JP2009537147A5 - - Google Patents
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- JP2009537147A5 JP2009537147A5 JP2009511210A JP2009511210A JP2009537147A5 JP 2009537147 A5 JP2009537147 A5 JP 2009537147A5 JP 2009511210 A JP2009511210 A JP 2009511210A JP 2009511210 A JP2009511210 A JP 2009511210A JP 2009537147 A5 JP2009537147 A5 JP 2009537147A5
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- JP
- Japan
- Prior art keywords
- item
- influenza
- virus
- subtype
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003472 neutralizing effect Effects 0.000 claims description 65
- 238000000034 method Methods 0.000 claims description 55
- 241000712431 Influenza A virus Species 0.000 claims description 46
- 241001473385 H5N1 subtype Species 0.000 claims description 17
- 208000037797 influenza A Diseases 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 4
- 238000002703 mutagenesis Methods 0.000 claims description 3
- 231100000350 mutagenesis Toxicity 0.000 claims description 3
- 101710154606 Hemagglutinin Proteins 0.000 claims 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
- 101710176177 Protein A56 Proteins 0.000 claims 2
- 239000000185 hemagglutinin Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 description 8
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 7
- 208000015181 infectious disease Diseases 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 101710169105 Minor spike protein Proteins 0.000 description 4
- 101710081079 Minor spike protein H Proteins 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000197306 H1N1 subtype Species 0.000 description 2
- 241000197304 H2N2 subtype Species 0.000 description 2
- 241000252870 H3N2 subtype Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 241000271566 Aves Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000037432 silent mutation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80078706P | 2006-05-15 | 2006-05-15 | |
| US85567906P | 2006-10-30 | 2006-10-30 | |
| PCT/US2007/068983 WO2007134327A2 (en) | 2006-05-15 | 2007-05-15 | Neutralizing antibodies to influenza viruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002320A Division JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009537147A JP2009537147A (ja) | 2009-10-29 |
| JP2009537147A5 true JP2009537147A5 (https=) | 2010-07-01 |
Family
ID=38694784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009511210A Pending JP2009537147A (ja) | 2006-05-15 | 2007-05-15 | インフルエンザウイルスに対する中和抗体 |
| JP2013002320A Pending JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002320A Pending JP2013067660A (ja) | 2006-05-15 | 2013-01-10 | インフルエンザウイルスに対する中和抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20080014205A1 (https=) |
| EP (2) | EP2024393A2 (https=) |
| JP (2) | JP2009537147A (https=) |
| CN (1) | CN103435697A (https=) |
| AU (1) | AU2007249160B2 (https=) |
| CA (1) | CA2652452C (https=) |
| IL (3) | IL195225A (https=) |
| WO (1) | WO2007134327A2 (https=) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8148085B2 (en) | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| WO2008110937A2 (en) * | 2007-03-13 | 2008-09-18 | Humabs Llc | Antibodies against h5n1 strains of influenza a virus |
| BRPI0809435A2 (pt) | 2007-03-27 | 2014-09-09 | Sea Lane Biotechnologies, Llc | Constructos e bibliotecas que compreendem sequências de cadeia leve substituida de anticorpos |
| EP2144617A4 (en) * | 2007-04-11 | 2011-04-27 | Immuron Ltd | RELEASE OF GRIP ANTIBODIES ON SURFACES IN CONTACT WITH AIR |
| EP3524619A1 (en) | 2007-12-06 | 2019-08-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
| ITTO20080204A1 (it) * | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| WO2009121004A2 (en) * | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| WO2010010467A2 (en) * | 2008-07-25 | 2010-01-28 | Institute For Research In Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| GB0818356D0 (en) * | 2008-10-07 | 2008-11-12 | Istituto Superiore Di Sanito | Antibodies |
| US20110195079A1 (en) * | 2008-10-21 | 2011-08-11 | Dormitzer Philip | Immunization protocol for directed expansion and maturation |
| BRPI0914092B1 (pt) | 2008-10-22 | 2021-08-31 | Institute For Research In Biomedicine | Método de produção de um anticorpo a partir de células plasmáticas, método de produção de um anticorpo monoclonal a partir de células plasmáticas e método de produção de um anticorpo ou de um fragmento de anticorpo |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| AU2010247530B2 (en) * | 2009-05-11 | 2016-10-13 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof |
| CN102482345A (zh) | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| AU2010254136B2 (en) * | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| CA2790380A1 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| EP3248615A1 (en) | 2010-03-30 | 2017-11-29 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| ES2687706T3 (es) * | 2010-06-17 | 2018-10-26 | Trellis Bioscience, Llc | Anticuerpos útiles en la inmunización pasiva contra la gripe |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| EP2436766A1 (en) * | 2010-09-29 | 2012-04-04 | Deutsches Krebsforschungszentrum | Means and methods for improved protein interaction screening |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| EP2640831A1 (en) * | 2010-11-17 | 2013-09-25 | Sea Lane Biotechnologies,llc. | Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody |
| HRP20190714T1 (hr) | 2011-07-18 | 2019-06-14 | Institute For Research In Biomedicine | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba |
| WO2013016714A1 (en) | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies | Sur-binding proteins against erbb3 |
| IN2014CN02114A (https=) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| MX350282B (es) | 2011-09-30 | 2017-09-01 | Celltrion Inc | Molecula de union que tiene actividad neutralizadora del virus de la influenza a, producida a partir de celulas b humanas. |
| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| ES2686526T3 (es) | 2011-12-05 | 2018-10-18 | Trellis Bioscience, Llc | Anticuerpos útiles en la inmunización pasiva contra la influenza |
| KR101749316B1 (ko) * | 2011-12-15 | 2017-06-21 | (주) 에이프로젠 | Ｈ１ｎ１―감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| EP3446707A1 (en) | 2011-12-22 | 2019-02-27 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
| SG11201404653UA (en) * | 2012-02-07 | 2014-09-26 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h3n2, h2n2, and b influenza viruses |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| EP4310191A3 (en) | 2012-06-14 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing modified fc region |
| EA201591164A1 (ru) | 2012-12-18 | 2015-11-30 | Икан Скул Оф Медсин Эт Маунт Синай | Вакцины против вируса гриппа и их применение |
| US11827693B2 (en) | 2013-03-14 | 2023-11-28 | Contrafect Corporation | Composition and methods based on neutralizing antibodies delivered intranasally for enhanced therapeutic efficacy |
| US9101597B2 (en) | 2013-03-14 | 2015-08-11 | The Administration Of The Tulane Educational Fund | Immunoprotective primary mesenchymal stem cells and methods |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| EP3037533A4 (en) | 2013-08-23 | 2017-07-05 | Fujita Health University | Anti-influenza virus-neutralizing antibody |
| EP3733244A1 (en) | 2013-10-02 | 2020-11-04 | Medlmmune, LLC | Neutralizing anti-influenza a antibodies and uses thereof |
| TWI712421B (zh) | 2013-11-11 | 2020-12-11 | 日商中外製藥股份有限公司 | 含改變的抗體可變區之抗原結合分子 |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| JP6712428B2 (ja) | 2014-02-04 | 2020-06-24 | コントラフェクト コーポレイション | インフルエンザ受動免疫に有用な抗体ならびにその使用のための組成物、組合せおよび方法 |
| EP3126384B1 (en) * | 2014-04-01 | 2020-12-02 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| CN119161468A (zh) | 2014-07-15 | 2024-12-20 | 免疫医疗有限责任公司 | 中和抗乙型流感抗体及其用途 |
| TWI880146B (zh) | 2014-11-11 | 2025-04-11 | 日商中外製藥股份有限公司 | 包含經改變之抗體可變區之抗原結合分子的資料庫 |
| EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
| CN113480640B (zh) | 2015-06-01 | 2024-07-30 | 免疫医疗有限责任公司 | 中和抗流感结合分子及其用途 |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| WO2017123685A1 (en) | 2016-01-13 | 2017-07-20 | Medimmune, Llc | Method of treating influenza a |
| CN109195629A (zh) | 2016-02-24 | 2019-01-11 | 威特拉公司 | 流行性感冒抗体分子制剂 |
| CA3023143A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| GB201614485D0 (en) * | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| DK3532612T3 (da) | 2016-10-31 | 2022-09-19 | Univ Zuerich | Samling af markører og fremgangsmåder til proteindetektion, fortrinsvis ved massespektrometri |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| US11434277B2 (en) | 2017-10-20 | 2022-09-06 | Academia Sinica | Method for high-throughput screening of neutralizing antibodies, neutralizing antibodies produced therefrom, and uses thereof |
| TW201938194A (zh) * | 2017-12-05 | 2019-10-01 | 日商中外製藥股份有限公司 | 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子 |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| MX2021000827A (es) | 2018-08-03 | 2021-03-25 | Chugai Pharmaceutical Co Ltd | Molecula de union a antigeno que contiene dos dominios de union a antigeno que estan enlazados entre si. |
| BR112021005472A2 (pt) | 2018-09-28 | 2021-06-15 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno compreendendo uma região variável do anticorpo alterada |
| CN113924147A (zh) | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| US20220267382A1 (en) * | 2019-09-20 | 2022-08-25 | Academia Sinica | Chimeric hemagglutinin protein and a vaccine composition comprising the same |
| TWI909146B (zh) | 2020-03-31 | 2025-12-21 | 日商中外製藥股份有限公司 | Dll3靶向之多特異性抗原結合分子及其用途 |
| CN113121680B (zh) * | 2021-04-12 | 2022-03-29 | 华南农业大学 | 一种抗h5亚型禽流感纳米抗体蛋白及其编码基因与应用 |
| CN113355344B (zh) * | 2021-08-10 | 2021-11-02 | 北京溯本源和生物科技有限公司 | 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用 |
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-
2007
- 2007-05-15 EP EP07762203A patent/EP2024393A2/en not_active Withdrawn
- 2007-05-15 CN CN2013102549131A patent/CN103435697A/zh active Pending
- 2007-05-15 CA CA2652452A patent/CA2652452C/en not_active Expired - Fee Related
- 2007-05-15 EP EP20120165672 patent/EP2522678A1/en not_active Withdrawn
- 2007-05-15 WO PCT/US2007/068983 patent/WO2007134327A2/en not_active Ceased
- 2007-05-15 AU AU2007249160A patent/AU2007249160B2/en not_active Ceased
- 2007-05-15 US US11/748,980 patent/US20080014205A1/en not_active Abandoned
- 2007-05-15 JP JP2009511210A patent/JP2009537147A/ja active Pending
-
2008
- 2008-11-11 IL IL195225A patent/IL195225A/en not_active IP Right Cessation
-
2010
- 2010-07-12 US US12/834,736 patent/US20100316654A1/en not_active Abandoned
-
2011
- 2011-08-10 US US13/207,083 patent/US20120107326A1/en not_active Abandoned
-
2012
- 2012-10-30 IL IL222762A patent/IL222762A0/en unknown
-
2013
- 2013-01-10 JP JP2013002320A patent/JP2013067660A/ja active Pending
- 2013-09-13 US US14/026,086 patent/US20140205614A1/en not_active Abandoned
-
2015
- 2015-05-27 IL IL239023A patent/IL239023A0/en unknown
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