JP2010503689A5 - - Google Patents
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- Publication number
- JP2010503689A5 JP2010503689A5 JP2009528340A JP2009528340A JP2010503689A5 JP 2010503689 A5 JP2010503689 A5 JP 2010503689A5 JP 2009528340 A JP2009528340 A JP 2009528340A JP 2009528340 A JP2009528340 A JP 2009528340A JP 2010503689 A5 JP2010503689 A5 JP 2010503689A5
- Authority
- JP
- Japan
- Prior art keywords
- tsh
- patient
- pharmaceutical composition
- pharmaceutically acceptable
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims description 22
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 9
- 229920001661 Chitosan Polymers 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 4
- 229940105329 carboxymethylcellulose Drugs 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
- 229920001817 Agar Polymers 0.000 claims description 2
- 229920000936 Agarose Polymers 0.000 claims description 2
- 229920000945 Amylopectin Polymers 0.000 claims description 2
- 229920000856 Amylose Polymers 0.000 claims description 2
- 229920002567 Chondroitin Polymers 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229920000896 Ethulose Polymers 0.000 claims description 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 2
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002971 Heparan sulfate Polymers 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920000037 Polyproline Polymers 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 239000008272 agar Substances 0.000 claims description 2
- 235000010419 agar Nutrition 0.000 claims description 2
- 229940072056 alginate Drugs 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 2
- 235000010418 carrageenan Nutrition 0.000 claims description 2
- 239000000679 carrageenan Substances 0.000 claims description 2
- 229920001525 carrageenan Polymers 0.000 claims description 2
- 229940113118 carrageenan Drugs 0.000 claims description 2
- 229920002678 cellulose Chemical class 0.000 claims description 2
- 239000001913 cellulose Chemical class 0.000 claims description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 239000008273 gelatin Substances 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920003063 hydroxymethyl cellulose Polymers 0.000 claims description 2
- 229940031574 hydroxymethyl cellulose Drugs 0.000 claims description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229960003943 hypromellose Drugs 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 108010026466 polyproline Proteins 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 210000002966 serum Anatomy 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 210000001685 thyroid gland Anatomy 0.000 claims 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 5
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 5
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 229940094517 chondroitin 4-sulfate Drugs 0.000 claims 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 glycosa Nogurikan Polymers 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84607706P | 2006-09-19 | 2006-09-19 | |
| PCT/US2007/020221 WO2008036271A1 (en) | 2006-09-19 | 2007-09-18 | Formulations for therapeutic administration of thyroid stimulating hormone (tsh) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010503689A JP2010503689A (ja) | 2010-02-04 |
| JP2010503689A5 true JP2010503689A5 (enExample) | 2010-11-11 |
Family
ID=39018092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009528340A Pending JP2010503689A (ja) | 2006-09-19 | 2007-09-18 | 甲状腺刺激ホルモン（ｔｓｈ）の治療的投与のための配合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100048455A1 (enExample) |
| EP (1) | EP2063909B1 (enExample) |
| JP (1) | JP2010503689A (enExample) |
| AR (1) | AR062894A1 (enExample) |
| BR (1) | BRPI0717077A2 (enExample) |
| CA (1) | CA2663323A1 (enExample) |
| DK (1) | DK2063909T3 (enExample) |
| ES (1) | ES2396502T3 (enExample) |
| MX (1) | MX2009002985A (enExample) |
| PL (1) | PL2063909T3 (enExample) |
| PT (1) | PT2063909E (enExample) |
| SI (1) | SI2063909T1 (enExample) |
| WO (1) | WO2008036271A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2793948B1 (en) * | 2011-12-19 | 2022-03-23 | Genzyme Corporation | Thyroid stimulating hormone compositions |
| ES2947985T3 (es) * | 2017-12-14 | 2023-08-25 | The London Psychiatry Centre | Tratamiento de la depresión resistente mediante la aplicación de estimulación magnética transcraneal repetitiva con tratamiento con hormona tiroidea |
| CN113740523A (zh) * | 2021-09-14 | 2021-12-03 | 首都医科大学附属北京朝阳医院 | 一种基于量值溯源的tsh多系统赋值方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0228604A3 (en) * | 1985-12-11 | 1988-10-12 | Sloan-Kettering Institute For Cancer Research | Isolation of a gene encoding human thyrotropin beta subunit |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| KR100642599B1 (ko) * | 1997-09-22 | 2006-11-10 | 유니버시티 어브 메릴랜드, 발티모어 | 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법 |
| CN1321092A (zh) * | 1998-06-30 | 2001-11-07 | 安姆根有限公司 | 用于生物活性剂的延缓给药的热敏生物可降解水凝胶 |
| ITMI20011401A1 (it) * | 2001-07-02 | 2003-01-02 | Altergon Sa | Formulazioni farmaceutiche per ormoni tiroidei |
| US20080167223A1 (en) * | 2004-04-16 | 2008-07-10 | Mount Sinai School Of Medicine | Methods and Compositions for Using Tsh in the Inhibition of Tnf Activity |
-
2007
- 2007-09-18 ES ES07838433T patent/ES2396502T3/es active Active
- 2007-09-18 EP EP07838433A patent/EP2063909B1/en not_active Not-in-force
- 2007-09-18 CA CA002663323A patent/CA2663323A1/en not_active Abandoned
- 2007-09-18 DK DK07838433.6T patent/DK2063909T3/da active
- 2007-09-18 PT PT78384336T patent/PT2063909E/pt unknown
- 2007-09-18 MX MX2009002985A patent/MX2009002985A/es active IP Right Grant
- 2007-09-18 SI SI200731102T patent/SI2063909T1/sl unknown
- 2007-09-18 PL PL07838433T patent/PL2063909T3/pl unknown
- 2007-09-18 US US12/441,836 patent/US20100048455A1/en not_active Abandoned
- 2007-09-18 BR BRPI0717077-7A patent/BRPI0717077A2/pt active Search and Examination
- 2007-09-18 JP JP2009528340A patent/JP2010503689A/ja active Pending
- 2007-09-18 WO PCT/US2007/020221 patent/WO2008036271A1/en not_active Ceased
- 2007-09-19 AR ARP070104133A patent/AR062894A1/es unknown
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