JP2010229138A5 - - Google Patents
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- Publication number
- JP2010229138A5 JP2010229138A5 JP2010110683A JP2010110683A JP2010229138A5 JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5 JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5
- Authority
- JP
- Japan
- Prior art keywords
- celiac disease
- agent
- epitope
- peptide
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 20
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 208000015943 Coeliac disease Diseases 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 241000209219 Hordeum Species 0.000 claims 4
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 108091008874 T cell receptors Proteins 0.000 claims 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108060008539 Transglutaminase Proteins 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 208000032309 susceptibility to 1 celiac disease Diseases 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 102000003601 transglutaminase Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047762 HLA-DQ8 antigen Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010061711 Gliadin Proteins 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212885.8 | 2002-06-05 | ||
| GBGB0212885.8A GB0212885D0 (en) | 2002-06-05 | 2002-06-05 | Therapeutic epitopes and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Division JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Division JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Division JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010229138A JP2010229138A (ja) | 2010-10-14 |
| JP2010229138A5 true JP2010229138A5 (OSRAM) | 2010-12-02 |
| JP5635302B2 JP5635302B2 (ja) | 2014-12-03 |
Family
ID=9937994
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
| JP2010110683A Expired - Lifetime JP5635302B2 (ja) | 2002-06-05 | 2010-05-12 | 治療用エピトープ及びそれらの使用 |
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10053497B2 (OSRAM) |
| EP (3) | EP2826787B1 (OSRAM) |
| JP (6) | JP2006512893A (OSRAM) |
| AU (1) | AU2003244771B2 (OSRAM) |
| CA (1) | CA2488218C (OSRAM) |
| CY (1) | CY1115730T1 (OSRAM) |
| DK (1) | DK1513873T3 (OSRAM) |
| ES (1) | ES2510440T3 (OSRAM) |
| GB (1) | GB0212885D0 (OSRAM) |
| MX (2) | MXPA04012117A (OSRAM) |
| NZ (1) | NZ537226A (OSRAM) |
| PT (1) | PT1513873E (OSRAM) |
| SI (1) | SI1513873T1 (OSRAM) |
| WO (1) | WO2003104273A2 (OSRAM) |
| ZA (1) | ZA200409740B (OSRAM) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| EP2364718B1 (en) | 2002-02-14 | 2016-07-06 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7202216B2 (en) * | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| AU2003234597A1 (en) * | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| GB0212885D0 (en) | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| EP1563300B1 (en) | 2002-11-20 | 2012-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| CA2561800C (en) | 2004-04-16 | 2011-10-18 | The Governors Of The University Of Alberta | Anti-gluten egg yolk antibodies for the treatment of celiac disease |
| US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| US7534426B2 (en) * | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| EP1755639B1 (en) * | 2004-04-28 | 2017-08-16 | BTG International Limited | Epitopes related to coeliac disease |
| CA2680590C (en) * | 2007-03-16 | 2017-10-17 | Jonathan David Gass | Combination enzyme therapy for digestion of dietary gluten |
| US8282928B2 (en) | 2007-05-30 | 2012-10-09 | The Governors Of The University Of Alberta | Anti-gluten egg yolk antibodies for the treatment of celiac disease |
| DE102007044673A1 (de) * | 2007-09-18 | 2009-03-19 | Zimmer, Klaus-Peter, Prof. Dr. med. | Impfstoff zur Behandlung von Zöliakie und Verfahren zur Herstellung des Impfstoffes, Verwendung einer mit einem bakteriellen Toxin konjugierten Peptidsequenz zur Aktivierung des Immunsystems gegen Prolamine sowie Designerpeptid |
| WO2010060155A1 (en) * | 2008-11-30 | 2010-06-03 | Nexpep Pty Ltd | Compositions and methods for treatment of celiac disease |
| AU2013204429B9 (en) * | 2008-11-30 | 2017-01-05 | Immusant, Inc. | Compositions and methods for treatment of celiac disease |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| CN108117586A (zh) | 2010-08-10 | 2018-06-05 | 洛桑聚合联合学院 | 红细胞结合性治疗剂 |
| US20140037661A1 (en) * | 2011-02-08 | 2014-02-06 | Phadia Ab | Wheat Antigens and Peptides for Diagnosis of Wheat Induced Hypersensitivity |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| EP2812344A4 (en) | 2012-02-07 | 2015-10-28 | Vibrant Holdings Llc | SUBSTRATES, PEPTIDE NETWORKS AND METHODS |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| US10816553B2 (en) | 2013-02-15 | 2020-10-27 | Vibrant Holdings, Llc | Methods and compositions for amplified electrochemiluminescence detection |
| CA2923822A1 (en) | 2013-09-10 | 2015-03-19 | Immusant, Inc. | Dosage of a gluten peptide composition |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| EA201691686A1 (ru) | 2014-02-21 | 2017-03-31 | Эколь Политекник Федераль Де Лозан (Эпфл) | Терапевтические средства с углевод-опосредованной адресной доставкой |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| EP3134730A4 (en) | 2014-04-24 | 2018-01-17 | Immusant Inc. | Methods for diagnosing celiac disease using circulating cytokines/chemokines |
| US10900964B2 (en) | 2014-09-10 | 2021-01-26 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| AU2015349728A1 (en) | 2014-11-21 | 2017-07-13 | Immusant, Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
| EP3109255A1 (en) | 2015-06-26 | 2016-12-28 | Institut National De La Recherche Agronomique | Immunogenic composition |
| EP3868777A1 (en) * | 2015-06-26 | 2021-08-25 | Institut national de recherche pour l'agriculture, l'alimentation et l'environnement | Immunogenic composition |
| WO2017146118A1 (ja) * | 2016-02-23 | 2017-08-31 | 田中貴金属工業株式会社 | グリアジン検出用免疫クロマト分析装置、免疫クロマト分析キットおよび免疫クロマト分析方法 |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| JP6568193B2 (ja) * | 2017-12-19 | 2019-08-28 | ホーユー株式会社 | エピトープ |
| EP3790985A4 (en) | 2018-05-09 | 2022-02-16 | Vibrant Holdings, LLC | METHOD OF SYNTHESIS OF A POLYNUCLEOTIDARRAY USING PHOTOACTIVATED AGENTS |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| CN114938647A (zh) * | 2019-07-04 | 2022-08-23 | 乌科公司 | 去表位的α-麦醇溶蛋白及其在乳糜泻和麸质敏感性管理中的用途 |
| WO2021059240A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| GB202113858D0 (en) * | 2021-09-28 | 2021-11-10 | Nextera As | Peptides |
| CN115124606B (zh) * | 2022-06-27 | 2025-03-28 | 上海理工大学 | 含有氨基酸结构pqqp的寡肽及其制备方法和应用 |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459355A (en) | 1982-07-12 | 1984-07-10 | International Paper Company | Method for transforming plant cells |
| US4536475A (en) | 1982-10-05 | 1985-08-20 | Phytogen | Plant vector |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| JPS6047683A (ja) | 1983-08-24 | 1985-03-15 | Kirin Brewery Co Ltd | プロモ−タ− |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US4943674A (en) | 1987-05-26 | 1990-07-24 | Calgene, Inc. | Fruit specific transcriptional factors |
| DK162399C (da) | 1986-01-28 | 1992-03-23 | Danisco | Fremgangsmaade til ekspression af gener i baelgplanteceller, dna-fragment, rekombineret dna-fragment samt plasmid til brug ved udoevelsen af fremgangsmaaden |
| ATE57390T1 (de) | 1986-03-11 | 1990-10-15 | Plant Genetic Systems Nv | Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen. |
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5187073A (en) | 1986-06-30 | 1993-02-16 | The University Of Toledo | Process for transforming gramineae and the products thereof |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| NZ221259A (en) | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| EP0267159A3 (de) | 1986-11-07 | 1990-05-02 | Ciba-Geigy Ag | Verfahren zur genetischen Modifikation monokotyler Pflanzen |
| US4866247A (en) | 1986-12-11 | 1989-09-12 | The Lincoln Electric Company | Apparatus and method of short circuiting arc welding |
| US4971908A (en) | 1987-05-26 | 1990-11-20 | Monsanto Company | Glyphosate-tolerant 5-enolpyruvyl-3-phosphoshikimate synthase |
| US5356799A (en) | 1988-02-03 | 1994-10-18 | Pioneer Hi-Bred International, Inc. | Antisense gene systems of pollination control for hybrid seed production |
| US5371014A (en) | 1988-02-12 | 1994-12-06 | Daicel Chemical Industries, Ltd. | Process for the production of optically active 2-hydroxy acid esters using microbes to reduce the 2-oxo precursor |
| US5179022A (en) | 1988-02-29 | 1993-01-12 | E. I. Du Pont De Nemours & Co. | Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner |
| US5614395A (en) | 1988-03-08 | 1997-03-25 | Ciba-Geigy Corporation | Chemically regulatable and anti-pathogenic DNA sequences and uses thereof |
| US5250515A (en) | 1988-04-11 | 1993-10-05 | Monsanto Company | Method for improving the efficacy of insect toxins |
| US5565346A (en) | 1988-07-27 | 1996-10-15 | Calgene, Inc. | Transformation and regeneration system for legumes |
| US5428146A (en) | 1988-11-07 | 1995-06-27 | Max-Planck-Gesellschaft Zur Forderung | Wound-stimulated DNA-sequence from solanum tuberosum and its use |
| US5110732A (en) | 1989-03-14 | 1992-05-05 | The Rockefeller University | Selective gene expression in plants |
| US5086169A (en) | 1989-04-20 | 1992-02-04 | The Research Foundation Of State University Of New York | Isolated pollen-specific promoter of corn |
| US5629183A (en) | 1989-05-08 | 1997-05-13 | The United States Of America As Represented By The Secretary Of Agriculture | Plant transformation by gene transfer into pollen |
| US5097025A (en) | 1989-08-01 | 1992-03-17 | The Rockefeller University | Plant promoters |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| WO1991002071A2 (en) | 1989-08-09 | 1991-02-21 | Dekalb Plant Genetics | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US4919813A (en) | 1989-08-25 | 1990-04-24 | The United States Of America As Represented By The Department Of Energy | Photoenhanced anaerobic digestion of organic acids |
| EP0497884B1 (en) | 1989-10-27 | 2004-04-28 | The Salk Institute For Biological Studies | Glutamate receptor compositions and methods |
| US5589583A (en) | 1990-01-11 | 1996-12-31 | Monsanto Company | Plant promoter |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| JP3209744B2 (ja) | 1990-01-22 | 2001-09-17 | デカルブ・ジェネティクス・コーポレーション | 結実能力のある遺伝子変換コーン |
| EP0442174A1 (en) | 1990-02-13 | 1991-08-21 | Pioneer Hi-Bred International, Inc. | Stable transformation of plant cells |
| US5618988A (en) | 1990-03-02 | 1997-04-08 | Amoco Corporation | Enhanced carotenoid accumulation in storage organs of genetically engineered plants |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5187267A (en) | 1990-06-19 | 1993-02-16 | Calgene, Inc. | Plant proteins, promoters, coding sequences and use |
| DE69132939T2 (de) | 1990-06-25 | 2002-11-14 | Monsanto Technology Llc | Glyphosattolerante pflanzen |
| NZ239977A (en) | 1990-11-14 | 1993-08-26 | Pioneer Hi Bred Int | Transforming plants by the use of agrobacterium |
| US5932782A (en) | 1990-11-14 | 1999-08-03 | Pioneer Hi-Bred International, Inc. | Plant transformation method using agrobacterium species adhered to microprojectiles |
| EP0559742A1 (en) | 1990-11-26 | 1993-09-15 | E.I. Du Pont De Nemours And Company | Herbicidal oxazine ethers |
| US5459252A (en) | 1991-01-31 | 1995-10-17 | North Carolina State University | Root specific gene promoter |
| DE69233718T2 (de) | 1991-02-07 | 2008-12-04 | Bayer Bioscience N.V. | Staubblatt spezifische promotoren aus mais |
| IL101508A0 (en) | 1991-04-08 | 1992-12-30 | Rhone Poulenc Agrochimie | Chimeric plant genes based on upstream regulatory elements of helianthinin |
| DK0539563T3 (da) | 1991-05-15 | 2001-11-12 | Monsanto Technology Llc | Fremgangsmåde til skabelse af en transformeret risplante |
| US5405765A (en) | 1991-08-23 | 1995-04-11 | University Of Florida | Method for the production of transgenic wheat plants |
| US5591616A (en) | 1992-07-07 | 1997-01-07 | Japan Tobacco, Inc. | Method for transforming monocotyledons |
| EP0669976B1 (en) | 1992-10-29 | 1999-06-16 | Medical Research Council | Screening method using transcription factor DP-1 |
| US5389226A (en) | 1992-12-17 | 1995-02-14 | Amorphous Technologies International, Inc. | Electrodeposition of nickel-tungsten amorphous and microcrystalline coatings |
| TW404844B (en) | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| AU6819194A (en) | 1993-05-03 | 1994-11-21 | Cornell Research Foundation Inc. | Isolated dna elements that direct pistil-specific and anther-specific gene expression and methods of using same |
| US5670349A (en) | 1993-08-02 | 1997-09-23 | Virginia Tech Intellectual Properties, Inc. | HMG2 promoter expression system and post-harvest production of gene products in plants and plant cell cultures |
| DK0672752T3 (da) | 1993-09-03 | 2004-10-04 | Japan Tobacco Inc | Fremgangsmåde til transformering af monocotyledoner ved anvendelse af scutella af uudviklede embryoner |
| US5495007A (en) | 1994-04-29 | 1996-02-27 | Thompson; Gary A. | Phloem-specific promoter |
| US5633363A (en) | 1994-06-03 | 1997-05-27 | Iowa State University, Research Foundation In | Root preferential promoter |
| US5646333A (en) | 1994-09-02 | 1997-07-08 | Drexel University | Plant promoter useful for directing the expression of foreign proteins to the plant epidermis |
| HUT76355A (en) | 1995-11-24 | 1997-08-28 | Bay Zoltan Alkalmazott Kutatas | Plant gene-expression vector family based on dna fragments regulating alfalfa h3 histon gene variant (ms h3g1) |
| US6036983A (en) | 1996-05-20 | 2000-03-14 | Novo Nordisk A/S | Method of obtaining protein hydrolysates |
| WO1997047647A1 (es) | 1996-06-13 | 1997-12-18 | Consejo Superior De Investigaciones Cientificas | Proteinas vegetales |
| GB9624456D0 (en) | 1996-11-25 | 1997-01-15 | Isis Innovation | Assay method |
| US5959175A (en) | 1997-04-09 | 1999-09-28 | Thomas; Terry L. | Sunflower albumin 5' regulatory region for the modification of plant seed lipid composition |
| US5977436A (en) | 1997-04-09 | 1999-11-02 | Rhone Poulenc Agrochimie | Oleosin 5' regulatory region for the modification of plant seed lipid composition |
| ES2132025B1 (es) | 1997-06-12 | 2000-12-01 | Consejo Superior Investigacion | Proteinas urag de las plantas. |
| EP0905518A1 (en) | 1997-09-23 | 1999-03-31 | Academisch Ziekenhuis Leiden | Peptides specific for gluten-sensitive T-cells and use thereof |
| US6100450A (en) | 1997-10-22 | 2000-08-08 | Rhone-Poulenc Agrochimie | Seed specific promoters based on arabidopsis genes |
| US6232445B1 (en) | 1997-10-29 | 2001-05-15 | Sunol Molecular Corporation | Soluble MHC complexes and methods of use thereof |
| EP1068335A2 (en) | 1998-04-09 | 2001-01-17 | E.I. Dupont De Nemours And Company | Cell cycle regulatory proteins |
| AU3828099A (en) | 1998-05-08 | 1999-11-29 | Consejo Superior De Investigaciones Cientificas | Transgenic plant cells expressing a recombinant plant e2f peptide |
| AU5645199A (en) * | 1998-09-03 | 2000-03-27 | Lene Molskov Bech | 17 kda foam protein |
| AU3230200A (en) | 1999-02-12 | 2000-08-29 | Pioneer Hi-Bred International, Inc. | Transgenic plants with modified expression of the dp protein |
| GB9923306D0 (en) * | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| MXPA03009313A (es) * | 2001-04-12 | 2004-11-12 | Academish Ziekenhuis Leiden | Metodos y medios para uso de receptores de celulas t restringidos por hla-dq y peptidos derivados de prolamina unidos a hla-dq. |
| EP1332760A1 (en) | 2002-02-04 | 2003-08-06 | Academisch Ziekenhuis Leiden | Novel epitopes for celiac disease and autoimmune diseases, methods for detecting those and novel non-antigenic food compounds |
| US7320788B2 (en) * | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| EP2364718B1 (en) * | 2002-02-14 | 2016-07-06 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7202216B2 (en) | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| AU2003234597A1 (en) * | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| EP1563300B1 (en) | 2002-11-20 | 2012-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| US6992916B2 (en) | 2003-06-13 | 2006-01-31 | Taiwan Semiconductor Manufacturing Co., Ltd. | SRAM cell design with high resistor CMOS gate structure for soft error rate improvement |
| EP1755639B1 (en) | 2004-04-28 | 2017-08-16 | BTG International Limited | Epitopes related to coeliac disease |
| WO2010060155A1 (en) * | 2008-11-30 | 2010-06-03 | Nexpep Pty Ltd | Compositions and methods for treatment of celiac disease |
| JP6520175B2 (ja) | 2015-02-10 | 2019-05-29 | 富士通株式会社 | 無線通信装置、基地局システム及び無線通信装置制御方法 |
-
2002
- 2002-06-05 GB GBGB0212885.8A patent/GB0212885D0/en not_active Ceased
-
2003
- 2003-06-05 DK DK03738256.1T patent/DK1513873T3/da active
- 2003-06-05 EP EP14184972.9A patent/EP2826787B1/en not_active Expired - Lifetime
- 2003-06-05 NZ NZ537226A patent/NZ537226A/en not_active IP Right Cessation
- 2003-06-05 EP EP03738256.1A patent/EP1513873B1/en not_active Expired - Lifetime
- 2003-06-05 ES ES03738256.1T patent/ES2510440T3/es not_active Expired - Lifetime
- 2003-06-05 MX MXPA04012117A patent/MXPA04012117A/es active IP Right Grant
- 2003-06-05 JP JP2004511341A patent/JP2006512893A/ja not_active Withdrawn
- 2003-06-05 WO PCT/GB2003/002450 patent/WO2003104273A2/en not_active Ceased
- 2003-06-05 US US10/516,837 patent/US10053497B2/en active Active
- 2003-06-05 PT PT37382561T patent/PT1513873E/pt unknown
- 2003-06-05 AU AU2003244771A patent/AU2003244771B2/en not_active Expired
- 2003-06-05 SI SI200332396T patent/SI1513873T1/sl unknown
- 2003-06-05 CA CA2488218A patent/CA2488218C/en not_active Expired - Lifetime
- 2003-06-05 EP EP10181717.9A patent/EP2292649B1/en not_active Expired - Lifetime
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2004
- 2004-12-01 ZA ZA200409740A patent/ZA200409740B/en unknown
- 2004-12-03 MX MX2012011506A patent/MX338122B/es unknown
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2010
- 2010-05-12 JP JP2010110683A patent/JP5635302B2/ja not_active Expired - Lifetime
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2013
- 2013-02-06 JP JP2013021737A patent/JP6055689B2/ja not_active Expired - Lifetime
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2014
- 2014-08-08 JP JP2014162664A patent/JP5977293B2/ja not_active Expired - Lifetime
- 2014-09-29 JP JP2014198382A patent/JP2015052599A/ja active Pending
- 2014-11-07 CY CY20141100928T patent/CY1115730T1/el unknown
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2016
- 2016-02-29 JP JP2016037111A patent/JP6438423B2/ja not_active Expired - Lifetime
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2018
- 2018-04-11 US US15/951,116 patent/US20180334484A1/en not_active Abandoned
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