AU2007286135B2 - N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors - Google Patents

N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors Download PDF

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Publication number
AU2007286135B2
AU2007286135B2 AU2007286135A AU2007286135A AU2007286135B2 AU 2007286135 B2 AU2007286135 B2 AU 2007286135B2 AU 2007286135 A AU2007286135 A AU 2007286135A AU 2007286135 A AU2007286135 A AU 2007286135A AU 2007286135 B2 AU2007286135 B2 AU 2007286135B2
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AU
Australia
Prior art keywords
compound
another embodiment
carbon atoms
compound according
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007286135A
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English (en)
Other versions
AU2007286135A1 (en
Inventor
Danny T. Dinh
David W. Old
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of AU2007286135A1 publication Critical patent/AU2007286135A1/en
Application granted granted Critical
Publication of AU2007286135B2 publication Critical patent/AU2007286135B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007286135A 2006-08-10 2007-08-09 N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors Ceased AU2007286135B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82199406P 2006-08-10 2006-08-10
US60/821,994 2006-08-10
PCT/US2007/075550 WO2008021933A2 (en) 2006-08-10 2007-08-09 N-aryl or n-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors

Publications (2)

Publication Number Publication Date
AU2007286135A1 AU2007286135A1 (en) 2008-02-21
AU2007286135B2 true AU2007286135B2 (en) 2013-03-28

Family

ID=38895586

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007286135A Ceased AU2007286135B2 (en) 2006-08-10 2007-08-09 N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives as prostaglandine receptor inhibitors

Country Status (7)

Country Link
US (2) US7507833B2 (enExample)
EP (1) EP2049495A2 (enExample)
JP (1) JP2010500378A (enExample)
AU (1) AU2007286135B2 (enExample)
BR (1) BRPI0715816A2 (enExample)
CA (1) CA2660308A1 (enExample)
WO (1) WO2008021933A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011519937A (ja) * 2008-05-09 2011-07-14 アラーガン インコーポレイテッド 治療用ｎ‐アリールまたはｎ‐ヘテロアリールピラゾリジンおよびピラゾリジノン誘導体
GB202211232D0 (en) 2022-08-02 2022-09-14 Heptares Therapeutics Ltd Prostaglandin EP4 receptor agonist compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035064A1 (en) * 2001-10-23 2003-05-01 Applied Research Systems Ars Holding N.V. Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
AU2003211574A1 (en) * 2002-03-05 2003-09-16 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
EP1581503A4 (en) 2002-11-08 2007-07-25 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035064A1 (en) * 2001-10-23 2003-05-01 Applied Research Systems Ars Holding N.V. Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors

Also Published As

Publication number Publication date
JP2010500378A (ja) 2010-01-07
AU2007286135A1 (en) 2008-02-21
US20090163560A1 (en) 2009-06-25
WO2008021933A3 (en) 2008-04-17
EP2049495A2 (en) 2009-04-22
CA2660308A1 (en) 2008-02-21
US7576112B2 (en) 2009-08-18
BRPI0715816A2 (pt) 2013-07-23
US20080045576A1 (en) 2008-02-21
WO2008021933A2 (en) 2008-02-21
US7507833B2 (en) 2009-03-24

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired