|
GB8809316D0
(en)
*
|
1987-05-11 |
1988-05-25 |
Ici America Inc |
Heterocyclic ketones
|
|
US5672582A
(en)
|
1993-04-30 |
1997-09-30 |
Merck & Co., Inc. |
Thrombin inhibitors
|
|
US5705487A
(en)
*
|
1994-03-04 |
1998-01-06 |
Eli Lilly And Company |
Antithrombotic agents
|
|
US5707966A
(en)
*
|
1994-03-04 |
1998-01-13 |
Eli Lilly And Company |
Antithrombotic agents
|
|
ZA951618B
(en)
|
1994-03-04 |
1996-08-27 |
Lilly Co Eli |
Antithrombotic agents
|
|
US5726159A
(en)
*
|
1994-03-04 |
1998-03-10 |
Eli Lilly And Company |
Antithrombotic agents
|
|
IL112795A
(en)
|
1994-03-04 |
2001-01-28 |
Astrazeneca Ab |
Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
|
|
EP0804465B1
(en)
|
1994-06-02 |
2003-08-06 |
Aventis Pharmaceuticals Inc. |
Novel elastase inhibitors
|
|
JPH0820597A
(ja)
|
1994-07-07 |
1996-01-23 |
Meiji Seika Kaisha Ltd |
トロンビン阻害作用を有する複素環カルボニル化合物
|
|
US5618792A
(en)
|
1994-11-21 |
1997-04-08 |
Cortech, Inc. |
Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
|
|
US5710130A
(en)
*
|
1995-02-27 |
1998-01-20 |
Eli Lilly And Company |
Antithrombotic agents
|
|
US5914319A
(en)
*
|
1995-02-27 |
1999-06-22 |
Eli Lilly And Company |
Antithrombotic agents
|
|
CA2176414A1
(en)
|
1995-05-18 |
1996-11-19 |
S. David Kimball |
Acyl guanidine and amidine prodrugs
|
|
US6022861A
(en)
*
|
1995-06-07 |
2000-02-08 |
Cor Therapeutics, Inc. |
Ketoheterocyclic inhibitors of factor Xa
|
|
US6211154B1
(en)
*
|
1995-06-07 |
2001-04-03 |
Cor Therapeutics, Inc. |
Ketoheterocyclic inhibitors of factor Xa
|
|
US5827866A
(en)
|
1995-06-07 |
1998-10-27 |
Ortho Pharmaceutical Corporation |
Peptidyl heterocycles useful in the treatment of thrombin related disorders
|
|
US5523308A
(en)
*
|
1995-06-07 |
1996-06-04 |
Costanzo; Michael J. |
Peptidyl heterocycles useful in the treatment of thrombin related disorders
|
|
US5827860A
(en)
|
1995-06-07 |
1998-10-27 |
Ortho Pharmaceutical Corporation |
Peptidyl heterocycles useful in the treatment of thrombin related disorders
|
|
US6069130A
(en)
|
1995-06-07 |
2000-05-30 |
Cor Therapeutics, Inc. |
Ketoheterocyclic inhibitors of factor Xa
|
|
IL119466A
(en)
|
1995-11-03 |
2001-08-26 |
Akzo Nobel Nv |
Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
|
|
TW523513B
(en)
|
1996-03-01 |
2003-03-11 |
Akzo Nobel Nv |
Serine protease inhibitors
|
|
US6291678B1
(en)
|
1996-06-18 |
2001-09-18 |
Warner-Lambert Company |
Process for the preparation of chiral keto-heterocycles of basic amino acids
|
|
IL121474A0
(en)
|
1996-08-23 |
1998-02-08 |
Akzo Nobel Nv |
Thrombin inhibitors
|
|
KR100509388B1
(ko)
|
1996-10-18 |
2005-08-23 |
버텍스 파마슈티칼스 인코포레이티드 |
세린 프로테아제, 특히 간염 c 바이러스 ns3 프로테아제의 저해제
|
|
CN1247542A
(zh)
|
1996-12-06 |
2000-03-15 |
康泰驰公司 |
丝氨酸蛋白酶抑制剂
|
|
US6004933A
(en)
|
1997-04-25 |
1999-12-21 |
Cortech Inc. |
Cysteine protease inhibitors
|
|
NZ500620A
(en)
|
1997-05-02 |
2000-10-27 |
Akzo Nobel Nv |
Synthetic peptides which inhibit serine proteases, specifically thrombin, factor VIIa tissue factor and factor Xa
|
|
ES2234144T3
(es)
|
1997-08-11 |
2005-06-16 |
Boehringer Ingelheim (Canada) Ltd. |
Analogos de peptidos inhibidores de la hepatitis c.
|
|
US6323219B1
(en)
*
|
1998-04-02 |
2001-11-27 |
Ortho-Mcneil Pharmaceutical, Inc. |
Methods for treating immunomediated inflammatory disorders
|
|
EP1114822A3
(en)
|
1998-06-03 |
2002-11-13 |
Cortech Inc. |
Indoles and tetrahydroisoquinolines containing alpha-keto oxadiazoles as serine protease inhibitors
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
AR022061A1
(es)
|
1998-08-10 |
2002-09-04 |
Boehringer Ingelheim Ca Ltd |
Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
|
|
US6242422B1
(en)
|
1998-10-22 |
2001-06-05 |
Idun Pharmacueticals, Inc. |
(Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
|
|
KR20000047461A
(ko)
|
1998-12-29 |
2000-07-25 |
성재갑 |
트롬빈 억제제
|
|
TR200102766T2
(tr)
*
|
1999-01-27 |
2001-12-21 |
Ortho-Mcneil Pharmaceutical, Inc. |
Triptaz inhibitörü olarak kullanılan peptidil heterosiklik ketonlar
|
|
JP2000256396A
(ja)
*
|
1999-03-03 |
2000-09-19 |
Dainippon Pharmaceut Co Ltd |
複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
|
|
GB9929552D0
(en)
|
1999-12-14 |
2000-02-09 |
Proteus Molecular Design |
Compounds
|
|
AU5920400A
(en)
|
1999-07-07 |
2001-01-22 |
Du Pont Pharmaceuticals Company |
Cell-based assay systems for examining hcv ns3 protease activity
|
|
GB9923710D0
(en)
|
1999-10-08 |
1999-12-08 |
Proteus Molecular Design |
Chemical compounds
|
|
JP2003526634A
(ja)
|
1999-12-03 |
2003-09-09 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
C型肝炎ウイルスNS3プロテアーゼのα−ケトアミド阻害剤
|
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
DK1385870T3
(da)
|
2000-07-21 |
2010-07-05 |
Schering Corp |
Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus
|
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
|
CA2438272A1
(en)
|
2001-03-02 |
2002-10-10 |
John Macor |
Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
|
|
CA2449504A1
(en)
|
2001-07-11 |
2003-01-23 |
Vertex Pharmaceuticals Incorporated |
Bridged bicyclic serine protease inhibitors
|
|
AU2002331064B2
(en)
*
|
2001-08-10 |
2007-08-23 |
Palatin Technologies, Inc. |
Peptidomimetics of biologically active metallopeptides
|
|
WO2003072528A2
(en)
|
2002-02-08 |
2003-09-04 |
Idun Pharmaceuticals, Inc. |
(substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
|
|
US7019019B2
(en)
*
|
2002-12-23 |
2006-03-28 |
Dendreon Corporation |
Matriptase inhibitors and methods of use
|
|
US7205384B2
(en)
*
|
2003-08-05 |
2007-04-17 |
Ortho-Mcneil Pharmaceutical Inc. |
Process for preparing peptidyl heterocyclic ketone derivatives
|
|
TWI359147B
(en)
|
2003-09-05 |
2012-03-01 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hcv n
|
|
WO2005037860A2
(en)
|
2003-10-10 |
2005-04-28 |
Vertex Pharmaceuticals Incoporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
WO2005058821A1
(en)
|
2003-12-11 |
2005-06-30 |
Schering Corporation |
Inhibitors of hepatitis c virus ns3/ns4a serine protease
|
|
US20050222383A1
(en)
|
2004-02-05 |
2005-10-06 |
Irm Llc |
Prostasin substrates and inhibitors
|
|
CN1946691A
(zh)
|
2004-02-27 |
2007-04-11 |
先灵公司 |
作为丙型肝炎病毒ns3丝氨酸蛋白酶抑制剂的化合物
|
|
RU2393154C2
(ru)
|
2004-03-24 |
2010-06-27 |
Йерини Аг |
Новые соединения для ингибирования ангиогенеза и их применение
|
|
ES2328596T3
(es)
|
2004-05-20 |
2009-11-16 |
Schering Corporation |
Prolinas sustituidas como inhibidores de la serina proteasa del virus ns3 de la hepatitis c.
|
|
WO2006006644A1
(ja)
|
2004-07-14 |
2006-01-19 |
Kyowa Hakko Kogyo Co., Ltd. |
複素環式化合物
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
US20060275366A1
(en)
*
|
2005-06-02 |
2006-12-07 |
Schering Corporation |
Controlled-release formulation
|
|
JP5270538B2
(ja)
*
|
2006-05-23 |
2013-08-21 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
|
|
CA2651762A1
(en)
*
|
2006-05-23 |
2007-11-29 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
RS51644B
(sr)
|
2007-01-10 |
2011-10-31 |
Irm Llc. |
Jedinjenja i preparati kao inhibitori kanal aktivirajuće proteaze
|
|
MX2009008493A
(es)
|
2007-02-09 |
2009-08-20 |
Irm Llc |
Compuestos y composiciones como inhibidores de la proteasa activadora de canal.
|
|
AU2008214217B2
(en)
|
2007-02-09 |
2011-10-13 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|