JP2010504983A - 核酸を鋳型とする化学による生物学的検出のための組成物および方法 - Google Patents

核酸を鋳型とする化学による生物学的検出のための組成物および方法 Download PDF

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JP2010504983A
JP2010504983A JP2009530463A JP2009530463A JP2010504983A JP 2010504983 A JP2010504983 A JP 2010504983A JP 2009530463 A JP2009530463 A JP 2009530463A JP 2009530463 A JP2009530463 A JP 2009530463A JP 2010504983 A JP2010504983 A JP 2010504983A
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alkyl
oligonucleotide
nucleic acid
reaction
dna
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ユメイ ファン，
ジェイムズ エム． コウル，
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アンサンブル ディスカバリー コーポレイション
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Priority claimed from PCT/US2007/020223 external-priority patent/WO2008036273A2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0091—Methine or polymethine dyes, e.g. cyanine dyes having only one heterocyclic ring at one end of the methine chain, e.g. hemicyamines, hemioxonol
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10—The polymethine chain containing an even number of >CH- groups
    • C09B23/105—The polymethine chain containing an even number of >CH- groups two >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
JP2009530463A 2006-09-28 2007-09-28 核酸を鋳型とする化学による生物学的検出のための組成物および方法 Pending JP2010504983A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US84785906P 2006-09-28 2006-09-28
US90536407P 2007-03-07 2007-03-07
US91802307P 2007-03-14 2007-03-14
PCT/US2007/020223 WO2008036273A2 (en) 2006-09-18 2007-09-18 Receptor family profiling
PCT/US2007/021094 WO2008054600A2 (en) 2006-09-28 2007-09-28 Compositions and methods for biodetection by nucleic acid-templated chemistry

Publications (1)

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JP2010504983A true JP2010504983A (ja) 2010-02-18

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US (1) US8071388B2 (US08071388-20111206-C00003.png)
EP (1) EP2066813A2 (US08071388-20111206-C00003.png)
JP (1) JP2010504983A (US08071388-20111206-C00003.png)
AU (1) AU2007314516A1 (US08071388-20111206-C00003.png)
CA (1) CA2664649A1 (US08071388-20111206-C00003.png)
WO (1) WO2008054600A2 (US08071388-20111206-C00003.png)

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WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
EP1487978B1 (en) 2002-03-15 2008-11-19 Nuevolution A/S An improved method for synthesising templated molecules
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
ES2368215T3 (es) 2002-10-30 2011-11-15 Nuevolution A/S Codificación enzimática.
EP1756277B1 (en) 2002-12-19 2009-12-02 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074429A2 (en) 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
US11118215B2 (en) 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US7968289B2 (en) * 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
JP2010503860A (ja) * 2006-09-18 2010-02-04 アンサンブル ディスカバリー コーポレイション 受容体ファミリーのプロファイリング
WO2009018003A2 (en) * 2007-07-27 2009-02-05 Ensemble Discovery Corporation Detection assays and use thereof
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
US20110059458A1 (en) * 2008-02-22 2011-03-10 Yumei Huang Compositions and methods for catalyzing dna-programmed chemistry
DK2558577T3 (en) 2010-04-16 2019-04-01 Nuevolution As Bi-functional complexes and methods for the preparation and use of such complexes
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2014108836A1 (en) 2013-01-09 2014-07-17 Actelion Pharmaceuticals Ltd Antibacterial oxadiazolone derivatives
CN103113283A (zh) * 2013-01-22 2013-05-22 天津理工大学 一种含给电子基团半菁蓝素温敏分子光学探针的制备方法
CN103113282A (zh) * 2013-01-22 2013-05-22 天津理工大学 一种含吸电子基团半菁蓝素温敏分子光学探针的制备方法
CN104849253B (zh) * 2014-06-11 2017-07-18 南方医科大学 苯并吲哚半菁染料检测葡萄糖的用途
EP3218479A1 (en) 2014-11-11 2017-09-20 Nanocore ApS Method for identification of molecules with desired characteristics
US11186719B2 (en) 2018-05-04 2021-11-30 Li-Cor, Inc. Hemicyanine dyes
WO2019213543A1 (en) * 2018-05-04 2019-11-07 Li-Cor, Inc. 2-[2-[4-[bis(2-sulfoethyl)amino]phenyl]ethenyl]-1-butyl-3,3-dimethyl-3h-indolium hemicyanine dyes for the detection of antibodies and other biomolecules
CN110862340B (zh) * 2019-11-19 2021-07-27 西北大学 一种探针分子的合成方法

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US2398999A (en) * 1942-09-01 1946-04-23 Eastman Kodak Co Polymethine dyes
US2734901A (en) * 1956-02-14 Process of preparing evdotlum
US3394130A (en) * 1965-07-17 1968-07-23 Eastman Kodak Co Quaternary methine compounds
GB1229429A (US08071388-20111206-C00003.png) * 1967-04-26 1971-04-21
JPS4836281A (US08071388-20111206-C00003.png) * 1971-09-03 1973-05-28
JPS5071326A (US08071388-20111206-C00003.png) * 1973-06-18 1975-06-13
US3890307A (en) * 1973-04-02 1975-06-17 Eastman Kodak Co Process for the production of methine dyes
JPH02245200A (ja) * 1989-02-13 1990-09-28 Miles Inc 発色性メロシアニン酵素基質
JPH0718586A (ja) * 1993-06-28 1995-01-20 Bayer Ag プラスチツクスのバルク染色法
JPH08100129A (ja) * 1994-09-30 1996-04-16 Matsushita Electric Ind Co Ltd メロシアニン系標識色素、その前駆体化合物及びメロシアニン系標識色素の合成方法、並びにメロシアニン標識タンパク質
JP2003234133A (ja) * 2002-02-06 2003-08-22 National Institute Of Advanced Industrial & Technology スチリル色素を光増感剤とする半導体電極、光電変換素子及び光電気化学太陽電池
JP2004184282A (ja) * 2002-12-04 2004-07-02 Matsushita Electric Ind Co Ltd 色素標識化合物およびこれを用いた糖化ヘモグロビンの測定方法
JP2006294360A (ja) * 2005-04-08 2006-10-26 Nippon Kayaku Co Ltd 色素増感光電変換素子
JP2008545416A (ja) * 2005-05-26 2008-12-18 アンサンブル ディスカバリー コーポレイション 核酸を鋳型とする化学による生物学的検出
JP2009511531A (ja) * 2005-10-11 2009-03-19 チバ ホールディング インコーポレーテッド スルフィド染料の混合物
JP2011098973A (ja) * 1999-09-14 2011-05-19 Hayashibara Biochem Lab Inc スチリル色素

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JP2010503860A (ja) 2006-09-18 2010-02-04 アンサンブル ディスカバリー コーポレイション 受容体ファミリーのプロファイリング
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734901A (en) * 1956-02-14 Process of preparing evdotlum
US2398999A (en) * 1942-09-01 1946-04-23 Eastman Kodak Co Polymethine dyes
US3394130A (en) * 1965-07-17 1968-07-23 Eastman Kodak Co Quaternary methine compounds
GB1229429A (US08071388-20111206-C00003.png) * 1967-04-26 1971-04-21
JPS4836281A (US08071388-20111206-C00003.png) * 1971-09-03 1973-05-28
JPS5685746A (en) * 1971-09-03 1981-07-13 Minnesota Mining & Mfg Image forming composition
US3890307A (en) * 1973-04-02 1975-06-17 Eastman Kodak Co Process for the production of methine dyes
JPS5071326A (US08071388-20111206-C00003.png) * 1973-06-18 1975-06-13
JPH02245200A (ja) * 1989-02-13 1990-09-28 Miles Inc 発色性メロシアニン酵素基質
JPH0718586A (ja) * 1993-06-28 1995-01-20 Bayer Ag プラスチツクスのバルク染色法
JPH08100129A (ja) * 1994-09-30 1996-04-16 Matsushita Electric Ind Co Ltd メロシアニン系標識色素、その前駆体化合物及びメロシアニン系標識色素の合成方法、並びにメロシアニン標識タンパク質
JP2011098973A (ja) * 1999-09-14 2011-05-19 Hayashibara Biochem Lab Inc スチリル色素
JP2003234133A (ja) * 2002-02-06 2003-08-22 National Institute Of Advanced Industrial & Technology スチリル色素を光増感剤とする半導体電極、光電変換素子及び光電気化学太陽電池
JP2004184282A (ja) * 2002-12-04 2004-07-02 Matsushita Electric Ind Co Ltd 色素標識化合物およびこれを用いた糖化ヘモグロビンの測定方法
JP2006294360A (ja) * 2005-04-08 2006-10-26 Nippon Kayaku Co Ltd 色素増感光電変換素子
JP2008545416A (ja) * 2005-05-26 2008-12-18 アンサンブル ディスカバリー コーポレイション 核酸を鋳型とする化学による生物学的検出
JP2009511531A (ja) * 2005-10-11 2009-03-19 チバ ホールディング インコーポレーテッド スルフィド染料の混合物

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WO2008054600A3 (en) 2009-04-16
EP2066813A2 (en) 2009-06-10
WO2008054600A2 (en) 2008-05-08
AU2007314516A1 (en) 2008-05-08
US8071388B2 (en) 2011-12-06
CA2664649A1 (en) 2008-05-08
US20090275142A1 (en) 2009-11-05

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