JP2010500378A5 - - Google Patents
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- Publication number
- JP2010500378A5 JP2010500378A5 JP2009523990A JP2009523990A JP2010500378A5 JP 2010500378 A5 JP2010500378 A5 JP 2010500378A5 JP 2009523990 A JP2009523990 A JP 2009523990A JP 2009523990 A JP2009523990 A JP 2009523990A JP 2010500378 A5 JP2010500378 A5 JP 2010500378A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- carbon atoms
- alkyl
- substituted
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- -1 5- (3-propyl) thiophen-2-yl Chemical group 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical class C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 239000004305 biphenyl Substances 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000007524 organic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 0 BN(C(C1=C)=*)N(*C(O)=O)C1=[U] Chemical compound BN(C(C1=C)=*)N(*C(O)=O)C1=[U] 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82199406P | 2006-08-10 | 2006-08-10 | |
| PCT/US2007/075550 WO2008021933A2 (en) | 2006-08-10 | 2007-08-09 | N-aryl or n-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500378A JP2010500378A (ja) | 2010-01-07 |
| JP2010500378A5 true JP2010500378A5 (enExample) | 2010-09-24 |
Family
ID=38895586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523990A Abandoned JP2010500378A (ja) | 2006-08-10 | 2007-08-09 | 治療用ｎ−アリールまたはｎ−ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7507833B2 (enExample) |
| EP (1) | EP2049495A2 (enExample) |
| JP (1) | JP2010500378A (enExample) |
| AU (1) | AU2007286135B2 (enExample) |
| BR (1) | BRPI0715816A2 (enExample) |
| CA (1) | CA2660308A1 (enExample) |
| WO (1) | WO2008021933A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011519937A (ja) * | 2008-05-09 | 2011-07-14 | アラーガン インコーポレイテッド | 治療用ｎ‐アリールまたはｎ‐ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体 |
| GB202211232D0 (en) | 2022-08-02 | 2022-09-14 | Heptares Therapeutics Ltd | Prostaglandin EP4 receptor agonist compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5902726A (en) * | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| AU2002340282B2 (en) * | 2001-10-23 | 2007-08-09 | Merck Serono Sa | Pyrazolidinone compounds as ligands of the prostaglandin EP2 and/or EP4 receptors |
| AU2003211574A1 (en) * | 2002-03-05 | 2003-09-16 | Ono Pharmaceutical Co., Ltd. | 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient |
| EP1581503A4 (en) | 2002-11-08 | 2007-07-25 | Merck & Co Inc | OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA |
-
2007
- 2007-08-08 US US11/836,094 patent/US7507833B2/en not_active Expired - Fee Related
- 2007-08-09 CA CA002660308A patent/CA2660308A1/en not_active Abandoned
- 2007-08-09 AU AU2007286135A patent/AU2007286135B2/en not_active Ceased
- 2007-08-09 JP JP2009523990A patent/JP2010500378A/ja not_active Abandoned
- 2007-08-09 EP EP07800062A patent/EP2049495A2/en not_active Withdrawn
- 2007-08-09 BR BRPI0715816-5A patent/BRPI0715816A2/pt not_active IP Right Cessation
- 2007-08-09 WO PCT/US2007/075550 patent/WO2008021933A2/en not_active Ceased
-
2009
- 2009-02-17 US US12/372,321 patent/US7576112B2/en active Active
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