JP2018505163A5 - - Google Patents

Download PDF

Info

Publication number
JP2018505163A5
JP2018505163A5 JP2017538332A JP2017538332A JP2018505163A5 JP 2018505163 A5 JP2018505163 A5 JP 2018505163A5 JP 2017538332 A JP2017538332 A JP 2017538332A JP 2017538332 A JP2017538332 A JP 2017538332A JP 2018505163 A5 JP2018505163 A5 JP 2018505163A5
Authority
JP
Japan
Prior art keywords
acid
lower alkyl
treat
chor
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017538332A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018505163A (ja
JP6826038B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/015353 external-priority patent/WO2016123335A1/en
Publication of JP2018505163A publication Critical patent/JP2018505163A/ja
Publication of JP2018505163A5 publication Critical patent/JP2018505163A5/ja
Application granted granted Critical
Publication of JP6826038B2 publication Critical patent/JP6826038B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017538332A 2015-01-30 2016-01-28 新規モノチオール粘液溶解剤 Expired - Fee Related JP6826038B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109999P 2015-01-30 2015-01-30
US62/109,999 2015-01-30
PCT/US2016/015353 WO2016123335A1 (en) 2015-01-30 2016-01-28 Novel monothiol mucolytic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020168248A Division JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

Publications (3)

Publication Number Publication Date
JP2018505163A JP2018505163A (ja) 2018-02-22
JP2018505163A5 true JP2018505163A5 (https=) 2019-02-28
JP6826038B2 JP6826038B2 (ja) 2021-02-03

Family

ID=56544326

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017538332A Expired - Fee Related JP6826038B2 (ja) 2015-01-30 2016-01-28 新規モノチオール粘液溶解剤
JP2020168248A Active JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020168248A Active JP7112464B2 (ja) 2015-01-30 2020-10-05 新規モノチオール粘液溶解剤

Country Status (13)

Country Link
US (2) US10106551B2 (https=)
EP (1) EP3250548A4 (https=)
JP (2) JP6826038B2 (https=)
KR (1) KR20170108088A (https=)
CN (2) CN107614480B (https=)
AU (1) AU2016211440B2 (https=)
BR (1) BR112017016067A2 (https=)
CA (1) CA2974210A1 (https=)
IL (1) IL253501B (https=)
MX (1) MX387071B (https=)
SG (1) SG11201705790SA (https=)
WO (1) WO2016123335A1 (https=)
ZA (1) ZA201705122B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3123075C (en) 2013-03-14 2023-09-19 The Regents Of The University Of California Thiosaccharide mucolytic agents
MX368243B (es) 2013-08-23 2019-09-25 Parion Sciences Inc Agentes mucolíticos de ditiol.
CA2974210A1 (en) 2015-01-30 2016-08-04 Parion Sciences, Inc. Novel monothiol mucolytic agents
CA2984424A1 (en) 2015-04-30 2016-11-03 Parion Sciences, Inc. Novel prodrugs of dithiol mucolytic agents
EP3849620A4 (en) 2018-09-10 2022-08-17 The Regents of the University of California DITHIOL SACCHARIDE MUCOLYTICS AND USES THEREOF
EP3797783A1 (en) 2019-09-27 2021-03-31 Freie Universität Berlin Novel medical uses of thiol-functionalized polyglycerol derivatives
WO2021231397A1 (en) 2020-05-13 2021-11-18 The Regents Of The University Of California Thiosaccharides for use in treating coronavirus infection
CN112758902B (zh) * 2021-01-06 2022-01-28 西南科技大学 用于高效析氧反应的优化电子构型Co4N纳米片的制备方法
EP4717268A1 (en) 2024-09-30 2026-04-01 Freie Universität Berlin Particularly appropriate thiol-functionalized polyglycerol derivatives and their medical uses

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639635A (en) 1969-02-11 1972-02-01 Riker Laboratories Inc Process for the liquefaction of mucus
US3663690A (en) 1969-08-12 1972-05-16 Hoechst Co American Mucolytic composition and method of treatment of broncho-pulmonary disorders therewith
FR2155776B1 (https=) 1971-10-04 1974-11-15 Rech Pharmaceut Scient
BE789811A (fr) * 1971-10-07 1973-04-06 Bristol Myers Co 1,4-bis-acylpiperazines
FR2434149A1 (fr) * 1978-06-22 1980-03-21 Parcor Nouveaux derives de la l-cysteine
JPH01226866A (ja) * 1988-03-08 1989-09-11 Wako Pure Chem Ind Ltd メルカプトメチル化方法
FR2685323B1 (fr) * 1991-12-19 1994-04-08 Rhone Poulenc Chimie Mercaptomethylbenzylamines et leur utilisation dans la synthese de bisphenols.
US20010037037A1 (en) 1995-10-31 2001-11-01 Kurt Dietliker Oximesulfonic acid esters and the use thereof as latent sulfonic acids
JP2002012583A (ja) * 2000-04-28 2002-01-15 Sumitomo Chem Co Ltd アミン誘導体の製造方法
US6858614B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
AU2003210808A1 (en) 2002-03-06 2003-09-22 Duke University Methods and composition based on discovery of metabolism of nitroclycerin
DE60302454T2 (de) 2002-04-19 2006-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonisten-verbindungen mit stickoxid-donatoren-gruppen und reaktionsfähige sauerstoffspezies-fängergruppen und ihre verwendung bei der behandlung von atemwegsstörungen
PE20040801A1 (es) * 2002-12-12 2004-11-25 Hoffmann La Roche Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
JP2007502829A (ja) 2003-08-18 2007-02-15 パリオン・サイエンシィズ・インコーポレーテッド 環状ピラジノイルグアニジンナトリウムチャネルブロッカー
ES2432529T3 (es) 2003-08-18 2013-12-04 Parion Sciences, Inc. Bloqueadores del canal de sodio de pirazinoilguanidina rematada
US7375107B2 (en) 2003-08-18 2008-05-20 Parion Sciences, Inc. Alaphatic pyrazinoylguanidine sodium channel blockers
US20050090505A1 (en) 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20050059639A1 (en) 2003-09-11 2005-03-17 Wei Edward T. Ophthalmic compositions and method for treating eye discomfort and pain
WO2005094269A2 (en) 2004-03-24 2005-10-13 National Jewish Medical And Research Center Mucolytic and anti-elastase compounds and methods of use thereof
US20090324724A1 (en) 2004-08-18 2009-12-31 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
CA2575680A1 (en) 2004-08-18 2006-03-02 Michael R. Johnson Cyclic amide & ester pyrazinoylguanidine sodium channel blockers
US7399766B2 (en) 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7956059B2 (en) 2004-08-18 2011-06-07 Parion Sciences, Inc. Aliphatic amide and ester pyrazinoylguanidine sodium channel blockers
US7807834B2 (en) 2005-08-03 2010-10-05 Parion Sciences, Inc. Capped pyrazinoylguanidine sodium channel blockers
US20090192227A1 (en) 2005-08-24 2009-07-30 Rabindra Tirouvanziam N-Acetylcysteine Compositions and Methods for Treating Acute Exacerbations of Inflammatory Lung Disease
EP2007358A4 (en) 2006-04-04 2012-01-25 Stc Unm INFLATING PARTICLES FOR THE ADMINISTRATION OF A MEDICINAL PRODUCT
US7560588B2 (en) 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
CA2653773A1 (en) 2006-06-09 2007-12-21 Parion Sciences, Inc. Cyclic substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
PL2035004T3 (pl) 2006-06-09 2013-01-31 Parion Sciences Inc Podstawione fenylem pirazynoiloguanidynowe blokery kanału sodowego o aktywności beta-agonistycznej
WO2007146867A2 (en) 2006-06-09 2007-12-21 Parion Sciences Inc. Aliphatic pyrazinoylguanidine sodium channel blockers with beta agonist activity
EA200970258A1 (ru) 2006-09-07 2009-08-28 Пэрион Сайенсиз, Инк. Способ усиления гидратации слизистой оболочки и клиренса слизистой оболочки обработкой блокаторами натриевых каналов и осмолитами
WO2008031048A2 (en) 2006-09-07 2008-03-13 Parion Sciences, Inc. Enhanced mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
CN101534813A (zh) * 2006-09-07 2009-09-16 帕里昂科学公司 通过使用钠通道阻断剂和渗透调节剂的治疗来增加粘膜水化和粘液清除的方法
US20080131500A1 (en) 2006-12-04 2008-06-05 The Board Of Regents Of The University Of Texas System Methods and compositions for rapid inactivation of proteins
US8288391B2 (en) 2007-04-03 2012-10-16 Parion Sciences, Inc. Pyrazinoylguanidine compounds for use as taste modulators
WO2008124496A1 (en) 2007-04-03 2008-10-16 Parion Sciences, Inc. Method of treating acid-sensing ion channel mediated pain, cough, and central nervous system disorders
CA2702094C (en) 2007-10-10 2018-05-01 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
EP2234626A4 (en) 2007-12-19 2011-01-12 Pharmalundensis Ab METHOD AND MEANS FOR PRODUCING BRONCHORELAXATION
WO2009076792A1 (en) 2007-12-19 2009-06-25 Givaudan Sa Cooling compounds
ES2485642T3 (es) 2008-02-26 2014-08-14 Parion Sciences, Inc. Bloqueantes poli-aromáticos de los canales de sodio
US20100074881A1 (en) 2008-07-11 2010-03-25 Parion Sciences, Inc. Multiple nebulizer systems
EP2385839B1 (en) 2009-01-09 2014-11-26 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of corneal disorders
EP2210936A1 (en) 2009-01-27 2010-07-28 Curetis AG Processing and analysis of viscous liquid biological samples
EP2428582B1 (en) 2010-09-14 2013-09-04 miacom Diagnostics GmbH Clearance buffer
EP3842074A1 (en) 2010-09-29 2021-06-30 Philogen S.p.A. Protein-drug conjugates
CN103687488B (zh) 2011-06-27 2015-06-10 帕里昂科学公司 化学和代谢稳定的具有钠通道阻滞剂活性的二肽
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
HUE039734T2 (hu) 2012-05-29 2019-01-28 Parion Sciences Inc Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére
WO2014036445A2 (en) 2012-08-31 2014-03-06 Johnson Michael R Novel mucolytic agents
EP2925719A4 (en) 2012-11-28 2016-07-13 Yansong Lu Novel Synthetic Antioxidants And Their Uses
CN108658876A (zh) 2012-12-17 2018-10-16 帕里昂科学公司 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
CA2895512C (en) 2012-12-17 2021-10-19 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
MX368243B (es) 2013-08-23 2019-09-25 Parion Sciences Inc Agentes mucolíticos de ditiol.
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
CN104078680B (zh) 2014-05-23 2015-09-09 南京中储新能源有限公司 一种碳硫复合正极及二次铝硫电池
US20150376145A1 (en) 2014-06-30 2015-12-31 Parion Sciences, Inc. Stable sodium channel blockers
FR3024801A1 (fr) 2014-08-08 2016-02-12 Commissariat Energie Atomique Materiau d'electrode positive a base d'un materiau carbone specifique fonctionnalise par des composes organiques specifiques
CA2974210A1 (en) 2015-01-30 2016-08-04 Parion Sciences, Inc. Novel monothiol mucolytic agents
CA2984424A1 (en) 2015-04-30 2016-11-03 Parion Sciences, Inc. Novel prodrugs of dithiol mucolytic agents

Similar Documents

Publication Publication Date Title
JP2018505163A5 (https=)
JP2018520986A5 (https=)
HRP20171044T1 (hr) Kemijski i metabolički stabilni dipeptid s potentnom aktivnošću blokatora natrijevog kanala
JP2009539882A5 (https=)
JP4805824B2 (ja) キャップ化ピラジノイルグアニジンナトリウムチャネルブロッカー
KR101654549B1 (ko) 다중방향족 나트륨 채널 차단제
JP7066321B2 (ja) エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
RU2018138195A (ru) Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
JP2022078126A (ja) エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
RU2015129065A (ru) Производные хлор-пиразинкарбоксамида, обладающие активностью блокирования эпителиальных натриевых каналов
JP6594853B2 (ja) チオ糖粘液溶解薬
JP2014518268A5 (https=)
HRP20151346T1 (hr) 3,5-diamino-6-klor-n-(n-(4-(4-(2-(heksil(2,3,4,5,6-pentahidroksiheksil)amino)etoksi)fenil)butil)karbamimidoil)pirazin-2-karboksamid
BR112021003071A2 (pt) composições especialmente formuladas de nintedanib e sais de nintedanib inalados
US20190255042A1 (en) Application of hedgehog pathway inhibitor in treating fibrosis diseases
JP2004514739A (ja) 有機化合物
KR20160045863A (ko) 디티올 점액 용해제
WO2005025496B1 (en) Aliphatic pyrazinoylguanidine sodium channel blockers
JP2008513416A (ja) ロフルミラストを含有する水性医薬調剤
KR20150023302A (ko) 안구 건조 및 다른 점막 질환의 치료를 위한 나트륨 채널 차단제 활성을 보유하는 덴드리머 유사 아미노 아미드
JP2018505192A5 (https=)
JP2007522141A (ja) 呼吸器疾患の処置のためのベンゾチアゾール−２−オンベータ２アドレナリン受容体アゴニストとコルチコステロイドの組合せ剤
RU2015129076A (ru) Арилалкил- и арилоксиалкил-замещенные соединения, блокирующие эпителиальный натриевый канал
JP7610055B2 (ja) ジチオール糖粘液剤およびその使用
CN1396827A (zh) 含二氨基三氟甲基吡啶衍生物的肺功能不全治疗药或预防药