JP2010090088A - Collagen production promoter, cosmetic having collagen production-promoting effect, and food and drink for cosmetological use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To find a raw material which is effective in promoting production of collagen in a skin fibroblast and does not induce strong skin irritation in order to fundamentally prevent and improve skin aging and the like, and to provide a collagen production promoter or a cosmetic having a collagen production-promoting effect or food and drink for cosmetological use containing the raw material. <P>SOLUTION: The collagen production promoter contains an extract from Rhinacanthus nasuta. The cosmetic having a collagen production-promoting effect contains an extract from Rhinacanthus nasuta. The food and drink for cosmetological use having a collagen production-promoting effect contains an extract from Rhinacanthus nasuta. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a collagen production promoter containing a white crane reishi extract, a cosmetic having a collagen production promoting action, and a cosmetic food and drink.

  The skin is composed of the stratum corneum, epidermis layer, dermis layer and subcutaneous tissue. Among them, fibroblasts mainly produce extracellular matrices such as collagen, elastin, and hyaluronic acid, and these extracellular matrices Gives the skin elasticity and flexibility.

  Skin tension caused by aging and ultraviolet rays, reduction of freshness, generation of wrinkles and sagging (hereinafter collectively referred to as skin aging, etc.) is one of the major cosmetic problems as apparent aging changes. One.

  Therefore, conventionally, in order to prevent and improve the above-mentioned skin aging and the like, a moisturizer composed of sugar, amino acid, organic acid, pyrrolidone carboxylate, glycerin, 1,3-butylene glycol, etc. is applied to the skin, It is known to improve the moisture retention (see, for example, Patent Document 1). It is also known to apply collagen directly to the skin in order to prevent and improve the above-mentioned skin aging and the like. It is also known to apply retinoic acid, which is known as a wrinkle improving agent, to the skin in order to prevent and improve the above-mentioned skin aging and the like.

Japanese Patent No. 3608088

  However, since the moisturizer simply slows the evaporation of moisture from the skin, applying it to the skin only improves the condition of the stratum corneum and epidermis, and fundamentally prevents skin aging, It cannot be improved. Further, even if collagen is directly applied to the skin, it does not penetrate into the dermis layer, so that it only improves the state of the epidermis layer and cannot fundamentally prevent or improve skin aging. There is also concern that retinoic acid may induce strong skin irritation.

  Therefore, the present invention has been made for the purpose of solving the above-described problems, and is effective in promoting the production of collagen in dermal fibroblasts in order to fundamentally prevent and improve skin aging and the like. It is another object of the present invention to find a material that does not induce strong skin irritation, and to provide a collagen production promoter containing the material or a cosmetic or cosmetic food or drink having a collagen production promoting action.

(1) The collagen production promoter of the present invention is characterized by containing an extract from white crane reishi.

(2) The cosmetics having a collagen production promoting action of the present invention is characterized by containing an extract from Hakutsuru Reishi.

(3) The cosmetic food and drink having the collagen production promoting action of the present invention is characterized by containing an extract from white crane reishi.

  The “extract” in this specification refers to an extract obtained by an extraction process, a diluted or concentrated solution of the extract, a dried product obtained by drying the extract, or a roughly purified product or a purified product thereof. Any of these shall be included.

  Hereinafter, the present invention will be described in detail.

[Collagen production promoter]
The collagen production promoter of the present invention contains an extract from white crane reishi.

Rhinacanthus nasuta (L.) Kurz is an evergreen small shrub belonging to the genus Linacanthus fox family that originates from the Deccan Plateau in southern India, and its entire plant (Linacantus grass) is an anthelmintic, anti-inflammatory, It is known that it has antibacterial activity against skin fungi (for example, see “Primary Color Makino Wakahan Medicinal Encyclopedia, 492, Hokuryukan, 1988”), mainly in China, Taiwan, etc., and recently in Japan. Is also used as a traditional Chinese medicine. In addition, in the previous application by the present applicant, this white crane reishi has an active oxygen scavenging ability (see, for example, JP-A-9-143091), skin aging and hair based on the active oxygen scavenging ability It has an action to prevent fatigue (for example, see JP-A-9-143025), an excretion-promoting action (for example, see JP-A-9-16962), and a lipid peroxide inhibiting action. (For example, refer to Japanese Patent Application Laid-Open No. 2000-16945), to have an antiallergic action (for example, refer to Japanese Patent Application Laid-Open No. 2001-10964), and to have an antimalignant tumor action (for example, Japanese Patent Application Laid-Open No. 2002-53481). (See Japanese Patent Laid-Open Publication No. 2002-11469), liver function improving action (for example, see JP-A No. 2002-114692), whitening action (for example, JP-A No. 2003-896). 02 see JP.), That there is a TNF-alpha inhibitory action (e.g., see JP Patent 2006-52145.) Is disclosed. However, it is not known that Hakutsuru Reishi or Hakutsuru Reishi extract has a collagen production promoting action by fibroblasts.

  The details of the substance with the collagen production-promoting action contained in the extract from Hakutsuru Ganoderma are unknown, but the extraction method that has the collagen production-promoting action from Hakutsuru Ganoderma by the extraction method generally used for plant extraction You can get things. For example, it can be obtained by drying the raw material for extraction and pulverizing it as it is or using a pulverizer and subjecting it to extraction with an extraction solvent.

  The white crane ganoderma used in the present invention is a commercially available raw or dried product. The whole grass (aboveground part) or each part of leaves, stems, branches and roots alone or two or more of them are appropriately used. What was mixed may be used.

  Such a white crane ganoderma is extracted with a solvent to obtain an extract, and examples of the solvent used for the extraction include water and an organic solvent, which are used alone or in an appropriate ratio. These water and organic solvent are used at normal temperature or in a heated state or in a cooled state. Organic solvents used for extraction include alcohols such as ethanol, methanol, propanol and 1,3-butylene glycol, ethers such as dimethyl ether, diethyl ether and methyl ethyl ether, ketones such as acetone, hexane, heptane, fluid These include hydrocarbons such as paraffin and squalane, and the like, and these can be used alone or in admixture of two or more.

  The resulting white crane reishi extract is a transparent, green-brown to deep green liquid with odorless to slight aroma and a unique rich taste, which may be used as it is, but preferably filtered, It is purified by centrifugation or other methods, and further concentrated to a suitable level by distillation or the like. It is also possible to use this extract as a odorless or slightly fragrant, greenish brown to deep green fine powder with a unique, rich taste obtained by further processing by distillation drying, freeze drying or the like. is there. The solvent extract of white crane reishi obtained in this way has an excellent collagen production promoting action.

  When a mixed solution of water and an organic solvent is used as the extraction solvent, the mixing ratio can be adjusted as appropriate. For example, when using the liquid mixture of water and a lower aliphatic alcohol, the mixing ratio of water and a lower aliphatic alcohol can be 99: 1 to 1:99 (weight ratio).

  The extraction treatment can be performed using an arbitrary apparatus at room temperature or under reflux heating. In general, the dried raw material of the extraction raw material is put into a processing tank filled with the extraction solvent, and the soluble components are eluted in the extraction solvent with appropriate stirring, and then filtered to remove the extraction residue, obtain. At this time, the extraction temperature is preferably 80 to 95 ° C., the extraction time is preferably 10 minutes to 4 hours, and the amount of extraction solvent is usually 5 to 100 times (weight ratio) of the extraction raw material. It is preferable to do this.

  The obtained extract (hereinafter referred to as “white crane reishi extract”) can be used as it is as a collagen production promoter, but a concentrated solution or a dried product thereof is easier to use.

  In addition, Hakutsuru Ganoderma extract has a unique odor and taste, so it may be purified for the purpose of decolorization, deodorization, etc. within the range that does not cause a decrease in physiological activity. In general, it is not used in a large amount, so there is no practical problem even if it is used without purification. In addition, when formulating, a pharmaceutically acceptable carrier such as dextrin, cyclodextrin, or any other auxiliary agent can be added to facilitate storage and handling. It can be formulated into any dosage form such as powder, granule, tablet, pill, etc.

  The white crane reishi extract obtained as described above, as a collagen production promoter of the present invention, is percutaneously absorbed to reach fibroblasts, and activates collagen production by fibroblasts to the dermis layer. By supplying sufficient collagen, skin aging and the like can be prevented and / or improved. In addition, by being absorbed orally, it can act in a multifaceted manner to prevent and / or improve skin aging, etc., and can activate the skin from the inside and keep it in a youthful state.

  In addition, since the white crane reishi extract obtained as described above is a naturally derived extract, the applicant company also applied various cosmetics (solid soaps, lotions, essences) containing the white crane reishi extract. , Clay packs, gels, etc.) and various foods and drinks (supplements, health drinks, health teas, etc.) have been continuously provided to the market, without causing strong skin irritation and safety problems. I know that there is no.

[Cosmetics having collagen production promoting effect]
The above-mentioned white crane reishi extract is suitable for blending in cosmetics because it is excellent in use feeling and safety when applied to the skin. The cosmetics having a collagen production promoting action of the present invention contains the above-mentioned white crane reishi extract and has a collagen production promoting action.

  Examples of the cosmetics having the collagen production promoting action of the present invention include solid soaps, creams, lotions, mousses, emulsions, ointments, hair creams, hair tonics, packs, bathing agents and the like. The suitable compounding ratio of the white crane reishi extract in the cosmetics having the collagen production promoting action of the present invention is about 0.01 to 30% by weight.

  Various main agents, auxiliaries, and the like that are usually used in the production of cosmetics can be blended with the cosmetics having the collagen production promoting action of the present invention as long as they do not interfere with the collagen production promoting action. In addition, the cosmetics having the collagen production promoting action of the present invention are not limited to those in which only the white crane reishi extract is the main agent for preventing and improving skin aging and the like.

  In the cosmetics having the collagen production promoting action of the present invention, those that can be used as constituents together with the white crane reishi extract include, for example, glycerin, collagen, hyaluronic acid and salts thereof, chondroitin sulfate and salts thereof, chitin and chitosan. Moisturizing agents such as: UV absorbers such as amyl paradimethylaminobenzoate; complex lipids such as glycerophospholipid and sphingophospholipid; β-carotene, oil-soluble licorice extract, lycochalcone A, baicalin, baicalein and other active oxygen scavenging action Substances having; azulene, glycyrrhizic acid and salts thereof, glycyrrhetinic acid and derivatives thereof, anti-inflammatory substances such as zinc oxide; vitamins and derivatives thereof such as riboflavin, tocopherol, ascorbic acid and folic acid; jojoba oil, lanolin, liquid paraffin, Squalane, Oily components such as sostearyl alcohol; surfactants such as sodium stearyl sulfate, diethanolamine cetyl sulfate, and glyceryl stearate; antioxidants such as sodium erythorbate; preservatives such as ethyl paraben; buckwheat extract, chamomile extract, licorice Cholesterols such as root extract, rosemary extract, maronier extract; plant sterols; lipoproteins; microorganism-derived components such as bifidobacteria cultures, lactic acid bacteria cultures, yeast extract, bucurium extract; brown algae extract Algae extracts such as red algae extract; blood circulation promoters such as γ-oryzanol; anti-seborrheic agents such as sulfur; fragrances; alcohols; thickeners such as carboxy polymers; titanium yellow, safflower and other colorants It is done.

  When producing cosmetics containing Hakutsuru Ganoderma extract, the choice of other production raw materials is rarely restricted, such as fats and oils, waxes, hydrocarbons, fatty acids, alcohols, esters, and interfaces. Common bases and auxiliaries such as activators and fragrances can be used.

[Beauty food and drink having collagen production promoting effect]
The above-mentioned Hakutsuru Ganoderma extract has good flavor and excellent safety, and is therefore suitable for oral intake as a food or drink. The cosmetic food and drink having the collagen production promoting action of the present invention contains the white crane reishi extract and has a collagen production promoting action. Of course, those containing the formulated collagen production promoter of the present invention are also included in the scope of the cosmetic food and drink having the collagen production promoting action of the present invention.

  The cosmetic food and drink having the collagen production promoting action of the present invention may be one obtained by blending the white crane reishi extract with any food that does not impede its activity, or the white crane reishi extract. It may be a food (nutritional supplement) containing as a main component. The optional foods here include, for example, processed cereal products such as noodles, bread, cooked rice and rice cakes, processed fats and oils such as margarine and mayonnaise, processed meat products such as ham and sausage, and processed fishery products such as kamaboko and chikuwa. Dairy products such as yogurt, butter, cheese, ice cream, processed fruit products such as jam, processed vegetable products such as pickles, chocolate, cookies, cakes, candy, chewing gum, jelly and other sweets, juice, coffee, tea, All forms of food are included, such as various beverages such as green tea, oolong tea, carbonated beverages and milk, and seasonings such as soy sauce, sauce and mirin.

  The amount of white crane reishi extract in the beauty food and drink having the collagen production promoting action of the present invention is determined by taking a standard white crane reishi extract into consideration per day It is preferable to set so that the ingestion amount is about 1-1000 mg.

  The collagen production promoter of the present invention described above and the cosmetics and cosmetic foods and drinks having the collagen production promoting action are preferably applied to humans, as long as the effects of the present invention are exhibited. It may be applied to animals other than humans.

〔Example〕
EXAMPLES Hereinafter, although an Example etc. demonstrate this invention further more concretely, this invention is not limited to these Examples etc.

1. Sample preparation (1) Sample 1
1kg of white crane reishi leaves dried in the sun and then drum dried are pulverized with a pulverizer, roasted with a roaster and further pulverized, and the resulting pulverized product is sieved and classified with 12 mesh. As a result, approximately 0.8 kg of crushed white crane reishi was obtained. 2.5 g of this white crane reishi pulverized product was soaked in 100 ml of hot water for 60 minutes and filtered to obtain a transparent green-brown extract having a slight jasmine-like fragrance and unique taste. This extract was used as an extract according to Sample 1. Thereafter, the obtained extract was freeze-dried to obtain a freeze-dried powder, and this freeze-dried powder was used as a freeze-dried powder according to Sample 1.

(2) Sample 2
2.5 g of the above-mentioned white crane reishi pulverized product was immersed in 100 ml of water for 60 minutes and filtered to obtain a transparent green-brown extract having a slight jasmine-like fragrance and unique taste. This extract was used as the extract according to Sample 2. Thereafter, the obtained extract was freeze-dried to obtain a freeze-dried powder, and this freeze-dried powder was used as a freeze-dried powder according to Sample 2.

(3) Sample 3
The above-mentioned 2.5 g of white crane reishi pulverized product is immersed in 100 ml of ethanol water (water: ethanol = 10% by weight: 90% by weight) for 60 minutes, filtered and transparent with a slight aroma like jasmine and a unique taste. A greenish brown extract was obtained. This extract was used as an extract according to Sample 3. Thereafter, the obtained extract was freeze-dried to obtain a freeze-dried powder, and this freeze-dried powder was used as a freeze-dried powder according to Sample 3.

2. Evaluation of Collagen Production Promoting Action For the freeze-dried powders according to Samples 1 to 3 above, the collagen production promoting action was evaluated by the following test method.

Human skin fibroblasts were seeded in 96-well plates in 2 × 10 ⁴ cells / well in MEM medium (Minimum Essential Medium) containing 10% fetal bovine serum (hereinafter referred to as FBS). 24 hours after seeding, after washing with PBS (Phosphate Buffered Saline / phosphate buffered saline), containing 0.5% FBS containing lyophilized powder (freeze-dried powder according to samples 1 to 3) of a predetermined concentration. MEM medium was added and cultured for 72 hours.

  At this time, the lyophilized powder according to Sample 1 was added so that the concentration in MEM after the addition was 100 μg / ml, 200 μg / ml, and 400 μg / ml. In addition, the lyophilized powder according to Sample 2 was added so that the concentration in MEM after addition was 200 μg / ml, 400 μg / ml, and 800 μg / ml. Further, the lyophilized powder according to Sample 3 was added so that the concentration in MEM after addition was 50 μg / ml, 100 μg / ml, and 200 μg / ml.

  Thereafter, the amount of collagen in the culture supernatant was measured by ELISA. Measurement by the ELISA method was performed using an ELISA kit (Procollagen Type I C-peptide (PIP) EIA kit) manufactured by Takara Bio. Collagen production promotion rate was calculated with the amount of collagen production when no sample was added as 100%. Table 1 shows the collagen production promotion rate (%) of each sample. Moreover, the relationship between the density | concentration in MEM and collagen production acceleration rate in each sample (samples 1-3) is shown in FIGS.

Table 1 shows the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 1. Table 2 shows the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 2. Table 3 shows the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 3.
FIG. 1 is a diagram showing the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 1. FIG. 2 is a diagram showing the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 2. FIG. 3 is a diagram showing the relationship between the lyophilized powder concentration in MEM and the collagen production promotion rate in Sample 3.

  From the results shown in Tables 1 to 3 and FIGS. 1 to 3, it was confirmed that all the samples 1 to 3 have a collagen production promoting action in a concentration-dependent manner.

(Example 1) Solid soap After sufficiently kneading the soap material of the formulation of the following Formulation Example 1, the base was put into an extrusion molding machine maintained at 50 ° C. and extruded, and the solid soap was produced by using a stamping molding machine. In addition, in the following prescription examples 1-11, all the compounding quantities of a raw material shall be displayed by weight%.

Formulation Example 1
Cetanol 10.00
Dibutylhydroxytoluene 0.02
Extraction liquid for sample 1 20.00
Coloring agent Trace amount Natural oil soap base ※ Remaining amount
(*: Beef tallow 40%, palm oil 20%, NaOH 30%, moisture 10%)

(Example 2) Solid soap A solid soap was produced in the same manner as in Example 1 except that Sample 2 was used instead of Sample 1.

(Example 3) Solid soap A solid soap was produced in the same manner as in Example 1 except that Sample 3 was used instead of Sample 1.

(Example 4) Cream A cream was prepared by treating the cream material of the formulation of the following Formulation Example 2 by conventional methods such as warming dissolution, stirring emulsification and cooling.

Formulation Example 2
Glycerol monostearate 5.00
Stearic acid 5.00
Polyethylene glycol monostearate 2.00
Behenyl alcohol 1.00
Liquid paraffin 10.00
Glyceryl trioctanoate 10.00
Extract liquid for sample 1 0.01
1,3-butylene glycol 5.00
P-Hydroxybenzoate 0.20
Edetic acid disodium 0.01
Purified water remaining

(Example 5) Lotion A lotion was produced by treating the lotion material of the following prescription example 3 with a conventional method such as stirring and dissolving.

Formulation Example 3
Ethanol 15.00
Polyoxyethylene hydrogenated castor oil 8.00
1,3-butylene glycol 4.00
Coconut oil 1.00
Sodium citrate 0.30
Citric acid 0.10
P-Hydroxybenzoate 0.10
Sodium citrate 0.30
Edetic acid disodium 0.01
Extract 10.0 for sample 1
Purified water remaining

(Example 6) Mousse After the mousse material of the formulation of the following formulation example 4 was stirred and dissolved, dimethyl ether and liquefied petroleum gas were pressure-filled and sealed in a container equipped with an injection device to produce a mousse.

Formulation Example 4
N-methacryloylethyl-N, N-diethylammonium / α-N-methylcarboxybetaine / butyl methacrylate copolymer (30%) 4.00
Ethanol 13.00
Polyoxyethylene cetyl ether 3.00
Edetic acid disodium 0.01
Extract 5.00 for sample 1
Purified water remaining

(Example 7) Emulsion An emulsion was prepared by treating the emulsion material of the formulation of the following Formulation Example 5 by conventional methods such as warming dissolution, stirring emulsification and cooling.

Formulation Example 5
Polyoxyethylene sorbitan monostearate 2.00
Stearic acid 0.50
Tetraoleic acid polyoxyethylene sorbit 0.50
Behenyl alcohol 0.50
Lipophilic glyceryl monostearate 1.00
Glyceryl trioctanoate 4.00
Avocado oil 4.00
Extraction liquid for sample 1 30.00
1,3-butylene glycol 5.00
P-Hydroxybenzoate 0.20
Edetic acid disodium 0.01
Xanthan gum 0.14
Glycerin 0.50
Purified water remaining

(Example 8) Emulsion An emulsion was prepared by stirring and mixing the emulsion material of the formulation of the following Formulation Example 6.

Formulation Example 7
Natural fat (beef tallow: palm oil = 7: 3, moisture 15%) 8.00
Ethanol 5.00
Behenyl alcohol 0.50
Citric acid 0.10
Sodium citrate 0.20
Extract 15.00 for sample 1
1,3-butylene glycol 4.00
P-Hydroxybenzoate 0.10
Edetic acid disodium 0.01
Purified water remaining

(Example 9) Ointment An ointment was prepared by treating the ointment material of the formulation of the following Formulation Example 7 by conventional methods such as warming dissolution, stirring emulsification and cooling.

Formulation Example 7
Polyethylene glycol monostearate 2.00
Stearic acid 5.00
Tetraoleic acid polyoxyethylene sorbit 0.50
Behenyl alcohol 1.00
Lipophilic glyceryl monostearate 5.00
Glyceryl trioctanoate 10.00
Liquid paraffin 10.00
Extract liquid according to sample 1.50
1,3-butylene glycol 5.00
P-Hydroxybenzoate 0.20
Edetic acid disodium 0.01
Propylene glycol 1.00
Purified water remaining

(Example 10) Hair cream A hair cream was produced by treating the hair cream material of the formulation of the following Formulation Example 8 by conventional methods such as warming dissolution, stirring emulsification and cooling.

Formulation Example 8
Solid paraffin 3.00
Liquid paraffin 10.00
Squalane 5.00
Jojoba oil 2.00
Polyoxyethylene cetyl ether 1.00
Extract solution for sample 1 0.50
Sorbitan sesquioleate 1.00
Glycerin 3.00
Ethylparaben 0.10
Purified water remaining

(Example 11) Hair tonic A hair tonic was prepared by heating and dissolving the hair tonic material of the following prescription example 9.

Formulation Example 9
Ethanol 20.00
1% chitosan aqueous solution 20.00
Extract liquid according to sample 1 0.30
Purified water remaining

(Example 12) Tablet-form dietary supplement The mixture of the prescription of the following prescription example 10 was tableted, and the tablet-form dietary supplement was manufactured.

Formulation Example 10
50 g of 10 times concentrated extract of sample 1
Sucrose 175g
Sorbit 10g
Glycerin fatty acid ester 15g

(Example 13) Granular dietary supplement A mixture of the formulation of the following Formulation Example 11 was formed into granules to produce a granular dietary supplement.

Formulation Example 11
50 g of 10 times concentrated extract of sample 1
1000g beet oligosaccharide
Vitamin C 200g
Glycerin fatty acid ester 25g

(Example 14) Beverages The ingredients of the following prescription example 11 were sequentially mixed to produce a beverage. The blending amount of each raw material is the blending amount in 100 ml of beverage.

Formulation Example 12
Extract 12000mg sample 1
Honey 500mg
Cyclic oligosaccharide 500mg
Sweetness amount appropriate amount Acidulant appropriate amount Preservative appropriate amount Fragrance appropriate amount
Appropriate amount of water

  The bar soap, cream, lotion, mousse, emulsion, ointment, hair cream, hair tonic, tablet-shaped dietary supplement, granular dietary supplement or beverage described in Examples 1 to 14 are used, edible or drunk, respectively. As a result, rough skin could be improved. In addition, the skin tension was restored and the skin was moist and moist.

  In addition, this invention is illustrated to the solid soap, cream, lotion, mousse, milky lotion, ointment, hair cream, hair tonic, tablet-shaped dietary supplement, granular dietary supplement, or drink as described in the said Examples 1-14. It is not limited to the prescribed formulation example. For example, in the prescription examples 4 to 14, the extract or the concentrated liquid according to the sample 2 or the sample 3 can be used instead of the extract or the concentrated liquid according to the sample 1. Moreover, in the prescription examples 1-14, the lyophilized powder which concerns on the samples 1-3 can also be used instead of the extract which concerns on the samples 1-3, or its concentrate. Moreover, in the prescription examples 1-14, white crane spirit other than the extract which concerns on test examples 1-3, its concentrate, or lyophilized powder instead of the extract which concerns on samples 1-3, its concentrate, or lyophilized powder Extracts from turf (for example, hot water, water, extracts extracted with a solvent other than ethanol water (for example, ethanol, acetone, benzene, ether, etc.) can be used. Extracts from raw materials (for example, white crane reishi stalks, roots, whole grass, etc.) can also be used.In addition to prescription examples 1-14, other than the extract from white crane reishi in each prescription example It is also possible to use a formulation example in which the types and blending amounts of these components are appropriately changed.

It is a figure which shows the relationship between the freeze-dried powder density | concentration in MEM and the collagen production acceleration rate in the sample 1. FIG. It is a figure which shows the relationship between the freeze-dried powder density | concentration in MEM and the collagen production promotion rate in the sample 2. FIG. It is a figure which shows the relationship between the freeze-dried powder density | concentration in MEM and the collagen production promotion rate in the sample 3. FIG.

Claims (3)

  A collagen production promoter comprising an extract from Hakutsuru Reishi.   A cosmetic having a collagen production promoting action, comprising an extract from white crane reishi.   A cosmetic food or drink having an action of promoting collagen production, comprising an extract from Hakutsuru Reishi.

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