JP2009537551A - ホルモン受容体を調節するためのピリミジン低分子量リガンド - Google Patents

ホルモン受容体を調節するためのピリミジン低分子量リガンド Download PDF

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JP2009537551A
JP2009537551A JP2009511097A JP2009511097A JP2009537551A JP 2009537551 A JP2009537551 A JP 2009537551A JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009511097 A JP2009511097 A JP 2009511097A JP 2009537551 A JP2009537551 A JP 2009537551A
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aralkyl
lower alkyl
compound
cycloalkyl
compounds
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JP2009511097A
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Japanese (ja)
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JP2009537551A5 (enExample
Inventor
マービン シー． ガーシェンゴーン
スザンヌ ネウマン
クレイグ トーマス
ホルガー ジャエスチケ
スザンナ モーア
ガード クラウセ
ブルース ラーカ
ラルフ パスチケ
ガンナー クレイナウ
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Government of the United States of America
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Government of the United States of America
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Application filed by Government of the United States of America filed Critical Government of the United States of America
Publication of JP2009537551A publication Critical patent/JP2009537551A/ja
Publication of JP2009537551A5 publication Critical patent/JP2009537551A5/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2009511097A 2006-05-17 2007-05-17 ホルモン受容体を調節するためのピリミジン低分子量リガンド Withdrawn JP2009537551A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80137006P 2006-05-17 2006-05-17
PCT/US2007/011951 WO2007136776A2 (en) 2006-05-17 2007-05-17 Pyrimidine low molecular weight ligands for modulating hormone receptors

Publications (2)

Publication Number Publication Date
JP2009537551A true JP2009537551A (ja) 2009-10-29
JP2009537551A5 JP2009537551A5 (enExample) 2010-07-01

Family

ID=38566208

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009511097A Withdrawn JP2009537551A (ja) 2006-05-17 2007-05-17 ホルモン受容体を調節するためのピリミジン低分子量リガンド

Country Status (6)

Country Link
US (1) US20090203716A1 (enExample)
EP (1) EP2018384A2 (enExample)
JP (1) JP2009537551A (enExample)
AU (1) AU2007254165A1 (enExample)
CA (1) CA2652061A1 (enExample)
WO (1) WO2007136776A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501883A (ja) * 2012-12-07 2016-01-21 シガ テクノロジーズ，インコーポレーテッド デングウイルス感染症の治療及び予防のためのチエノピリジン誘導体

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5718233B2 (ja) 2008-10-20 2015-05-13 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 甲状腺刺激ホルモン受容体（ｔｓｈｒ）の低分子量アゴニスト
KR20110136819A (ko) 2009-02-27 2011-12-21 시가 테크놀로지스, 인크. 뎅기 바이러스 감염의 치료 및 예방을 위한 티에노피리딘 유도체
WO2011127388A2 (en) 2010-04-08 2011-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inverse agonists and neutral antagonists for the tsh receptor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008528A1 (en) * 1989-01-11 1990-08-09 The United States Of America, Represented By The Secretary, United States Department Of Commerce Biologically active synthetic thyrotropin and cloned gene for producing same
CA2339018A1 (en) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
US6426357B1 (en) * 1999-07-27 2002-07-30 Affymax, Inc. Antagonists of follicle stimulating hormone activity
CZ297136B6 (cs) * 2000-09-22 2006-09-13 Akzo Nobel N. V. Bicyklické heteroaromatické slouceniny
US20080004271A1 (en) * 2006-01-17 2008-01-03 Mckenna Jeffrey M Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501883A (ja) * 2012-12-07 2016-01-21 シガ テクノロジーズ，インコーポレーテッド デングウイルス感染症の治療及び予防のためのチエノピリジン誘導体

Also Published As

Publication number Publication date
EP2018384A2 (en) 2009-01-28
CA2652061A1 (en) 2007-11-29
WO2007136776A3 (en) 2008-01-24
WO2007136776A2 (en) 2007-11-29
AU2007254165A1 (en) 2007-11-29
US20090203716A1 (en) 2009-08-13

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