JP2010503382A - 低分子干渉核酸（ｓｉＮＡ）を用いたプロタンパク質転換酵素サブチリシンケクシン９（ＰＣＳＫ９）遺伝子発現のＲＮＡ干渉媒介性阻害 - Google Patents

低分子干渉核酸（ｓｉＮＡ）を用いたプロタンパク質転換酵素サブチリシンケクシン９（ＰＣＳＫ９）遺伝子発現のＲＮＡ干渉媒介性阻害 Download PDF

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JP2010503382A
JP2010503382A JP2009520964A JP2009520964A JP2010503382A JP 2010503382 A JP2010503382 A JP 2010503382A JP 2009520964 A JP2009520964 A JP 2009520964A JP 2009520964 A JP2009520964 A JP 2009520964A JP 2010503382 A JP2010503382 A JP 2010503382A
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nucleotide
nucleic acid
nucleotides
sina
strand
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マクスウイゲン，ジエイムズ
ジヤダブ，バサント
バルギーズ，チヤンドラ
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Sirna Therapeutics Inc
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JP2009520964A 2006-07-17 2007-07-17 低分子干渉核酸（ｓｉＮＡ）を用いたプロタンパク質転換酵素サブチリシンケクシン９（ＰＣＳＫ９）遺伝子発現のＲＮＡ干渉媒介性阻害 Withdrawn JP2010503382A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/487,788 US20070173473A1 (en) 2001-05-18 2006-07-17 RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA)
US86136906P 2006-11-28 2006-11-28
PCT/US2007/073723 WO2008011431A2 (en) 2006-07-17 2007-07-17 Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina)

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JP2010503382A true JP2010503382A (ja) 2010-02-04
JP2010503382A5 JP2010503382A5 (cg-RX-API-DMAC7.html) 2010-03-25

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EP (1) EP2052079A2 (cg-RX-API-DMAC7.html)
JP (1) JP2010503382A (cg-RX-API-DMAC7.html)
CN (1) CN102124107A (cg-RX-API-DMAC7.html)
AU (1) AU2007275365A1 (cg-RX-API-DMAC7.html)
CA (1) CA2658183A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008011431A2 (cg-RX-API-DMAC7.html)

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JP2013118839A (ja) * 2011-12-07 2013-06-17 Bio Think Tank Co Ltd 遺伝子発現阻害剤及び阻害方法
JP2014511692A (ja) * 2011-04-08 2014-05-19 バイオ−ラッド ラボラトリーズ インコーポレーティッド 非特異的活性が低下したｐｃｒ反応混合物
JP2016506240A (ja) * 2012-12-05 2016-03-03 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法
WO2018062510A1 (ja) * 2016-09-29 2018-04-05 国立大学法人東京医科歯科大学 オーバーハングを有する二本鎖核酸複合体
JP2021521796A (ja) * 2018-04-18 2021-08-30 ディセルナ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症及び関連状態を治療するための、ｐｃｓｋ９を標的とするオリゴヌクレオチド
JP2022546040A (ja) * 2019-08-27 2022-11-02 サノフイ Ｐｃｓｋ９を阻害するための組成物および方法

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US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
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EP2835429B1 (en) 2006-05-11 2017-12-13 Alnylam Pharmaceuticals Inc. Compositions and methods for inhibiting expression of the PCSK9 gene
EP2076597A2 (en) * 2006-10-09 2009-07-08 Santaris Pharma A/S Rna antagonist compounds for the modulation of pcsk9
US8093222B2 (en) 2006-11-27 2012-01-10 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
US8084437B2 (en) 2006-11-27 2011-12-27 Isis Pharmaceuticals, Inc. Methods for treating hypercholesterolemia
EP2245039A4 (en) * 2008-01-31 2012-06-06 Alnylam Pharmaceuticals Inc OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN
WO2009114475A2 (en) * 2008-03-09 2009-09-17 Intradigm Corporation Compositions comprising human pcsk9 and apolipoprotein b sirna and methods of use
WO2009127680A1 (en) * 2008-04-16 2009-10-22 Santaris Pharma A/S Pharmaceutical composition comprising anti pcsk9 oligomers
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
EP2331071A1 (en) 2008-09-05 2011-06-15 Institut National De La Sante Et De La Recherche Medicale Novel multimodular assembly useful for intracellular delivery
US9051567B2 (en) 2009-06-15 2015-06-09 Tekmira Pharmaceuticals Corporation Methods for increasing efficacy of lipid formulated siRNA
NZ597504A (en) 2009-06-15 2013-10-25 Alnylam Pharmaceuticals Inc Lipid formulated dsrna targeting the pcsk9 gene
EP2456870A1 (en) 2009-07-21 2012-05-30 Santaris Pharma A/S Antisense oligomers targeting pcsk9
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JP7273417B2 (ja) 2017-12-01 2023-05-15 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用
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JP7727308B2 (ja) 2017-12-01 2025-08-21 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物および複合体ならびに調製方法と使用
JP7365052B2 (ja) 2017-12-01 2023-10-19 スーチョウ リボ ライフ サイエンス カンパニー、リミテッド 核酸、当該核酸を含む組成物及び複合体ならびに調製方法と使用
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CN109666727B (zh) * 2018-12-29 2020-11-06 中国药科大学 一种高活性抑制pcsk9表达的微小rna的用途
JP7574206B2 (ja) * 2019-03-20 2024-10-28 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ステロール調節エレメント結合転写因子１（ｓｒｅｂｆ１）阻害剤による上昇した脂質レベルの治療
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JP2014511692A (ja) * 2011-04-08 2014-05-19 バイオ−ラッド ラボラトリーズ インコーポレーティッド 非特異的活性が低下したｐｃｒ反応混合物
US9556423B2 (en) 2011-04-08 2017-01-31 Bio-Rad Laboratories, Inc. PCR reaction mixtures with decreased non-specific activity
JP2013118839A (ja) * 2011-12-07 2013-06-17 Bio Think Tank Co Ltd 遺伝子発現阻害剤及び阻害方法
JP7239335B2 (ja) 2012-12-05 2023-03-14 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2016506240A (ja) * 2012-12-05 2016-03-03 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法
JP2019103501A (ja) * 2012-12-05 2019-06-27 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP7670747B2 (ja) 2012-12-05 2025-04-30 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
JP2023103244A (ja) * 2012-12-05 2023-07-26 アルナイラム ファーマシューティカルズ， インコーポレイテッド ＰＣＳＫ９ ｉＲＮＡ組成物及びその使用方法
WO2018062510A1 (ja) * 2016-09-29 2018-04-05 国立大学法人東京医科歯科大学 オーバーハングを有する二本鎖核酸複合体
JP7129702B2 (ja) 2016-09-29 2022-09-02 国立大学法人 東京医科歯科大学 オーバーハングを有する二本鎖核酸複合体
US11260134B2 (en) 2016-09-29 2022-03-01 National University Corporation Tokyo Medical And Dental University Double-stranded nucleic acid complex having overhang
JPWO2018062510A1 (ja) * 2016-09-29 2019-07-18 国立大学法人 東京医科歯科大学 オーバーハングを有する二本鎖核酸複合体
JP2021521796A (ja) * 2018-04-18 2021-08-30 ディセルナ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症及び関連状態を治療するための、ｐｃｓｋ９を標的とするオリゴヌクレオチド
JP7357002B2 (ja) 2018-04-18 2023-10-05 ディセルナ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症及び関連状態を治療するための、ｐｃｓｋ９を標的とするオリゴヌクレオチド
JP2023174697A (ja) * 2018-04-18 2023-12-08 ディセルナ ファーマシューティカルズ インコーポレイテッド 高コレステロール血症及び関連状態を治療するための、ｐｃｓｋ９を標的とするオリゴヌクレオチド
JP2022546040A (ja) * 2019-08-27 2022-11-02 サノフイ Ｐｃｓｋ９を阻害するための組成物および方法
JP2025013845A (ja) * 2019-08-27 2025-01-28 サノフイ Ｐｃｓｋ９を阻害するための組成物および方法

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