JP2009539827A5 - - Google Patents

Info

Publication number

JP2009539827A5

JP2009539827A5 JP2009514226A JP2009514226A JP2009539827A5 JP 2009539827 A5 JP2009539827 A5 JP 2009539827A5 JP 2009514226 A JP2009514226 A JP 2009514226A JP 2009514226 A JP2009514226 A JP 2009514226A JP 2009539827 A5 JP2009539827 A5 JP 2009539827A5

Authority

JP

Japan

Prior art keywords

antibody

subunit

insulin receptor

reacts

active form

Prior art date

2007-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims description 10
• 102000003746 Insulin Receptor Human genes 0.000 claims description 8
• 108010001127 Insulin Receptor Proteins 0.000 claims description 8
• 229940079593 drug Drugs 0.000 claims description 7
• 230000001632 homeopathic effect Effects 0.000 claims description 6
• 206010012601 diabetes mellitus Diseases 0.000 claims description 5
• 208000002705 Glucose Intolerance Diseases 0.000 claims description 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
• 238000000034 method Methods 0.000 claims description 4
• 201000009104 prediabetes syndrome Diseases 0.000 claims description 4
• 201000010099 disease Diseases 0.000 claims description 3
• 238000004519 manufacturing process Methods 0.000 claims description 3
• 239000007787 solid Substances 0.000 claims description 3
• 239000000243 solution Substances 0.000 claims description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
• 208000008589 Obesity Diseases 0.000 claims description 2
• 238000001035 drying Methods 0.000 claims description 2
• 235000020824 obesity Nutrition 0.000 claims description 2
• 238000010790 dilution Methods 0.000 claims 2
• 239000012895 dilution Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 1
• 239000008101 lactose Substances 0.000 claims 1
• 239000002245 particle Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 description 3
• 238000013207 serial dilution Methods 0.000 description 3
• 239000000654 additive Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 238000001599 direct drying Methods 0.000 description 1
• 208000018914 glucose metabolism disease Diseases 0.000 description 1
• 230000001404 mediated effect Effects 0.000 description 1
• 230000035790 physiological processes and functions Effects 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1