JP2009542683A - Ｄ−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 - Google Patents

Ｄ−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Download PDF

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JP2009542683A
JP2009542683A JP2009518342A JP2009518342A JP2009542683A JP 2009542683 A JP2009542683 A JP 2009542683A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009518342 A JP2009518342 A JP 2009518342A JP 2009542683 A JP2009542683 A JP 2009542683A
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substituted
unsubstituted
member selected
alkyl
heterocycloalkyl
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JP2009542683A5 (pt
Inventor
ドーシー，ジェームス，エム．
ホプキンス，セス，シー．
フォグレソング，ロバート，ジェイ．
ヘファーナン，ミシェル，エル．アール．
ジョーンズ，マイケル，エル．
ペラレス，ジョー，ビー．
ファン，クン，ケビン
オグブ，シプリアン，オー．
ジョーンズ，スティーブン，ダブリュー．
ソウクリ，ムスタファ
バーニー，マーク，エー．
スペア，ケリー，エル．
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セプラコア インコーポレーテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Anesthesiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • AIDS & HIV (AREA)
JP2009518342A 2006-06-30 2007-07-02 Ｄ−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤 Pending JP2009542683A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80639106P 2006-06-30 2006-06-30
US84246506P 2006-09-05 2006-09-05
US91429307P 2007-04-26 2007-04-26
PCT/US2007/015396 WO2008005456A2 (en) 2006-06-30 2007-07-02 Fused heterocyclic inhibitors of d-amino acid oxidase

Publications (2)

Publication Number Publication Date
JP2009542683A true JP2009542683A (ja) 2009-12-03
JP2009542683A5 JP2009542683A5 (pt) 2010-08-05

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JP2009518342A Pending JP2009542683A (ja) 2006-06-30 2007-07-02 Ｄ−アミノ酸オキシダーゼの縮合ヘテロ環式阻害剤

Country Status (9)

Country Link
EP (1) EP2057162A2 (pt)
JP (1) JP2009542683A (pt)
KR (1) KR20090024823A (pt)
AU (1) AU2007269646A1 (pt)
BR (1) BRPI0713216A2 (pt)
CA (1) CA2659060A1 (pt)
IL (1) IL195921A0 (pt)
MX (1) MX2008016525A (pt)
WO (1) WO2008005456A2 (pt)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びｄａａｏ阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Ｄａａｏ酵素阻害剤としてのピリダジノン
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2006427A3 (cs) 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
ES2566479T3 (es) 2006-01-06 2016-04-13 Sunovion Pharmaceuticals Inc. Inhibidores de reabsorción de monoamina con base en tetralona
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
EP2816024B8 (en) 2006-03-31 2018-04-04 Sunovion Pharmaceuticals Inc. Chiral amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US8492405B2 (en) 2006-10-18 2013-07-23 Takeda Pharmaceutical Company Limited Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
TW201041869A (en) 2009-05-14 2010-12-01 Japan Tobacco Inc Azetidine compound and pharmaceutical use thereof

Citations (3)

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JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンｈ４受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド Ｄ−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9803228D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
EP1391460A1 (en) * 1999-09-30 2004-02-25 Pfizer Products Inc. Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
CZ2006427A3 (cs) * 2003-12-29 2006-11-15 Sepracor Inc. Pyrrolové a pyrazolové inhibitory DAAO
CA2569530C (en) * 2004-07-01 2013-07-30 Daiichi Asubio Pharma Co.,Ltd. Thienopyrazole derivative having pde 7 inhibitory activity
JP2008527032A (ja) * 2005-01-19 2008-07-24 バイオリポックス エービー 炎症の治療に有用なチエノピロール
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001131181A (ja) * 1999-09-30 2001-05-15 Pfizer Prod Inc グリコーゲンホスホリラーゼ阻害物質としての二環式ピロリルアミド類
JP2006500394A (ja) * 2002-09-06 2006-01-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チエノピロリルおよびフラノピロリル化合物並びにヒスタミンｈ４受容体リガンドとしてのそれらの使用
JP2009511462A (ja) * 2005-10-06 2009-03-19 メルク シャープ エンド ドーム リミテッド Ｄ−アミノ酸酸化酵素阻害剤として神経変性および精神疾患を治療するための縮合ピロールカルボン酸の使用

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522830A (ja) * 2011-07-07 2014-09-08 武田薬品工業株式会社 ピリミジノン化合物およびそれらの使用
JP2014524461A (ja) * 2011-08-22 2014-09-22 武田薬品工業株式会社 ピリダジノン化合物、及びｄａａｏ阻害剤としてのその使用
JP2016502998A (ja) * 2012-12-17 2016-02-01 武田薬品工業株式会社 Ｄａａｏ酵素阻害剤としてのピリダジノン
US9750748B2 (en) 2012-12-17 2017-09-05 Takeda Pharmaceutical Company Limited Pyridazinones as DAAO enzyme inhibitors
KR20220123738A (ko) * 2014-04-30 2022-09-08 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
KR102537686B1 (ko) 2014-04-30 2023-05-30 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도

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Publication number Publication date
BRPI0713216A2 (pt) 2012-12-04
EP2057162A2 (en) 2009-05-13
WO2008005456A2 (en) 2008-01-10
IL195921A0 (en) 2009-09-01
CA2659060A1 (en) 2008-01-10
MX2008016525A (es) 2009-03-09
KR20090024823A (ko) 2009-03-09
AU2007269646A1 (en) 2008-01-10
WO2008005456A3 (en) 2008-07-31

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