JP2009536623A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009536623A5 JP2009536623A5 JP2009507924A JP2009507924A JP2009536623A5 JP 2009536623 A5 JP2009536623 A5 JP 2009536623A5 JP 2009507924 A JP2009507924 A JP 2009507924A JP 2009507924 A JP2009507924 A JP 2009507924A JP 2009536623 A5 JP2009536623 A5 JP 2009536623A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound
- compound according
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 208000010412 Glaucoma Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 7
- 206010030043 Ocular hypertension Diseases 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002431 hydrogen Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 230000004410 intraocular pressure Effects 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229940054534 ophthalmic solution Drugs 0.000 claims 2
- 239000002997 ophthalmic solution Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- VKDUGMGFBQIQNP-UHFFFAOYSA-N 1-cyclohexyl-6-methylpiperidine-2,4-dione Chemical compound CC1CC(=O)CC(=O)N1C1CCCCC1 VKDUGMGFBQIQNP-UHFFFAOYSA-N 0.000 claims 1
- VRRQHWODKANWJS-UHFFFAOYSA-N 5-chloro-4-(3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl)benzene-1,3-diol Chemical compound CC(=C)C1CCC(C)=CC1C1=C(O)C=C(O)C=C1Cl VRRQHWODKANWJS-UHFFFAOYSA-N 0.000 claims 1
- GHFGFXOHQSQRKU-UHFFFAOYSA-N 5-methyl-4-(4-methyl-1-propan-2-yl-3,6-dihydro-2h-pyridin-6-yl)benzene-1,3-diol Chemical compound CC(C)N1CCC(C)=CC1C1=C(C)C=C(O)C=C1O GHFGFXOHQSQRKU-UHFFFAOYSA-N 0.000 claims 1
- 229940122459 Glutamate antagonist Drugs 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- OGLDWXZKYODSOB-SNVBAGLBSA-N alpha-phellandrene Natural products CC(C)[C@H]1CC=C(C)C=C1 OGLDWXZKYODSOB-SNVBAGLBSA-N 0.000 claims 1
- 125000003067 alpha-phellandrene group Chemical group 0.000 claims 1
- 239000003194 amino acid receptor blocking agent Substances 0.000 claims 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 claims 1
- 239000000064 cholinergic agonist Substances 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000000890 drug combination Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 150000003180 prostaglandins Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/409,868 US7718830B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US11/409,871 US7618966B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| US11/409,570 US7612101B2 (en) | 2006-04-24 | 2006-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
| PCT/US2007/067267 WO2007127711A2 (en) | 2006-04-24 | 2007-04-24 | Abnormal cannabidiols as agents for lowering intraocular pressure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228274A Division JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536623A JP2009536623A (ja) | 2009-10-15 |
| JP2009536623A5 true JP2009536623A5 (https=) | 2010-06-17 |
Family
ID=38229040
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507924A Pending JP2009536623A (ja) | 2006-04-24 | 2007-04-24 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
| JP2013228274A Pending JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013228274A Pending JP2014058536A (ja) | 2006-04-24 | 2013-11-01 | 眼圧降下剤としてのアブノーマル・カンナビジオール化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7968711B2 (https=) |
| EP (2) | EP2010165A2 (https=) |
| JP (2) | JP2009536623A (https=) |
| AU (1) | AU2007244978B2 (https=) |
| BR (1) | BRPI0710732A2 (https=) |
| CA (3) | CA2648884C (https=) |
| WO (1) | WO2007127711A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050282902A1 (en) * | 2004-06-22 | 2005-12-22 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US7618966B2 (en) * | 2006-04-24 | 2009-11-17 | Allergan, Inc. | Abnormal Cannabidiols as agents for lowering intraocular pressure |
| US20120172339A1 (en) * | 2009-07-10 | 2012-07-05 | Northeastern University | Angiogenic resorcinol derivatives |
| MA55556A (fr) | 2019-04-02 | 2022-02-09 | Aligos Therapeutics Inc | Composés ciblant prmt5 |
| JP2022540586A (ja) * | 2019-07-12 | 2022-09-16 | キャノピー グロウス コーポレイション | カンナビノイド誘導体 |
| AU2020345656A1 (en) | 2019-09-09 | 2022-04-21 | Kare Chemical Technologies Inc. | Cannabinoid derivatives, precursors and uses |
| KR20250116719A (ko) * | 2022-12-02 | 2025-08-01 | 베네테라 (샤오싱) 바이오테크놀로지 코., 엘티디. | 화합물 및 Treg 관련 질환의 치료에서의 이의 응용 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL288407A (https=) * | 1960-09-09 | |||
| US3281424A (en) * | 1964-04-15 | 1966-10-25 | Geigy Chem Corp | Certain pyridobenzodiazepine derivatives |
| SE431085B (sv) * | 1977-09-13 | 1984-01-16 | Pfizer | 3-(2-hydroxi-4-(substituerade)fenyl)cykloalkanoner och -cykloalkanoder och vissa derivat derav till anvendning for farmakologiska och medicinska endamal |
| BE870404A (fr) * | 1977-09-13 | 1979-03-12 | Pfizer | Cycloalcanones et cycloalcanols substitues en position 3 par un groupe 2-hydroxyphenyle substitue en position 4 et composition pharmaceutique les contenant |
| US4529732A (en) | 1983-03-14 | 1985-07-16 | Pfizer Inc. | 2-[2-Hydroxy-4-(substituted)phenyl]piperidines |
| GB8329531D0 (en) | 1983-11-04 | 1983-12-07 | Ici America Inc | Pyrazolopyridine cycloalkanones |
| YU134686A (en) | 1985-07-30 | 1988-02-29 | Nissan Chemical Ind Ltd | Process for preparing new derivatives 3-(2h)-pyridazinone |
| GB8711525D0 (en) | 1987-05-15 | 1987-06-17 | Shell Int Research | Oximino ether compounds |
| GB8722838D0 (en) | 1987-09-29 | 1987-11-04 | Shell Int Research | Oximino ether compounds |
| EP0492904A1 (en) * | 1990-12-21 | 1992-07-01 | MERCK SHARP & DOHME LTD. | Substituted benzene derivatives for use in the treatment of glaucoma |
| US6646001B2 (en) * | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6828460B2 (en) | 1999-03-22 | 2004-12-07 | Pfizer Inc. | Resorcinol derivatives |
| HUP0200468A3 (en) * | 1999-03-22 | 2002-12-28 | Pfizer | Resorcinol derivatives and pharmaceutical compositions containing them |
| BR0114059A (pt) * | 2000-09-21 | 2003-07-01 | Pfizer Prod Inc | Derivados de resorcinol |
| EP1441750A4 (en) * | 2001-07-11 | 2006-10-18 | Palatin Technologies Inc | LINEAR AND CYCLIC PEPTIDES SPECIFIC TO THE MELANOCORTIN RECEPTOR |
| ATE448784T1 (de) * | 2002-02-14 | 2009-12-15 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| US6863897B2 (en) | 2002-03-22 | 2005-03-08 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Stabilization of resorcinol derivatives in cosmetic compositions |
| US7285687B2 (en) | 2002-04-25 | 2007-10-23 | Virginia Commonwealth University | Cannabinoids |
| US7323607B2 (en) | 2003-04-24 | 2008-01-29 | Mallinckrodt Inc. | Process for preparation of (+)-p-mentha-2,8-diene-1-ol |
| WO2005007632A1 (en) | 2003-07-18 | 2005-01-27 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| CN1964627B (zh) * | 2004-06-04 | 2011-10-19 | 华盛顿大学 | 治疗神经病变的方法和组合物 |
| US20050282913A1 (en) | 2004-06-22 | 2005-12-22 | June Chen | Abnormal cannabidiols as agents for lowering intraocular pressure |
| US20050282912A1 (en) | 2004-06-22 | 2005-12-22 | June Chen | Abnormal cannabidiols as neuroprotective agents for the eye |
| WO2006007227A2 (en) * | 2004-06-22 | 2006-01-19 | Allergan, Inc. | Abnormal cannabidiols for lowering intraocular pressure |
| US20050282902A1 (en) * | 2004-06-22 | 2005-12-22 | Allergan, Inc. | Abnormal cannabidiols as agents for lowering intraocular pressure |
| EP1898897A2 (en) | 2005-07-07 | 2008-03-19 | Sirtris Pharmaceuticals, Inc. | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| WO2007014226A2 (en) * | 2005-07-26 | 2007-02-01 | The Board Of Trustees Of The University Of Illinois | Compounds for the treatment of neurodegeneration and stroke |
| US20080282902A1 (en) | 2007-01-05 | 2008-11-20 | Dayton Douglas C | Automatic cooking appliance shutoff apparatus |
-
2007
- 2007-04-24 AU AU2007244978A patent/AU2007244978B2/en not_active Ceased
- 2007-04-24 CA CA2648884A patent/CA2648884C/en active Active
- 2007-04-24 EP EP07761166A patent/EP2010165A2/en not_active Withdrawn
- 2007-04-24 EP EP09167706A patent/EP2123264A1/en not_active Withdrawn
- 2007-04-24 CA CA2823767A patent/CA2823767A1/en not_active Abandoned
- 2007-04-24 WO PCT/US2007/067267 patent/WO2007127711A2/en not_active Ceased
- 2007-04-24 JP JP2009507924A patent/JP2009536623A/ja active Pending
- 2007-04-24 US US11/739,183 patent/US7968711B2/en not_active Expired - Lifetime
- 2007-04-24 BR BRPI0710732-3A patent/BRPI0710732A2/pt not_active IP Right Cessation
- 2007-04-24 CA CA2823724A patent/CA2823724A1/en not_active Abandoned
-
2011
- 2011-06-02 US US13/151,675 patent/US20110269715A1/en not_active Abandoned
-
2013
- 2013-11-01 JP JP2013228274A patent/JP2014058536A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009536623A5 (https=) | ||
| CA2858787C (en) | Prodrugs of tertiary amine compounds | |
| ES2928162T3 (es) | Composiciones, formulaciones y métodos para tratar enfermedades oculares | |
| KR100378494B1 (ko) | 카파 작용제 화합물 및 이들의 약제학적 제형 | |
| KR102576011B1 (ko) | 암의 치료를 위한 조합 요법 | |
| JP7546027B2 (ja) | ピリジルアミノ酢酸化合物とポリオキシエチレンヒマシ油含有医薬組成物 | |
| AR056155A1 (es) | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica | |
| JP2010513319A5 (https=) | ||
| JP2013523821A5 (https=) | ||
| ECSP066584A (es) | Procedimiento para la producción de una composición farmacéutica sólida de administración oral | |
| JP2005523316A5 (https=) | ||
| CN106562962A (zh) | 用于治疗眼部水肿、新血管形成及相关疾病的组合物和方法 | |
| DK2888239T3 (en) | REDUCED CENTRAL CORCHET THICKENING USING HYDROFILE ESTER PRODUGS OF BETA-CHLORCYCLOPENTANE | |
| RU2012116877A (ru) | Соединения 2-пиридона, применяемые в качестве ингибиторов нейтрофильной эластазы | |
| RU2013154733A (ru) | Производные бензоциклогептенуксусной кислоты | |
| RU2018101473A (ru) | Депо-препарат, содержащий сложный эфир лимонной кислоты | |
| KR102544132B1 (ko) | 항종양 활성을 갖는 화합물 | |
| JP2005519885A5 (https=) | ||
| JP2004534781A5 (https=) | ||
| JP2005536531A5 (https=) | ||
| JP2010514733A5 (https=) | ||
| CN102781914B (zh) | 吲哚衍生物 | |
| JP2017226652A (ja) | 水性の組成物 | |
| JP2019534296A5 (https=) | ||
| DK3107906T3 (en) | REDUCED CENTRAL CORNER MAP THICKNESS USING HYDROFILE ESTER PRODRUGS OF BETA-CHLORCYCLOPENTANE |