JP2009536617A5 - - Google Patents
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- Publication number
- JP2009536617A5 JP2009536617A5 JP2009505430A JP2009505430A JP2009536617A5 JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5 JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009505430 A JP2009505430 A JP 2009505430A JP 2009536617 A5 JP2009536617 A5 JP 2009536617A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- compound
- disease
- formula
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*C1=NC(C)=C(C)*1 Chemical compound C*C1=NC(C)=C(C)*1 0.000 description 4
- QZFLYWCLTRUQCM-UHFFFAOYSA-N CC1(CC1)C(C)=N Chemical compound CC1(CC1)C(C)=N QZFLYWCLTRUQCM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79108306P | 2006-04-11 | 2006-04-11 | |
| PCT/US2007/008819 WO2007117692A2 (en) | 2006-04-11 | 2007-04-11 | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009536617A JP2009536617A (ja) | 2009-10-15 |
| JP2009536617A5 true JP2009536617A5 (https=) | 2011-05-12 |
Family
ID=38508761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505430A Pending JP2009536617A (ja) | 2006-04-11 | 2007-04-11 | タンパク質キナーゼの阻害剤として有用なチアゾール、イミダゾール、およびピラゾール |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7589214B2 (https=) |
| EP (1) | EP2007732B1 (https=) |
| JP (1) | JP2009536617A (https=) |
| CN (1) | CN101460466B (https=) |
| AT (1) | ATE534632T1 (https=) |
| AU (1) | AU2007235237B2 (https=) |
| CA (1) | CA2648923A1 (https=) |
| ES (1) | ES2376765T3 (https=) |
| WO (1) | WO2007117692A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007117692A2 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
| RU2528231C2 (ru) * | 2009-04-24 | 2014-09-10 | Тиботек Фармасьютикалз | Диариловые эфиры |
| US8735417B2 (en) | 2009-12-17 | 2014-05-27 | Merck Sharp & Dohme Corp. | Aminopyrimidines as Syk inhibitors |
| WO2011075517A1 (en) | 2009-12-17 | 2011-06-23 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| MX2013013090A (es) | 2011-05-10 | 2013-12-16 | Merck Sharp & Dohme | Aminopirimidinas como inhibidores de tirosina cinaza del bazo. |
| US9145391B2 (en) | 2011-05-10 | 2015-09-29 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines as Syk inhibitors |
| EP2707357B1 (en) | 2011-05-10 | 2017-01-18 | Merck Sharp & Dohme Corp. | Pyridyl aminopyridines as syk inhibitors |
| JP6170944B2 (ja) | 2011-12-28 | 2017-07-26 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Ｈｃｖ阻害剤としてのヘテロ−二環式誘導体 |
| SG11201500499TA (en) | 2012-08-10 | 2015-03-30 | Boehringer Ingelheim Int | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| JP6178861B2 (ja) | 2012-11-02 | 2017-08-09 | ファイザー・インク | ブルトン型チロシンキナーゼ阻害剤 |
| CN103848810A (zh) | 2012-11-30 | 2014-06-11 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| JP6403751B2 (ja) * | 2013-03-14 | 2018-10-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用 |
| WO2014152114A1 (en) | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
| JP6615752B2 (ja) * | 2013-09-30 | 2019-12-04 | グアンジョウ・イノケア・ファーマ・テク・カンパニー・リミテッド | Ｂｔｋの置換ニコチンイミド阻害剤およびそれらの調製、ならびにがん、炎症および自己免疫疾患の治療における使用 |
| BR112016013540B1 (pt) | 2013-12-13 | 2021-03-02 | F. Hoffmann-La Roche Ag | inibidores de tirosina quinase de bruton |
| WO2015116485A1 (en) * | 2014-01-29 | 2015-08-06 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as btk inhibitors |
| CN105085474B (zh) * | 2014-05-07 | 2018-05-18 | 北京赛林泰医药技术有限公司 | 鲁顿酪氨酸激酶抑制剂 |
| TW201607930A (zh) * | 2014-07-18 | 2016-03-01 | 百濟神州有限公司 | 作為ｔ７９０ｍ／ｗｔ－ｅｇｆｒ的選擇性和不可逆的激酶抑制劑的５－氨基－４－氨甲醯基－吡唑化合物及其用途 |
| US9975882B2 (en) | 2015-12-16 | 2018-05-22 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as BTK inhibitors |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| WO2020173407A1 (en) * | 2019-02-25 | 2020-09-03 | Beijing Innocare Pharma Tech Co., Ltd. | Process for preparing 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide |
| WO2022012550A1 (en) * | 2020-07-13 | 2022-01-20 | Henan Normal University | Substituted 1h-imidazo [1, 2-b] pyrazole-3-carboxamide as bruton's tyrosine kinase inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| US6288061B1 (en) * | 1997-12-26 | 2001-09-11 | Welfide Corporation | Imidazole derivatives |
| EP1317450B1 (en) * | 2000-09-15 | 2006-11-22 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2002064136A2 (en) * | 2001-01-26 | 2002-08-22 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| PL2256106T3 (pl) * | 2003-07-22 | 2015-08-31 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
| WO2005123671A1 (ja) * | 2004-06-22 | 2005-12-29 | Taisho Pharmaceutical Co., Ltd. | ピロール誘導体 |
| FR2881426B1 (fr) | 2005-02-03 | 2007-03-30 | Aventis Pharma Sa | Pyrolles et imidazoles substitues, compositions les contenant, procede de frabrication et utilisation |
| WO2007117692A2 (en) * | 2006-04-11 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases |
-
2007
- 2007-04-11 WO PCT/US2007/008819 patent/WO2007117692A2/en not_active Ceased
- 2007-04-11 EP EP07755181A patent/EP2007732B1/en not_active Not-in-force
- 2007-04-11 CN CN2007800208154A patent/CN101460466B/zh not_active Expired - Fee Related
- 2007-04-11 ES ES07755181T patent/ES2376765T3/es active Active
- 2007-04-11 US US11/786,464 patent/US7589214B2/en not_active Expired - Fee Related
- 2007-04-11 AU AU2007235237A patent/AU2007235237B2/en not_active Ceased
- 2007-04-11 CA CA002648923A patent/CA2648923A1/en not_active Abandoned
- 2007-04-11 JP JP2009505430A patent/JP2009536617A/ja active Pending
- 2007-04-11 AT AT07755181T patent/ATE534632T1/de active
-
2009
- 2009-08-10 US US12/538,396 patent/US8236832B2/en not_active Expired - Fee Related
-
2012
- 2012-07-03 US US13/540,651 patent/US8865751B2/en not_active Expired - Fee Related
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