JP2010241747A - Hair growth promoter composition, effect enhancing agent for hair growth promoter, and method for producing hair growth promoter - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To enhance hitherto insufficient effects of hair growth promoters. <P>SOLUTION: There are provided a hair growth promoter composition containing sodium polyacrylate; and an agent for enhancing the effect of the hair growth promoter, containing the sodium polyacrylate and enhancing the effect of the hair growth promoter by adding it to the hair growth promoter composition. There is further provided a method for producing the hair growth promoter by adding the sodium polyacrylate to enhance the hair growing effect of the hair growth promoter. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a hair restorer composition, a hair restorer effect promoter, and a method for producing a hair restorer.

  There are various causes of thinning hair or wharf, but the number of people suffering from hair loss and hair loss tends to increase due to factors such as stress due to aging and changes in the social environment. Under such circumstances, a medicinal component for the purpose of treatment / improvement such as hair loss and hair loss has been searched, and many hair restorers are commercially available.

  Currently known medicinal ingredients for hair growth agents include vasodilators such as assembly extract and vitamin E acetate, stimulants such as pepper tincture, vitamins such as pantothenic acid and biotin, hormones, anti-inflammatory agents, Examples include bactericides. In addition, N-acylamino acids have a hair-growth effect, and among them, N-acylamino acids having an odd carbon number acyl group or salts and derivatives thereof have been reported to have a particularly excellent hair-growth effect (for example, Patent Document 1: JP-A-8-337515).

  However, even at the present time, the effect of the hair restorer is still limited, as hair thickening by wigs and flocking is actively performed. In recent years, hair growth agents containing a compound such as minoxidil as an active ingredient are well known, but minoxidil has been developed as a vasodilator, and therefore it is suitable for people with abnormal cardiovascular system. Use is restricted. As described above, a hair restorer containing a compound having a large effect as an active ingredient requires attention in use, and has a limited amount. Therefore, a substance that can be used with confidence and has a sufficient hair-growth effect is desired.

  On the other hand, sodium polyacrylate absorbs a large amount of water to form a high water content polymer gel, so that thickeners, ink composition components, capsule raw materials in polymer absorbents, water treatment agents, foods, etc. It is used in a wide range of fields such as dental paste compositions, dentifrice ingredients, and agricultural chemical fixing agents. In addition, sodium polyacrylate may be used as a water-soluble gel in patch bases and cosmetics, and a mixture of polyacrylic acid and a crosslinking agent has been proposed as a hair cosmetic ingredient (patents). Literature 2: JP 2007-297368). However, Patent Document 2 has good elongation and familiarity when applied to hair, gives hair coherence, has no unnatural luster, has excellent re-hairing properties after application, and protects hair from the heat of a dryer or the like. The present invention relates to a hair styling agent that imparts an effect and is not used as a hair restorer. Moreover, there are few examples of using sodium polyacrylate as an active ingredient for disease treatment, and there are only limited examples such as an active ingredient of a therapeutic agent for mastitis in dairy cows (Patent Document 3: Japanese Patent Publication No. 06-060104). is there.

JP-A-8-337515 JP2007-297368 JP 06-060104

  This invention makes it a subject to raise the effect of the hair restorer which was conventionally insufficient.

  As a result of various investigations for solving the above problems, the present inventor has heretofore obtained a hair restoration action or an effect promoting action of other hair restoration agents on sodium polyacrylate, which has never been known to be related to the hair restoration action. As a result, the present inventors have completed the present invention.

The photograph of the female head made into the object to which the hair restorer of this invention is applied (just before application). The same female head photograph as described in FIG. 1 after 2 weeks of applying the hair restorer of the present invention. The head photograph of the same woman as described in FIG. 1 4 weeks after applying the hair restorer of this invention. The same female head photograph as described in FIG. 1 after 5 weeks of applying the hair restorer of the present invention.

  As a result of intensive studies to achieve the above object, the present inventor has found that a preparation having an excellent hair-growing effect can be realized by blending sodium polyacrylate with a hair-growing agent. In the present invention, “hair growth agent” means “hair growth agent” that causes hair growth from a complete wrinkle state, and increases the amount and thickness of hair from the state of thin hair unless otherwise specified. It includes both “hair growth agents” and “hair growth agents” that prevent the phenomenon of hair loss or hair thickness reduction due to aging or the like. Unless otherwise noted, "hair growth effect" that causes hair growth from a complete wharf state, "hair growth effect" that increases the amount and thickness of thin hair from the thin hair state, hair by aging, etc. It includes any of the “hair restoration effects” that prevent the phenomenon that the amount is reduced or the thickness of the hair is reduced. The same applies to other similar terms such as “hair growth ingredient”.

  The causes of hair loss and the like include male pattern hair loss (male pattern baldness), circular hair loss (alopecia areata), hair loss due to side effects of drugs such as anticancer agents, and the like. In particular, in the case of circular hair removal, hair often grows again, whereas aging or male hair removal is difficult to regenerate hair, and therefore, the application of the hair restorer according to the present invention is particularly preferable.

  Generally, hair growth has a cycle, which is called the hair cycle. The hair cycle consists of “growth period” (2 to 7 years) in which hair grows (regenerates), “regression period” (2 to 3 weeks) in which hair growth stops, and “rest period” in which hair loss progresses (4 Repeated in order of ~ 5 months). If the resting period is prolonged due to deterioration of the scalp's nutritional status, stimulation of sebum accumulation in the scalp, an increase in male hormones, or the proportion of hair in the resting period increases, men Causes sexual hair loss. Hair growth promotes hair growth by converting the roots in the resting phase to the growth phase, and promotes hair growth by preventing the transition to the regression phase or resting phase by extending the growth phase. Is done by. Although the mechanism of action by which the polyacrylic acid sodium exhibits the hair-growth effect is not clear according to the present invention, the action is clearly shown in reality and is completely unexpected.

  The sodium polyacrylate that can be used in the present invention is not particularly limited as long as it is in a state suitable for application to the scalp. However, since the handleability and dispersibility are poor when the viscosity is too high, for example, a molecular weight of 7 million or less is preferred, and 3 million or less is preferred depending on the mode of application. There is no restriction | limiting in particular in a lower limit, For example, what is obtained as thousands to tens of thousands of aqueous solution may be used. That is, sodium polyacrylate can be used as an aqueous solution, or can be used as a dispersion liquid such as a microgel or other embodiments. Although it depends on the viscosity of the aqueous solution, it is in the range of about 0.05 to 30% by mass. If it is less than 0.05% by mass, the effect is hardly exhibited, and if it is 30% by mass, there is generally a problem in handleability. About 0.1-20 mass% is preferable.

  Although sodium polyacrylate itself exhibits a hair-growth effect, it exhibits a particularly synergistic effect when combined with existing hair-growth ingredients. Examples of such hair-growth agent components include, for example, assembly extract component, button skin extract component, enamel extract component, body extract component, coleus forskori root extract component, licorice extract component, quince isoform extract component, cucumber extract component, capsicum extract component , Toucha extract component, carrot extract component, dandelion extract component, mandarin extract component, yew extract component, hypericum extract component, adduct extract component, loquat extract component, kawara mugwort extract component, comfrey extract component, ashitaba extract component, saffron extract component, Sansushi extract component, rosemary extract component, sage extract component, mokko extract component, sesame extract extract component, hop extract component, sophora extract component, quacharate extract component and other plant-derived components, hinokitiol, swell thiamarin, cephalatin, foal Compounds known as plant-derived components such as choline, finasteride, catechins, plant-derived component-like synthetic substances such as t-flavanone, seaweed-derived components such as fucoidan, microorganism-derived components, thermolysin degradation products of soybean protein, placenta extract, etc. Animal-derived components, tocopherol acetate, minoxidil or analogs thereof, adenosine, pentadecanoic acid or a derivative thereof such as pentadecanoic acid glyceride, pantothenic acid, pantothenyl alcohol, pantothenyl ethyl ether, glycyrrhetinic acid or a derivative thereof, glycyrrhizic acid or a derivative thereof, Isopropyl methylphenol, piroctone olamine, benzyl nicotinate, tocopherol nicotinate, β-butoxy ester of nicotinate, nicotinamide, carpronium chloride, 6-benzylamino Phosphorus, salicylic acid and the like can be mentioned, and these can be used singly or in appropriate combination of two or more. In addition, what was mentioned here is an example, Comprising: The combined use with the hair restorer component other than this is not excluded.

  When combined with a known hair-restoring agent component, the amount of sodium polyacrylate in the hair-restoring agent of the present invention is appropriately selected depending on the dosage formulation and dosage, but is preferably 0.01 to 30% by mass, 0 About 1-20 mass% is preferable, and about 5-15 mass% is more preferable. Moreover, the compounding quantity of a known hair restorer component should just be an effective amount of each active ingredient. The amount ratio of extractable substances and the like cannot always be clearly defined, but is preferably 0.001 to 20 mass%, more preferably 0.01 to 10 mass%, for example, with respect to the total amount of the hair restorer composition. If the blending amount is too small, a sufficient hair-growth effect may not be obtained, and if it is too much, it may be uneconomical, but according to the present invention, it may be reduced to 0.05 to 3% by mass in some cases. it can.

  For the purpose of enhancing the hair-growth effect, the hair-growth agent may be blended with an anti-androgen hormone agent, a blood circulation promoter and the like. Furthermore, arbitrary components can be used individually by 1 type or in combination of 2 or more types in the range which does not impair the effect of this invention. Optional ingredients include, for example, humectants, vitamins, peptides, amino acids, water, lower alcohols such as ethanol, polyhydric alcohols, anti-inflammatory agents, bactericides / preservatives, surfactants, fats and oils, ester oils, Examples thereof include polymer resins such as gums, polymer compounds, chelating agents, antioxidants, pH adjusters, dyes, fragrances, and UV absorbers.

  Examples of the humectant include agar, diglycerin, distearyldimonium hectorite, butylene glycol, polyethylene glycol, propylene glycol, hexylene glycol, yokinein extract, petrolatum, urea, hyaluronic acid, chondroitin sulfate, ceramide, lipid, isoflavone. Amino acids, collagen, mucopolysaccharides, fucodyne, lactoferrin, sorbitol, chitin / chitosan and the like.

  Examples of vitamins include carotenes, retinoic acid, retinol, vitamin C and derivatives thereof, vitamin E and derivatives thereof, thiamine nitrate, cyanocobalamin, biotin, riboflavin and the like.

  Antioxidants include the above vitamins, kinetin, astaxanthin, tretinoin, sesamin, α-lipoic acid, coenzyme Q10, flavonoids, erythorbic acid, propyl gallate, BHT (di-n-butylhydroxytoluene), Examples thereof include BHA (butylhydroxyanisole), koki extract, soybean extract, black tea extract, tea extract, and age extract.

  Surfactants include polyoxyethylene (60%) hydrogenated castor oil, polyoxyethylene (8%) oleyl ether, polyoxyethylene (10%) oleyl ether, polyoxyethylene monooleate (10%), polyoxy Ethylene (30%) glyceryl monostearate, sorbitan monostearate, polyoxyethylene (30%) glyceryl monostearate, polyoxyethylene (20%) sorbitan monooleate, sucrose fatty acid ester, hexaglycerin monooleate, Hexaglycerol monolaurate, polyoxyethylene reduced lanolin, polyoxyethylene (20%) lanolin alcohol, polyoxyethylene (25%) glyceryl pyroglutamic acid isostearic acid diester, N-acetylglutamine isos Allyl ester, and the like.

Anti-inflammatory agents include allantoin, diphenhydramine hydrochloride, guaiazulene, l-menthol and the like.
Bactericides and preservatives include trichlorohydroxydiphenyl ether, hinokitiol, triclosan, chlorhexidine gluconate, phenoxyethanol, resorcin, isopropylmethylphenol, azulene, salicylic acid, paraben, zinc pyrithione, benzalkonium chloride, photosensitizer 301, mononitroguaiacol Examples include sodium.

Examples of hormone agents include ethinyl estradiol, estrone, estradiol and the like.
Examples of UV inhibitors include homomenthyl salicylate, 2-methoxyhexycin 2-ethylhexyl, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone sulfonic acid, 2-hydroxy-4-methoxybenzophenone sulfonic acid Examples thereof include sodium, 4-t-butyl-4′-methoxy-dibenzoylmethane, titanium oxide, and zinc oxide.

  Examples of fragrances include natural fragrances such as orange oil, lemon oil, bergamot oil, lime oil, lemongrass oil, lavender oil, and mint oil, and synthetic fragrances such as menthol, rose oxide, linalool, citral, and linalyl acetate. .

The hair restorer of the present invention can take any form of liquid, foam (form), gel, cream, and spray as long as the effects of the invention are not impaired. Therefore, in each form, it is also possible to mix | blend the conventional additive as mentioned above of the range which does not impair the effect of invention.
Moreover, when using spray (aerosol), you may contain propellants, such as liquefied gas and compressed gas. For example, a hair-growth ingredient, an optional ingredient, and the balance (water and / or ethanol) are mixed and combustible gas selected from butane, propane, isobutane, liquefied petroleum gas, and dimethyl ether and / or according to a conventional method of each dosage form A compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas can be blended.

  In the present invention, the hair-restoring agent is applied to the scalp at least once a day, preferably at least twice a day (for example, by applying or spraying a liquid amount of about 1 ml), and preferably by massaging or tapping to adjust to the scalp. A remarkable hair-growth effect can be achieved.

Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto.
[Example 1] Production example Button skin extract 50% (volume%, the same applies hereinafter), Enmezo extract 5%, Bodaige extract 10%, glycerin 5%, ethanol 10%, purified water 10%, and swell thiamarin (Assembly component), green tea extract, paraben, 1,3-butyleneglycol each appropriate amount was added to 100% of the hair restorer to make 100%, and 10 parts of sodium polyacrylate was added and mixed to produce the hair restorer of the present invention. An agent was prepared.

[Example 2] Hair growth test and results An amount of hair growth agent obtained in Example 1 was rubbed into the scalp twice a day, morning and evening on the scalp of a 69-year-old woman, and the hair growth effect was visually observed for about 1 month. did. The results are shown in FIGS.
As shown in this figure, (a) at the time of application first day (February 6), the scalp was visible centering on the toothpick part and the amount of hair around the scalp was reduced. (B) February 20 At the time of day, the exposed area of the scalp is reduced, and the amount of hair appears to increase overall. In addition, (c) the toothpick part is almost invisible at the time of March 7, the hair is full throughout the head, and (d) the toothpick part is completely invisible at the time of March 14, It can be seen that the amount of hair is rich and black and glossy throughout the head.

[Example 3] Hair-growth test and results A hair-growth test was carried out in the same manner as in Example 2 on 3 men who were completely bald at the age of 55-65. The results are shown in Table 1.

[Table 1]
Subject # Age Effect
1 50s ++
2 60s +++
3 60s
++

Explanation of the effects in the table:
−: Deteriorated.
0: No effect was visually observed.
+: Although it could not be judged visually, the effect could be confirmed with a microscope.
++: The effect was confirmed visually.
+++: A remarkable effect was visually confirmed.

  Thus, a significant effect was seen in any male. For example, in the male of subject # 2, interstitial hair grew on the bun and remarkable hair growth was observed. Therefore, according to this example, it was found that the hair restorer of the present invention can be effectively used for the prevention or treatment of alopecia.

[Example 4] Comparative test and results Sofora extract (a perennial plant inhabiting Japanese and Chinese plant components, known to have blood circulation promoting effects in roots), Achacha extract, delamide, beta-glycyrrhizic acid , A 47-year-old woman who has used hair restorers including benzyl nicotinate, pantotenyl ethyl ether, vitamin E derivatives, nicotinamide, and l-menthol for the past six months but has not had a significant effect On the other hand, when 10 parts of sodium polyacrylate was added to 100 parts of the above-described hair restorer, other conditions were applied in the same manner, and it was confirmed that the amount of hair was clearly increased in 2 weeks. Therefore, it turns out that the effect of a hair restorer is significantly improved by adding sodium polyacrylate by this invention.

Claims (3)

A hair restorer composition comprising sodium polyacrylate. The effect promoter of the hair restorer which contains sodium polyacrylate and has the effect which improves the hair restorer effect of a hair restorer by adding to a hair restorer composition. In the manufacturing method of a hair restoring agent, the hair restoring effect of a hair restoring agent is heightened by adding sodium polyacrylate, The manufacturing method of the hair restoring agent characterized by the above-mentioned.