CN101460466B - 适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 - Google Patents

适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 Download PDF

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CN101460466B
CN101460466B CN2007800208154A CN200780020815A CN101460466B CN 101460466 B CN101460466 B CN 101460466B CN 2007800208154 A CN2007800208154 A CN 2007800208154A CN 200780020815 A CN200780020815 A CN 200780020815A CN 101460466 B CN101460466 B CN 101460466B
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compound
formula
define
disease
compounds
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CN101460466A (zh
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J-M·吉米内斯
R·克内戈泰尔
D·罗宾森
P·克里尔
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Vertex Pharmaceuticals Inc
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
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    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C07D277/593—Z being doubly bound oxygen or doubly bound nitrogen, which nitrogen is part of a possibly substituted oximino radical
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN2007800208154A 2006-04-11 2007-04-11 适用作蛋白激酶抑制剂的噻唑类、咪唑类和吡唑类 Expired - Fee Related CN101460466B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79108306P 2006-04-11 2006-04-11
US60/791,083 2006-04-11
PCT/US2007/008819 WO2007117692A2 (en) 2006-04-11 2007-04-11 Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases

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CN101460466A CN101460466A (zh) 2009-06-17
CN101460466B true CN101460466B (zh) 2012-06-13

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US (3) US7589214B2 (https=)
EP (1) EP2007732B1 (https=)
JP (1) JP2009536617A (https=)
CN (1) CN101460466B (https=)
AT (1) ATE534632T1 (https=)
AU (1) AU2007235237B2 (https=)
CA (1) CA2648923A1 (https=)
ES (1) ES2376765T3 (https=)
WO (1) WO2007117692A2 (https=)

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US10301297B2 (en) 2013-09-30 2019-05-28 Guangzhou Innocare Pharma Tech Co., Ltd. Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
RU2810260C2 (ru) * 2019-02-25 2023-12-25 Бэйцзин Иннокэа Фарма Тек Ко., Лтд. Способ получения 6-(1-акрилоилпиперидин-4-ил)-2-(4-феноксифенил)никотинамида

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WO2007117692A2 (en) * 2006-04-11 2007-10-18 Vertex Pharmaceuticals Incorporated Thiazoles, imidazoles, and pyrazoles useful as inhibitors of protein kinases
RU2528231C2 (ru) * 2009-04-24 2014-09-10 Тиботек Фармасьютикалз Диариловые эфиры
US8735417B2 (en) 2009-12-17 2014-05-27 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
WO2011075517A1 (en) 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
MX2013013090A (es) 2011-05-10 2013-12-16 Merck Sharp & Dohme Aminopirimidinas como inhibidores de tirosina cinaza del bazo.
US9145391B2 (en) 2011-05-10 2015-09-29 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as Syk inhibitors
EP2707357B1 (en) 2011-05-10 2017-01-18 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as syk inhibitors
JP6170944B2 (ja) 2011-12-28 2017-07-26 ヤンセン・サイエンシズ・アイルランド・ユーシー Ｈｃｖ阻害剤としてのヘテロ−二環式誘導体
SG11201500499TA (en) 2012-08-10 2015-03-30 Boehringer Ingelheim Int Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
JP6178861B2 (ja) 2012-11-02 2017-08-09 ファイザー・インク ブルトン型チロシンキナーゼ阻害剤
CN103848810A (zh) 2012-11-30 2014-06-11 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
JP6403751B2 (ja) * 2013-03-14 2018-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ５−チアゾールカルボキサミン誘導体及びｂｔｋ阻害剤としてのその使用
WO2014152114A1 (en) 2013-03-15 2014-09-25 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as btk inhibitors
BR112016013540B1 (pt) 2013-12-13 2021-03-02 F. Hoffmann-La Roche Ag inibidores de tirosina quinase de bruton
WO2015116485A1 (en) * 2014-01-29 2015-08-06 Boehringer Ingelheim International Gmbh Pyrazole compounds as btk inhibitors
CN105085474B (zh) * 2014-05-07 2018-05-18 北京赛林泰医药技术有限公司 鲁顿酪氨酸激酶抑制剂
TW201607930A (zh) * 2014-07-18 2016-03-01 百濟神州有限公司 作為ｔ７９０ｍ／ｗｔ－ｅｇｆｒ的選擇性和不可逆的激酶抑制劑的５－氨基－４－氨甲醯基－吡唑化合物及其用途
US9975882B2 (en) 2015-12-16 2018-05-22 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as BTK inhibitors
US10570118B2 (en) 2016-01-13 2020-02-25 Boehringer Ingelheim International Gmbh Isoquinolones as BTK inhibitors
WO2020173407A1 (en) * 2019-02-25 2020-09-03 Beijing Innocare Pharma Tech Co., Ltd. Process for preparing 6- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) nicotinamide
WO2022012550A1 (en) * 2020-07-13 2022-01-20 Henan Normal University Substituted 1h-imidazo [1, 2-b] pyrazole-3-carboxamide as bruton's tyrosine kinase inhibitors

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WO2007117692A2 (en) 2007-10-18
CN101460466A (zh) 2009-06-17
US20130090479A1 (en) 2013-04-11
AU2007235237B2 (en) 2011-08-18
CA2648923A1 (en) 2007-10-18
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US20070298065A1 (en) 2007-12-27
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US7589214B2 (en) 2009-09-15
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