JP2010132703A - 生薬材抽出物混合物および骨粗鬆症の予防または治療剤 - Google Patents
生薬材抽出物混合物および骨粗鬆症の予防または治療剤 Download PDFInfo
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Abstract
【解決手段】 エリンギの水抽出物またはこれと均等なエリンギ抽出物、および五加皮の水抽出物またはこれと均等な五加皮抽出物を用いて、骨芽細胞増殖活性および破骨細胞増殖抑制活性を有する生薬材抽出物混合物(組成物)を構成する。
【選択図】なし
Description
そこで、本発明は、長期投与した場合にも従来のような副作用がなく、骨粗鬆症に対して優れた薬効を有する物質を提供することを目的とする。
また、本発明は、上記の生薬材抽出物混合物を有効成分とする骨粗鬆症の治療または予防剤、および上記の生薬材抽出物混合物を含有する健康食品をも提供する。
なかでも、上記生薬材抽出物混合物は、前記エリンギ抽出物を固形分として0.5〜2.5重量部、および前記五加皮抽出物を固形分として0.5〜5.0重量部含むのが好ましい。
また、抽出工程に供するエリンギおよび五加皮は、例えば粉末状にあらかじめ粉砕されていてもよい。さらに、まずエリンギと五加皮とを混合して混合物を得、得られた混合物を上記抽出工程に供してエリンギ抽出物および五加皮抽出物を同時に生成してもよい。したがって、例えば粉末状のエリンギおよび五加皮を混合した後、当該混合物から抽出によって本発明に係る生薬材抽出物混合物を得ることもできる。
なお、本発明に係る生薬材抽出物混合物は、上記のエリンギ抽出物および五加皮抽出物に加えて、これらと同一または類似の機能を示す有効成分をさらに1種以上含有してもよい。
1.エリンギ抽出物の製造
エリンギ100gを3L抽出容器に入れ、蒸留水1Lを加えて、100℃で4時間熱水抽出した。前記過程(蒸留水1Lを加えて100℃で4時間熱水抽出する過程)を3回繰り返した後、得られた溶液(抽出液)を室温で冷やし、濾過紙で濾過した。濾過によって得られた抽出液(濾液)は、真空回転蒸発器を用いて40℃以下で減圧濃縮し、凍結乾燥して、粉末状のエリンギ抽出物を得た(収率:42%、凍結乾燥後固形分を測定して得られる固形分収率)。
五加皮100gを3L抽出容器に入れ、蒸留水1Lを加えて、100℃で4時間熱水抽出した。前記過程を3回繰り返した後、得られた溶液を室温で冷やし、濾過紙で濾過した。濾過によって得られた抽出液を、真空回転蒸発器を用いて40℃以下で減圧濃縮し、凍結乾燥して、粉末状の五加皮抽出物を得た(固形分収率:5.8%)。
上記1で得られたエリンギ抽出物0.5〜2.5重量部と上記2で得られた五加皮抽出物0.5〜5.0重量部とを混合して、生薬材抽出物混合物を製造した。
前記生薬材抽出物混合物は、培養液に希釈して、下記実験に使用した。すなわち、以下の実験においては、各生薬抽出物を培養液で表に示した濃度に希釈して実験を行った。
本発明に係る生薬材抽出物混合物が骨芽細胞の増殖および細胞活性度に及ぼす影響を調べるために、下記のような実験を行った。
本発明に係る生薬材抽出物混合物が骨芽細胞の増殖に及ぼす影響を評価するために、人間骨肉腫から由来した細胞株であるMG−63およびHOS細胞株をATCC(American Type Culture Collection, Rockville, USA)で購入して使用し、10%FBS(fetal bovine serum)を含有するDMEM(Dulbecco's modified Eagle's medium)培地で培養して使用した。
結果を表1および図1に示す。
本発明に係る生薬材抽出物混合物が骨芽細胞の活性に及ぼす影響を評価するために、上記1で培養したHOS骨芽細胞を96−ウェルプレートに各ウェル当たり5×103細胞となるように分株し、単層で増殖した後、生薬材抽出物混合物を0.08、0.4、1.0、5.0、10.0mg/mlの濃度で培養液に添加し、10%FBSが含有されたDMEMで96−ウェルプレートにおいて48時間培養した後、細胞を0.1%トリトンX−100/生理食塩水(saline)で37℃で30分間処理した。
結果を表2および図2に示す。
したがって、本発明に係る生薬材抽出物混合物は、骨芽細胞の標識酵素である塩基性リン酸分解酵素に優秀な活性を示すので、骨芽細胞の増殖に有効であることが分かる。
本発明に係る生薬材抽出物混合物が破骨細胞の成長および活性にいかなる影響を及ぼすかを調べるために、カルシウム−ホスフェートで被膜されたプレート(OAAS, OCT Inc.)に破骨細胞前駆細胞を培養し、破骨細胞の標識酵素であるTRAP(Tartrate-resistant acid phosphatase;以下、TRAPと略称する)の活性を分析した。
マウスの骨髄細胞を分離するために、7〜9週の雄性マウスを頸部捻転で犠牲させた後、大腿骨と脛骨を無菌的に摘出し、軟組織を除去し、腸骨の両端を切断した。ついで、26G注射針を用いて一端の骨髄腔に0.1%コラゲナーゼ(Gibco)、0.05%トリプシンおよび0.5mM EDTA(Gibco)が含有された酵素溶液1mlを注射して、骨髄を取り出した。その後、30分間攪拌し、骨髄細胞を集めて、10%FBSが含有されたα−MEM(α−minimum essential medium)に24時間前培養し、未付着細胞を集めた。
破骨細胞の形成測定は、破骨細胞の前駆細胞を、カルシウム−ホスフェートでコートしたプレート上で培養した後、TRAP(+)を示す多核細胞の数により観察した。具体的には、細胞培養後、付着細胞をPBSで洗浄した後、シートレート−アセテート−ホルムアルデヒド(citrate-acetate-formaldehyde)で5分間固定させ、ナフトール(naphthol)AS−BIホスフェート(phosphate)、ファストガーネット(fast Garnet)GBC溶液、および7mMタルトレート緩衝液(tartrate buffer、pH5)を含有する37℃アセテート緩衝液(pH5.0)に1時間培養し、TRAP染色を実施した。3つ以上の核を有するTRAP(+)多核細胞を破骨細胞とみなした。
結果を表3および図3に示す。
以上の実験結果から、本発明に係る生薬材抽出物混合物は、エリンギ抽出物および五加皮抽出物を各々単独で処理した場合に比べて、破骨細胞の形成を顕著に抑制することが分かる。
本発明の生薬材抽出物混合物の急性毒性を調べるために、下記のような方法で急性毒性実験を実施した。すなわち、実験動物として6週齢の特定病原体不在(specific pathogen-free, SPF)SD系ラットを使用して急性毒性実験を実施した。群当たり2匹ずつの動物に、本発明における生薬材抽出物を各々0.5%メチルセルロース溶液に懸濁して1g/kg/mlの容量で1回経口投与した。試験物質の投与後、動物の廃死可否、臨床症状、体重変化を観察し、血液学的検査と血液生化学的検査を実施し、剖検して目視で腹腔臓器と胸腔臓器の異常有無を観察した。
《製剤例1:薬学的製剤の製造》
1.散剤の製造
生薬材抽出物混合物 2g
乳糖 1g
前記の成分を混合し、気密袋に充填して、散剤を製造した。
生薬材抽出物混合物 100mg
とうもろこし澱粉 100mg
乳糖 100mg
ステアリン酸マグネシウム 2mg
前記の成分を混合した後、通常の錠剤の製造方法により打錠して、錠剤を製造した。
生薬材抽出物混合物 100mg
とうもろこし澱粉 100mg
乳糖 100mg
ステアリン酸マグネシウム 2mg
前記の成分を混合した後、通常のカプセル剤の製造方法によりゼラチンカプセルに充填して、カプセル剤を製造した。
本発明の生薬材抽出物混合物を含む食品を次のように製造した。
1.調理用薬味の製造
本発明の生薬材抽出物混合物を20〜95重量%となるような量使用して健康増進用調理用薬味を製造した。
本発明の生薬材抽出物混合物が0.2〜1.0重量%となるようにトマトケチャップ又はソースに添加して、健康増進用トマトケチャップ又はソースを製造した。
本発明の生薬材抽出物混合物0.5〜5.0重量%を小麦粉に添加し、この混合物を用いてパン、ケーキ、クッキー、クラッカーおよび麺類を製造して、健康増進用食品を製造した。
本発明の生薬材抽出物混合物0.1〜5.0重量%をスープおよび肉汁に添加して、健康増進用肉加工製品、麺類のスープおよび肉汁を製造した。
本発明の生薬材抽出物混合物10重量%をグラウンドビーフに添加して、健康増進用グラウンドビーフを製造した。
本発明の生薬材抽出物混合物5〜10重量%を牛乳に添加し、前記牛乳を用いてバターおよびアイスクリームのような多様な乳製品を製造した。
玄米、大麦、餅米、鳩麦を公知の方法でアルファ化させて乾燥させたものを焙煎した後、粉砕器を用いて粒度60メッシュの粉末に製造した。
黒豆、黒胡麻、荏胡麻を公知の方法で蒸して乾燥させたものを焙煎した後、粉砕器を用いて粒度60メッシュの粉末に製造した。
本発明の生薬材抽出物混合物を真空濃縮器で減圧・濃縮し、噴霧、熱風乾燥器で乾燥して得た乾燥物を、粉砕器を用いて粒度60メッシュに粉砕し、乾燥粉末を得た。
前記で製造した穀物類、種実類および生薬材抽出物混合物の乾燥粉末を次の割合で配合して製造した。
種実類(荏胡麻7重量%、黒豆8重量%、黒胡麻7重量%)、
生薬材抽出物混合物の乾燥粉末(3重量%)、
霊芝(0.5重量%)、
地黄(0.5重量%)
1.炭酸飲料の製造
砂糖5〜10%、クエン酸0.05〜0.3%、カラメル0.005〜0.02%、ビタミンC0.1〜1%の添加物を混合し、これに、79〜94%の精製水を混合してシロップを作り、前記シロップを85〜98℃で20〜180秒間殺菌して、冷却水と1:4の割合で混合した後、炭酸ガスを0.5〜0.82%注入して、本発明の生薬材抽出物混合物を含有する炭酸飲料を製造した。
液状果糖0.5%、オリゴ糖2%、砂糖2%、食塩0.5%、水75%のような副材料と、生薬材抽出物混合物とを均質に配合して、瞬間殺菌を実施した後、これをガラス瓶、PET瓶など小包装容器に包装して、健康飲料を製造した。
本発明の生薬材抽出物混合物5gをトマト又はニンジンジュース1,000mlに加えて、健康増進用野菜ジュースを製造した。
本発明の生薬材抽出物混合物1gをリンゴ又はブドウジュース1,000mlに加えて、健康増進用果物ジュースを製造した。
Claims (1)
- エリンギの水抽出物0.5〜2.5重量部、および五加皮の水抽出物0.5〜5.0重量部を含む骨粗鬆症改善用健康食品。
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KR100661398B1 (ko) * | 2005-02-18 | 2006-12-27 | 주식회사 오스코텍 | 큰느타리버섯, 오가피 및 삼칠근의 혼합 생약재 추출물 및이를 유효성분으로 함유하는 치주질환 예방 및 치료용 조성물 |
KR100680628B1 (ko) * | 2005-02-23 | 2007-02-09 | 주식회사 오스코텍 | 숙지황과 오가피의 혼합 생약재 추출물 및 이를 유효성분으로 하는 골다공증 예방 및 치료용 조성물 |
JP2010018563A (ja) * | 2008-07-11 | 2010-01-28 | Iwade Kingaku Kenkyusho:Kk | 新規化合物及び当該化合物を有効成分とする骨疾患の予防又は治療剤 |
JP2015059087A (ja) * | 2013-09-17 | 2015-03-30 | 新田ゼラチン株式会社 | 変形性関節症または骨粗鬆症の治療剤もしくは予防剤 |
JP2019189532A (ja) * | 2018-04-18 | 2019-10-31 | 青木 文夫 | ビタミンc混合物 |
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KR20030034825A (ko) * | 2001-10-27 | 2003-05-09 | 주식회사 오스코텍 | 오가피 추출물 및 이를 포함하는 성장기 뼈 형성 촉진 및 골다공증 예방 또는 치료용 약학적 조성물 |
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