JP2010502738A - ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法 - Google Patents
ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法 Download PDFInfo
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- JP2010502738A JP2010502738A JP2009527584A JP2009527584A JP2010502738A JP 2010502738 A JP2010502738 A JP 2010502738A JP 2009527584 A JP2009527584 A JP 2009527584A JP 2009527584 A JP2009527584 A JP 2009527584A JP 2010502738 A JP2010502738 A JP 2010502738A
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Otolaryngology (AREA)
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- Toxicology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US84266906P | 2006-09-07 | 2006-09-07 | |
| US84517106P | 2006-09-18 | 2006-09-18 | |
| PCT/US2007/077880 WO2008031028A2 (en) | 2006-09-07 | 2007-09-07 | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
Publications (2)
| Publication Number | Publication Date |
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| JP2010502738A true JP2010502738A (ja) | 2010-01-28 |
| JP2010502738A5 JP2010502738A5 (https=) | 2010-10-21 |
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| JP2009527584A Pending JP2010502738A (ja) | 2006-09-07 | 2007-09-07 | ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8058278B2 (https=) |
| EP (1) | EP2059237A4 (https=) |
| JP (1) | JP2010502738A (https=) |
| KR (1) | KR20090065508A (https=) |
| AR (1) | AR062741A1 (https=) |
| AU (1) | AU2007294547A1 (https=) |
| BR (1) | BRPI0716884A2 (https=) |
| CA (1) | CA2663041A1 (https=) |
| EA (1) | EA200970258A1 (https=) |
| MX (1) | MX2009002602A (https=) |
| TW (1) | TW200817343A (https=) |
| WO (1) | WO2008031028A2 (https=) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010502739A (ja) * | 2006-09-07 | 2010-01-28 | パリオン・サイエンシィズ・インコーポレーテッド | ナトリウムチャネル阻害剤及び浸透圧調節物質を用いた処置による粘膜水和及び粘液クリアランスの改善 |
| JP2011500860A (ja) * | 2007-10-31 | 2011-01-06 | ビトップ アクチエンゲゼルシャフト | 乾燥した粘膜での適用のためのオスモライト含有調製物 |
| JP2014518268A (ja) * | 2011-06-27 | 2014-07-28 | パリオン・サイエンシィズ・インコーポレーテッド | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
| JP2016503028A (ja) * | 2012-12-17 | 2016-02-01 | パリオン・サイエンシィズ・インコーポレーテッド | 粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体 |
| JP2016503027A (ja) * | 2012-12-17 | 2016-02-01 | パリオン・サイエンシィズ・インコーポレーテッド | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−フェニルブチル）カルバムイミドイル）ピラジン−２−カルボキサミド化合物 |
| JP2016503031A (ja) * | 2012-12-17 | 2016-02-01 | パリオン・サイエンシィズ・インコーポレーテッド | アリールアルキル及びアリールオキシアルキル置換の上皮ナトリウムチャネル遮断化合物 |
| US9586911B2 (en) | 2013-12-13 | 2017-03-07 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epthelial sodium channel blocking compounds |
| US10167266B2 (en) | 2002-02-19 | 2019-01-01 | Parion Sciences, Inc. | Sodium channel blockers |
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| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| ES2432529T3 (es) * | 2003-08-18 | 2013-12-04 | Parion Sciences, Inc. | Bloqueadores del canal de sodio de pirazinoilguanidina rematada |
| WO2006016530A1 (ja) * | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) * | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| WO2007146867A2 (en) * | 2006-06-09 | 2007-12-21 | Parion Sciences Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| PL2035004T3 (pl) * | 2006-06-09 | 2013-01-31 | Parion Sciences Inc | Podstawione fenylem pirazynoiloguanidynowe blokery kanału sodowego o aktywności beta-agonistycznej |
| CN101668544B (zh) | 2006-12-26 | 2013-04-24 | 株式会社新日本科学 | 经鼻投用制剂 |
| US8288391B2 (en) * | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| WO2008124496A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
| DE102007040615A1 (de) * | 2007-08-27 | 2009-03-05 | Bitop Ag | Osmolyte zur Behandlung von allergisch oder viral bedingten Atemwegserkrankungen |
| CA2702094C (en) | 2007-10-10 | 2018-05-01 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| ES2485642T3 (es) | 2008-02-26 | 2014-08-14 | Parion Sciences, Inc. | Bloqueantes poli-aromáticos de los canales de sodio |
| WO2009126695A2 (en) * | 2008-04-08 | 2009-10-15 | Dynamis Therapeutics, Inc. | Method for treating or preventing dry eye disorders using alkylamino-polyhydroxyalkanes |
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| CN103687488B (zh) | 2011-06-27 | 2015-06-10 | 帕里昂科学公司 | 化学和代谢稳定的具有钠通道阻滞剂活性的二肽 |
| HUE039734T2 (hu) | 2012-05-29 | 2019-01-28 | Parion Sciences Inc | Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére |
| WO2014036445A2 (en) * | 2012-08-31 | 2014-03-06 | Johnson Michael R | Novel mucolytic agents |
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| MX368243B (es) | 2013-08-23 | 2019-09-25 | Parion Sciences Inc | Agentes mucolíticos de ditiol. |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CA2974210A1 (en) | 2015-01-30 | 2016-08-04 | Parion Sciences, Inc. | Novel monothiol mucolytic agents |
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-
2007
- 2007-09-07 EA EA200970258A patent/EA200970258A1/ru unknown
- 2007-09-07 MX MX2009002602A patent/MX2009002602A/es unknown
- 2007-09-07 CA CA002663041A patent/CA2663041A1/en not_active Abandoned
- 2007-09-07 EP EP07842049A patent/EP2059237A4/en not_active Withdrawn
- 2007-09-07 WO PCT/US2007/077880 patent/WO2008031028A2/en not_active Ceased
- 2007-09-07 AR ARP070103971A patent/AR062741A1/es unknown
- 2007-09-07 BR BRPI0716884-5A2A patent/BRPI0716884A2/pt not_active IP Right Cessation
- 2007-09-07 KR KR1020097004814A patent/KR20090065508A/ko not_active Withdrawn
- 2007-09-07 US US11/851,803 patent/US8058278B2/en not_active Expired - Fee Related
- 2007-09-07 AU AU2007294547A patent/AU2007294547A1/en not_active Abandoned
- 2007-09-07 JP JP2009527584A patent/JP2010502738A/ja active Pending
- 2007-09-07 TW TW096133769A patent/TW200817343A/zh unknown
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| JPN6013001145; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４９， Ｎｏ．１４, 20060713, ｐ．４０９８-４１１５ * |
| JPN6013001148; Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．３５４， Ｎｏ．３, 20060119, ｐ．２２９-２４０ * |
| JPN6013001150; Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．３５４， Ｎｏ．３, 20060119, ｐ．２４１-２５０ * |
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| JP2011500860A (ja) * | 2007-10-31 | 2011-01-06 | ビトップ アクチエンゲゼルシャフト | 乾燥した粘膜での適用のためのオスモライト含有調製物 |
| JP2014518268A (ja) * | 2011-06-27 | 2014-07-28 | パリオン・サイエンシィズ・インコーポレーテッド | ３，５−ジアミノ−６−クロロ−ｎ−（ｎ−（４−（４−（２−（ヘキシル（２，３，４，５，６−ペンタヒドロキシヘキシル）アミノ）エトキシ）フェニル）ブチル）カルバミミドイル）ピラジン−２−カルボキサミド |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2059237A2 (en) | 2009-05-20 |
| MX2009002602A (es) | 2009-05-28 |
| WO2008031028A3 (en) | 2008-11-13 |
| WO2008031028A2 (en) | 2008-03-13 |
| KR20090065508A (ko) | 2009-06-22 |
| BRPI0716884A2 (pt) | 2013-10-15 |
| AU2007294547A2 (en) | 2009-03-19 |
| EA200970258A1 (ru) | 2009-08-28 |
| TW200817343A (en) | 2008-04-16 |
| US20080090841A1 (en) | 2008-04-17 |
| EP2059237A4 (en) | 2010-06-30 |
| CA2663041A1 (en) | 2008-03-13 |
| AR062741A1 (es) | 2008-12-03 |
| AU2007294547A1 (en) | 2008-03-13 |
| US8058278B2 (en) | 2011-11-15 |
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