JP2010505836A - ヒンバシンの修飾された三環単位に基づいたトロンビン受容体アンタゴニスト - Google Patents

ヒンバシンの修飾された三環単位に基づいたトロンビン受容体アンタゴニスト Download PDF

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JP2010505836A
JP2010505836A JP2009531440A JP2009531440A JP2010505836A JP 2010505836 A JP2010505836 A JP 2010505836A JP 2009531440 A JP2009531440 A JP 2009531440A JP 2009531440 A JP2009531440 A JP 2009531440A JP 2010505836 A JP2010505836 A JP 2010505836A
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disease
compound
radiation
cancer
renal
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JP2010505836A5 (enExample
Inventor
サミュエル チャックラマニール，
ユーグアン ワン，
ティルベッチプラム ケー． シルベンガダム，
イリア エー． ザビアロブ，
タオ リー，
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Merck Sharp & Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
JP2009531440A 2006-10-04 2007-10-02 ヒンバシンの修飾された三環単位に基づいたトロンビン受容体アンタゴニスト Withdrawn JP2010505836A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84928406P 2006-10-04 2006-10-04
PCT/US2007/021259 WO2008060372A2 (en) 2006-10-04 2007-10-02 Thrombin receptor antagonists based on the modified tricyclic unit of himbacine

Publications (2)

Publication Number Publication Date
JP2010505836A true JP2010505836A (ja) 2010-02-25
JP2010505836A5 JP2010505836A5 (enExample) 2010-04-22

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ID=39284222

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Application Number Title Priority Date Filing Date
JP2009531440A Withdrawn JP2010505836A (ja) 2006-10-04 2007-10-02 ヒンバシンの修飾された三環単位に基づいたトロンビン受容体アンタゴニスト

Country Status (12)

Country Link
US (1) US20080085923A1 (enExample)
EP (1) EP2078012A2 (enExample)
JP (1) JP2010505836A (enExample)
KR (1) KR20090058583A (enExample)
CN (1) CN101553484A (enExample)
AR (1) AR063095A1 (enExample)
AU (1) AU2007320029A1 (enExample)
CA (1) CA2666903A1 (enExample)
IL (1) IL198011A0 (enExample)
MX (1) MX2009003758A (enExample)
TW (1) TW200823206A (enExample)
WO (1) WO2008060372A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016114386A1 (ja) * 2015-01-15 2016-07-21 国立研究開発法人国立精神・神経医療研究センター 進行型免疫性脱髄疾患治療剤

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8227412B2 (en) * 2007-03-29 2012-07-24 Tsopanoglou Nikos E Bioactive parstatin peptides and methods of use
SI2438060T1 (sl) * 2009-06-04 2014-04-30 Merck Sharp & Dohme Corp. Aktivni metabolit trombin receptorskega antagonista
EP2488026A4 (en) * 2009-10-02 2013-04-10 Merck Sharp & Dohme USE OF A PAR-1 ANTAGONIST IN COMBINATION WITH A P2Y12ADP RECEPTOR ANTAGONIST FOR INHIBITING THROMBOSE
CN105777681B (zh) * 2014-12-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 喜巴辛类似物及其中间体的制备方法
CN105985303B (zh) * 2015-02-13 2020-08-14 上海彩迩文生化科技有限公司 抗凝血剂的制备方法、中间体及其制备方法
CN106866450B (zh) * 2017-01-13 2019-01-11 阜阳欣奕华材料科技有限公司 硫酸沃拉帕沙中间体的制备方法
CN110483455A (zh) * 2019-09-29 2019-11-22 天津力生制药股份有限公司 一种硫酸沃拉帕沙中间体醛基物的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063847A (en) * 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
KR100604742B1 (ko) * 2000-06-15 2006-07-26 쉐링 코포레이션 트롬빈 수용체 길항제
CA2463628A1 (en) * 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
EP1982984B1 (en) * 2002-04-16 2013-02-13 Merck Sharp & Dohme Corp. Manufacture of tricyclic thrombin receptor antagonists and pharmaceutical compositions comprising them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016114386A1 (ja) * 2015-01-15 2016-07-21 国立研究開発法人国立精神・神経医療研究センター 進行型免疫性脱髄疾患治療剤

Also Published As

Publication number Publication date
IL198011A0 (en) 2009-12-24
WO2008060372A3 (en) 2008-12-24
WO2008060372A2 (en) 2008-05-22
CN101553484A (zh) 2009-10-07
MX2009003758A (es) 2009-04-22
AR063095A1 (es) 2008-12-30
AU2007320029A1 (en) 2008-05-22
KR20090058583A (ko) 2009-06-09
CA2666903A1 (en) 2008-05-22
TW200823206A (en) 2008-06-01
US20080085923A1 (en) 2008-04-10
EP2078012A2 (en) 2009-07-15

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