JP2010187666A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010187666A5 JP2010187666A5 JP2010016775A JP2010016775A JP2010187666A5 JP 2010187666 A5 JP2010187666 A5 JP 2010187666A5 JP 2010016775 A JP2010016775 A JP 2010016775A JP 2010016775 A JP2010016775 A JP 2010016775A JP 2010187666 A5 JP2010187666 A5 JP 2010187666A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorescence
- baseline
- ligand
- ligand addition
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091006027 G proteins Proteins 0.000 claims description 2
- 102000030782 GTP binding Human genes 0.000 claims description 2
- 108091000058 GTP-Binding Proteins 0.000 claims description 2
- 239000003446 ligand Substances 0.000 description 8
- 230000004913 activation Effects 0.000 description 6
- 108020003175 receptors Proteins 0.000 description 6
- 102000005962 receptors Human genes 0.000 description 6
- 238000000423 cell based assay Methods 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 108091005708 gustatory receptors Proteins 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000019583 umami taste Nutrition 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43479002P | 2002-12-18 | 2002-12-18 | |
| US60/434,790 | 2002-12-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559553A Division JP4654038B2 (ja) | 2002-12-18 | 2003-12-17 | キメラアルファｑ−ガストデューシンｇタンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010187666A JP2010187666A (ja) | 2010-09-02 |
| JP2010187666A5 true JP2010187666A5 (https=) | 2011-04-21 |
| JP5425651B2 JP5425651B2 (ja) | 2014-02-26 |
Family
ID=32595305
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559553A Expired - Lifetime JP4654038B2 (ja) | 2002-12-18 | 2003-12-17 | キメラアルファｑ−ガストデューシンｇタンパク質 |
| JP2010016775A Expired - Lifetime JP5425651B2 (ja) | 2002-12-18 | 2010-01-28 | キメラアルファｑ−ガストデューシンｇタンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004559553A Expired - Lifetime JP4654038B2 (ja) | 2002-12-18 | 2003-12-17 | キメラアルファｑ−ガストデューシンｇタンパク質 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7919236B2 (https=) |
| EP (1) | EP1581555B1 (https=) |
| JP (2) | JP4654038B2 (https=) |
| CN (1) | CN1726224A (https=) |
| AT (1) | ATE393778T1 (https=) |
| AU (1) | AU2003286069A1 (https=) |
| CA (1) | CA2507387A1 (https=) |
| DE (1) | DE60320682T2 (https=) |
| ES (1) | ES2305536T3 (https=) |
| WO (1) | WO2004055048A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7368285B2 (en) | 2001-03-07 | 2008-05-06 | Senomyx, Inc. | Heteromeric umami T1R1/T1R3 taste receptors and isolated cells that express same |
| DK2327985T3 (en) | 2001-06-26 | 2016-09-05 | Senomyx Inc | H1 Oligomeric T1R Taste Receptors and Cell Lines Expressing the Receptors, and Their Use to Identify Taste Compounds |
| AU2003286069A1 (en) * | 2002-12-18 | 2004-07-09 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
| WO2006046854A2 (en) | 2004-10-29 | 2006-05-04 | Quest International B.V. | Flavour modulating substances |
| BRPI0518075B8 (pt) | 2004-10-29 | 2017-05-16 | Quest Int Services B V | composição flavorizante, produto, e, processo de melhorar o flavor de um alimento, de uma bebida ou de um produto farmacêutico |
| DE602005015849D1 (de) | 2005-09-02 | 2009-09-17 | Givaudan Nederland Services B | Geschmackverstärker |
| WO2007121604A2 (en) | 2006-04-20 | 2007-11-01 | Givaudan Sa | Method relating to sweetness enhancement |
| US20110097741A1 (en) * | 2006-04-20 | 2011-04-28 | Jay Patrick Slack | Partial t1r2 nucleic acid sequence, receptor protein and its use in screening assays |
| JP2009533065A (ja) * | 2006-04-20 | 2009-09-17 | ジボダン エス エー | 味覚物質同定のための機能的方法 |
| ATE444280T1 (de) | 2006-05-05 | 2009-10-15 | Givaudan Nederland Services B | Zusammensetzung zur verbesserung von geschmack |
| US8039233B2 (en) * | 2007-01-18 | 2011-10-18 | Givaudan S.A. | Nucleic acid sequences and their use in methods to identify umami modulatiors |
| EP1975611A1 (en) | 2007-03-29 | 2008-10-01 | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand | Agonists of bitter taste receptors and uses thereof |
| EP2137322B1 (en) * | 2007-03-30 | 2013-02-27 | Givaudan SA | Methods to identify tas2r modulators |
| KR20100131969A (ko) * | 2007-12-10 | 2010-12-16 | 메타프로테오믹스, 엘엘씨 | 암, 혈관신생 및 이와 관련된 염증 경로의 치환된 1,3-시클로펜타디온 다중-표적 단백질 키나아제 조절제 |
| EP2108954A1 (en) | 2008-04-10 | 2009-10-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | A test system for detecting intracellular cyclic nucleotide level and methods and uses thereof |
| US8546085B2 (en) * | 2008-06-13 | 2013-10-01 | Givaudan Sa | Methods of identifying modulators of the bitter taste receptor TAS2R44 |
| JP5576653B2 (ja) * | 2008-12-26 | 2014-08-20 | サントリー食品インターナショナル株式会社 | 環状ジペプチド含有飲料 |
| EP2924112A1 (en) * | 2009-02-02 | 2015-09-30 | Chromocell Corporation | Novel cell lines and methods |
| US20130123135A1 (en) | 2010-05-07 | 2013-05-16 | Jay Patrick Slack | Methods To Identify Modulators of TAS2R48 Receptors |
| US20130115624A1 (en) | 2010-05-07 | 2013-05-09 | Givaudan S.A. | Methods To Identify Modulators |
| JP5906013B2 (ja) * | 2010-12-10 | 2016-04-20 | 花王株式会社 | 苦味抑制剤の評価・選択方法 |
| EP2661266B1 (en) | 2011-01-07 | 2020-09-16 | Anji Pharma (US) LLC | Chemosensory receptor ligand-based therapies |
| US9795792B2 (en) | 2011-02-25 | 2017-10-24 | Medtronic, Inc. | Emergency mode switching for non-pacing modes |
| US9128079B2 (en) | 2011-08-08 | 2015-09-08 | The Coca-Cola Company | Methods of using lung or bronchial epithelial cells to identify bitter taste modulators |
| WO2013072332A1 (en) | 2011-11-14 | 2013-05-23 | Givaudan Sa | Methods of using antagonists of bitter taste receptors |
| KR20190120430A (ko) | 2012-01-06 | 2019-10-23 | 엘셀릭스 테라퓨틱스 인코포레이티드 | 바이구아나이드 조성물 및 대사 장애를 치료하는 방법 |
| EP2800562A2 (en) | 2012-01-06 | 2014-11-12 | Elcelyx Therapeutics, Inc. | Compositions and methods for treating metabolic disorders |
| HK1210825A1 (en) | 2012-07-11 | 2016-05-06 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN105101956B (zh) | 2013-01-05 | 2018-12-07 | 埃尔舍利克斯治疗公司 | 包含双胍的延迟释放组合物 |
| EP2983507B1 (en) | 2013-03-15 | 2020-04-22 | Applied Food Biotechnology, Inc. | Feline bitter taste receptors and methods |
| US9804157B1 (en) | 2013-03-15 | 2017-10-31 | Senomyx, Inc. | Screening assays to identify compounds which modulate T1R associated taste modalities which eliminate false positives |
| JP6367315B2 (ja) * | 2013-05-10 | 2018-08-01 | ペプシコ, インコーポレイテッドPepsiCo Inc. | 潜在的味覚調節物質を特定するためのモデルとしての細胞 |
| WO2014183041A1 (en) | 2013-05-10 | 2014-11-13 | Pepsico, Inc. | Taste receptor internalization assay |
| JP6755640B2 (ja) | 2014-03-28 | 2020-09-16 | 味の素株式会社 | 甘味受容体キメラタンパク質及びその利用 |
| WO2017066799A1 (en) * | 2015-10-16 | 2017-04-20 | Cornell University | Sweeteners having enhanced organoleptic properties |
| JP6924590B2 (ja) * | 2016-03-14 | 2021-08-25 | サントリーホールディングス株式会社 | 苦味評価のための融合タンパク質および苦味評価方法 |
| CN108611324A (zh) * | 2018-05-07 | 2018-10-02 | 云南中烟工业有限责任公司 | 一种稳定共表达重组人源甜味受体蛋白的真核细胞系及其制备方法 |
| WO2025183058A1 (ja) * | 2024-02-29 | 2025-09-04 | 味の素株式会社 | 植物由来タンパク質含有食品における異味・異風味をマスキングする物質のスクリーニング方法および異味・異風味のマスキング用の組成物 |
| CN119193656A (zh) * | 2024-09-24 | 2024-12-27 | 上海交通大学 | 一种响应鲜味信号的酵母细胞模型及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817759A (en) * | 1992-04-09 | 1998-10-06 | Linguagen Corporation | Gustducin polypeptides and fragments |
| EP1214343A2 (en) | 1999-09-10 | 2002-06-19 | The Regents Of The University Of California | T2r taste receptor family |
| US6462178B1 (en) * | 1999-11-17 | 2002-10-08 | Yong Hou Wong | G protein |
| WO2002036622A2 (en) | 2000-10-30 | 2002-05-10 | Senomyx, Inc. | GαqPROETIN VARIANTS AND THEIR USE IN THE ANALYSIS AND DISCOVERY OF AGONISTS AND ANTAGONISTS OF CHEMOSENSORY RECEPTORS |
| US7041457B2 (en) * | 2000-10-30 | 2006-05-09 | Senomyx, Inc. | Gαq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors |
| AU2003286069A1 (en) * | 2002-12-18 | 2004-07-09 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
-
2003
- 2003-12-17 AU AU2003286069A patent/AU2003286069A1/en not_active Abandoned
- 2003-12-17 CA CA002507387A patent/CA2507387A1/en not_active Abandoned
- 2003-12-17 AT AT03776743T patent/ATE393778T1/de not_active IP Right Cessation
- 2003-12-17 JP JP2004559553A patent/JP4654038B2/ja not_active Expired - Lifetime
- 2003-12-17 US US10/538,038 patent/US7919236B2/en not_active Expired - Lifetime
- 2003-12-17 EP EP03776743A patent/EP1581555B1/en not_active Expired - Lifetime
- 2003-12-17 CN CNA2003801065075A patent/CN1726224A/zh active Pending
- 2003-12-17 ES ES03776743T patent/ES2305536T3/es not_active Expired - Lifetime
- 2003-12-17 WO PCT/CH2003/000830 patent/WO2004055048A2/en not_active Ceased
- 2003-12-17 DE DE60320682T patent/DE60320682T2/de not_active Expired - Lifetime
-
2010
- 2010-01-28 JP JP2010016775A patent/JP5425651B2/ja not_active Expired - Lifetime
-
2011
- 2011-02-25 US US13/035,435 patent/US8609362B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010187666A5 (https=) | ||
| Shiraki et al. | α, β-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor γ | |
| Si et al. | Selective artificial transmembrane channels for protons by formation of water wires. | |
| BR112014007332A2 (pt) | mensagens de conclusão agregada em uma interface de banda lateral | |
| DK2089343T3 (da) | Click-kemi til fremstilling af reportermolekyler | |
| PL398781A1 (pl) | Sposoby i zestawy do prognozowania ryzyka wystapienia reakcji na wlew oraz zaniku odpowiedzi której posrednicza przeciwciala poprzez monitorowanie kwasu moczowego w surowicy podczas terapii z zastosowaniem pegylowanej urykazy | |
| WO2017040930A3 (en) | Biomarkers predictive of cytokine release syndrome | |
| JP2015523003A5 (https=) | ||
| BRPI0907444A2 (pt) | Estolides sulfonados e outros derivados de ácidos graxos, métodos de fazê-los, e composições e processos os empregam | |
| CL2015000379A1 (es) | Proteína de fusión que comprende un agonista de glp-1r, fgf-21 o un compuesto mimético y un conector; composición farmacéutica que la comprende; ácido nucleico que la codifica; vector; célula huésped; método de preparación; y uso para tratar enfermedad cardiovascular, diabetes mellitus y/o síndrome metabólico. | |
| Milligan | Orthologue selectivity and ligand bias: translating the pharmacology of GPR35 | |
| JP2012228272A5 (https=) | ||
| Seabrook et al. | Methylarginine targeting chimeras for lysosomal degradation of intracellular proteins | |
| CN104853774A8 (zh) | Il-20拮抗剂用于治疗肝脏疾病 | |
| EP2539354A4 (en) | FOR RANTES-CODING NUCLEIC ACID MOLECULES AND COMPOSITIONS AND METHODS THEREWITH | |
| Iwashima et al. | Additive interaction of metabolic syndrome and chronic kidney disease on cardiac hypertrophy, and risk of cardiovascular disease in hypertension | |
| HK1258716A1 (zh) | 与表面结合的核酸分子的检测和量化 | |
| NO20090358L (no) | Retinoid-induserbar faktor, og anvendelse derav | |
| Bunnage et al. | TAFIa inhibitors in the treatment of thrombosis. | |
| JP2010528630A5 (https=) | ||
| WO2012068519A3 (en) | Markers associated with response to activated protein c administration, and uses thereof | |
| Chambers et al. | Determinants of left ventricular mass in aortic stenosis. | |
| Vaishampayan et al. | An unusual case of isolated sixth cranial nerve palsy in leprosy. | |
| Németh et al. | Asymmetric dimethylarginine: predictor of cardiovascular diseases? | |
| IuD et al. | Thermodynamic models, describing formation of" bridges" between nucleic acid molecules and liquid crystals |