JP2009536617A5 - - Google Patents
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- Publication number
- JP2009536617A5 JP2009536617A5 JP2009505430A JP2009505430A JP2009536617A5 JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5 JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- compound
- disease
- formula
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*C1=NC(C)=C(C)*1 Chemical compound C*C1=NC(C)=C(C)*1 0.000 description 4
- QZFLYWCLTRUQCM-UHFFFAOYSA-N CC1(CC1)C(C)=N Chemical compound CC1(CC1)C(C)=N QZFLYWCLTRUQCM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79108306P | 2006-04-11 | 2006-04-11 | |
| PCT/US2007/008819 WO2007117692A2 (en) | 2006-04-11 | 2007-04-11 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536617A JP2009536617A (ja) | 2009-10-15 |
| JP2009536617A5 true JP2009536617A5 (https=) | 2011-05-12 |
Family
ID=38508761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505430A Pending JP2009536617A (ja) | 2006-04-11 | 2007-04-11 | タンパク質キナーゼの阻害剤として有用なチアゾール、イミダゾール、およびピラゾール |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7589214B2 (https=) |
| EP (1) | EP2007732B1 (https=) |
| JP (1) | JP2009536617A (https=) |
| CN (1) | CN101460466B (https=) |
| AT (1) | ATE534632T1 (https=) |
| AU (1) | AU2007235237B2 (https=) |
| CA (1) | CA2648923A1 (https=) |
| ES (1) | ES2376765T3 (https=) |
| WO (1) | WO2007117692A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2648923A1 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| MX2011011136A (es) * | 2009-04-24 | 2011-11-18 | Tibotec Pharm Ltd | Eteres diarilicos. |
| EP2512246B1 (en) | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| KR101445012B1 (ko) | 2009-12-17 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | Ｓｙｋ 억제제로서의 아미노피리미딘 |
| US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
| EP2706853B1 (en) | 2011-05-10 | 2017-06-14 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| CA2834062A1 (en) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as syk inhibitors |
| MX340033B (es) | 2011-12-28 | 2016-06-21 | Janssen Sciences Ireland Uc | Derivados heterobiciclicos como inhibidores del virus de la hepatitis c. |
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| KR101668574B1 (ko) | 2012-11-02 | 2016-10-24 | 화이자 인코포레이티드 | 브루톤 티로신 키나제 억제제 |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| JP6403751B2 (ja) | 2013-03-14 | 2018-10-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用 |
| JP6495886B2 (ja) | 2013-03-15 | 2019-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としての複素環式芳香族化合物 |
| KR102272792B1 (ko) | 2013-09-30 | 2021-07-05 | 광저우 이노케어 파마 테크 씨오., 엘티디. | Ｂｔｋ의 치환된 니코틴이미드 저해제 및 그의 제조 방법 및 암, 염증 및 자가면역 질환에의 용도 |
| RU2653504C2 (ru) | 2013-12-13 | 2018-05-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
| JP6486954B2 (ja) * | 2014-01-29 | 2019-03-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｔｋ阻害剤としてのピラゾール化合物 |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| CN106687446B (zh) * | 2014-07-18 | 2020-04-28 | 百济神州(北京)生物科技有限公司 | 作为t790m/wt-egfr的选择性和不可逆的激酶抑制剂的5-氨基-4-氨甲酰基-吡唑化合物及其用途 |
| LT3390390T (lt) | 2015-12-16 | 2021-11-25 | Boehringer Ingelheim International Gmbh | Bipirazolilo dariniai, tinkami naudoti autoimuninių ligų gydymui |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| AU2020229919B2 (en) | 2019-02-25 | 2025-06-05 | Beijing Innocare Pharma Tech Co., Ltd. | Process for preparing 6- (1-Acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide |
| CN116018138B (zh) * | 2020-07-13 | 2025-08-15 | 河南知微生物医药有限公司 | 作为布鲁诺酪氨酸激酶抑制剂的取代的1H-咪唑并[1,2-b]吡唑-3-甲酰胺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| US6288061B1 (en) * | 1997-12-26 | 2001-09-11 | Welfide Corporation | Imidazole derivatives |
| WO2002022605A1 (en) * | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ES2274005T3 (es) * | 2001-01-26 | 2007-05-16 | Chugai Seiyaku Kabushiki Kaisha | Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos. |
| CA2532965C (en) | 2003-07-22 | 2013-05-14 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| WO2005123671A1 (ja) * | 2004-06-22 | 2005-12-29 | Taisho Pharmaceutical Co., Ltd. | ピロール誘導体 |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| CA2648923A1 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
-
2007
- 2007-04-11 CA CA002648923A patent/CA2648923A1/en not_active Abandoned
- 2007-04-11 WO PCT/US2007/008819 patent/WO2007117692A2/en not_active Ceased
- 2007-04-11 JP JP2009505430A patent/JP2009536617A/ja active Pending
- 2007-04-11 CN CN2007800208154A patent/CN101460466B/zh not_active Expired - Fee Related
- 2007-04-11 ES ES07755181T patent/ES2376765T3/es active Active
- 2007-04-11 AT AT07755181T patent/ATE534632T1/de active
- 2007-04-11 EP EP07755181A patent/EP2007732B1/en not_active Not-in-force
- 2007-04-11 AU AU2007235237A patent/AU2007235237B2/en not_active Ceased
- 2007-04-11 US US11/786,464 patent/US7589214B2/en not_active Expired - Fee Related
-
2009
- 2009-08-10 US US12/538,396 patent/US8236832B2/en not_active Expired - Fee Related
-
2012
- 2012-07-03 US US13/540,651 patent/US8865751B2/en not_active Expired - Fee Related
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