JP2009537498A - Ａｚｄ１１５２のマレエート共結晶 - Google Patents

Ａｚｄ１１５２のマレエート共結晶 Download PDF

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Publication number
JP2009537498A
JP2009537498A JP2009510536A JP2009510536A JP2009537498A JP 2009537498 A JP2009537498 A JP 2009537498A JP 2009510536 A JP2009510536 A JP 2009510536A JP 2009510536 A JP2009510536 A JP 2009510536A JP 2009537498 A JP2009537498 A JP 2009537498A
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JP
Japan
Prior art keywords
azd1152
maleate
crystal
amino
aurora
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009510536A
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English (en)
Japanese (ja)
Other versions
JP2009537498A5 (enExample
Inventor
セペンダ，ジョージ・ジョーゼフ
ストーリー，リチャード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36637528&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2009537498(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2009537498A publication Critical patent/JP2009537498A/ja
Publication of JP2009537498A5 publication Critical patent/JP2009537498A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009510536A 2006-05-16 2007-05-14 Ａｚｄ１１５２のマレエート共結晶 Pending JP2009537498A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0609621.8A GB0609621D0 (en) 2006-05-16 2006-05-16 Novel co-crystal
PCT/GB2007/001771 WO2007132227A1 (en) 2006-05-16 2007-05-14 Maleate co-crystal of azd1152

Publications (2)

Publication Number Publication Date
JP2009537498A true JP2009537498A (ja) 2009-10-29
JP2009537498A5 JP2009537498A5 (enExample) 2010-07-01

Family

ID=36637528

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009510536A Pending JP2009537498A (ja) 2006-05-16 2007-05-14 Ａｚｄ１１５２のマレエート共結晶

Country Status (22)

Country Link
US (1) US7625910B2 (enExample)
EP (1) EP2027114A1 (enExample)
JP (1) JP2009537498A (enExample)
KR (1) KR20090009297A (enExample)
CN (1) CN101448823A (enExample)
AR (1) AR060963A1 (enExample)
AU (1) AU2007251304A1 (enExample)
BR (1) BRPI0712791A2 (enExample)
CA (1) CA2650519A1 (enExample)
CL (1) CL2007001388A1 (enExample)
EC (1) ECSP088890A (enExample)
GB (1) GB0609621D0 (enExample)
IL (1) IL194862A0 (enExample)
MX (1) MX2008014550A (enExample)
NO (1) NO20084580L (enExample)
RU (1) RU2008149242A (enExample)
SA (1) SA07280243B1 (enExample)
TW (1) TW200813026A (enExample)
UA (1) UA95108C2 (enExample)
UY (1) UY30351A1 (enExample)
WO (1) WO2007132227A1 (enExample)
ZA (1) ZA200809172B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE446093T1 (de) * 2001-12-24 2009-11-15 Astrazeneca Ab Substituierte chinazolin-derivate als aurora- kinase inhibitoren
CA2526285A1 (en) * 2003-05-15 2004-12-23 Arqule, Inc. Inhibitors of p38 and methods of using the same
CA2584368A1 (en) * 2004-10-19 2006-04-27 Arqule, Inc. Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
WO2007123892A2 (en) * 2006-04-17 2007-11-01 Arqule Inc. Raf inhibitors and their uses
CA2744713A1 (en) * 2008-12-05 2010-06-10 Arqule, Inc. Raf inhibitors and their uses
NZ598758A (en) * 2009-09-11 2013-12-20 Amgen Inc N-4 (-((3-(2-amino-4 pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
HUE034490T2 (en) 2013-09-16 2018-02-28 Astrazeneca Ab Therapeutic polymer nanoparticles and methods for their preparation and use
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
BR112016022056B1 (pt) 2014-03-26 2023-04-11 Astex Therapeutics Limited Combinação, composição farmacêutica, uso de uma combinação ou uma composição farmacêutica, e, produto farmacêutico
US10736900B2 (en) 2014-03-26 2020-08-11 Astex Therapeutics Ltd Combinations of an FGFR inhibitor and an IGF1R inhibitor
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
HUE050567T2 (hu) 2015-09-23 2020-12-28 Janssen Pharmaceutica Nv Triciklusos heterociklusok rák kezelésére
WO2017050865A1 (en) 2015-09-23 2017-03-30 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055491A1 (en) * 2001-12-24 2003-07-10 Astrazeneca Ab Substituted quinazoline derivatives as inhibitors of aurora kinases
JP2006512418A (ja) * 2002-12-24 2006-04-13 アストラゼネカ アクチボラグ ホスホノオキシキナゾリン誘導体及びその医薬用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055491A1 (en) * 2001-12-24 2003-07-10 Astrazeneca Ab Substituted quinazoline derivatives as inhibitors of aurora kinases
JP2006512418A (ja) * 2002-12-24 2006-04-13 アストラゼネカ アクチボラグ ホスホノオキシキナゾリン誘導体及びその医薬用途

Also Published As

Publication number Publication date
US20080045481A1 (en) 2008-02-21
NO20084580L (no) 2009-02-05
UY30351A1 (es) 2008-01-02
GB0609621D0 (en) 2006-06-21
CA2650519A1 (en) 2007-11-22
ZA200809172B (en) 2009-12-30
SA07280243B1 (ar) 2010-12-01
KR20090009297A (ko) 2009-01-22
UA95108C2 (en) 2011-07-11
IL194862A0 (en) 2009-08-03
US7625910B2 (en) 2009-12-01
BRPI0712791A2 (pt) 2012-09-04
WO2007132227A1 (en) 2007-11-22
CN101448823A (zh) 2009-06-03
MX2008014550A (es) 2008-11-27
EP2027114A1 (en) 2009-02-25
AR060963A1 (es) 2008-07-23
RU2008149242A (ru) 2010-06-27
AU2007251304A1 (en) 2007-11-22
CL2007001388A1 (es) 2008-01-18
ECSP088890A (es) 2008-12-30
TW200813026A (en) 2008-03-16

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