JP2010505831A - 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド - Google Patents

安定化した、治療用の小型のヘリックス性抗ウイルスペプチド Download PDF

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Publication number
JP2010505831A
JP2010505831A JP2009531418A JP2009531418A JP2010505831A JP 2010505831 A JP2010505831 A JP 2010505831A JP 2009531418 A JP2009531418 A JP 2009531418A JP 2009531418 A JP2009531418 A JP 2009531418A JP 2010505831 A JP2010505831 A JP 2010505831A
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peptide
capsid
mammal
amino acids
amino acid
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Japanese (ja)
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JP2010505831A5 (enExample
Inventor
アシム クマール デブナス,
ホンタオ チャン,
キアン チャオ,
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ニューヨーク ブラッド センター, インコーポレイテッド
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Publication of JP2010505831A publication Critical patent/JP2010505831A/ja
Publication of JP2010505831A5 publication Critical patent/JP2010505831A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2009531418A 2006-10-05 2007-10-02 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド Pending JP2010505831A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84955106P 2006-10-05 2006-10-05
PCT/US2007/021156 WO2008045238A2 (en) 2006-10-05 2007-10-02 Stabilized therapeutic small helical antiviral peptides

Publications (2)

Publication Number Publication Date
JP2010505831A true JP2010505831A (ja) 2010-02-25
JP2010505831A5 JP2010505831A5 (enExample) 2011-07-14

Family

ID=39283347

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009531418A Pending JP2010505831A (ja) 2006-10-05 2007-10-02 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド

Country Status (8)

Country Link
US (1) US8940864B2 (enExample)
EP (2) EP2517720A1 (enExample)
JP (1) JP2010505831A (enExample)
AU (1) AU2007307254A1 (enExample)
CA (1) CA2665186A1 (enExample)
ES (1) ES2387827T3 (enExample)
WO (1) WO2008045238A2 (enExample)
ZA (1) ZA200901248B (enExample)

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WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도

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US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
WO2009137532A1 (en) * 2008-05-06 2009-11-12 New York Blood Center Antiviral cell penetrating peptides
CA2737916A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BRPI1006139A2 (pt) 2009-01-14 2017-05-30 Aileron Therapeutics Inc macrociclos peptidomiméticos
KR20180058866A (ko) 2010-08-13 2018-06-01 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
BR112014009418A2 (pt) 2011-10-18 2017-04-18 Aileron Therapeutics Inc macrociclos peptidomiméticos
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN112500466B (zh) 2012-02-15 2022-05-03 艾瑞朗医疗公司 拟肽大环化合物
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017018595A1 (ko) * 2015-07-28 2017-02-02 동국대학교 산학협력단 이중 스테이플화된 펩타이드 및 이의 용도
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
WO2019133179A2 (en) * 2017-12-01 2019-07-04 Massachusetts Institute Of Technology Solution-phase affinity selection of inhibitors from combinatorial peptide libraries
US20200102356A1 (en) * 2018-10-01 2020-04-02 NMC Inc. Compositions and Methods for the Treatment of Huanglongbing (HLB) aka Citrus Greening in Citrus Plants
WO2022036049A2 (en) * 2020-08-12 2022-02-17 New York Blood Center, Inc. Antiviral stapled peptides against sars-cov-2

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US6187548B1 (en) * 1993-05-23 2001-02-13 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods using human calcium sensor protein, fragments thereof and DNA encoding same
US6239270B1 (en) * 1993-05-24 2001-05-29 Rhone-Poulenc Rorer S.A. Nucleic acids encoding human calcium sensor protein
CN1351653A (zh) * 1999-04-09 2002-05-29 法玛西雅厄普约翰美国公司 抗细菌疫苗组合物
US6790950B2 (en) * 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US20020164655A1 (en) * 2000-10-17 2002-11-07 Myriad Genetics, Inc. Protein-protein interactions in neurodegenerative diseases
ES2437567T3 (es) * 2003-11-05 2014-01-13 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales estabilizados y utilizaciones de los mismos
US10005821B2 (en) * 2004-10-07 2018-06-26 The Board Of Trustees Of The University Of Illinois Modifications of cupredoxin derived peptides and methods of use thereof
WO2008008998A2 (en) * 2006-07-13 2008-01-17 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways
US20100159477A1 (en) * 2006-07-13 2010-06-24 Peter Hornbeck Reagents for the detection of protein phosphorylation in signaling pathways
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
JP5078401B2 (ja) * 2007-03-27 2012-11-21 株式会社Adeka 防水シート
CA2700925C (en) * 2007-09-26 2016-08-23 Dana Farber Cancer Institute Methods and compositions for modulating bcl-2 family polypeptides
WO2009108261A2 (en) * 2008-01-23 2009-09-03 Dana Farber Cancer Institute Compositions and methods for the treatment of viral infections
WO2009137532A1 (en) * 2008-05-06 2009-11-12 New York Blood Center Antiviral cell penetrating peptides
WO2010042225A2 (en) * 2008-10-10 2010-04-15 Dana Farber Cancer Institute Chemical modulators of pro-apoptotic bax and bcl-2 polypeptides

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JPN6012039229; Nat.Struct.Mol.Biol.,2005,12(8),p.678-82 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도

Also Published As

Publication number Publication date
ES2387827T3 (es) 2012-10-02
EP2073829A2 (en) 2009-07-01
WO2008045238A3 (en) 2008-07-24
AU2007307254A1 (en) 2008-04-17
US8940864B2 (en) 2015-01-27
ZA200901248B (en) 2010-04-28
US20100130430A1 (en) 2010-05-27
WO2008045238A2 (en) 2008-04-17
EP2073829A4 (en) 2010-03-03
EP2517720A1 (en) 2012-10-31
CA2665186A1 (en) 2008-04-17
EP2073829B1 (en) 2012-06-20

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