JP2009538640A - 薬剤分配装置と薬剤分配方法 - Google Patents
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
- A61M5/16859—Evaluation of pressure response, e.g. to an applied pulse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16877—Adjusting flow; Devices for setting a flow rate
- A61M5/16881—Regulating valves
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/13—General characteristics of the apparatus with means for the detection of operative contact with patient, e.g. lip sensor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3355—Controlling downstream pump pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
- A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
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Abstract
【解決手段】 本発明の薬剤分配装置は、流路を経て流出口へ連通する圧力容器を有する。この流路は、通常は閉鎖位置にある2つのバルブと流れ規制部とを有する。圧力測定装置が流路にそった2つのポイントの間の圧力差を測定する。この2つのポイント間に流れ規制部の少なくとも一部が入る。この2つのポイントの一方が2つのバルブの間にある。コントローラが、選択的にバルブを開き、所定量の薬剤を放出する。
【選択図】図1
Description
12 ばねで加圧された貯蔵室
14 流出口
16 第1バルブ
18 流れ規制部
20 第2バルブ
22 圧力センサー
28 制御部
30 温度センサー
130 一方向バルブ
図2、19
32 第2バルブを開ける
34 圧力読取値ΔPを得る
36 液体残量を計算する
38 液体残量を表示し低下したときはユーザーに警告する、
40 閉塞をチェックする
42 ユーザーに警告する
44 カテーテルの外れをチェックする、
46 ユーザーに警告する
48 両方のバルブを開いている時間を計算する、
50 第1バルブを開く
52 所定時間後に第2バルブを閉じる
54 僅かな所定時間後に第1バルブを閉じる
56 圧力読取値ΔP1を得る
58 所定時間後に圧力読取値ΔP2を得る
60 ΔP1とΔP2を比較する
62 第1バルブの漏れをユーザーに警告する
64 第2バルブの漏れをユーザーに警告する
66 サイクルを終了する
200 気泡の存在を確認するためにΔP1を予想値と比較する
202 気泡存在警告を発する
図3A: 貯蔵庫 流出口 通常の流れ 開
図3B: 閉塞 開
図3C: バルブ試験状態 定数 閉
図3D: 貯蔵庫内容量テスト 貯蔵庫は満杯 V1閉 V2開
図3E: 貯蔵庫内容量テスト 貯蔵庫は空 V1閉 V2開
図3F: 離脱 Pが増加している V1閉 V2開
図6: 時計回りに、PZT保持機構 第1バルブ、フィルタ 毛細管 入り口バルブ
スプリング スプリングガイド スプリングカバー 流体出口
図7 ピエゾ結合機構の断面 スプリング スプリング保持用ネジ部材 バルブ
図12: エラストマ ポンプ本体 針 膜 カートリッジ本体
図11: 第2ポート用針 差圧センサ 第1ポート用針
図13: フィルタ エラストマ カートリッジ本体 シール用リング ピストン
図14D: 3.毛細管の流路流体がボートと第2バルブ入口に行った後
4.第2バルブからカートリッジ出口に
図14F: 2.第1バルブから通路に
1.カートリッジ内の高圧が第1バルブ入口から第1ポートへ
図15: 第1バルブ−可変流れ規制部
図16: ソレノイドが針をエラストマ・シール部材内に押し込む
図20A、B: 貯蔵庫 出口
70 本体
72 カートリッジ
90 アクチュエータ組立
92 圧電層
94 圧電増幅器
100 カム
102 シャフト
104 ノブ
106 ボール
169 ピストン
Claims (12)
- 流路を経て流出口へ液状薬剤を分配する液状薬剤の圧力源を有する薬剤分配装置において、前記流路は流れ規制部と第1バルブと第2バルブを有し、前記流路中の気泡の存在を確認する方法において、
(a)第1バルブと第2バルブの間の圧力が、圧力源の圧力より低くなるよう、第1と第2バルブを操作するステップと、
(b)圧力蓄積期間のあいだ、第1バルブを開に、第2バルブを閉に維持するステップと、
(c)圧力蓄積期間の最後に、流路中の気泡の存在又は不存在を、第1と第2バルブの間の圧力測定に基いて、確認するステップと
を有する
ことを特徴とする気泡確認方法。 - 前記第1と第2バルブの間の圧力の測定が、前記圧力源とバルブ間の流路中の流体との間の、差圧測定によって行われる
ことを特徴とする請求項1の方法。 - 第1バルブが圧力蓄積期間の終わりに閉じられる
ことを特徴とする請求項1の方法。 - 流路を経て流出口へ液状薬剤を分配する液状薬剤の圧力源を有する薬剤分配装置において、前記流路は流れ規制部と第1バルブと第2バルブを有し、前記流路中の気泡の存在を確認する方法において、
(a)流れ規制部をまたいだ圧力低下によって影響される少なくとも一つのパラメータを監視するステップと、
(b)前記少なくとも一つのパラメータが、流れ規制部をまたいだ圧力低下の減少が示す気泡検出条件を満たしたときに、流路中の気泡の存在を表示するステップと
を有する
ことを特徴とする気泡確認方法。 - 前記少なくとも一つのパラメータが、流れ規制部の少なくとも一部の下流の液体圧力に影響される圧力測定値である
ことを特徴とする請求項4の方法。 - 前記圧力測定値が、圧力源と流れ規制部の少なくとも一部の下流の流路の部分との間の差圧を示す差圧測定値である
ことを特徴とする請求項5の方法。 - 気泡検出条件が、流れ規制部の少なくとも一部分と比較して下流のしきい値を越える流体圧力を示す圧力測定値である
ことを特徴とする請求項5の方法。 - 前記しきい値が、前記圧力源の圧力と関連して定義される
ことを特徴とする請求項7の方法。 - 気泡検出状態が、流れ規制部で最初に規制された量の液状薬剤の流れの間に評価される
ことを特徴とする請求項5の方法。 - 気泡検出状態が、流れ規制部の下流でのバルブ閉の後の圧力増加の度合いを示す圧力測定を用いて、評価される
ことを特徴とする請求項5の方法。 - 前記圧力測定が、圧力測定位置の上流のバルブの閉の後で行われる
ことを特徴とする請求項10の方法。 - 前記少なくとも一つのパラメータが、流れ規制部の下流のバルブの閉の後の流体圧の圧力増加の度合いを示す
ことを特徴とする請求項4の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/379,791 US7311693B2 (en) | 2001-11-26 | 2006-04-23 | Drug delivery device and method |
PCT/IL2007/000505 WO2007122621A2 (en) | 2006-04-23 | 2007-04-23 | Drug delivery device and method |
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JP2011022823A Division JP5097831B2 (ja) | 2006-04-23 | 2011-02-04 | 薬剤分配装置における気泡確認方法 |
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JP2009538640A true JP2009538640A (ja) | 2009-11-12 |
JP4681666B2 JP4681666B2 (ja) | 2011-05-11 |
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JP2009506040A Expired - Fee Related JP4681666B2 (ja) | 2006-04-23 | 2007-04-23 | 薬剤分配装置における気泡確認方法 |
JP2011022823A Expired - Fee Related JP5097831B2 (ja) | 2006-04-23 | 2011-02-04 | 薬剤分配装置における気泡確認方法 |
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JP2011022823A Expired - Fee Related JP5097831B2 (ja) | 2006-04-23 | 2011-02-04 | 薬剤分配装置における気泡確認方法 |
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US (1) | US7311693B2 (ja) |
EP (1) | EP2010246A4 (ja) |
JP (2) | JP4681666B2 (ja) |
KR (1) | KR20080113250A (ja) |
CN (1) | CN101511402B (ja) |
CA (1) | CA2640881C (ja) |
WO (1) | WO2007122621A2 (ja) |
Cited By (1)
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JP2013519829A (ja) * | 2010-02-18 | 2013-05-30 | グルンドフォス マネージメント アー/エス | 定量ポンプ装置 |
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Also Published As
Publication number | Publication date |
---|---|
JP5097831B2 (ja) | 2012-12-12 |
CN101511402B (zh) | 2012-06-06 |
WO2007122621A2 (en) | 2007-11-01 |
JP2011131070A (ja) | 2011-07-07 |
KR20080113250A (ko) | 2008-12-29 |
CN101511402A (zh) | 2009-08-19 |
EP2010246A2 (en) | 2009-01-07 |
CA2640881C (en) | 2009-09-08 |
JP4681666B2 (ja) | 2011-05-11 |
WO2007122621A3 (en) | 2009-04-09 |
US7311693B2 (en) | 2007-12-25 |
EP2010246A4 (en) | 2013-06-05 |
US20060206054A1 (en) | 2006-09-14 |
CA2640881A1 (en) | 2007-11-01 |
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