JP2010500375A5 - - Google Patents
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- Publication number
- JP2010500375A5 JP2010500375A5 JP2009523983A JP2009523983A JP2010500375A5 JP 2010500375 A5 JP2010500375 A5 JP 2010500375A5 JP 2009523983 A JP2009523983 A JP 2009523983A JP 2009523983 A JP2009523983 A JP 2009523983A JP 2010500375 A5 JP2010500375 A5 JP 2010500375A5
- Authority
- JP
- Japan
- Prior art keywords
- stage
- particle
- stage particle
- composition
- nanoporous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002245 particle Substances 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 17
- 239000011148 porous material Substances 0.000 claims 9
- 230000008685 targeting Effects 0.000 claims 8
- 239000002105 nanoparticle Substances 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 3
- 239000007783 nanoporous material Substances 0.000 claims 3
- 239000003961 penetration enhancing agent Substances 0.000 claims 3
- 210000005166 vasculature Anatomy 0.000 claims 3
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 108091023037 Aptamer Proteins 0.000 claims 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000000591 Tight Junction Proteins Human genes 0.000 claims 1
- 108010002321 Tight Junction Proteins Proteins 0.000 claims 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 210000002469 basement membrane Anatomy 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002041 carbon nanotube Substances 0.000 claims 1
- 229910021393 carbon nanotube Inorganic materials 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- -1 essome Substances 0.000 claims 1
- 229910003472 fullerene Inorganic materials 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229920000831 ionic polymer Polymers 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002082 metal nanoparticle Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 239000004065 semiconductor Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82175006P | 2006-08-08 | 2006-08-08 | |
| US91434807P | 2007-04-27 | 2007-04-27 | |
| PCT/US2007/075516 WO2008021908A2 (en) | 2006-08-08 | 2007-08-08 | Multistage delivery of active agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500375A JP2010500375A (ja) | 2010-01-07 |
| JP2010500375A5 true JP2010500375A5 (enExample) | 2010-09-24 |
Family
ID=39082940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523983A Pending JP2010500375A (ja) | 2006-08-08 | 2007-08-08 | 活性剤の多段階送達 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20080311182A1 (enExample) |
| EP (1) | EP2056794A4 (enExample) |
| JP (1) | JP2010500375A (enExample) |
| CN (1) | CN101652126B (enExample) |
| AU (1) | AU2007286203B2 (enExample) |
| CA (1) | CA2664919A1 (enExample) |
| MX (1) | MX2009001461A (enExample) |
| WO (1) | WO2008021908A2 (enExample) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2567741A1 (en) | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
| US7854944B2 (en) * | 2004-12-17 | 2010-12-21 | Advanced Cardiovascular Systems, Inc. | Tissue regeneration |
| AU2007348315A1 (en) | 2006-04-07 | 2008-09-12 | Chimeros, Inc. | Compositions and methods for treating B- cell malignancies |
| US8563022B2 (en) * | 2006-10-11 | 2013-10-22 | Board Of Regents Of The University Of Texas System | Particles for cell targeting |
| WO2008106350A1 (en) * | 2007-02-26 | 2008-09-04 | Board Of Regents Of The University Of Texas System | Endocytotic particles |
| US8920625B2 (en) * | 2007-04-27 | 2014-12-30 | Board Of Regents Of The University Of Texas System | Electrochemical method of making porous particles using a constant current density |
| AU2009238607B2 (en) * | 2008-04-25 | 2015-08-06 | Northwestern University | Nanostructures suitable for sequestering cholesterol |
| US8173115B2 (en) | 2008-07-29 | 2012-05-08 | The Board Of Regents Of The University Of Texas System | Particle compositions with a pre-selected cell internalization mode |
| CA2732252A1 (en) * | 2008-07-29 | 2010-02-04 | Paolo Decuzzi | Particle compositions with a pre-selected cell internalization mode |
| WO2010025322A2 (en) * | 2008-08-28 | 2010-03-04 | The Florida International University Board Of Trustees | Magnetic nanodelivery of therapeutic agents across the blood brain barrier |
| CA2747318A1 (en) * | 2008-12-23 | 2010-07-01 | Mauro Ferrari | Inflammation targeting particles |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| EP2376064A4 (en) * | 2009-01-15 | 2013-08-21 | Univ Texas | POROUS STRUCTURES WITH MODIFIED ORGANIC BIOLOGICAL DERIVATION |
| JP5960434B2 (ja) * | 2009-02-18 | 2016-08-02 | アラダイム コーポレーション | 肺送達のためのpH調節された製剤 |
| US8808733B2 (en) | 2009-03-31 | 2014-08-19 | The Board Of Trustees Of The University Of Arkansas | Method of controlled drug release from a liposome carrier |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| JP2012526130A (ja) * | 2009-05-05 | 2012-10-25 | アルテルムネ テクフノロジエス,エルエルシー | 化学的にプログラム可能な免疫 |
| FR2948024B1 (fr) * | 2009-07-17 | 2020-01-10 | Centre National De La Recherche Scientifique - Cnrs - | Emulsion activable par ultrasons et son procede de fabrication. |
| WO2011038111A1 (en) * | 2009-09-23 | 2011-03-31 | Crystalplex Corporation | Passivated nanoparticles |
| ES2367959B1 (es) * | 2009-12-22 | 2013-01-24 | Centro De Investigación Biomédica En Red En Bioingeniería, Biomateriales Y Nanomedicina | Particulas magnético-luminiscentes para aplicaciones biomédicas. |
| AU2011207563B2 (en) | 2010-01-19 | 2016-03-10 | Northwestern University | Synthetic nanostructures including nucleic acids and/or other entities |
| EP2540311A4 (en) * | 2010-02-26 | 2016-07-06 | Univ Nagasaki | COMPOSITE BODY FOR THE ADMINISTRATION OF ANTIGENES OR MEDICINES |
| CN103081107B (zh) | 2010-03-09 | 2017-02-08 | 得克萨斯州大学系统董事会 | 多孔和非多孔纳米结构 |
| EP2547329A4 (en) * | 2010-03-17 | 2014-06-25 | Univ Texas | THEROSTATIC DELIVERY SYSTEMS WITH MODIFIED SURFACES |
| EP2590605A1 (en) | 2010-07-09 | 2013-05-15 | Board of Regents of the University of Texas System | Biodegradable scaffolds |
| CA2808019C (en) * | 2010-08-16 | 2019-12-03 | Australian Nuclear Science & Technology Organisation | Particulate substances comprising ceramic particles for delivery of biomolecules |
| US20130224282A1 (en) * | 2010-09-21 | 2013-08-29 | Massachusetts Institute Of Technology | Multistage Nanoparticles |
| RU2475233C2 (ru) * | 2010-12-01 | 2013-02-20 | Учреждение Российской академии наук Институт кристаллографии им. А.В. Шубникова РАН | Фармакологическая композиция, предназначенная для интраназального введения с целью доставки в мозг фармакологически активного компонента, и способ ее получения |
| US9089498B2 (en) * | 2011-04-14 | 2015-07-28 | The Regents Of The University Of California | Multifunctional nanoparticle designs and applications |
| US9541480B2 (en) | 2011-06-29 | 2017-01-10 | Academia Sinica | Capture, purification, and release of biological substances using a surface coating |
| US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
| US8859004B2 (en) | 2011-08-04 | 2014-10-14 | Nano And Advanced Materials Institute Limited | pH-sensitive nanoparticles for oral insulin delivery |
| JP2014527072A (ja) | 2011-09-09 | 2014-10-09 | バイオメド リアルティー, エル.ピー. | ウイルスタンパク質の集合を制御するための方法および組成物 |
| WO2013095736A2 (en) * | 2011-09-27 | 2013-06-27 | The Methodist Hospital Research Institute | Gold-in-silicon nanoassembly for thermal therapy and methods of use |
| WO2013070872A1 (en) | 2011-11-08 | 2013-05-16 | The Board Of Trustees Of The University Of Arkansas | Methods and compositions for x-ray induced release from ph sensitive liposomes |
| US8926994B2 (en) * | 2011-12-07 | 2015-01-06 | The Methodist Hospital Research Institute | Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity |
| US20130304050A1 (en) * | 2012-05-10 | 2013-11-14 | Wake Forest University Health Sciences | Methods of treating cancerous tissue |
| US10842749B2 (en) * | 2012-06-12 | 2020-11-24 | The Methodist Hospital Research Institute | Compositions and methods of treating therapy resistant cancer and uses thereof |
| US8883216B2 (en) * | 2012-08-27 | 2014-11-11 | Red Lion Chem Tech, Llc | Methods and ceramic nanoparticle compositions for heavy metal removal and for oral delivery of desirable agents |
| US20140120157A1 (en) * | 2012-09-19 | 2014-05-01 | Georgetown University | Targeted liposomes |
| CA2912975A1 (en) * | 2012-10-16 | 2014-04-24 | William Marsh Rice University | An improved nanovector based drug delivery system for overcoming drug resistance |
| WO2014110449A1 (en) * | 2013-01-10 | 2014-07-17 | Amrita Vishwa Vidyapeetham | Stannous doped micro and nano particles for augmented radiofrequency ablation |
| JP2015007209A (ja) * | 2013-05-31 | 2015-01-15 | 株式会社リコー | コアシェル型粒子、及びその製造方法 |
| WO2015013673A1 (en) | 2013-07-25 | 2015-01-29 | Aurasense Therapeutics, Llc | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| WO2015023797A1 (en) | 2013-08-13 | 2015-02-19 | Northwestern University | Lipophilic nanoparticles for drug delivery |
| WO2015066212A2 (en) * | 2013-10-31 | 2015-05-07 | University Of Hawaii | Calpain inhibitors for treatment of inflammatory bowel disease and colorectal cancer |
| US10182988B2 (en) | 2013-12-03 | 2019-01-22 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| EP3126814B1 (en) | 2014-04-01 | 2019-06-12 | Academia Sinica | Methods and systems for cancer diagnosis and prognosis |
| WO2015176025A1 (en) | 2014-05-15 | 2015-11-19 | The Methodist Hospital | Discoidal polymeric nanoconstructs and methods of use in cancer theranostics |
| US10995267B2 (en) | 2014-05-29 | 2021-05-04 | Crystalplex Corporation | Dispersion system for quantum dots having organic coatings comprising free polar and non-polar groups |
| AU2015269412B2 (en) | 2014-06-04 | 2020-03-12 | Exicure Operating Company | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| CN115607688A (zh) | 2014-07-22 | 2023-01-17 | 雷莫内克斯生物制药有限公司 | 用于递送生物活性物质或蛋白质的组合物及其用途 |
| EP3183007B1 (en) | 2014-08-19 | 2020-06-17 | Northwestern University | Protein/oligonucleotide core-shell nanoparticle therapeutics |
| EP2998026B1 (en) | 2014-08-26 | 2024-01-17 | Academia Sinica | Collector architecture layout design |
| KR102510540B1 (ko) | 2014-10-03 | 2023-03-16 | 나노틱스 엘엘씨 | 가용성 생물분자의 생물학적 활성을 억제하기 위한 조성물 및 방법 |
| JP6741673B2 (ja) | 2014-10-06 | 2020-08-19 | イグジキュア, インコーポレーテッドExicure, Inc. | 抗tnf化合物 |
| JP2017537619A (ja) | 2014-11-21 | 2017-12-21 | ノースウェスタン ユニバーシティ | 球状核酸ナノ粒子複合体の配列特異的細胞内取込 |
| US10736845B2 (en) | 2015-03-03 | 2020-08-11 | Cureport Inc. | Dual loaded liposomal pharmaceutical formulations |
| US9895313B2 (en) | 2015-03-03 | 2018-02-20 | Cureport, Inc. | Combination liposomal pharmaceutical formulations |
| US10078092B2 (en) | 2015-03-18 | 2018-09-18 | Northwestern University | Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules |
| CN114533898B (zh) * | 2015-07-09 | 2025-07-01 | 加利福尼亚大学董事会 | 融合脂质体包被的多孔硅纳米颗粒 |
| US20170056327A1 (en) * | 2015-08-25 | 2017-03-02 | The Methodist Hospital | Micro/nano composite drug delivery formulations and uses thereof |
| ITUB20159209A1 (it) * | 2015-12-21 | 2017-06-21 | Fidia Farm Spa | Nanosistemi per il trasporto controllato di molecole attive a fini diagnostici, prognostici e terapeutici |
| WO2017156191A1 (en) * | 2016-03-08 | 2017-09-14 | Los Gatos Pharmaceuticals, Inc. | Composite nanoparticles and uses thereof |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| WO2017193087A1 (en) | 2016-05-06 | 2017-11-09 | Exicure, Inc. | Liposomal spherical nucleic acid (sna) constructs prsenting antisense oligonucleotides(aso) for specific knockdown of interleukin 17 receptor mrna |
| US20190177615A1 (en) | 2016-05-19 | 2019-06-13 | Crystalplex Corporation | Cadmium-free quantum dots, tunable quantum dots, quantum dot containing polymer, articles, films, and 3d structure containing them and methods of making and using them |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| IL299915A (en) | 2017-01-04 | 2023-03-01 | Nanotics Llc | Methods for assembling cleaning particles |
| CN110475546A (zh) | 2017-02-06 | 2019-11-19 | 雷莫内克斯生物制药有限公司 | 生理活性物质载体 |
| WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
| WO2019032241A1 (en) | 2017-07-13 | 2019-02-14 | Northwestern University | GENERAL AND DIRECT METHOD FOR PREPARING NANOPARTICLES WITH ORGANOMETALLIC STRUCTURE FUNCTIONALIZED BY OLIGONUCLEOTIDES |
| JP6865491B2 (ja) * | 2017-07-25 | 2021-04-28 | レモネックス インコーポレイテッドLemonex Inc. | 血管内生理活性物質送達用組成物 |
| KR102152348B1 (ko) | 2017-09-05 | 2020-09-08 | 주식회사 레모넥스 | 세포 운명 조절용 조성물 |
| HUE068741T2 (hu) | 2017-12-19 | 2025-01-28 | Nanobiotix | Nanorészecskék idegi zavarok kezelésére |
| ES2998117T3 (en) | 2017-12-19 | 2025-02-19 | Nanobiotix | Nanoparticles for use in enhancing brain performances or in treating stress |
| WO2019157319A1 (en) * | 2018-02-12 | 2019-08-15 | Flagship Pioneering Innovations V, Inc. | Devices and methods for delivering material into a biological tissue or cell |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
| CN112546406B (zh) * | 2020-11-20 | 2022-04-22 | 广东药科大学 | 一种微型机器人给药装置及给药系统 |
| EP4568708A1 (en) * | 2022-08-10 | 2025-06-18 | Auburn University | Shrinking nanomaterial for biomedical applications |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4933185A (en) | 1986-09-24 | 1990-06-12 | Massachusetts Institute Of Technology | System for controlled release of biologically active compounds |
| US5010167A (en) | 1989-03-31 | 1991-04-23 | Massachusetts Institute Of Technology | Poly(amide-and imide-co-anhydride) for biological application |
| US6099864A (en) | 1994-12-02 | 2000-08-08 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | In situ activation of microcapsules |
| US6107102A (en) | 1995-06-07 | 2000-08-22 | Regents Of The University Of California | Therapeutic microdevices and methods of making and using same |
| US6395302B1 (en) * | 1996-11-19 | 2002-05-28 | Octoplus B.V. | Method for the preparation of microspheres which contain colloidal systems |
| ES2130056B1 (es) * | 1997-01-16 | 2000-02-01 | Lipotec Sa | Un nuevo preparado farmaceutico para mejorar la biodisponibilidad oral de drogas de dificil absorcion. |
| CA2356705A1 (en) * | 1998-11-20 | 2000-06-02 | The General Hospital Corporation | Permanent, removable tissue markings |
| US6355270B1 (en) * | 1999-01-11 | 2002-03-12 | The Regents Of The University Of California | Particles for oral delivery of peptides and proteins |
| US20030114366A1 (en) * | 1999-01-11 | 2003-06-19 | Francis J. Martin | Microfabricated particles and method for treating solid tumors |
| US6887493B2 (en) * | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| US6685927B2 (en) * | 2001-09-27 | 2004-02-03 | Ceramoptec Industries, Inc. | Topical application of chromophores for hair removal |
| US7563451B2 (en) * | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| CN101031287A (zh) * | 2004-03-02 | 2007-09-05 | 麻省理工学院 | 纳米细胞药物递送系统 |
| KR20090007275A (ko) | 2005-12-20 | 2009-01-16 | 더 오하이오 스테이트 유니버시티 리서치 파운데이션 | 분석방법용 나노다공성 기판 |
| WO2008054874A2 (en) * | 2006-05-12 | 2008-05-08 | Brown University | Particles with high uniform loading of nanoparticles and methods of preparation thereof |
| US20100074958A1 (en) | 2006-09-28 | 2010-03-25 | Board Of Regents Of The University Of Texas System | Methods and compositions for targeting fenestrated vasculature |
| US8563022B2 (en) * | 2006-10-11 | 2013-10-22 | Board Of Regents Of The University Of Texas System | Particles for cell targeting |
| US8920625B2 (en) * | 2007-04-27 | 2014-12-30 | Board Of Regents Of The University Of Texas System | Electrochemical method of making porous particles using a constant current density |
-
2007
- 2007-08-08 JP JP2009523983A patent/JP2010500375A/ja active Pending
- 2007-08-08 US US11/836,004 patent/US20080311182A1/en not_active Abandoned
- 2007-08-08 CA CA002664919A patent/CA2664919A1/en not_active Abandoned
- 2007-08-08 EP EP07840796A patent/EP2056794A4/en not_active Withdrawn
- 2007-08-08 AU AU2007286203A patent/AU2007286203B2/en active Active
- 2007-08-08 MX MX2009001461A patent/MX2009001461A/es active IP Right Grant
- 2007-08-08 WO PCT/US2007/075516 patent/WO2008021908A2/en not_active Ceased
- 2007-08-08 CN CN2007800374243A patent/CN101652126B/zh active Active
-
2015
- 2015-05-29 US US14/725,570 patent/US10143658B2/en active Active
-
2018
- 2018-10-12 US US16/158,644 patent/US20190111000A1/en not_active Abandoned
-
2021
- 2021-07-06 US US17/368,401 patent/US20210338593A1/en active Pending
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