JP2009543579A5 - - Google Patents
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- JP2009543579A5 JP2009543579A5 JP2009520824A JP2009520824A JP2009543579A5 JP 2009543579 A5 JP2009543579 A5 JP 2009543579A5 JP 2009520824 A JP2009520824 A JP 2009520824A JP 2009520824 A JP2009520824 A JP 2009520824A JP 2009543579 A5 JP2009543579 A5 JP 2009543579A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- soluble
- wsx
- isolated
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100040066 Interleukin-27 receptor subunit alpha Human genes 0.000 claims 17
- 101710089672 Interleukin-27 receptor subunit alpha Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 102000005754 Cytokine Receptor gp130 Human genes 0.000 claims 9
- 108010006197 Cytokine Receptor gp130 Proteins 0.000 claims 9
- 101000852964 Homo sapiens Interleukin-27 subunit beta Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 2
- 102100022338 Integrin alpha-M Human genes 0.000 claims 2
- 102100022297 Integrin alpha-X Human genes 0.000 claims 2
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 2
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000853002 Homo sapiens Interleukin-25 Proteins 0.000 claims 1
- 101001128431 Homo sapiens Myeloid-derived growth factor Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000013691 Interleukin-17 Human genes 0.000 claims 1
- 108050003558 Interleukin-17 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102100036712 Interleukin-27 subunit beta Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 108010002616 Interleukin-5 Proteins 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 230000009390 immune abnormality Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83221306P | 2006-07-19 | 2006-07-19 | |
| US83745006P | 2006-08-11 | 2006-08-11 | |
| PCT/US2007/016329 WO2008011081A2 (en) | 2006-07-19 | 2007-07-18 | Wsx-1/p28 as a target for anti-inflammatory responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009543579A JP2009543579A (ja) | 2009-12-10 |
| JP2009543579A5 true JP2009543579A5 (https=) | 2010-09-02 |
Family
ID=38957359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520824A Pending JP2009543579A (ja) | 2006-07-19 | 2007-07-18 | 抗炎症反応のための標的としてのＷＳＸ−１／ｐ２８ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9683026B2 (https=) |
| EP (1) | EP2046809B1 (https=) |
| JP (1) | JP2009543579A (https=) |
| AU (1) | AU2007275654A1 (https=) |
| CA (1) | CA2657934C (https=) |
| DK (1) | DK2046809T3 (https=) |
| ES (1) | ES2612383T3 (https=) |
| MX (1) | MX2009000696A (https=) |
| WO (1) | WO2008011081A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3345620B1 (en) * | 2009-05-13 | 2024-08-28 | Genzyme Corporation | Methods and compositions for treating lupus |
| AU2012205384B2 (en) | 2011-01-14 | 2015-09-10 | Five Prime Therapeutics, Inc. | IL-27 antagonists for treating inflammatory diseases |
| EP3631450B1 (en) * | 2017-05-29 | 2022-11-23 | Charité - Universitätsmedizin Berlin | Cd8 t cell subsets as a biomarker for predicting non-fusion after spinal fusion surgery |
| JP7382625B2 (ja) * | 2019-08-29 | 2023-11-17 | 国立大学法人 鹿児島大学 | 掻痒治療剤 |
| EP4192489A4 (en) | 2020-08-05 | 2024-12-11 | Synthekine, Inc. | IL2RB-BINDING MOLECULES AND METHODS OF USE |
| MX2023001415A (es) | 2020-08-05 | 2023-04-24 | Synthekine Inc | Composiciones y métodos relacionados con la unión al receptor de il27. |
| US12291572B2 (en) | 2020-08-05 | 2025-05-06 | Synthekine, Inc. | IL12 receptor synthetic cytokines and methods of use |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| KR102773428B1 (ko) | 2020-08-05 | 2025-02-28 | 신테카인, 인크. | Il10 수용체 결합 분자 및 사용 방법 |
| WO2022031885A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10ra binding molecules and methods of use |
| US12012457B1 (en) | 2020-08-05 | 2024-06-18 | Synthekine, Inc. | IL23R binding molecules and methods of use |
| WO2022031884A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il2rg binding molecules and methods of use |
| WO2022031890A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Ifngr2 binding molecules and methods of use |
| BR112023001723A2 (pt) | 2020-08-05 | 2023-05-02 | Synthekine Inc | Moléculas de ligação à gp130 e métodos de uso |
| US11859001B2 (en) | 2020-08-05 | 2024-01-02 | Synthekine, Inc. | IL12RB1-Binding molecules and methods of use |
| US12540188B2 (en) | 2020-08-05 | 2026-02-03 | Synthekine, Inc. | IL10Rα/IL2Rγ synthetic cytokines |
| EP4200339A4 (en) * | 2020-08-05 | 2025-04-30 | Synthekine, Inc. | Compositions and methods related to receptor pairings |
| US12286482B2 (en) | 2020-08-05 | 2025-04-29 | Synthekine, Inc. | IL10RB binding molecules and encoding nucleic acids |
| EP4192490A4 (en) | 2020-08-05 | 2025-01-01 | Synthekine, Inc. | IL27RA-BINDING MOLECULES AND METHODS OF USE |
| CN119757761B (zh) * | 2024-12-16 | 2026-03-06 | 新疆医科大学第一附属医院 | 一种鉴别诊断活动性肺结核的生物标志物 |
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-
2007
- 2007-07-18 JP JP2009520824A patent/JP2009543579A/ja active Pending
- 2007-07-18 EP EP07836143.3A patent/EP2046809B1/en active Active
- 2007-07-18 ES ES07836143.3T patent/ES2612383T3/es active Active
- 2007-07-18 MX MX2009000696A patent/MX2009000696A/es active IP Right Grant
- 2007-07-18 WO PCT/US2007/016329 patent/WO2008011081A2/en not_active Ceased
- 2007-07-18 DK DK07836143.3T patent/DK2046809T3/en active
- 2007-07-18 US US11/880,121 patent/US9683026B2/en active Active
- 2007-07-18 AU AU2007275654A patent/AU2007275654A1/en not_active Abandoned
- 2007-07-18 CA CA2657934A patent/CA2657934C/en active Active
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