JP2011516423A5 - - Google Patents
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- JP2011516423A5 JP2011516423A5 JP2011502108A JP2011502108A JP2011516423A5 JP 2011516423 A5 JP2011516423 A5 JP 2011516423A5 JP 2011502108 A JP2011502108 A JP 2011502108A JP 2011502108 A JP2011502108 A JP 2011502108A JP 2011516423 A5 JP2011516423 A5 JP 2011516423A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- sequence
- virus
- item
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101710154606 Hemagglutinin Proteins 0.000 claims description 36
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 36
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 36
- 101710176177 Protein A56 Proteins 0.000 claims description 36
- 239000000185 hemagglutinin Substances 0.000 claims description 32
- 239000000427 antigen Substances 0.000 claims description 27
- 102000036639 antigens Human genes 0.000 claims description 27
- 108091007433 antigens Proteins 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 241000712431 Influenza A virus Species 0.000 claims description 25
- 229920001184 polypeptide Polymers 0.000 claims description 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
- 238000006467 substitution reaction Methods 0.000 claims description 19
- 229960005486 vaccine Drugs 0.000 claims description 14
- 230000003472 neutralizing effect Effects 0.000 claims description 13
- 108010018324 Surrogate Immunoglobulin Light Chains Proteins 0.000 claims description 12
- 102000002663 Surrogate Immunoglobulin Light Chains Human genes 0.000 claims description 12
- 101000854886 Homo sapiens Immunoglobulin iota chain Proteins 0.000 claims description 8
- 102100020744 Immunoglobulin iota chain Human genes 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 230000035931 haemagglutination Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- -1 Kabat amino acid Chemical class 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 18
- 108091035707 Consensus sequence Proteins 0.000 description 8
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 2
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000598436 Human T-cell lymphotropic virus Species 0.000 description 1
- 206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 description 1
- 241000714260 Human T-lymphotropic virus 1 Species 0.000 description 1
- 241000714259 Human T-lymphotropic virus 2 Species 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 241000315672 SARS coronavirus Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 102220352372 c.148T>G Human genes 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 102200006531 rs121913529 Human genes 0.000 description 1
- 102200077933 rs137854432 Human genes 0.000 description 1
- 102200008957 rs387906911 Human genes 0.000 description 1
- 102200133079 rs74315446 Human genes 0.000 description 1
- 201000005404 rubella Diseases 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4045908P | 2008-03-28 | 2008-03-28 | |
| US61/040,459 | 2008-03-28 | ||
| PCT/US2009/038636 WO2009121004A2 (en) | 2008-03-28 | 2009-03-27 | Neutralizing molecules to viral antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516423A JP2011516423A (ja) | 2011-05-26 |
| JP2011516423A5 true JP2011516423A5 (https=) | 2013-05-23 |
Family
ID=41021445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502108A Pending JP2011516423A (ja) | 2008-03-28 | 2009-03-27 | ウイルス抗原に対する中和分子 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100040635A1 (https=) |
| EP (2) | EP2698380A1 (https=) |
| JP (1) | JP2011516423A (https=) |
| CN (1) | CN102046656A (https=) |
| AU (1) | AU2009228058A1 (https=) |
| CA (1) | CA2719201A1 (https=) |
| IL (1) | IL208313A0 (https=) |
| WO (1) | WO2009121004A2 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| CA2761681A1 (en) | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| US8673314B2 (en) | 2009-05-26 | 2014-03-18 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US9592287B2 (en) | 2009-10-09 | 2017-03-14 | New York Blood Center, Inc. | Immunopotentiator-linked oligomeric influenza immunogenic compositions |
| EP2536425B1 (en) | 2010-02-18 | 2019-06-19 | Icahn School of Medicine at Mount Sinai | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| EP3098236A1 (en) * | 2010-03-08 | 2016-11-30 | Celltrion, Inc. | Human monoclonal antibodies derived from human b cells and having neutralizing activity against influenza a viruses |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| KR101849738B1 (ko) * | 2010-06-17 | 2018-04-17 | 트렐리스 바이오싸이언스 인코포레이티드 | 수동 인플루엔자 면역에 유용한 항체 |
| US9534042B2 (en) | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| EP2640831A1 (en) | 2010-11-17 | 2013-09-25 | Sea Lane Biotechnologies,llc. | Influenza virus neutralizing agents that mimic the binding site of an influenza neutralizing antibody |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| EP2736928B1 (en) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Sur-binding proteins against erbb3 |
| EP2748184A1 (en) * | 2011-08-27 | 2014-07-02 | Universität Zürich | Multi-strain-reactive antibodies for therapy and diagnosis of influenza |
| EP4241785B1 (en) | 2011-09-20 | 2026-01-28 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| JP5998222B2 (ja) | 2011-09-30 | 2016-09-28 | セルトリオン・インコーポレイテッド | ヒトｂ細胞で生産されたインフルエンザａウイルス中和活性を持つ結合分子 |
| MX367743B (es) | 2011-12-05 | 2019-09-04 | Trellis Bioscience Llc | Anticuerpos utiles para la inmunizacion pasiva de influenza. |
| US9975956B2 (en) | 2011-12-22 | 2018-05-22 | I2 Pharmaceuticals, Inc. | Surrogate binding proteins which bind DR4 and/or DR5 |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| MX387277B (es) | 2013-03-14 | 2025-03-12 | Contrafect Corp | Composiciones basadas en anticuerpos neutralizantes suministrados intranasalmente para eficacia terapéutica aumentada. |
| SMT202100464T1 (it) | 2013-03-14 | 2021-11-12 | Macrogenics Inc | Molecole bispecifiche che sono immunoreattive con cellule effettrici immunitarie che esprimono un recettore di attivazione |
| CN104045709B (zh) * | 2013-08-02 | 2017-05-24 | 中国医学科学院病原生物学研究所 | 人源抗h7n9禽流感病毒中和性抗体a6、其制备方法及应用 |
| EP3037533A4 (en) * | 2013-08-23 | 2017-07-05 | Fujita Health University | Anti-influenza virus-neutralizing antibody |
| JP6712428B2 (ja) | 2014-02-04 | 2020-06-24 | コントラフェクト コーポレイション | インフルエンザ受動免疫に有用な抗体ならびにその使用のための組成物、組合せおよび方法 |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| MX386297B (es) | 2014-09-29 | 2025-03-18 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
| JP6499420B2 (ja) * | 2014-11-13 | 2019-04-10 | 公益財団法人ヒューマンサイエンス振興財団 | ワクチン及び感染防御キット |
| WO2016089181A1 (ko) * | 2014-12-05 | 2016-06-09 | (주)셀트리온 | 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물 |
| US20180008702A1 (en) | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| US10736956B2 (en) | 2015-01-23 | 2020-08-11 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| MY186585A (en) | 2015-02-05 | 2021-07-28 | Janssen Vaccines & Prevention Bv | Binding molecules directed against influenza hemagglutinin and uses thereof |
| EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| AU2017222564A1 (en) | 2016-02-24 | 2018-09-06 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| MX2018015755A (es) | 2016-06-15 | 2019-08-29 | Icahn School Med Mount Sinai | Proteinas de hemaglutinina de virus de influenza y usos de las mismas. |
| CA3051839A1 (en) | 2017-02-17 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| PT3589730T (pt) | 2017-02-28 | 2024-02-28 | Univ Pennsylvania | Vetor de vírus adenoassociado (aav) de clado f e suas utilizações |
| UY37620A (es) | 2017-02-28 | 2018-08-31 | Univ Pennsylvania | Vacunas contra la gripe mediadas por aav novedosas |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| US11440951B2 (en) | 2017-03-13 | 2022-09-13 | The Government Of The United States, As Represented By The Secretary Of The Army | Therapeutic antibodies to Marburg virus |
| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| US11780907B2 (en) | 2018-01-26 | 2023-10-10 | Regeneron Pharmaceuticals, Inc. | Human antibodies to influenza hemagglutinin |
| WO2019210144A1 (en) * | 2018-04-27 | 2019-10-31 | Vanderbilt University | Broadly neutralizing antibodies against hepatitis c virus |
| CA3104297A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| JP7566257B2 (ja) * | 2018-10-29 | 2024-10-15 | 株式会社 免疫生物研究所 | 抗ｈｉｖ抗体及びその製造方法 |
| US11230593B2 (en) | 2019-03-25 | 2022-01-25 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| US12545718B2 (en) | 2019-04-24 | 2026-02-10 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| WO2023092314A1 (zh) * | 2021-11-24 | 2023-06-01 | 苏州方科生物科技有限公司 | 结合bp特异性抗原肽的人源抗体、制备方法及用途 |
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| FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
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| CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
| FR2916107B1 (fr) | 2007-05-11 | 2015-11-27 | Centre Nat Etd Spatiales | Actionneur alternatif a asservissement en boucle fermee |
| WO2008153236A1 (en) | 2007-06-15 | 2008-12-18 | Protheon Co., Ltd | An attenuated influenza virus and a live vaccine comprising the same |
| RU2010127156A (ru) | 2007-12-06 | 2012-01-20 | Дана-Фарбер Кэнсер Инститьют, Инк. (Us) | Антитела против вируса гриппа и их применение |
| WO2010117786A1 (en) * | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
-
2009
- 2009-03-27 JP JP2011502108A patent/JP2011516423A/ja active Pending
- 2009-03-27 WO PCT/US2009/038636 patent/WO2009121004A2/en not_active Ceased
- 2009-03-27 US US12/413,308 patent/US20100040635A1/en not_active Abandoned
- 2009-03-27 EP EP13177665.0A patent/EP2698380A1/en not_active Withdrawn
- 2009-03-27 CN CN2009801192684A patent/CN102046656A/zh active Pending
- 2009-03-27 CA CA2719201A patent/CA2719201A1/en not_active Abandoned
- 2009-03-27 AU AU2009228058A patent/AU2009228058A1/en not_active Abandoned
- 2009-03-27 EP EP09726334A patent/EP2274334A2/en not_active Withdrawn
-
2010
- 2010-09-21 IL IL208313A patent/IL208313A0/en unknown
-
2011
- 2011-07-18 US US13/185,386 patent/US9169318B2/en active Active
-
2016
- 2016-06-08 US US15/177,232 patent/US20170136118A1/en not_active Abandoned
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