JP2010502738A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010502738A5 JP2010502738A5 JP2009527584A JP2009527584A JP2010502738A5 JP 2010502738 A5 JP2010502738 A5 JP 2010502738A5 JP 2009527584 A JP2009527584 A JP 2009527584A JP 2009527584 A JP2009527584 A JP 2009527584A JP 2010502738 A5 JP2010502738 A5 JP 2010502738A5
- Authority
- JP
- Japan
- Prior art keywords
- chor
- lower alkyl
- independently
- sodium channel
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YSHYUNBUWSXLBP-LBPRGKRZSA-N N[C@@H](COc1ccc(CCCCNC(NC(c2nc(Cl)c(N)nc2N)=O)=N)cc1)C(N)=O Chemical compound N[C@@H](COc1ccc(CCCCNC(NC(c2nc(Cl)c(N)nc2N)=O)=N)cc1)C(N)=O YSHYUNBUWSXLBP-LBPRGKRZSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84266906P | 2006-09-07 | 2006-09-07 | |
| US84517106P | 2006-09-18 | 2006-09-18 | |
| PCT/US2007/077880 WO2008031028A2 (en) | 2006-09-07 | 2007-09-07 | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010502738A JP2010502738A (ja) | 2010-01-28 |
| JP2010502738A5 true JP2010502738A5 (https=) | 2010-10-21 |
Family
ID=39158091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009527584A Pending JP2010502738A (ja) | 2006-09-07 | 2007-09-07 | ナトリウムチャネル遮断剤および浸透圧調節物質での処置により粘膜水和および粘膜クリアランスを増強する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8058278B2 (https=) |
| EP (1) | EP2059237A4 (https=) |
| JP (1) | JP2010502738A (https=) |
| KR (1) | KR20090065508A (https=) |
| AR (1) | AR062741A1 (https=) |
| AU (1) | AU2007294547A1 (https=) |
| BR (1) | BRPI0716884A2 (https=) |
| CA (1) | CA2663041A1 (https=) |
| EA (1) | EA200970258A1 (https=) |
| MX (1) | MX2009002602A (https=) |
| TW (1) | TW200817343A (https=) |
| WO (1) | WO2008031028A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| ES2432529T3 (es) * | 2003-08-18 | 2013-12-04 | Parion Sciences, Inc. | Bloqueadores del canal de sodio de pirazinoilguanidina rematada |
| WO2006016530A1 (ja) * | 2004-08-10 | 2006-02-16 | Translational Research, Ltd. | 速効性でかつ高い吸収性を可能とする経鼻投与用組成物 |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) * | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| WO2007146867A2 (en) * | 2006-06-09 | 2007-12-21 | Parion Sciences Inc. | Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity |
| PL2035004T3 (pl) * | 2006-06-09 | 2013-01-31 | Parion Sciences Inc | Podstawione fenylem pirazynoiloguanidynowe blokery kanału sodowego o aktywności beta-agonistycznej |
| WO2008031048A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
| CN101668544B (zh) | 2006-12-26 | 2013-04-24 | 株式会社新日本科学 | 经鼻投用制剂 |
| US8288391B2 (en) * | 2007-04-03 | 2012-10-16 | Parion Sciences, Inc. | Pyrazinoylguanidine compounds for use as taste modulators |
| WO2008124496A1 (en) * | 2007-04-03 | 2008-10-16 | Parion Sciences, Inc. | Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders |
| DE102007040615A1 (de) * | 2007-08-27 | 2009-03-05 | Bitop Ag | Osmolyte zur Behandlung von allergisch oder viral bedingten Atemwegserkrankungen |
| CA2702094C (en) | 2007-10-10 | 2018-05-01 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| DE102007052380A1 (de) * | 2007-10-31 | 2009-05-07 | Bitop Ag | Osmolythaltige Zubereitungen zur Anwendung bei trockenen Schleimhäuten |
| ES2485642T3 (es) | 2008-02-26 | 2014-08-14 | Parion Sciences, Inc. | Bloqueantes poli-aromáticos de los canales de sodio |
| WO2009126695A2 (en) * | 2008-04-08 | 2009-10-15 | Dynamis Therapeutics, Inc. | Method for treating or preventing dry eye disorders using alkylamino-polyhydroxyalkanes |
| US20100074881A1 (en) * | 2008-07-11 | 2010-03-25 | Parion Sciences, Inc. | Multiple nebulizer systems |
| US9101539B2 (en) * | 2009-05-15 | 2015-08-11 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal pharmaceutical compositions with improved pharmacokinetics |
| GB2472327B (en) | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Methods of Treatment |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| CN103687488B (zh) | 2011-06-27 | 2015-06-10 | 帕里昂科学公司 | 化学和代谢稳定的具有钠通道阻滞剂活性的二肽 |
| HUE039734T2 (hu) | 2012-05-29 | 2019-01-28 | Parion Sciences Inc | Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére |
| WO2014036445A2 (en) * | 2012-08-31 | 2014-03-06 | Johnson Michael R | Novel mucolytic agents |
| CA2894279A1 (en) * | 2012-12-07 | 2014-06-12 | Paul Boucher | Nasal cannula for delivery of aerosolized medicaments |
| CN108658876A (zh) | 2012-12-17 | 2018-10-16 | 帕里昂科学公司 | 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物 |
| ES2674665T3 (es) * | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| CA2895512C (en) | 2012-12-17 | 2021-10-19 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| MX368243B (es) | 2013-08-23 | 2019-09-25 | Parion Sciences Inc | Agentes mucolíticos de ditiol. |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| US20150376145A1 (en) | 2014-06-30 | 2015-12-31 | Parion Sciences, Inc. | Stable sodium channel blockers |
| CA2974210A1 (en) | 2015-01-30 | 2016-08-04 | Parion Sciences, Inc. | Novel monothiol mucolytic agents |
| CA2984424A1 (en) | 2015-04-30 | 2016-11-03 | Parion Sciences, Inc. | Novel prodrugs of dithiol mucolytic agents |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| AU654979B2 (en) | 1990-10-05 | 1994-12-01 | University Of North Carolina At Chapel Hill, The | Method of administering amiloride |
| AUPM411494A0 (en) | 1994-02-25 | 1994-03-24 | Central Sydney Area Health Service | Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum |
| US5656256A (en) | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| EP1143896B1 (en) | 1998-10-20 | 2006-12-13 | The University of North Carolina at Chapel Hill | Methods of hydrating the nasal mucosal surface |
| US6926911B1 (en) | 1998-12-22 | 2005-08-09 | The University Of North Carolina At Chapel Hill | Compounds and methods for the treatment of airway diseases and for the delivery of airway drugs |
| KR20020038694A (ko) | 1999-07-19 | 2002-05-23 | 프란시스 제이 메이어 | 소듐 채널 차단제의 콘쥬게이트 및 그 이용방법 |
| WO2001055390A1 (en) | 2000-01-28 | 2001-08-02 | Human Genome Sciences, Inc. | Human serpin polynucleotides, polypeptides, and antibodies |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| JP2007502829A (ja) | 2003-08-18 | 2007-02-15 | パリオン・サイエンシィズ・インコーポレーテッド | 環状ピラジノイルグアニジンナトリウムチャネルブロッカー |
| ES2432529T3 (es) | 2003-08-18 | 2013-12-04 | Parion Sciences, Inc. | Bloqueadores del canal de sodio de pirazinoilguanidina rematada |
| US7375107B2 (en) | 2003-08-18 | 2008-05-20 | Parion Sciences, Inc. | Alaphatic pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US7399766B2 (en) | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US7807834B2 (en) | 2005-08-03 | 2010-10-05 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| WO2008031048A2 (en) * | 2006-09-07 | 2008-03-13 | Parion Sciences, Inc. | Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes |
-
2007
- 2007-09-07 EA EA200970258A patent/EA200970258A1/ru unknown
- 2007-09-07 MX MX2009002602A patent/MX2009002602A/es unknown
- 2007-09-07 CA CA002663041A patent/CA2663041A1/en not_active Abandoned
- 2007-09-07 EP EP07842049A patent/EP2059237A4/en not_active Withdrawn
- 2007-09-07 WO PCT/US2007/077880 patent/WO2008031028A2/en not_active Ceased
- 2007-09-07 AR ARP070103971A patent/AR062741A1/es unknown
- 2007-09-07 BR BRPI0716884-5A2A patent/BRPI0716884A2/pt not_active IP Right Cessation
- 2007-09-07 KR KR1020097004814A patent/KR20090065508A/ko not_active Withdrawn
- 2007-09-07 US US11/851,803 patent/US8058278B2/en not_active Expired - Fee Related
- 2007-09-07 AU AU2007294547A patent/AU2007294547A1/en not_active Abandoned
- 2007-09-07 JP JP2009527584A patent/JP2010502738A/ja active Pending
- 2007-09-07 TW TW096133769A patent/TW200817343A/zh unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010502738A5 (https=) | ||
| KR102109223B1 (ko) | 안구 건조 및 다른 점막 질환의 치료를 위한 나트륨 채널 차단제 활성을 보유하는 덴드리머 유사 아미노 아미드 | |
| JP2020019812A5 (https=) | ||
| JP2010502739A5 (https=) | ||
| JP6392242B2 (ja) | 粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体 | |
| JP4805824B2 (ja) | キャップ化ピラジノイルグアニジンナトリウムチャネルブロッカー | |
| JP2009539882A5 (https=) | ||
| KR20060037450A (ko) | 사이클릭 피라지노일구아니딘 나트륨 채널 차단제 | |
| NZ599199A (en) | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same | |
| RU2018138195A (ru) | Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида | |
| JP2014530900A5 (https=) | ||
| AR062741A1 (es) | Metodo para aumentar la hidratacion de la mucosa y la evacuacion de l a mucosa mediante tratamiento con bloquadores de los canales del sodio y osmolitos | |
| US20070043012A1 (en) | Methods to enhance chemotherapy | |
| AR035611A1 (es) | 2 -azetidinonas sustituidas con azucares, composicion farmaceutica, un kit, uso de dichos compuestos para la fabricacion de medicamentos utiles como agentes hipocolesterolemicos. | |
| TW201920122A (zh) | ３，５－二胺基－６－氯－ｎ－（ｎ－（４－（４－（２－（己基（２，３，４，５，６－五羥基己基）胺基）乙氧基）苯基）丁基）甲脒基）吡－２－甲醯胺 | |
| RU2014115290A (ru) | Производные 1-фенил 2-пиридинилалкиловых спиртов в качестве ингибиторов | |
| JP2013520473A5 (https=) | ||
| JP2015509075A5 (https=) | ||
| JP2018505163A5 (https=) | ||
| JP2013526520A5 (https=) | ||
| JP2004502732A5 (https=) | ||
| JP2010505865A5 (https=) | ||
| JP2018520986A5 (https=) | ||
| KR102258465B1 (ko) | 아릴알킬- 및 아릴옥시알킬-치환된 상피 나트륨 채널 차단 화합물 | |
| UY32435A (es) | 5-(2-{[6-(2,2-difluoro-2-feniletoxi)hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona útil en el tratamiento de enfermedades pulmonares |