JP2009535385A5 - - Google Patents

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Publication number

JP2009535385A5

JP2009535385A5 JP2009508455A JP2009508455A JP2009535385A5 JP 2009535385 A5 JP2009535385 A5 JP 2009535385A5 JP 2009508455 A JP2009508455 A JP 2009508455A JP 2009508455 A JP2009508455 A JP 2009508455A JP 2009535385 A5 JP2009535385 A5 JP 2009535385A5

Authority

JP

Japan

Prior art keywords

amino

hydrogen

optionally substituted

alkyl

phenyl

Prior art date

2007-05-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229910052739 hydrogen Inorganic materials 0.000 claims 17
• 239000001257 hydrogen Substances 0.000 claims 17
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 14
• -1 tetrahydrofuran-3-yl Chemical group 0.000 claims 14
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 11
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
• 125000002619 bicyclic group Chemical group 0.000 claims 5
• 125000000623 heterocyclic group Chemical group 0.000 claims 5
• 125000002950 monocyclic group Chemical group 0.000 claims 5
• 125000002837 carbocyclic group Chemical group 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
• IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 3
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
• 125000004185 ester group Chemical group 0.000 claims 3
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
• 125000002843 carboxylic acid group Chemical group 0.000 claims 2
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
• 125000006413 ring segment Chemical group 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims 1
• 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
• 125000006334 2,4-difluoro benzoyl group Chemical group [H]C1=C([H])C(C(*)=O)=C(F)C([H])=C1F 0.000 claims 1
• 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 1
• 108090000371 Esterases Proteins 0.000 claims 1
• 239000004395 L-leucine Substances 0.000 claims 1
• YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 claims 1
• DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims 1
• DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 1
• 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
• 235000008206 alpha-amino acids Nutrition 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• NRSJYJODRRLMKB-MHZLTWQESA-N cyclopentyl (2s)-2-[3-[4-[2-amino-3-(2,4-difluorobenzoyl)-6-oxopyridin-1-yl]-3,5-difluorophenoxy]propylamino]-4-methylpentanoate Chemical compound N([C@@H](CC(C)C)C(=O)OC1CCCC1)CCCOC(C=C1F)=CC(F)=C1N(C(C=C1)=O)C(N)=C1C(=O)C1=CC=C(F)C=C1F NRSJYJODRRLMKB-MHZLTWQESA-N 0.000 claims 1
• RFLRUVLHHXEVTD-LJAQVGFWSA-N cyclopentyl (2s)-2-[5-[4-[2-amino-3-(2,4-difluorobenzoyl)-6-oxopyridin-1-yl]-3,5-difluorophenoxy]pentylamino]-4-methylpentanoate Chemical compound N([C@@H](CC(C)C)C(=O)OC1CCCC1)CCCCCOC(C=C1F)=CC(F)=C1N(C(C=C1)=O)C(N)=C1C(=O)C1=CC=C(F)C=C1F RFLRUVLHHXEVTD-LJAQVGFWSA-N 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 150000002431 hydrogen Chemical class 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 229960003136 leucine Drugs 0.000 claims 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229940049953 phenylacetate Drugs 0.000 claims 1
• WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 150000003568 thioethers Chemical class 0.000 claims 1