JP2009533473A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009533473A5 JP2009533473A5 JP2009505615A JP2009505615A JP2009533473A5 JP 2009533473 A5 JP2009533473 A5 JP 2009533473A5 JP 2009505615 A JP2009505615 A JP 2009505615A JP 2009505615 A JP2009505615 A JP 2009505615A JP 2009533473 A5 JP2009533473 A5 JP 2009533473A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- pyrimidin
- methoxy
- ethylamino
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 3-carboxy-pyrrolidinyl Chemical group 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 9
- 229940002612 prodrug Drugs 0.000 claims 9
- 239000000651 prodrug Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 8
- YZBNKRGGHAGNIQ-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]piperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(N)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl YZBNKRGGHAGNIQ-UHFFFAOYSA-N 0.000 claims 4
- AVJUTAMMINWDOQ-UHFFFAOYSA-N 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-2-methylpropanamide Chemical compound C=1C(C=2C=C(C=CC=2)C(C)(C)C(N)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl AVJUTAMMINWDOQ-UHFFFAOYSA-N 0.000 claims 4
- 208000003251 Pruritus Diseases 0.000 claims 4
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 3
- UAFGSVNTULDWDU-UHFFFAOYSA-N 5-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-1-methyl-2,3-dihydroindole-2-carboxylic acid Chemical compound C=1C(C=2C=C3CC(N(C)C3=CC=2)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl UAFGSVNTULDWDU-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 201000008937 atopic dermatitis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000036571 hydration Effects 0.000 claims 3
- 238000006703 hydration reaction Methods 0.000 claims 3
- LSGOBZJXRYUSIW-UHFFFAOYSA-N 1-[2-methoxy-6-[2-[4-(trifluoromethoxy)phenyl]ethylamino]pyrimidin-4-yl]-n-methylsulfonylpiperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(=O)NS(C)(=O)=O)=NC(OC)=NC=1NCCC1=CC=C(OC(F)(F)F)C=C1 LSGOBZJXRYUSIW-UHFFFAOYSA-N 0.000 claims 2
- TWCVFANBWVBQJJ-UHFFFAOYSA-N 1-[2-methoxy-6-[2-[4-(trifluoromethoxy)phenyl]ethylamino]pyrimidin-4-yl]piperidine-3-carboxylic acid Chemical compound C=1C(N2CC(CCC2)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(OC(F)(F)F)C=C1 TWCVFANBWVBQJJ-UHFFFAOYSA-N 0.000 claims 2
- UKDFCFRWPVYUIR-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-n,n-dimethylpiperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(=O)N(C)C)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl UKDFCFRWPVYUIR-UHFFFAOYSA-N 0.000 claims 2
- HSALOGALOUSABH-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-n-(2h-tetrazol-5-yl)piperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(=O)NC=2NN=NN=2)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl HSALOGALOUSABH-UHFFFAOYSA-N 0.000 claims 2
- GNCRHHPZSOAUMZ-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-n-(trifluoromethylsulfonyl)piperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(=O)NS(=O)(=O)C(F)(F)F)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl GNCRHHPZSOAUMZ-UHFFFAOYSA-N 0.000 claims 2
- VMLHPGXVJSKWHY-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-n-ethylsulfonylpiperidine-3-carboxamide Chemical compound C1C(C(=O)NS(=O)(=O)CC)CCCN1C1=CC(NCCC=2C(=CC(Cl)=CC=2)Cl)=NC(OC)=N1 VMLHPGXVJSKWHY-UHFFFAOYSA-N 0.000 claims 2
- XEOVLKHUDVRVLK-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-n-methylsulfonylpiperidine-3-carboxamide Chemical compound C=1C(N2CC(CCC2)C(=O)NS(C)(=O)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl XEOVLKHUDVRVLK-UHFFFAOYSA-N 0.000 claims 2
- IYJLGFKDKLUCRP-UHFFFAOYSA-N 1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methylpyrimidin-4-yl]pyrrolidine-3-carboxylic acid Chemical compound C=1C(N2CC(CC2)C(O)=O)=NC(C)=NC=1NCCC1=CC=C(Cl)C=C1Cl IYJLGFKDKLUCRP-UHFFFAOYSA-N 0.000 claims 2
- YDEULJMWFOJROS-UHFFFAOYSA-N 2-[1-[2-methoxy-6-[2-[4-(trifluoromethoxy)phenyl]ethylamino]pyrimidin-4-yl]piperidin-3-yl]-2-methylpropanoic acid Chemical compound C=1C(N2CC(CCC2)C(C)(C)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(OC(F)(F)F)C=C1 YDEULJMWFOJROS-UHFFFAOYSA-N 0.000 claims 2
- ONJOLWLTTNQBFD-UHFFFAOYSA-N 2-[1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]piperidin-3-yl]acetic acid Chemical compound C=1C(N2CC(CC(O)=O)CCC2)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl ONJOLWLTTNQBFD-UHFFFAOYSA-N 0.000 claims 2
- KTRNNQBBPZPDFO-UHFFFAOYSA-N 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-2-methyl-1-thiomorpholin-4-ylpropan-1-one Chemical compound C=1C(C=2C=C(C=CC=2)C(C)(C)C(=O)N2CCSCC2)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl KTRNNQBBPZPDFO-UHFFFAOYSA-N 0.000 claims 2
- AGUDOSNOSGSAPX-UHFFFAOYSA-N 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-n,n,2-trimethylpropanamide Chemical compound C=1C(C=2C=C(C=CC=2)C(C)(C)C(=O)N(C)C)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl AGUDOSNOSGSAPX-UHFFFAOYSA-N 0.000 claims 2
- XCJGLBWDZKLQCY-UHFFFAOYSA-N 2-methylpropane-2-sulfonic acid Chemical compound CC(C)(C)S(O)(=O)=O XCJGLBWDZKLQCY-UHFFFAOYSA-N 0.000 claims 2
- 125000004863 4-trifluoromethoxyphenyl group Chemical group [H]C1=C([H])C(OC(F)(F)F)=C([H])C([H])=C1* 0.000 claims 2
- MGHZKNFIOQBZTR-UHFFFAOYSA-N 5-[2-methoxy-6-[2-[4-(trifluoromethoxy)phenyl]ethylamino]pyrimidin-4-yl]thiophene-2-carboxylic acid Chemical compound C=1C(C=2SC(=CC=2)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(OC(F)(F)F)C=C1 MGHZKNFIOQBZTR-UHFFFAOYSA-N 0.000 claims 2
- RTJZFAGJGHSINY-UHFFFAOYSA-N 5-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-2,3-dihydro-1-benzofuran-2-carboxylic acid Chemical compound C=1C(C=2C=C3CC(OC3=CC=2)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl RTJZFAGJGHSINY-UHFFFAOYSA-N 0.000 claims 2
- MFLVQFHQVXBUIP-UHFFFAOYSA-N 6-(3-aminopiperidin-1-yl)-n-[2-(2,4-dichlorophenyl)ethyl]-2-methoxypyrimidin-4-amine Chemical compound C=1C(N2CC(N)CCC2)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl MFLVQFHQVXBUIP-UHFFFAOYSA-N 0.000 claims 2
- DADRKLXYGIHKDF-UHFFFAOYSA-N 6-(4-aminopiperidin-1-yl)-n-[2-(2,4-dichlorophenyl)ethyl]-2-methoxypyrimidin-4-amine Chemical compound C=1C(N2CCC(N)CC2)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl DADRKLXYGIHKDF-UHFFFAOYSA-N 0.000 claims 2
- 229940124003 CRTH2 antagonist Drugs 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 2
- LDXDSHIEDAPSSA-OAHLLOKOSA-N Ramatroban Chemical group N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CCC(=O)O)S(=O)(=O)C1=CC=C(F)C=C1 LDXDSHIEDAPSSA-OAHLLOKOSA-N 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 2
- 208000024780 Urticaria Diseases 0.000 claims 2
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000001387 anti-histamine Effects 0.000 claims 2
- 239000000739 antihistaminic agent Substances 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 2
- 208000010668 atopic eczema Diseases 0.000 claims 2
- 229940125388 beta agonist Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 2
- 239000003199 leukotriene receptor blocking agent Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- RLKLTDOTIXEKFE-UHFFFAOYSA-N n-[1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]piperidin-4-yl]acetamide Chemical compound C=1C(N2CCC(CC2)NC(C)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl RLKLTDOTIXEKFE-UHFFFAOYSA-N 0.000 claims 2
- ZTKQZYQPZSJIDK-UHFFFAOYSA-N n-tert-butylsulfonyl-2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-2-methylpropanamide Chemical compound C=1C(C=2C=C(C=CC=2)C(C)(C)C(=O)NS(=O)(=O)C(C)(C)C)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl ZTKQZYQPZSJIDK-UHFFFAOYSA-N 0.000 claims 2
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 2
- 229950004496 ramatroban Drugs 0.000 claims 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 1
- NEXSRFDRKBDAPJ-UHFFFAOYSA-N 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]-5-(2-hydroxypropan-2-yl)phenyl]propan-2-ol Chemical compound C=1C(C=2C=C(C=C(C=2)C(C)(C)O)C(C)(C)O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl NEXSRFDRKBDAPJ-UHFFFAOYSA-N 0.000 claims 1
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical group CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 201000008736 Systemic mastocytosis Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- YEEZWCHGZNKEEK-UHFFFAOYSA-N Zafirlukast Chemical compound COC1=CC(C(=O)NS(=O)(=O)C=2C(=CC=CC=2)C)=CC=C1CC(C1=C2)=CN(C)C1=CC=C2NC(=O)OC1CCCC1 YEEZWCHGZNKEEK-UHFFFAOYSA-N 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 230000020411 cell activation Effects 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- CFBUZOUXXHZCFB-OYOVHJISSA-N chembl511115 Chemical compound COC1=CC=C([C@@]2(CC[C@H](CC2)C(O)=O)C#N)C=C1OC1CCCC1 CFBUZOUXXHZCFB-OYOVHJISSA-N 0.000 claims 1
- 229950001653 cilomilast Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- MAAOYSWBZXNTOB-UHFFFAOYSA-N ethyl 2-[1-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]piperidin-3-yl]acetate Chemical compound C1C(CC(=O)OCC)CCCN1C1=CC(NCCC=2C(=CC(Cl)=CC=2)Cl)=NC(OC)=N1 MAAOYSWBZXNTOB-UHFFFAOYSA-N 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 229960003592 fexofenadine Drugs 0.000 claims 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical group C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 229960003088 loratadine Drugs 0.000 claims 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 claims 1
- 229960005127 montelukast Drugs 0.000 claims 1
- 208000008423 pleurisy Diseases 0.000 claims 1
- 230000004264 retinal detachment Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical group FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 1
- 229960002586 roflumilast Drugs 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 208000037921 secondary disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229960000195 terbutaline Drugs 0.000 claims 1
- 229960004764 zafirlukast Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74467606P | 2006-04-12 | 2006-04-12 | |
| PCT/US2007/066481 WO2007121280A1 (en) | 2006-04-12 | 2007-04-12 | 2,6-substituted-4-monosubstituted amino-pyrimidine as prostaglandin d2 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009533473A JP2009533473A (ja) | 2009-09-17 |
| JP2009533473A5 true JP2009533473A5 (enExample) | 2010-05-27 |
Family
ID=38294040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505615A Abandoned JP2009533473A (ja) | 2006-04-12 | 2007-04-12 | プロスタグランジンｄ２受容体アンタゴニストとしての２，６−置換−４−モノ置換アミノ−ピリミジン |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20090036469A1 (enExample) |
| EP (1) | EP2010503A1 (enExample) |
| JP (1) | JP2009533473A (enExample) |
| KR (1) | KR20080108287A (enExample) |
| CN (1) | CN101421252B (enExample) |
| AR (1) | AR060403A1 (enExample) |
| AU (1) | AU2007238052B2 (enExample) |
| BR (1) | BRPI0710710A2 (enExample) |
| CA (1) | CA2649083C (enExample) |
| CR (1) | CR10249A (enExample) |
| DO (1) | DOP2007000068A (enExample) |
| EC (1) | ECSP088813A (enExample) |
| HN (1) | HN2008001530A (enExample) |
| MA (1) | MA30409B1 (enExample) |
| MX (1) | MX2008011369A (enExample) |
| NO (1) | NO20084291L (enExample) |
| NZ (1) | NZ571793A (enExample) |
| PE (1) | PE20080186A1 (enExample) |
| RU (1) | RU2431631C2 (enExample) |
| TN (1) | TNSN08339A1 (enExample) |
| TW (1) | TW200815395A (enExample) |
| UA (1) | UA95950C2 (enExample) |
| UY (1) | UY30283A1 (enExample) |
| WO (1) | WO2007121280A1 (enExample) |
| ZA (1) | ZA200807380B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5039594B2 (ja) * | 2008-02-08 | 2012-10-03 | 株式会社日立ハイテクノロジーズ | レビュー装置，検査領域設定支援システム、および、欠陥の画像得方法 |
| AR074776A1 (es) * | 2008-12-18 | 2011-02-09 | Sanofi Aventis | Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente |
| TW201204708A (en) * | 2010-03-16 | 2012-02-01 | Aventis Pharma Inc | A substituted pyrimidine as a prostaglandin D2 receptor antagonist |
| EP2547672A1 (en) * | 2010-03-16 | 2013-01-23 | Aventis Pharmaceuticals Inc. | Substituted pyrimidines as prostaglandin d2 receptor antagonists |
| EP2590944B1 (en) | 2010-07-05 | 2015-09-30 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators |
| US8785467B2 (en) * | 2010-09-30 | 2014-07-22 | Merck Sharp & Dohme Corp. | Alkoxy pyrimidine PDE10 inhibitors |
| US9255090B2 (en) | 2011-12-21 | 2016-02-09 | Actelion Pharmaceuticals Ltd. | Heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| EP2912458B1 (en) | 2012-10-24 | 2018-07-18 | NYU Winthrop Hospital | Non-invasive biomarker to identify subjects at risk of preterm delivery |
| RU2673084C2 (ru) * | 2013-11-08 | 2018-11-22 | Киссеи Фармасьютикал Ко., Лтд. | Производное карбоксиметилпиперидина |
| SG11201700777VA (en) | 2014-08-04 | 2017-02-27 | Nuevolution As | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| WO2018210992A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| AU2018268311B2 (en) | 2017-05-18 | 2022-02-10 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as PGE2 receptor modulators |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| WO2018210994A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Phenyl derivatives as pge2 receptor modulators |
| US20200264188A1 (en) | 2017-09-13 | 2020-08-20 | Progenity, Inc. | Preeclampsia biomarkers and related systems and methods |
| US20220408745A1 (en) * | 2019-09-13 | 2022-12-29 | Meiji Co., Ltd. | Solid food and solid milk having hole penetrating first face and second face |
| EP4070113A4 (en) | 2019-12-04 | 2023-12-20 | Biora Therapeutics, Inc. | ASSESSMENT OF PREECAMPSIA USING FREE AND DISSOCIATE PLACENTAL GROWTH FACTOR ASSAYS |
| EP4076661A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4126875A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| WO2021198955A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3644799A1 (de) * | 1986-06-04 | 1987-12-10 | Hoechst Ag | Neue pyrimidin-derivate, deren herstellung und verwendung |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| HN2005000795A (es) * | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| GT200600457A (es) * | 2005-10-13 | 2007-04-27 | Aventis Pharma Inc | Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2 |
-
2007
- 2007-04-10 AR ARP070101501A patent/AR060403A1/es not_active Application Discontinuation
- 2007-04-10 DO DO2007000068A patent/DOP2007000068A/es unknown
- 2007-04-12 EP EP07760526A patent/EP2010503A1/en not_active Withdrawn
- 2007-04-12 MX MX2008011369A patent/MX2008011369A/es active IP Right Grant
- 2007-04-12 WO PCT/US2007/066481 patent/WO2007121280A1/en not_active Ceased
- 2007-04-12 NZ NZ571793A patent/NZ571793A/en not_active IP Right Cessation
- 2007-04-12 BR BRPI0710710-2A patent/BRPI0710710A2/pt not_active IP Right Cessation
- 2007-04-12 AU AU2007238052A patent/AU2007238052B2/en not_active Expired - Fee Related
- 2007-04-12 KR KR1020087024764A patent/KR20080108287A/ko not_active Withdrawn
- 2007-04-12 TW TW096112790A patent/TW200815395A/zh unknown
- 2007-04-12 PE PE2007000450A patent/PE20080186A1/es not_active Application Discontinuation
- 2007-04-12 CN CN2007800127354A patent/CN101421252B/zh not_active Expired - Fee Related
- 2007-04-12 UY UY30283A patent/UY30283A1/es not_active Application Discontinuation
- 2007-04-12 CA CA2649083A patent/CA2649083C/en not_active Expired - Fee Related
- 2007-04-12 JP JP2009505615A patent/JP2009533473A/ja not_active Abandoned
- 2007-04-12 UA UAA200813109A patent/UA95950C2/ru unknown
- 2007-04-12 RU RU2008144578/04A patent/RU2431631C2/ru not_active IP Right Cessation
-
2008
- 2008-08-26 CR CR10249A patent/CR10249A/es not_active Application Discontinuation
- 2008-08-27 TN TNP2008000339A patent/TNSN08339A1/en unknown
- 2008-08-27 ZA ZA200807380A patent/ZA200807380B/xx unknown
- 2008-10-07 US US12/246,918 patent/US20090036469A1/en not_active Abandoned
- 2008-10-09 EC EC2008008813A patent/ECSP088813A/es unknown
- 2008-10-10 HN HN2008001530A patent/HN2008001530A/es unknown
- 2008-10-14 NO NO20084291A patent/NO20084291L/no not_active Application Discontinuation
- 2008-11-10 MA MA31375A patent/MA30409B1/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009533473A5 (enExample) | ||
| RU2008144578A (ru) | 2,6-замещенные-4-монозамещенные аминопиримидины как антогонисты рецепторов простагландина d2 | |
| JP2009544721A5 (enExample) | ||
| JP5085659B2 (ja) | Ｌ−ｃｐｔ１阻害剤として有用なインダゾール誘導体 | |
| TNSN08131A1 (en) | Dihydrogen phosphate salt of a prostaglandin d2 receptor antagonist | |
| UA88485C2 (en) | 2,6-substituted-4-monosubstituted amino-pyrimidines as prostaglandin d2 receptor antagonists | |
| NO20076450L (no) | Heterosykliske forbindelser som nikotinsyrereseptoragonister for behandling av dyslipidemi | |
| TNSN07251A1 (en) | 2-phenyl-indoles as prostaglandin d2 receptor antagonists | |
| JP2013542937A5 (enExample) | ||
| CN101970405A (zh) | 吲哚及其治疗用途 | |
| PE20081889A1 (es) | Indol carboxamidas como inhibidores de ikk2 | |
| JP2008528606A5 (enExample) | ||
| RU2012143897A (ru) | Замещенные пиримидины как антагонисты рецепторов простагландина d2 | |
| EP1486491A4 (en) | CARBOXYLIC ACID COMPOUNDS AND COMPOUND-CONTAINING MEDICAMENTS AS ACTIVE INGREDIENT | |
| JP2012527487A5 (enExample) | ||
| NZ595797A (en) | 2,5-disubstituted arylsulfonamide ccr3 antagonists | |
| JP2009521431A5 (enExample) | ||
| NZ595838A (en) | Arylsulfonamide ccr3 antagonists | |
| RU2012143978A (ru) | Замещенный пиримидин в качестве антагониста рецептора простагландина d2 | |
| EP1666473A4 (en) | CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS ACTIVE INGREDIENT | |
| NZ587153A (en) | Pyrimidine-containing compounds for treating inflammation and immunological diseases | |
| EP1539158A1 (en) | Aryl piperidine derivatives as inducers of ldl-receptor expression for the treatment of hypercholesterolemia | |
| WO2007005534A3 (en) | Chemical compounds | |
| UA95303C2 (en) | 2-phenyl-indoles as prostaglandin d2 receptor antagonists | |
| RU2013142188A (ru) | Производные диаминопиримидина и способы их получения |