JP2009537176A5 - - Google Patents
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- Publication number
- JP2009537176A5 JP2009537176A5 JP2009512060A JP2009512060A JP2009537176A5 JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5 JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009512060 A JP2009512060 A JP 2009512060A JP 2009537176 A5 JP2009537176 A5 JP 2009537176A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- cells
- subpopulation
- antibody
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 41
- 102000036639 antigens Human genes 0.000 claims 41
- 108091007433 antigens Proteins 0.000 claims 41
- 238000000034 method Methods 0.000 claims 39
- 210000003719 b-lymphocyte Anatomy 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 11
- 210000000628 antibody-producing cell Anatomy 0.000 claims 10
- 230000006698 induction Effects 0.000 claims 6
- 230000001629 suppression Effects 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
- 239000011324 bead Substances 0.000 claims 3
- 241000282414 Homo sapiens Species 0.000 claims 2
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 230000008484 agonism Effects 0.000 claims 2
- 230000008485 antagonism Effects 0.000 claims 2
- 230000008236 biological pathway Effects 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000006037 cell lysis Effects 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 241000283984 Rodentia Species 0.000 claims 1
- 238000001261 affinity purification Methods 0.000 claims 1
- 239000003636 conditioned culture medium Substances 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80141206P | 2006-05-19 | 2006-05-19 | |
| US60/801,412 | 2006-05-19 | ||
| PCT/US2007/011980 WO2008045140A1 (en) | 2006-05-19 | 2007-05-21 | Culture method for obtaining a clonal population of antigen-specific b cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009537176A JP2009537176A (ja) | 2009-10-29 |
| JP2009537176A5 true JP2009537176A5 (cg-RX-API-DMAC10.html) | 2010-07-08 |
| JP5607357B2 JP5607357B2 (ja) | 2014-10-15 |
Family
ID=39283142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512060A Expired - Fee Related JP5607357B2 (ja) | 2006-05-19 | 2007-05-21 | 抗原特異的ｂ細胞のクローン集団を獲得するための培養方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20070269868A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2021463B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5607357B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN101600793B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007307324B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2652392C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2021463T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL195285A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2008014692A (cg-RX-API-DMAC10.html) |
| NO (1) | NO20084835L (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ572807A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008045140A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US9452227B2 (en) | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| KR20110091780A (ko) * | 2008-11-25 | 2011-08-12 | 앨더 바이오파마슈티컬즈, 인코포레이티드 | 악액질, 쇠약, 피로 및／또는 발열을 예방하거나 치료하는 ｉｌ６의 길항제 |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9079942B2 (en) * | 2009-02-09 | 2015-07-14 | Epitomics, Inc. | CDR-anchored amplification method |
| US20100317539A1 (en) * | 2009-06-12 | 2010-12-16 | Guo-Liang Yu | Library of Engineered-Antibody Producing Cells |
| IN2015DN02826A (cg-RX-API-DMAC10.html) | 2009-09-03 | 2015-09-11 | Merck Sharp & Dohme | |
| US8293483B2 (en) | 2009-09-11 | 2012-10-23 | Epitomics, Inc. | Method for identifying lineage-related antibodies |
| EP2504032A4 (en) | 2009-11-24 | 2013-06-19 | Alderbio Holdings Llc | IL-6 ANTAGONISTS FOR PREVENTING OR TREATING THROMBOSIS |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| SI2400298T1 (sl) * | 2010-05-28 | 2013-11-29 | F. Hoffmann-La Roche Ag | Postopek kultivacije posamezne B-celice in izdelava specifičnih protiteles |
| US8992908B2 (en) | 2010-11-23 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of oral mucositis |
| US9783601B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9487583B2 (en) | 2011-03-30 | 2016-11-08 | National University Corporation University Of Toyama | Method for selecting plasma cells or plasmablasts, method for producing target antigen specific antibodies, and novel monoclonal antibodies |
| EA033109B1 (ru) | 2011-05-20 | 2019-08-30 | Олдербайо Холдингз Ллк | Способы ингибирования, профилактики или лечения диареи и/или поддержания соответствующих уровней электролитов и жидкости в толстой кишке субъекта, подвергающегося связанному с диареей состоянию, с помощью антитела против cgrp или фрагмента антитела против cgrp |
| CN108014334B (zh) | 2011-05-20 | 2021-11-30 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| PT3495392T (pt) | 2011-05-20 | 2021-09-22 | H Lundbeck As | Composições anti-cgrp e a sua utilização |
| EP2724157B1 (en) * | 2011-06-27 | 2017-03-08 | Valneva | Method for screening cells |
| JP2014528001A (ja) * | 2011-09-28 | 2014-10-23 | シービー バイオテクノロジーズ インコーポレイテッド | アームｐｃｒおよび高処理シーケンシングを用いた抗原特異的適応免疫応答の同定法 |
| WO2013076139A1 (en) | 2011-11-23 | 2013-05-30 | F. Hoffmann-La Roche Ag | Cd40l expressing mammalian cells and their use |
| RU2612910C2 (ru) | 2011-12-21 | 2017-03-13 | Ф. Хоффманн-Ля Рош Аг | Быстрый способ клонирования и экспрессии сегментов гена родственной вариабельной области антитела |
| EP2727943A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Trispecific antibodies against human EGFR, HER2 and HER3 |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727942A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Bispecific antibodies against human EGFR, HER2, and HER3 |
| WO2014067642A1 (en) | 2012-11-05 | 2014-05-08 | Mab Discovery Gmbh | Method for the production of multispecific antibodies |
| KR102149206B1 (ko) | 2012-11-08 | 2020-08-31 | 세센 바이오, 아이엔씨. | 인터루킨-6의 길항제 및 이의 용도 |
| BR112015009933A2 (pt) * | 2012-11-13 | 2017-12-12 | Genentech Inc | métodos de obtenção de uma população de plasmablastos, de enriquecimento de plasmablastos e de identificação de plasmablasto |
| CN104884470A (zh) * | 2013-02-15 | 2015-09-02 | 艾斯巴技术-诺华有限责任公司 | 用于cdr移植的接受体框架 |
| TW201444868A (zh) * | 2013-03-14 | 2014-12-01 | Alder Biopharmaceuticals Inc | Ｈｇｆ抗體及其組成物 |
| WO2014145744A1 (en) | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Antibody purification and purity monitoring |
| US20140287952A1 (en) * | 2013-03-15 | 2014-09-25 | Alderbio Holdings Llc | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| TWI636136B (zh) | 2013-03-15 | 2018-09-21 | 艾爾德生物製藥股份有限公司 | 在酵母菌及其它轉型細胞中多肽高產量表現用之溫度變動技術 |
| US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| CN104232577B (zh) * | 2013-06-20 | 2017-12-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种获得自身反应性b细胞的方法 |
| US20150017166A1 (en) | 2013-07-03 | 2015-01-15 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| SI3215530T1 (sl) | 2014-11-07 | 2020-02-28 | Sesen Bio, Inc. | Izboljšana protitelesa IL-6 |
| EP3233916A4 (en) | 2014-12-19 | 2018-06-06 | Alder Biopharmaceuticals, Inc. | Humanized anti-acth antibodies and use thereof |
| EP3271393A4 (en) | 2015-03-18 | 2018-10-31 | Epitomics, Inc. | High throughput monoclonal antibody generation by b cell panning and proliferation |
| JP7128460B2 (ja) | 2015-06-04 | 2022-08-31 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６阻害剤を有効成分とする精神疾患治療剤 |
| CN108026172B (zh) | 2015-06-26 | 2022-04-29 | 赛诺菲生物技术公司 | 单克隆抗il-1racp抗体 |
| BR112018017031A2 (pt) | 2016-02-23 | 2019-01-22 | Sesen Bio Inc | formulações de antagonista de il-6 e usos das mesmas |
| JP7026634B2 (ja) | 2016-03-30 | 2022-02-28 | エフ．ホフマン－ラ ロシュ アーゲー | Ｂ細胞培養法 |
| SG10202109691UA (en) | 2016-04-15 | 2021-10-28 | Alder Biopharmaceuticals Inc | Anti-pacap antibodies and uses thereof |
| EP3241845A1 (en) | 2016-05-06 | 2017-11-08 | MAB Discovery GmbH | Humanized anti-il-1r3 antibodies |
| CN106350485B (zh) * | 2016-08-24 | 2020-02-21 | 杭州百凌生物科技有限公司 | 一种快速高效分离单个抗原特异性b细胞的方法 |
| EP3562936B1 (en) | 2017-01-02 | 2024-05-22 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| EP3401332A1 (en) | 2017-05-08 | 2018-11-14 | MAB Discovery GmbH | Anti-il-1r3 antibodies for use in inflammatory conditions |
| EP3625332B1 (en) | 2017-05-19 | 2022-02-02 | F. Hoffmann-La Roche AG | Method for the production of thymocyte supernatant |
| US11125757B2 (en) * | 2017-05-26 | 2021-09-21 | Emory University | Methods of culturing and characterizing antibody secreting cells |
| EP3717632B1 (en) | 2017-11-30 | 2022-10-26 | F. Hoffmann-La Roche AG | B-cell cultivation method |
| CN119823260A (zh) * | 2018-05-18 | 2025-04-15 | 陈扎克伯格生物中心旧金山公司 | 从人中分离过敏原特异性抗体的方法及其用途 |
| BR112021005478A2 (pt) | 2019-07-24 | 2021-06-15 | H. Lundbeck A/S | anticorpos anti-mglur5 e uso dos mesmos |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| JPWO2022004620A1 (cg-RX-API-DMAC10.html) * | 2020-06-29 | 2022-01-06 | ||
| EP4305190A4 (en) | 2021-03-11 | 2025-03-26 | Iggenix, Inc. | METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION |
| US20240228595A1 (en) * | 2021-05-11 | 2024-07-11 | Yale University | Methods for Monoclonal Antibody Generation |
| US12054552B2 (en) | 2022-09-21 | 2024-08-06 | Sanofi Biotechnology | Humanized anti-IL-1R3 antibody and methods of use |
| WO2026120069A1 (en) | 2024-12-05 | 2026-06-11 | H. Lundbeck A/S | Humanized anti-pacap antibody and uses thereof |
Family Cites Families (25)
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|---|---|---|---|---|
| US6657103B1 (en) * | 1990-01-12 | 2003-12-02 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1991017177A1 (en) * | 1990-05-04 | 1991-11-14 | Baxter Diagnostics Inc. | High affinity antibodies to small peptides |
| CA2090126C (en) | 1990-08-02 | 2002-10-22 | John W. Schrader | Methods for the production of proteins with a desired function |
| DE69126281T2 (de) * | 1990-11-26 | 1997-10-16 | Akzo Nobel Nv | Verfahren zur Herstellung von Antikörpern |
| US6277969B1 (en) * | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US5256542A (en) * | 1992-03-09 | 1993-10-26 | Tanox Biosystems, Inc. | Selecting low frequency antigen-specific single B lymphocytes with correction for background noise |
| US6972125B2 (en) * | 1999-02-12 | 2005-12-06 | Genetics Institute, Llc | Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith |
| BRPI0214168B8 (pt) * | 2001-11-14 | 2021-05-25 | Centocor Inc | anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos |
| US20040185040A1 (en) * | 2001-11-21 | 2004-09-23 | Celltech R & D Limited | Modulating immune responses |
| US8188231B2 (en) * | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| WO2004051268A1 (en) | 2002-12-03 | 2004-06-17 | Celltech R & D Limited | Assay for identifying antibody producing cells |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| CN100415765C (zh) * | 2003-08-07 | 2008-09-03 | 宜康公司 | 兔单克隆抗体的人源化方法 |
| ES2385829T3 (es) | 2003-08-20 | 2012-08-01 | Ucb Pharma, S.A. | Métodos para obtener anticuerpos |
| US7771969B2 (en) | 2003-08-20 | 2010-08-10 | Celltech R&D Limited | Methods for obtaining antibodies |
| AU2004266159A1 (en) * | 2003-08-22 | 2005-03-03 | Biogen Idec Ma Inc. | Improved antibodies having altered effector function and methods for making the same |
| EP1664774A4 (en) * | 2003-08-29 | 2007-06-27 | Centocor Inc | RAPID MEANS FOR OBTAINING HIGH-EXPRESSION CLONES OF MAMMALIAN CELLS, ACCORDING TO A METHYLCELLULOSE SCREENING METHOD AND IMMUNOPRECIPITATION |
| DK1678314T3 (da) * | 2003-10-22 | 2012-12-03 | Keck Graduate Inst | Fremgangsmåde til syntetisering af heteromultimere polypeptider i gær ved anvendelse af en haploid parringsstrategi |
| GB0412973D0 (en) | 2004-06-10 | 2004-07-14 | Celltech R&D Ltd | Identification of antibody producing cells |
| US20060051348A1 (en) * | 2004-09-09 | 2006-03-09 | Jorn Gorlach | Method of producing a plurality of isolated antibodies to a plurality of cognate antigens |
| JP2008517914A (ja) * | 2004-10-22 | 2008-05-29 | ジェネンコー・インターナショナル・インク | ヒトの抗体の分離方法 |
| US7462697B2 (en) * | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
| GB0425972D0 (en) | 2004-11-25 | 2004-12-29 | Celltech R&D Ltd | Biological products |
| PA8672101A1 (es) * | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| US20070092943A1 (en) * | 2005-09-28 | 2007-04-26 | The University Of Chicago | Versatile vectors for expression of foreign proteins in photosynthetic bacteria |
-
2007
- 2007-05-21 EP EP07861311.4A patent/EP2021463B1/en not_active Revoked
- 2007-05-21 NZ NZ572807A patent/NZ572807A/en not_active IP Right Cessation
- 2007-05-21 CA CA2652392A patent/CA2652392C/en not_active Expired - Fee Related
- 2007-05-21 AU AU2007307324A patent/AU2007307324B2/en not_active Ceased
- 2007-05-21 JP JP2009512060A patent/JP5607357B2/ja not_active Expired - Fee Related
- 2007-05-21 MX MX2008014692A patent/MX2008014692A/es active IP Right Grant
- 2007-05-21 US US11/802,235 patent/US20070269868A1/en not_active Abandoned
- 2007-05-21 DK DK07861311.4T patent/DK2021463T3/en active
- 2007-05-21 CN CN200780027028.2A patent/CN101600793B/zh not_active Expired - Fee Related
- 2007-05-21 WO PCT/US2007/011980 patent/WO2008045140A1/en not_active Ceased
-
2008
- 2008-11-13 IL IL195285A patent/IL195285A/en active IP Right Grant
- 2008-11-18 NO NO20084835A patent/NO20084835L/no unknown
-
2011
- 2011-08-08 US US13/204,915 patent/US20120141982A1/en not_active Abandoned
-
2013
- 2013-04-12 US US13/861,518 patent/US20130316353A1/en not_active Abandoned
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