JP2009532052A5 - - Google Patents

Info

Publication number

JP2009532052A5

JP2009532052A5 JP2009503659A JP2009503659A JP2009532052A5 JP 2009532052 A5 JP2009532052 A5 JP 2009532052A5 JP 2009503659 A JP2009503659 A JP 2009503659A JP 2009503659 A JP2009503659 A JP 2009503659A JP 2009532052 A5 JP2009532052 A5 JP 2009532052A5

Authority

JP

Japan

Prior art keywords

protease

flow path

liquid flow

component

detection product

Prior art date

2007-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108091005804 Peptidases Proteins 0.000 claims description 39
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 39
• 239000007788 liquid Substances 0.000 claims description 35
• 239000004365 Protease Substances 0.000 claims description 32
• 238000001514 detection method Methods 0.000 claims description 27
• 238000000034 method Methods 0.000 claims description 10
• 238000011144 upstream manufacturing Methods 0.000 claims description 10
• 230000004888 barrier function Effects 0.000 claims description 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
• 239000000126 substance Substances 0.000 claims description 5
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
• 229920002678 cellulose Polymers 0.000 claims description 4
• 239000001913 cellulose Substances 0.000 claims description 4
• OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 claims description 2
• 229920000926 Galactomannan Polymers 0.000 claims description 2
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 2
• 108010090804 Streptavidin Proteins 0.000 claims description 2
• 229920002000 Xyloglucan Polymers 0.000 claims description 2
• 239000000427 antigen Substances 0.000 claims description 2
• 102000036639 antigens Human genes 0.000 claims description 2
• 108091007433 antigens Proteins 0.000 claims description 2
• 229960002685 biotin Drugs 0.000 claims description 2
• 235000020958 biotin Nutrition 0.000 claims description 2
• 239000011616 biotin Substances 0.000 claims description 2
• 230000001066 destructive effect Effects 0.000 claims description 2
• 239000012634 fragment Substances 0.000 claims description 2
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 2
• 239000010931 gold Substances 0.000 claims description 2
• 229910052737 gold Inorganic materials 0.000 claims description 2
• 239000002245 particle Substances 0.000 claims description 2
• 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
• 239000011534 wash buffer Substances 0.000 claims description 2
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1