JP2009544711A5 - - Google Patents
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- Publication number
- JP2009544711A5 JP2009544711A5 JP2009521823A JP2009521823A JP2009544711A5 JP 2009544711 A5 JP2009544711 A5 JP 2009544711A5 JP 2009521823 A JP2009521823 A JP 2009521823A JP 2009521823 A JP2009521823 A JP 2009521823A JP 2009544711 A5 JP2009544711 A5 JP 2009544711A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- composition
- cell
- polynucleotide
- lethal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 54
- 239000002157 polynucleotide Substances 0.000 claims 20
- 102000040430 polynucleotide Human genes 0.000 claims 20
- 108091033319 polynucleotide Proteins 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 231100000518 lethal Toxicity 0.000 claims 19
- 230000001665 lethal effect Effects 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 239000003550 marker Substances 0.000 claims 15
- 201000010099 disease Diseases 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 238000003780 insertion Methods 0.000 claims 7
- 230000037431 insertion Effects 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108010091086 Recombinases Proteins 0.000 claims 2
- 102000018120 Recombinases Human genes 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 108010077544 Chromatin Proteins 0.000 claims 1
- 210000003483 chromatin Anatomy 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 210000003897 hepatic stem cell Anatomy 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 210000004216 mammary stem cell Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
- 238000003153 stable transfection Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000003146 transient transfection Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82038106P | 2006-07-26 | 2006-07-26 | |
| US88909507P | 2007-02-09 | 2007-02-09 | |
| PCT/US2007/016747 WO2008073154A2 (en) | 2006-07-26 | 2007-07-26 | Methods and compositions for treating disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009544711A JP2009544711A (ja) | 2009-12-17 |
| JP2009544711A5 true JP2009544711A5 (enExample) | 2010-09-09 |
Family
ID=39512236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521823A Pending JP2009544711A (ja) | 2006-07-26 | 2007-07-26 | 疾病の治療方法及び疾病治療用組成物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20100003226A1 (enExample) |
| EP (1) | EP2043662B1 (enExample) |
| JP (1) | JP2009544711A (enExample) |
| KR (1) | KR20090035011A (enExample) |
| AU (1) | AU2007332980A1 (enExample) |
| CA (1) | CA2658836C (enExample) |
| DK (1) | DK2043662T3 (enExample) |
| ES (1) | ES2553332T3 (enExample) |
| HU (1) | HUE027142T2 (enExample) |
| IL (1) | IL196638A (enExample) |
| MX (1) | MX2009000966A (enExample) |
| NZ (1) | NZ575075A (enExample) |
| PL (1) | PL2043662T3 (enExample) |
| PT (1) | PT2043662E (enExample) |
| RU (1) | RU2468820C2 (enExample) |
| WO (1) | WO2008073154A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013109944A1 (en) * | 2012-01-18 | 2013-07-25 | The Trustees Of The University Of Pennsylvania | Methods for assessing risk for cancer using biomarkers |
| EA029382B1 (ru) | 2012-05-09 | 2018-03-30 | Кантекс Фармасьютикалз, Инк. | Лечение миелосупрессии |
| EP3258941A4 (en) | 2015-02-17 | 2018-09-26 | Cantex Pharmaceuticals, Inc. | Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction |
| WO2016133907A1 (en) * | 2015-02-17 | 2016-08-25 | Cantex Pharmaceuticals, Inc. | Adoptive cell transfer methods |
| KR20180069081A (ko) | 2015-11-11 | 2018-06-22 | 인트렉손 코포레이션 | 심장 이상 및 기타 병리 이상의 치료를 위한 복수의 생물학적으로 활성화된 폴리펩티드를 단일 벡터로부터 발현하기 위한 조성물 및 방법 |
| JP7051060B2 (ja) * | 2017-05-09 | 2022-04-11 | 学校法人慶應義塾 | 脳腫瘍治療用細胞製剤 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| EP1188448A3 (en) * | 1994-03-15 | 2002-04-17 | Prizm Pharmaceuticals, Inc. | Heparin-binding growth factors for gene therapy and anterior eye disorders |
| WO1996036362A1 (en) * | 1995-05-16 | 1996-11-21 | Prizm Pharmaceuticals, Inc. | Compositions containing nucleic acids and ligands for therapeutic treatment |
| WO1997049434A2 (en) * | 1996-06-24 | 1997-12-31 | Prizm Pharmaceuticals, Inc. | Heparinized medical devices containing heparin-binding growth factor conjugates |
| AU755251B2 (en) * | 1998-02-19 | 2002-12-05 | St. Jude Children's Research Hospital | Compositions and methods for sensitizing and inhibiting growth of human tumor cells |
| US7691370B2 (en) * | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| DE60043889D1 (en) * | 1999-06-07 | 2010-04-08 | Tet Systems Holding Gmbh & Co | Tet repressor basierte transkriptionale regulatorische proteine |
| JP5031967B2 (ja) | 2000-03-22 | 2012-09-26 | イントレキソン コーポレーション | 新規エクジソン受容体ベースの誘導性遺伝子発現系 |
| US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
| DK1311661T3 (da) * | 2000-08-14 | 2012-11-26 | Us Gov Health & Human Serv | Forøget homolog rekombination medieret ved lambda-rekombinationsproteiner |
| US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
| CA2435503C (en) * | 2001-01-19 | 2011-02-22 | Ludwig Institute For Cancer Research | Flt4(vegfr-3) as a target for tumor imaging and anti-tumor therapy |
| ES2422303T3 (es) | 2001-02-20 | 2013-09-10 | Intrexon Corp | Receptores mutantes por sustitución novedosos y su uso en un sistema de expresión génica inducible basado en receptores nucleares |
| CA2438119C (en) | 2001-02-20 | 2014-12-16 | Rheogene Holdings, Inc. | Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system |
| AU2002248500B2 (en) | 2001-02-20 | 2007-12-13 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| ES2385598T3 (es) | 2001-02-20 | 2012-07-27 | Intrexon Corporation | Sistema novedoso de expresión génica inducible basado en el receptor de ecdisona/receptor X retinoide de invertebrado |
| US6828102B2 (en) * | 2001-11-20 | 2004-12-07 | Albany Medical College | Plasmids and methods for monitoring endonuclease digestion efficiency |
| EP1327688A1 (en) * | 2002-01-14 | 2003-07-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Adenoviruses with enhanced lytic potency |
| EP1529110B1 (en) * | 2002-08-01 | 2011-10-05 | Evolva Ltd. | Methods of mixing large numbers of heterologous genes |
| US7785871B2 (en) | 2002-10-09 | 2010-08-31 | Intrexon Corporation | DNA cloning vector plasmids and methods for their use |
| EP1631319A4 (en) * | 2003-05-30 | 2007-10-31 | Cleveland Clinic Foundation | IN VIVO PRODUCTION OF A CLOSTRIDIUM NEUROTOXIN LIGHT CHAIN PEPTIDE |
| CA2436196A1 (en) * | 2003-07-25 | 2005-01-25 | Oncolytics Biotech Inc. | Oncolytic virus for purging cellular compositions of cells of lymphoid malignancies |
| US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
| AU2005248371B2 (en) | 2004-05-18 | 2011-12-15 | Intrexon Corporation | Methods for dynamic vector assembly of DNA cloning vector plasmids |
-
2007
- 2007-07-26 NZ NZ575075A patent/NZ575075A/en not_active IP Right Cessation
- 2007-07-26 AU AU2007332980A patent/AU2007332980A1/en not_active Abandoned
- 2007-07-26 RU RU2009103208/15A patent/RU2468820C2/ru not_active IP Right Cessation
- 2007-07-26 EP EP07870731.2A patent/EP2043662B1/en not_active Not-in-force
- 2007-07-26 WO PCT/US2007/016747 patent/WO2008073154A2/en not_active Ceased
- 2007-07-26 DK DK07870731.2T patent/DK2043662T3/en active
- 2007-07-26 JP JP2009521823A patent/JP2009544711A/ja active Pending
- 2007-07-26 CA CA2658836A patent/CA2658836C/en not_active Expired - Fee Related
- 2007-07-26 ES ES07870731.2T patent/ES2553332T3/es active Active
- 2007-07-26 MX MX2009000966A patent/MX2009000966A/es active IP Right Grant
- 2007-07-26 PL PL07870731T patent/PL2043662T3/pl unknown
- 2007-07-26 KR KR1020097003901A patent/KR20090035011A/ko not_active Ceased
- 2007-07-26 HU HUE07870731A patent/HUE027142T2/en unknown
- 2007-07-26 PT PT78707312T patent/PT2043662E/pt unknown
- 2007-07-26 US US12/374,691 patent/US20100003226A1/en not_active Abandoned
-
2009
- 2009-01-21 IL IL196638A patent/IL196638A/en active IP Right Grant
-
2014
- 2014-11-07 US US14/535,758 patent/US20150132265A1/en not_active Abandoned
-
2017
- 2017-01-27 US US15/417,598 patent/US20170191027A1/en not_active Abandoned
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