JP2011516423A5 - - Google Patents
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- JP2011516423A5 JP2011516423A5 JP2011502108A JP2011502108A JP2011516423A5 JP 2011516423 A5 JP2011516423 A5 JP 2011516423A5 JP 2011502108 A JP2011502108 A JP 2011502108A JP 2011502108 A JP2011502108 A JP 2011502108A JP 2011516423 A5 JP2011516423 A5 JP 2011516423A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- sequence
- virus
- item
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims description 36
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 36
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 36
- 101710176177 Protein A56 Proteins 0.000 claims description 36
- 239000000185 hemagglutinin Substances 0.000 claims description 32
- 239000000427 antigen Substances 0.000 claims description 27
- 102000036639 antigens Human genes 0.000 claims description 27
- 108091007433 antigens Proteins 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 241000712431 Influenza A virus Species 0.000 claims description 25
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 238000006467 substitution reaction Methods 0.000 claims description 19
- 229960005486 vaccine Drugs 0.000 claims description 14
- 230000003472 neutralizing effect Effects 0.000 claims description 13
- 108010018324 Surrogate Immunoglobulin Light Chains Proteins 0.000 claims description 12
- 102000002663 Surrogate Immunoglobulin Light Chains Human genes 0.000 claims description 12
- 101000854886 Homo sapiens Immunoglobulin iota chain Proteins 0.000 claims description 8
- 102100020744 Immunoglobulin iota chain Human genes 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 230000035931 haemagglutination Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- -1 Kabat amino acid Chemical class 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 18
- 108091035707 Consensus sequence Proteins 0.000 description 8
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 241000315672 SARS coronavirus Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 102220352372 c.148T>G Human genes 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 102200006531 rs121913529 Human genes 0.000 description 1
- 102200077933 rs137854432 Human genes 0.000 description 1
- 102200008957 rs387906911 Human genes 0.000 description 1
- 102200133079 rs74315446 Human genes 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4045908P | 2008-03-28 | 2008-03-28 | |
| US61/040,459 | 2008-03-28 | ||
| PCT/US2009/038636 WO2009121004A2 (en) | 2008-03-28 | 2009-03-27 | Neutralizing molecules to viral antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516423A JP2011516423A (ja) | 2011-05-26 |
| JP2011516423A5 true JP2011516423A5 (https=) | 2013-05-23 |
Family
ID=41021445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502108A Pending JP2011516423A (ja) | 2008-03-28 | 2009-03-27 | ウイルス抗原に対する中和分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100040635A1 (https=) |
| EP (2) | EP2274334A2 (https=) |
| JP (1) | JP2011516423A (https=) |
| CN (1) | CN102046656A (https=) |
| AU (1) | AU2009228058A1 (https=) |
| CA (1) | CA2719201A1 (https=) |
| IL (1) | IL208313A0 (https=) |
| WO (1) | WO2009121004A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0809435A2 (pt) | 2007-03-27 | 2014-09-09 | Sea Lane Biotechnologies, Llc | Constructos e bibliotecas que compreendem sequências de cadeia leve substituida de anticorpos |
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| CN102482345A (zh) | 2009-05-13 | 2012-05-30 | 航道生物技术有限责任公司 | 针对流感病毒的中和分子 |
| AU2010254136B2 (en) | 2009-05-26 | 2016-09-29 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| AU2010303568B2 (en) | 2009-10-09 | 2014-07-31 | New York Blood Center, Inc. | Immunopotentiator-linked oligomeric influenza immunogenic compositions |
| CA2790380A1 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| WO2011111966A2 (en) * | 2010-03-08 | 2011-09-15 | Celltrion, Inc. | Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses |
| EP3248615A1 (en) | 2010-03-30 | 2017-11-29 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| ES2687706T3 (es) * | 2010-06-17 | 2018-10-26 | Trellis Bioscience, Llc | Anticuerpos útiles en la inmunización pasiva contra la gripe |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| EP2640831A1 (en) | 2010-11-17 | 2013-09-25 | Sea Lane Biotechnologies,llc. | Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| WO2013016714A1 (en) | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies | Sur-binding proteins against erbb3 |
| EP2748184A1 (en) * | 2011-08-27 | 2014-07-02 | Universität Zürich | Multi-strain-reactive antibodies for therapy and diagnosis of influenza |
| IN2014CN02114A (https=) | 2011-09-20 | 2015-05-29 | Sinai School Medicine | |
| MX350282B (es) * | 2011-09-30 | 2017-09-01 | Celltrion Inc | Molecula de union que tiene actividad neutralizadora del virus de la influenza a, producida a partir de celulas b humanas. |
| ES2686526T3 (es) | 2011-12-05 | 2018-10-18 | Trellis Bioscience, Llc | Anticuerpos útiles en la inmunización pasiva contra la influenza |
| EP3446707A1 (en) | 2011-12-22 | 2019-02-27 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| EA201591164A1 (ru) | 2012-12-18 | 2015-11-30 | Икан Скул Оф Медсин Эт Маунт Синай | Вакцины против вируса гриппа и их применение |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| JP6676521B2 (ja) | 2013-03-14 | 2020-04-08 | マクロジェニクス，インコーポレーテッド | 二重特異性分子、薬学的組成物及びそれらの使用 |
| US11827693B2 (en) | 2013-03-14 | 2023-11-28 | Contrafect Corporation | Composition and methods based on neutralizing antibodies delivered intranasally for enhanced therapeutic efficacy |
| CN104045709B (zh) * | 2013-08-02 | 2017-05-24 | 中国医学科学院病原生物学研究所 | 人源抗h7n9禽流感病毒中和性抗体a6、其制备方法及应用 |
| EP3037533A4 (en) * | 2013-08-23 | 2017-07-05 | Fujita Health University | Anti-influenza virus-neutralizing antibody |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| JP6712428B2 (ja) | 2014-02-04 | 2020-06-24 | コントラフェクト コーポレイション | インフルエンザ受動免疫に有用な抗体ならびにその使用のための組成物、組合せおよび方法 |
| EP3201227A4 (en) | 2014-09-29 | 2018-04-18 | Duke University | Bispecific molecules comprising an hiv-1 envelope targeting arm |
| JP6499420B2 (ja) * | 2014-11-13 | 2019-04-10 | 公益財団法人ヒューマンサイエンス振興財団 | ワクチン及び感染防御キット |
| US20180008702A1 (en) | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| WO2016089181A1 (ko) * | 2014-12-05 | 2016-06-09 | (주)셀트리온 | 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물 |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3247389A4 (en) | 2015-01-23 | 2019-10-30 | Icahn School of Medicine at Mount Sinai | INFLUENZAVIRUSSCHUTZIMPFPLÄNE |
| EA038407B1 (ru) * | 2015-02-05 | 2021-08-24 | Янссен Вэксинс Энд Превеншн Б.В. | Связывающие молекулы, направленные против гемагглютинина вируса гриппа, и пути их применения |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CN109195629A (zh) | 2016-02-24 | 2019-01-11 | 威特拉公司 | 流行性感冒抗体分子制剂 |
| CA3023143A1 (en) | 2016-06-15 | 2017-12-21 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| CN110506057B (zh) | 2017-02-17 | 2023-09-29 | 百时美施贵宝公司 | Alpha突触核蛋白抗体及其应用 |
| CA3052487A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Influenza vaccines based on aav vectors |
| JP7455579B2 (ja) | 2017-02-28 | 2024-03-26 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 新規アデノ随伴ウイルス（ａａｖ）クレードｆベクター及びその用途 |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| WO2018169785A2 (en) | 2017-03-13 | 2018-09-20 | The Government Of The United States Of America As Represented By The Secretary Of The Army | Therapeutic antibodies to marburg virus |
| WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| KR102820941B1 (ko) | 2018-01-26 | 2025-06-16 | 리제너론 파마슈티칼스 인코포레이티드 | 인플루엔자 헤마글루티닌에 대한 인간 항체 |
| WO2019210144A1 (en) * | 2018-04-27 | 2019-10-31 | Vanderbilt University | Broadly neutralizing antibodies against hepatitis c virus |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| WO2020090747A1 (ja) * | 2018-10-29 | 2020-05-07 | 株式会社免疫生物研究所 | 抗ｈｉｖ抗体及びその製造方法 |
| CN113924147A (zh) | 2019-03-25 | 2022-01-11 | 威特拉公司 | 用于治疗和预防流感的组合物和方法 |
| EP3959216A4 (en) | 2019-04-24 | 2023-01-11 | Icahn School of Medicine at Mount Sinai | ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| WO2023092314A1 (zh) * | 2021-11-24 | 2023-06-01 | 苏州方科生物科技有限公司 | 结合bp特异性抗原肽的人源抗体、制备方法及用途 |
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| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4943529A (en) | 1982-05-19 | 1990-07-24 | Gist-Brocades Nv | Kluyveromyces as a host strain |
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
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| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| DD228737A1 (de) * | 1984-11-06 | 1985-10-23 | Inst F Angewandte Virologie | Verfahren zur herstellung von influenza-inaktivimpfstoffen mit geringer stammabhaengigkeit |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| DE3852304T3 (de) | 1987-03-02 | 1999-07-01 | Enzon Labs Inc., Piscataway, N.J. | Organismus als Träger für "Single Chain Antibody Domain (SCAD)". |
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| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
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| BRPI0809435A2 (pt) * | 2007-03-27 | 2014-09-09 | Sea Lane Biotechnologies, Llc | Constructos e bibliotecas que compreendem sequências de cadeia leve substituida de anticorpos |
| FR2916107B1 (fr) | 2007-05-11 | 2015-11-27 | Centre Nat Etd Spatiales | Actionneur alternatif a asservissement en boucle fermee |
| WO2008153236A1 (en) | 2007-06-15 | 2008-12-18 | Protheon Co., Ltd | An attenuated influenza virus and a live vaccine comprising the same |
| EP3524619A1 (en) | 2007-12-06 | 2019-08-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
| EP3009145A1 (en) * | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
-
2009
- 2009-03-27 WO PCT/US2009/038636 patent/WO2009121004A2/en not_active Ceased
- 2009-03-27 EP EP09726334A patent/EP2274334A2/en not_active Withdrawn
- 2009-03-27 US US12/413,308 patent/US20100040635A1/en not_active Abandoned
- 2009-03-27 AU AU2009228058A patent/AU2009228058A1/en not_active Abandoned
- 2009-03-27 EP EP13177665.0A patent/EP2698380A1/en not_active Withdrawn
- 2009-03-27 CA CA2719201A patent/CA2719201A1/en not_active Abandoned
- 2009-03-27 JP JP2011502108A patent/JP2011516423A/ja active Pending
- 2009-03-27 CN CN2009801192684A patent/CN102046656A/zh active Pending
-
2010
- 2010-09-21 IL IL208313A patent/IL208313A0/en unknown
-
2011
- 2011-07-18 US US13/185,386 patent/US9169318B2/en active Active
-
2016
- 2016-06-08 US US15/177,232 patent/US20170136118A1/en not_active Abandoned
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