JP2009537176A5 - - Google Patents
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- Publication number
- JP2009537176A5 JP2009537176A5 JP2009512060A JP2009512060A JP2009537176A5 JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5 JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- cells
- subpopulation
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 41
- 108091007433 antigens Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 39
- 210000003719 b-lymphocyte Anatomy 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 11
- 210000000628 antibody-producing cell Anatomy 0.000 claims 10
- 230000006698 induction Effects 0.000 claims 6
- 230000001629 suppression Effects 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000008484 agonism Effects 0.000 claims 2
- 230000008485 antagonism Effects 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000006037 cell lysis Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80141206P | 2006-05-19 | 2006-05-19 | |
| US60/801,412 | 2006-05-19 | ||
| PCT/US2007/011980 WO2008045140A1 (en) | 2006-05-19 | 2007-05-21 | Culture method for obtaining a clonal population of antigen-specific b cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537176A JP2009537176A (ja) | 2009-10-29 |
| JP2009537176A5 true JP2009537176A5 (cg-RX-API-DMAC7.html) | 2010-07-08 |
| JP5607357B2 JP5607357B2 (ja) | 2014-10-15 |
Family
ID=39283142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512060A Expired - Fee Related JP5607357B2 (ja) | 2006-05-19 | 2007-05-21 | 抗原特異的ｂ細胞のクローン集団を獲得するための培養方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20070269868A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2021463B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5607357B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101600793B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007307324B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2652392C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2021463T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL195285A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008014692A (cg-RX-API-DMAC7.html) |
| NO (1) | NO20084835L (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ572807A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008045140A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| KR101829776B1 (ko) | 2007-05-21 | 2018-02-19 | 앨더바이오 홀딩스 엘엘씨 | Ｉｌ-６에 대한 항체 및 이의 용도 |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| WO2010065077A2 (en) * | 2008-11-25 | 2010-06-10 | Alder Biopharmaceuticals, Inc. | Antagonists of il-6 to prevent or treat thrombosis |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| IN2012DN01920A (cg-RX-API-DMAC7.html) | 2009-09-03 | 2015-07-24 | Schering Corp | |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| EP2504030A4 (en) | 2009-11-24 | 2013-06-26 | Alderbio Holdings Llc | IL-6 ANTAGONISTS FOR INCREASING ALBUMIN AND / OR REDUCING CRP |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| SI2400298T1 (sl) | 2010-05-28 | 2013-11-29 | F. Hoffmann-La Roche Ag | Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles |
| AU2011332817A1 (en) | 2010-11-23 | 2013-06-13 | Alder Biopharmaceuticals, Inc. | Anti-IL-6 antibodies for the treatment of anemia |
| NZ611076A (en) | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
| JP5963746B2 (ja) * | 2011-03-30 | 2016-08-03 | 国立大学法人富山大学 | 形質細胞または形質芽細胞の選択方法、目的抗原特異的な抗体の製造方法、新規モノクローナル抗体 |
| JP6374789B2 (ja) | 2011-05-20 | 2018-08-15 | アルダーバイオ・ホールディングズ・エルエルシー | 羞明または光嫌悪症を予防または抑制する抗ｃｇｒｐ抗体および抗体断片のそれを必要とする対象、特に片頭痛患者における使用 |
| SG10201604040PA (en) | 2011-05-20 | 2016-07-28 | Alderbio Holdings Llc | Anti-cgrp compositions and use thereof |
| CN103957935B (zh) | 2011-05-20 | 2018-04-03 | 奥尔德生物控股有限责任公司 | 抗cgrp或抗cgrp‑r抗体或抗体片段用于治疗或预防慢性和急性形式的腹泻的用途 |
| EP2724157B1 (en) * | 2011-06-27 | 2017-03-08 | Valneva | Method for screening cells |
| US11782053B2 (en) * | 2011-09-28 | 2023-10-10 | iRepertoire, Inc. | Identification of antigen-specific adaptive immune responses using ARM-PCR and high-throughput sequencing |
| JP6374791B2 (ja) | 2011-11-23 | 2018-08-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｄ４０ｌ発現哺乳動物細胞およびその使用 |
| MX354049B (es) | 2011-12-21 | 2018-02-09 | Hoffmann La Roche | Método rápido para la clonación y expresión de segmentos génicos de regiones variables de anticuerpos cognados. |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| WO2014067642A1 (en) | 2012-11-05 | 2014-05-08 | Mab Discovery Gmbh | Method for the production of multispecific antibodies |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| BR112015010360A8 (pt) | 2012-11-08 | 2018-01-16 | Eleven Biotherapeutics Inc | antagonistas de il-6 e utilização dos mesmos. |
| CN104822828A (zh) * | 2012-11-13 | 2015-08-05 | 弗·哈夫曼-拉罗切有限公司 | 抗原特异性浆母细胞的富集 |
| EP2956478A1 (en) * | 2013-02-15 | 2015-12-23 | ESBATech - a Novartis Company LLC | Acceptor framework for cdr grafting |
| WO2014153166A2 (en) * | 2013-03-14 | 2014-09-25 | Alder Biopharmaceuticals, Inc. | Therapeutic use of antibodies to hgf |
| CA2907570A1 (en) * | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| EP3754012A1 (en) | 2013-03-15 | 2020-12-23 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
| JP6412552B2 (ja) | 2013-03-15 | 2018-10-24 | アルダー・バイオファーマシューティカルズ・インコーポレーテッド | 酵母及び他の形質転換細胞中のポリペプチドの高収率発現のための温度シフト |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
| MX374612B (es) | 2013-07-03 | 2025-03-06 | H Lundbeck As Star | Regulacion del metabolismo de glucosa usando anticuerpos anti-cgrp. |
| UA122673C2 (uk) | 2014-11-07 | 2020-12-28 | Елевен Байотерапьютікс, Інк. | Антитіло, що специфічно зв'язується з людським il-6 |
| WO2016149137A1 (en) * | 2015-03-18 | 2016-09-22 | Epitomics, Inc. | High throughput monoclonal antibody generation by b cell panning and proliferation |
| EP3305325B1 (en) | 2015-06-04 | 2025-07-30 | National Center of Neurology and Psychiatry | Mental illness therapeutic agent having il-6 inhibitor as active ingredient |
| US10906971B2 (en) | 2015-06-26 | 2021-02-02 | Sanofi Biotechnology SAS | Monoclonal anti-IL-1RAcP antibodies |
| JP2019510078A (ja) | 2016-02-23 | 2019-04-11 | セセン バイオ， インコーポレイテッド | Ｉｌ−６アンタゴニスト製剤およびその使用 |
| EP4273232A3 (en) | 2016-03-30 | 2024-01-03 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| JP2019515671A (ja) | 2016-04-15 | 2019-06-13 | アルダー バイオファーマシューティカルズ、インコーポレイテッド | 抗ｐａｃａｐ抗体及びそれらの使用 |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| CN106350485B (zh) * | 2016-08-24 | 2020-02-21 | 杭州百凌生物科技有限公司 | 一种快速高效分离单个抗原特异性b细胞的方法 |
| CN110121554B (zh) | 2017-01-02 | 2023-08-15 | 豪夫迈·罗氏有限公司 | B细胞培养方法 |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| EP3625332B1 (en) | 2017-05-19 | 2022-02-02 | F. Hoffmann-La Roche AG | Method for the production of thymocyte supernatant |
| US11125757B2 (en) * | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| EP3717632B1 (en) | 2017-11-30 | 2022-10-26 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| AU2019270181B2 (en) * | 2018-05-18 | 2023-06-01 | Cz Biohub Sf, Llc | Methods of isolating allergen-specific antibodies from humans and uses thereof |
| CN114144436A (zh) | 2019-07-24 | 2022-03-04 | H.隆德贝克有限公司 | 抗mGluR5抗体及其用途 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| WO2022004620A1 (ja) * | 2020-06-29 | 2022-01-06 | 株式会社Npt | 抗原特異的抗体産生細胞を含む組成物の製造方法、ワクチン組成物の製造方法、細胞分離キットおよびワクチン組成物 |
| WO2022192625A1 (en) | 2021-03-11 | 2022-09-15 | IgGenix, Inc. | Methods and systems for predicting allergic response |
| WO2022241415A1 (en) * | 2021-05-11 | 2022-11-17 | Yale University | Methods for monoclonal antibody generation |
| KR20250060305A (ko) | 2022-09-21 | 2025-05-07 | 사노피 바이오테크놀로지 | 인간화 항-il-1r3 항체 및 사용 방법 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| AU7796291A (en) * | 1990-05-04 | 1991-11-27 | Baxter Diagnostics Inc. | High affinity antibodies to small peptides |
| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| ZA919299B (en) * | 1990-11-26 | 1992-08-26 | Akzo Nv | Method for the production of antibodies |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5256542A (en) * | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| RU2318829C2 (ru) * | 2001-11-14 | 2008-03-10 | Сентокор, Инк. | Антитела против il-6, композиции, способы и применение |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| CA2507004A1 (en) | 2002-12-03 | 2004-06-17 | Celltech R & D Limited | Assay for identifying antibody producing cells |
| GB0312481D0 (en) * | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| WO2005016950A1 (en) * | 2003-08-07 | 2005-02-24 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
| EP1658498A1 (en) | 2003-08-20 | 2006-05-24 | Celltech R & D Limited | Methods for obtaining antibodies |
| EP1658500B1 (en) | 2003-08-20 | 2012-04-18 | UCB Pharma, S.A. | Methods for obtaining antibodies |
| CN1871259A (zh) * | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| WO2005020924A2 (en) * | 2003-08-29 | 2005-03-10 | Centocor, Inc. | A rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method |
| ES2630224T3 (es) * | 2003-10-22 | 2017-08-18 | Keck Graduate Institute | Métodos para sintetizar polipéptidos heteromultiméricos en levadura con el uso de una estrategia de apareamiento haploide |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060051348A1 (en) * | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| US7968308B2 (en) * | 2004-10-22 | 2011-06-28 | Danisco Us Inc. | Isolating human antibodies |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| GB0425972D0 (en) | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| US20070092943A1 (en) * | 2005-09-28 | 2007-04-26 | The University Of Chicago | Versatile vectors for expression of foreign proteins in photosynthetic bacteria |
-
2007
- 2007-05-21 WO PCT/US2007/011980 patent/WO2008045140A1/en not_active Ceased
- 2007-05-21 CN CN200780027028.2A patent/CN101600793B/zh not_active Expired - Fee Related
- 2007-05-21 DK DK07861311.4T patent/DK2021463T3/en active
- 2007-05-21 US US11/802,235 patent/US20070269868A1/en not_active Abandoned
- 2007-05-21 AU AU2007307324A patent/AU2007307324B2/en not_active Ceased
- 2007-05-21 CA CA2652392A patent/CA2652392C/en not_active Expired - Fee Related
- 2007-05-21 JP JP2009512060A patent/JP5607357B2/ja not_active Expired - Fee Related
- 2007-05-21 MX MX2008014692A patent/MX2008014692A/es active IP Right Grant
- 2007-05-21 NZ NZ572807A patent/NZ572807A/en not_active IP Right Cessation
- 2007-05-21 EP EP07861311.4A patent/EP2021463B1/en not_active Revoked
-
2008
- 2008-11-13 IL IL195285A patent/IL195285A/en active IP Right Grant
- 2008-11-18 NO NO20084835A patent/NO20084835L/no unknown
-
2011
- 2011-08-08 US US13/204,915 patent/US20120141982A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,518 patent/US20130316353A1/en not_active Abandoned
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