JP2009537551A5 - - Google Patents
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- Publication number
- JP2009537551A5 JP2009537551A5 JP2009511097A JP2009511097A JP2009537551A5 JP 2009537551 A5 JP2009537551 A5 JP 2009537551A5 JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009537551 A5 JP2009537551 A5 JP 2009537551A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- aralkyl
- alkyl
- formula
- thyroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 28
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 11
- 125000002252 acyl group Chemical group 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- 208000024799 Thyroid disease Diseases 0.000 claims description 7
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 206010020850 Hyperthyroidism Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 208000023328 Basedow disease Diseases 0.000 claims description 2
- 108010060374 FSH Receptors Proteins 0.000 claims description 2
- 102100027627 Follicle-stimulating hormone receptor Human genes 0.000 claims description 2
- 208000015023 Graves' disease Diseases 0.000 claims description 2
- 229940122574 Thyroid-stimulating hormone receptor antagonist Drugs 0.000 claims description 2
- 102000003911 Thyrotropin Receptors Human genes 0.000 claims description 2
- 108090000253 Thyrotropin Receptors Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003981 vehicle Substances 0.000 claims description 2
- 229940123712 Thyroid hormone receptor antagonist Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- DVSFSADBOJYPGF-UHFFFAOYSA-N 5-amino-N-tert-butyl-4-(3-methoxyphenyl)-2-(methylthio)-6-thieno[2,3-d]pyrimidinecarboxamide Chemical compound COC1=CC=CC(C=2C=3C(N)=C(C(=O)NC(C)(C)C)SC=3N=C(SC)N=2)=C1 DVSFSADBOJYPGF-UHFFFAOYSA-N 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80137006P | 2006-05-17 | 2006-05-17 | |
| PCT/US2007/011951 WO2007136776A2 (en) | 2006-05-17 | 2007-05-17 | Pyrimidine low molecular weight ligands for modulating hormone receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537551A JP2009537551A (ja) | 2009-10-29 |
| JP2009537551A5 true JP2009537551A5 (enExample) | 2010-07-01 |
Family
ID=38566208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511097A Withdrawn JP2009537551A (ja) | 2006-05-17 | 2007-05-17 | ホルモン受容体を調節するためのピリミジン低分子量リガンド |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090203716A1 (enExample) |
| EP (1) | EP2018384A2 (enExample) |
| JP (1) | JP2009537551A (enExample) |
| AU (1) | AU2007254165A1 (enExample) |
| CA (1) | CA2652061A1 (enExample) |
| WO (1) | WO2007136776A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5718233B2 (ja) | 2008-10-20 | 2015-05-13 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 甲状腺刺激ホルモン受容体（ｔｓｈｒ）の低分子量アゴニスト |
| KR20110136819A (ko) | 2009-02-27 | 2011-12-21 | 시가 테크놀로지스, 인크. | 뎅기 바이러스 감염의 치료 및 예방을 위한 티에노피리딘 유도체 |
| WO2011127388A2 (en) | 2010-04-08 | 2011-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inverse agonists and neutral antagonists for the tsh receptor |
| CA2893318A1 (en) * | 2012-12-07 | 2014-06-12 | Siga Technologies, Inc. | Thienopyridine derivatives for the treatment and prevention of dengue virus infections |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990008528A1 (en) * | 1989-01-11 | 1990-08-09 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Biologically active synthetic thyrotropin and cloned gene for producing same |
| CA2339018A1 (en) * | 1998-08-07 | 2000-02-17 | Applied Research Systems Ars Holding N.V. | Fsh mimetics for the treatment of infertility |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| US6426357B1 (en) * | 1999-07-27 | 2002-07-30 | Affymax, Inc. | Antagonists of follicle stimulating hormone activity |
| CZ297136B6 (cs) * | 2000-09-22 | 2006-09-13 | Akzo Nobel N. V. | Bicyklické heteroaromatické slouceniny |
| US20080004271A1 (en) * | 2006-01-17 | 2008-01-03 | Mckenna Jeffrey M | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith |
-
2007
- 2007-05-17 CA CA002652061A patent/CA2652061A1/en not_active Abandoned
- 2007-05-17 JP JP2009511097A patent/JP2009537551A/ja not_active Withdrawn
- 2007-05-17 EP EP07777162A patent/EP2018384A2/en not_active Withdrawn
- 2007-05-17 AU AU2007254165A patent/AU2007254165A1/en not_active Abandoned
- 2007-05-17 WO PCT/US2007/011951 patent/WO2007136776A2/en not_active Ceased
-
2008
- 2008-11-14 US US12/291,932 patent/US20090203716A1/en not_active Abandoned
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