/GEP20125531B/en unknown
- 2007-09-28 AU AU2007306075A patent/AU2007306075B2/en active Active
- 2007-09-28 ME MEP-2016-20A patent/ME02326B/me unknown
- 2007-10-11 JO JO2007436A patent/JO2963B1/en active
- 2007-10-11 TW TW096137965A patent/TWI388333B/zh active
- 2007-10-11 PE PE2007001375A patent/PE20081184A1/es active IP Right Grant
- 2007-10-11 CL CL200702931A patent/CL2007002931A1/es unknown
- 2007-10-11 AR ARP070104520A patent/AR063263A1/es not_active Application Discontinuation
-
2009
- 2009-03-25 TN TN2009000099A patent/TN2009000099A1/fr unknown
- 2009-04-07 IL IL198075A patent/IL198075A/en active IP Right Grant
- 2009-04-08 CO CO09036247A patent/CO6400235A2/es not_active Application Discontinuation
- 2009-04-13 US US12/422,581 patent/US8183210B2/en active Active
- 2009-04-14 NO NO20091441A patent/NO342038B1/no unknown
- 2009-05-08 MA MA31854A patent/MA31062B1/fr unknown
- 2009-12-10 HK HK09111596.6A patent/HK1134497A1/xx unknown
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2012
- 2012-04-10 US US13/443,164 patent/US9238058B2/en active Active
-
2013
- 2013-08-02 JP JP2013161238A patent/JP2013241449A/ja active Pending
- 2013-11-14 HK HK13112762.6A patent/HK1185274A1/xx unknown
- 2013-12-11 CY CY20131101121T patent/CY1114716T1/el unknown
-
2014
- 2014-01-17 HR HRP20140052TT patent/HRP20140052T1/hr unknown
-
2018
- 2018-11-05 AR ARP180103211A patent/AR113422A2/es unknown
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