JP2009539970A5 - - Google Patents

Info

Publication number

JP2009539970A5

JP2009539970A5 JP2009514986A JP2009514986A JP2009539970A5 JP 2009539970 A5 JP2009539970 A5 JP 2009539970A5 JP 2009514986 A JP2009514986 A JP 2009514986A JP 2009514986 A JP2009514986 A JP 2009514986A JP 2009539970 A5 JP2009539970 A5 JP 2009539970A5

Authority

JP

Japan

Prior art keywords

pharmaceutically acceptable

cancer

derivatives

acceptable salts

tylosin

Prior art date

2007-06-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 12
• 239000003120 macrolide antibiotic agent Substances 0.000 claims 9
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 6
• 239000004182 Tylosin Substances 0.000 claims 5
• 229930194936 Tylosin Natural products 0.000 claims 5
• 229960004059 tylosin Drugs 0.000 claims 5
• WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 claims 5
• 235000019375 tylosin Nutrition 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 claims 3
• 206010005003 Bladder cancer Diseases 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 3
• 208000026310 Breast neoplasm Diseases 0.000 claims 3
• 206010009944 Colon cancer Diseases 0.000 claims 3
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
• 239000004104 Oleandomycin Substances 0.000 claims 3
• RZPAKFUAFGMUPI-UHFFFAOYSA-N Oleandomycin Natural products O1C(C)C(O)C(OC)CC1OC1C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C2(OC2)CC(C)C(OC2C(C(CC(C)O2)N(C)C)O)C1C RZPAKFUAFGMUPI-UHFFFAOYSA-N 0.000 claims 3
• 239000004187 Spiramycin Substances 0.000 claims 3
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 3
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
• 229960003276 erythromycin Drugs 0.000 claims 3
• 206010017758 gastric cancer Diseases 0.000 claims 3
• RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 claims 3
• 229960002351 oleandomycin Drugs 0.000 claims 3
• 235000019367 oleandomycin Nutrition 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 229960001294 spiramycin Drugs 0.000 claims 3
• 235000019372 spiramycin Nutrition 0.000 claims 3
• 229930191512 spiramycin Natural products 0.000 claims 3
• 201000011549 stomach cancer Diseases 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 201000005112 urinary bladder cancer Diseases 0.000 claims 3
• ICVKYYINQHWDLM-KBEWXLTPSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4 Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 ICVKYYINQHWDLM-KBEWXLTPSA-N 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 229960001717 tylosin tartrate Drugs 0.000 claims 2
• 108700001666 APC Genes Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1