JP2010099090A5 - - Google Patents
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- Publication number
- JP2010099090A5 JP2010099090A5 JP2010015946A JP2010015946A JP2010099090A5 JP 2010099090 A5 JP2010099090 A5 JP 2010099090A5 JP 2010015946 A JP2010015946 A JP 2010015946A JP 2010015946 A JP2010015946 A JP 2010015946A JP 2010099090 A5 JP2010099090 A5 JP 2010099090A5
- Authority
- JP
- Japan
- Prior art keywords
- probe
- sequence
- label
- pair
- target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000523 sample Substances 0.000 claims 190
- 230000000295 complement effect Effects 0.000 claims 74
- 230000002452 interceptive effect Effects 0.000 claims 34
- 238000003556 assay Methods 0.000 claims 31
- 238000003776 cleavage reaction Methods 0.000 claims 15
- 230000007017 scission Effects 0.000 claims 15
- 238000006243 chemical reaction Methods 0.000 claims 14
- 150000007523 nucleic acids Chemical group 0.000 claims 13
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 12
- 239000000411 inducer Substances 0.000 claims 12
- 238000001514 detection method Methods 0.000 claims 10
- 230000003993 interaction Effects 0.000 claims 10
- 102000004190 Enzymes Human genes 0.000 claims 8
- 108090000790 Enzymes Proteins 0.000 claims 8
- 108091005804 Peptidases Proteins 0.000 claims 8
- 239000004365 Protease Substances 0.000 claims 8
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 230000010287 polarization Effects 0.000 claims 7
- 241000894007 species Species 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 230000000368 destabilizing effect Effects 0.000 claims 4
- 239000003623 enhancer Substances 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000009830 intercalation Methods 0.000 claims 3
- 241000701022 Cytomegalovirus Species 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 241001502974 Human gammaherpesvirus 8 Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 244000052637 human pathogen Species 0.000 claims 2
- 230000001965 increasing effect Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 102100031780 Endonuclease Human genes 0.000 claims 1
- 108010042407 Endonucleases Proteins 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 241000244206 Nematoda Species 0.000 claims 1
- 229940122426 Nuclease inhibitor Drugs 0.000 claims 1
- 241000224016 Plasmodium Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003068 molecular probe Substances 0.000 claims 1
- 239000008191 permeabilizing agent Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41786402P | 2002-10-11 | 2002-10-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542913A Division JP2006513701A (ja) | 2002-10-11 | 2003-10-11 | 核酸ベースのシグナルトランスデューサーを含む立体構造的に敏感なプローブを有する標的検出システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010099090A JP2010099090A (ja) | 2010-05-06 |
| JP2010099090A5 true JP2010099090A5 (https=) | 2010-09-30 |
Family
ID=32094107
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542913A Pending JP2006513701A (ja) | 2002-10-11 | 2003-10-11 | 核酸ベースのシグナルトランスデューサーを含む立体構造的に敏感なプローブを有する標的検出システム |
| JP2010015946A Abandoned JP2010099090A (ja) | 2002-10-11 | 2010-01-27 | 核酸ベースのシグナルトランスデューサーを含む立体構造的に敏感なプローブを有する標的検出システム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004542913A Pending JP2006513701A (ja) | 2002-10-11 | 2003-10-11 | 核酸ベースのシグナルトランスデューサーを含む立体構造的に敏感なプローブを有する標的検出システム |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1558626A4 (https=) |
| JP (2) | JP2006513701A (https=) |
| AU (1) | AU2003269522A1 (https=) |
| WO (1) | WO2004033476A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006075735A1 (ja) * | 2005-01-14 | 2006-07-20 | Ngk Insulators, Ltd. | アレイおよびハイブリダイズ方法 |
| US20060194240A1 (en) * | 2005-02-28 | 2006-08-31 | Gen-Probe Incorporated | Compositions and methods of detecting an analyte by using a nucleic acid hybridization switch probe |
| JP2011067174A (ja) * | 2009-09-28 | 2011-04-07 | Fujitsu Ltd | 標的検出装置及びその製造方法 |
| FR2998969B1 (fr) * | 2012-12-04 | 2015-01-09 | Univ Limoges | Utilisation de biotine greffee pour le dosage de metaux dans une solution |
| WO2016163345A1 (ja) * | 2015-04-07 | 2016-10-13 | コニカミノルタ株式会社 | 核酸プローブ |
| MX2020008581A (es) | 2018-02-21 | 2020-09-21 | Bristol Myers Squibb Co | Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos. |
| US20220170918A1 (en) * | 2020-11-30 | 2022-06-02 | Palamedrix, Inc. | Substrate for single molecule organization |
| CN120254257A (zh) * | 2025-03-28 | 2025-07-04 | 浙江大学 | 一种基于颗粒酶b存在条件的荧光杂交链式反应生物传感器及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE88761T1 (de) * | 1986-01-10 | 1993-05-15 | Amoco Corp | Kompetitiver homogener test. |
| US5283174A (en) * | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| DE69010506T2 (de) * | 1989-10-04 | 1994-12-22 | Du Pont | Bestimmungsverfahren für biologische zielkomplexe auf der oberfläche eines biosensors. |
| US5925517A (en) * | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| EP0791008A4 (en) * | 1995-09-08 | 2003-04-23 | Anadys Pharmaceuticals Inc | SCREENING FOR COMPOUNDS WITH RNA AFFINITY |
| EP0851228A4 (en) * | 1996-06-10 | 2000-07-26 | Lab Molecular Biophotonics | HIGH SENSITIVITY FLUORESCENCE IMMUNOASSAY |
| WO1999049293A2 (en) * | 1998-03-24 | 1999-09-30 | Boston Probes, Inc. | Methods, kits and compositions pertaining to detection complexes |
| US6399302B1 (en) * | 1998-08-21 | 2002-06-04 | University Of Virginia Patent Foundation | Signal generating oligonucleotide-based biosensor |
| DE19950969A1 (de) * | 1999-10-22 | 2001-05-10 | Aventis Res & Tech Gmbh & Co | Doppelstrang-Nukleinsäure-Sonden und deren Verwendung |
| US6753141B2 (en) * | 2000-01-25 | 2004-06-22 | The University Of Utah | Simultaneous screening and identification of sequence alterations from amplified target |
| AU6299401A (en) * | 2000-05-08 | 2001-11-20 | Qtl Biosystems Llc | Improvements to the fluorescent polymer-qtl approach to biosensing |
-
2003
- 2003-10-11 WO PCT/KR2003/002101 patent/WO2004033476A1/en not_active Ceased
- 2003-10-11 JP JP2004542913A patent/JP2006513701A/ja active Pending
- 2003-10-11 EP EP03751517A patent/EP1558626A4/en not_active Withdrawn
- 2003-10-11 AU AU2003269522A patent/AU2003269522A1/en not_active Abandoned
-
2010
- 2010-01-27 JP JP2010015946A patent/JP2010099090A/ja not_active Abandoned
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