AR060963A1 - Forma cristalina de fosfato diacido de 2-{etil[3-({4-[(5-{2-[(3-fluorofenil)amino]-2-oxoetil}-1h-pirazol-3-il)amino]quinazolin-7-il}oxi)propil]amino}etilo - Google Patents
Forma cristalina de fosfato diacido de 2-{etil[3-({4-[(5-{2-[(3-fluorofenil)amino]-2-oxoetil}-1h-pirazol-3-il)amino]quinazolin-7-il}oxi)propil]amino}etiloInfo
- Publication number
- AR060963A1 AR060963A1 ARP070102121A ARP070102121A AR060963A1 AR 060963 A1 AR060963 A1 AR 060963A1 AR P070102121 A ARP070102121 A AR P070102121A AR P070102121 A ARP070102121 A AR P070102121A AR 060963 A1 AR060963 A1 AR 060963A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- quinazolin
- fluorophenyl
- phosphate
- oxoetil
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- -1 3-FLUOROPHENYL Chemical class 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 abstract 1
- GBJVVSCPOBPEIT-UHFFFAOYSA-N AZT-1152 Chemical compound N=1C=NC2=CC(OCCCN(CC)CCOP(O)(O)=O)=CC=C2C=1NC(=NN1)C=C1CC(=O)NC1=CC=CC(F)=C1 GBJVVSCPOBPEIT-UHFFFAOYSA-N 0.000 abstract 1
- 229940123877 Aurora kinase inhibitor Drugs 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000003719 aurora kinase inhibitor Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0609621.8A GB0609621D0 (en) | 2006-05-16 | 2006-05-16 | Novel co-crystal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060963A1 true AR060963A1 (es) | 2008-07-23 |
Family
ID=36637528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102121A AR060963A1 (es) | 2006-05-16 | 2007-05-16 | Forma cristalina de fosfato diacido de 2-{etil[3-({4-[(5-{2-[(3-fluorofenil)amino]-2-oxoetil}-1h-pirazol-3-il)amino]quinazolin-7-il}oxi)propil]amino}etilo |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7625910B2 (enExample) |
| EP (1) | EP2027114A1 (enExample) |
| JP (1) | JP2009537498A (enExample) |
| KR (1) | KR20090009297A (enExample) |
| CN (1) | CN101448823A (enExample) |
| AR (1) | AR060963A1 (enExample) |
| AU (1) | AU2007251304A1 (enExample) |
| BR (1) | BRPI0712791A2 (enExample) |
| CA (1) | CA2650519A1 (enExample) |
| CL (1) | CL2007001388A1 (enExample) |
| EC (1) | ECSP088890A (enExample) |
| GB (1) | GB0609621D0 (enExample) |
| IL (1) | IL194862A0 (enExample) |
| MX (1) | MX2008014550A (enExample) |
| NO (1) | NO20084580L (enExample) |
| RU (1) | RU2008149242A (enExample) |
| SA (1) | SA07280243B1 (enExample) |
| TW (1) | TW200813026A (enExample) |
| UA (1) | UA95108C2 (enExample) |
| UY (1) | UY30351A1 (enExample) |
| WO (1) | WO2007132227A1 (enExample) |
| ZA (1) | ZA200809172B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ533440A (en) * | 2001-12-24 | 2006-08-31 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| CA2526285A1 (en) * | 2003-05-15 | 2004-12-23 | Arqule, Inc. | Inhibitors of p38 and methods of using the same |
| US8178672B2 (en) * | 2004-10-19 | 2012-05-15 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase |
| WO2007123892A2 (en) * | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
| KR20110100241A (ko) * | 2008-12-05 | 2011-09-09 | 아르퀼 인코포레이티드 | Ｒａｆ 억제제 및 이들의 용도 |
| HRP20150104T1 (xx) * | 2009-09-11 | 2015-03-13 | Amgen, Inc. | N-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oksi)fenil)-4-(4-metil-2-thienil)-1-ftalazinamin za primjenu u tretmanu kancera rezistentnog na antimitotiäśke agense |
| GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
| GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
| GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
| GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
| GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
| GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
| ES2784423T3 (es) * | 2013-09-16 | 2020-09-25 | Astrazeneca Ab | Nanopartículas poliméricas terapéuticas y métodos para su fabricación y uso |
| MX370099B (es) | 2014-03-26 | 2019-12-02 | Astex Therapeutics Ltd | Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer. |
| JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
| KR102479696B1 (ko) | 2014-03-26 | 2022-12-22 | 아스텍스 테라퓨틱스 리미티드 | Fgfr 억제제 및 igf1r 억제제의 조합물 |
| JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| KR102691777B1 (ko) | 2015-09-23 | 2024-08-02 | 얀센 파마슈티카 엔브이 | 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도 |
| CA2996857C (en) | 2015-09-23 | 2024-05-21 | Janssen Pharmaceutica Nv | Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ533440A (en) * | 2001-12-24 | 2006-08-31 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| PT1578755E (pt) * | 2002-12-24 | 2007-10-19 | Astrazeneca Ab | Derivados de fosfonooxiquinazolina e sua utilização farmacêutica |
-
2006
- 2006-05-16 GB GBGB0609621.8A patent/GB0609621D0/en not_active Ceased
-
2007
- 2007-05-10 TW TW096116652A patent/TW200813026A/zh unknown
- 2007-05-14 MX MX2008014550A patent/MX2008014550A/es active IP Right Grant
- 2007-05-14 SA SA07280243A patent/SA07280243B1/ar unknown
- 2007-05-14 RU RU2008149242/04A patent/RU2008149242A/ru not_active Application Discontinuation
- 2007-05-14 EP EP07732795A patent/EP2027114A1/en not_active Withdrawn
- 2007-05-14 WO PCT/GB2007/001771 patent/WO2007132227A1/en not_active Ceased
- 2007-05-14 BR BRPI0712791-0A patent/BRPI0712791A2/pt not_active IP Right Cessation
- 2007-05-14 CN CNA2007800179575A patent/CN101448823A/zh active Pending
- 2007-05-14 KR KR1020087029569A patent/KR20090009297A/ko not_active Withdrawn
- 2007-05-14 JP JP2009510536A patent/JP2009537498A/ja active Pending
- 2007-05-14 UA UAA200813934A patent/UA95108C2/ru unknown
- 2007-05-14 AU AU2007251304A patent/AU2007251304A1/en not_active Abandoned
- 2007-05-14 CA CA002650519A patent/CA2650519A1/en not_active Abandoned
- 2007-05-15 US US11/748,651 patent/US7625910B2/en not_active Expired - Fee Related
- 2007-05-15 UY UY30351A patent/UY30351A1/es unknown
- 2007-05-15 CL CL2007001388A patent/CL2007001388A1/es unknown
- 2007-05-16 AR ARP070102121A patent/AR060963A1/es not_active Application Discontinuation
-
2008
- 2008-10-23 IL IL194862A patent/IL194862A0/en unknown
- 2008-10-24 ZA ZA200809172A patent/ZA200809172B/xx unknown
- 2008-11-03 NO NO20084580A patent/NO20084580L/no not_active Application Discontinuation
- 2008-11-14 EC EC2008008890A patent/ECSP088890A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7625910B2 (en) | 2009-12-01 |
| EP2027114A1 (en) | 2009-02-25 |
| RU2008149242A (ru) | 2010-06-27 |
| GB0609621D0 (en) | 2006-06-21 |
| CN101448823A (zh) | 2009-06-03 |
| UY30351A1 (es) | 2008-01-02 |
| US20080045481A1 (en) | 2008-02-21 |
| TW200813026A (en) | 2008-03-16 |
| JP2009537498A (ja) | 2009-10-29 |
| IL194862A0 (en) | 2009-08-03 |
| WO2007132227A1 (en) | 2007-11-22 |
| UA95108C2 (en) | 2011-07-11 |
| MX2008014550A (es) | 2008-11-27 |
| ECSP088890A (es) | 2008-12-30 |
| ZA200809172B (en) | 2009-12-30 |
| BRPI0712791A2 (pt) | 2012-09-04 |
| CL2007001388A1 (es) | 2008-01-18 |
| CA2650519A1 (en) | 2007-11-22 |
| KR20090009297A (ko) | 2009-01-22 |
| AU2007251304A1 (en) | 2007-11-22 |
| SA07280243B1 (ar) | 2010-12-01 |
| NO20084580L (no) | 2009-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR060963A1 (es) | Forma cristalina de fosfato diacido de 2-{etil[3-({4-[(5-{2-[(3-fluorofenil)amino]-2-oxoetil}-1h-pirazol-3-il)amino]quinazolin-7-il}oxi)propil]amino}etilo | |
| ECSP099078A (es) | Derivados de amino-piperidina como inhibidores de la proteina de transferencia de colesteril-ester (cetp) | |
| CR10479A (es) | Modulares bencimidazolicos de vr1 | |
| BR112012024117A2 (pt) | inibidores de pirrolopirazina quinase | |
| MA32551B1 (fr) | Nouveaux composes utiles pour le traitement de maladies degeneratives et inflammatoires | |
| ATE540029T1 (de) | 2,4-substituierte chinazoline als lipidkinasehemmer | |
| PA8848201A1 (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevención de diabetes | |
| SV2011003809A (es) | Derivados de heteroarilo como inhibidores de dgat1 | |
| ATE517107T1 (de) | Pyrrolopyrazinkinaseinhibitoren | |
| ATE552255T1 (de) | 4-aminoindazole | |
| CR10343A (es) | Aminotetrahidropiranos como inihibidores de dipeptidil peptidasa-iv para el tratamiento o prevencion de diabetes | |
| NI200900032A (es) | Compuestos de pirido (2, 3-d) pirimidinonay su uso como inhibidores de pi3 | |
| EP2116543A4 (en) | NEW AMINOPYRIMIDINE DERIVATIVE AS PLK1 INHIBITOR | |
| CR9947A (es) | Compuestos de pirimidinil benzotiofeno | |
| MX2009006481A (es) | Derivados de imidazol 1-sustituidos, y su uso como inhibidores de la sintasa de aldosterona. | |
| MX2012013130A (es) | Compuestos heterociclicos de nitrogeno utiles como inhibidores de pde10. | |
| MA32594B1 (fr) | Amidophenoxyindazoles utiles comme inhibiteurs du c-met | |
| ATE522534T1 (de) | Pyrrolopyrazin-kinasehemmer | |
| BR112013029730A2 (pt) | composição farmacêutica de rosuvastatina cálcica | |
| EP2142868A4 (en) | CONTROL METHOD FOR REFRIGERATOR | |
| SV2009003153A (es) | Bencilaminas, un proceso para su produccion y su uso como agentes antiinflamatorios | |
| SV2009003286A (es) | Sal de potasio cristalina de analogos de lipoxina a4 | |
| MX2009005249A (es) | Compuestos organicos. | |
| BR112013033836A2 (pt) | terapia de combinação | |
| EP2140214A4 (en) | Controlling process for refrigerator |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |