JP2009529926A5 - - Google Patents

Info

Publication number

JP2009529926A5

JP2009529926A5 JP2008557416A JP2008557416A JP2009529926A5 JP 2009529926 A5 JP2009529926 A5 JP 2009529926A5 JP 2008557416 A JP2008557416 A JP 2008557416A JP 2008557416 A JP2008557416 A JP 2008557416A JP 2009529926 A5 JP2009529926 A5 JP 2009529926A5

Authority

JP

Japan

Prior art keywords

foam

gel

forming

polysaccharide

pores

Prior art date

2007-03-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000006260 foam Substances 0.000 claims description 69
• 238000000034 method Methods 0.000 claims description 55
• 150000004676 glycans Chemical class 0.000 claims description 42
• 229920001282 polysaccharide Polymers 0.000 claims description 42
• 239000005017 polysaccharide Substances 0.000 claims description 42
• 150000002500 ions Chemical class 0.000 claims description 38
• 239000011148 porous material Substances 0.000 claims description 30
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 28
• 229940072056 alginate Drugs 0.000 claims description 25
• 235000010443 alginic acid Nutrition 0.000 claims description 25
• 229920000615 alginic acid Polymers 0.000 claims description 25
• 239000002131 composite material Substances 0.000 claims description 25
• 239000007788 liquid Substances 0.000 claims description 19
• 229920000642 polymer Polymers 0.000 claims description 6
• WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 4
• 239000006185 dispersion Substances 0.000 claims description 4
• 238000005187 foaming Methods 0.000 claims description 4
• 229940014041 hyaluronate Drugs 0.000 claims description 4
• 238000001727 in vivo Methods 0.000 claims description 4
• 239000000203 mixture Substances 0.000 claims description 4
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
• 229920001661 Chitosan Polymers 0.000 claims description 3
• 239000000679 carrageenan Substances 0.000 claims description 3
• 235000010418 carrageenan Nutrition 0.000 claims description 3
• 229920001525 carrageenan Polymers 0.000 claims description 3
• 229940113118 carrageenan Drugs 0.000 claims description 3
• 229940045110 chitosan Drugs 0.000 claims description 3
• 239000004615 ingredient Substances 0.000 claims description 3
• 230000002401 inhibitory effect Effects 0.000 claims description 3
• 235000010987 pectin Nutrition 0.000 claims description 3
• 239000001814 pectin Substances 0.000 claims description 3
• 229920001277 pectin Polymers 0.000 claims description 3
• 229960000292 pectin Drugs 0.000 claims description 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
• 239000002250 absorbent Substances 0.000 claims description 2
• 230000002745 absorbent Effects 0.000 claims description 2
• 230000015572 biosynthetic process Effects 0.000 claims description 2
• 230000004663 cell proliferation Effects 0.000 claims description 2
• 239000003431 cross linking reagent Substances 0.000 claims description 2
• 238000001035 drying Methods 0.000 claims description 2
• 238000001879 gelation Methods 0.000 claims description 2
• 238000000338 in vitro Methods 0.000 claims description 2
• 230000001939 inductive effect Effects 0.000 claims description 2
• 239000011159 matrix material Substances 0.000 claims description 2
• 238000010907 mechanical stirring Methods 0.000 claims description 2
• 238000000465 moulding Methods 0.000 claims description 2
• 239000003002 pH adjusting agent Substances 0.000 claims description 2
• 239000004014 plasticizer Substances 0.000 claims description 2
• 230000035755 proliferation Effects 0.000 claims description 2
• 239000000499 gel Substances 0.000 claims 10
• 239000004088 foaming agent Substances 0.000 claims 1
• 229910052712 strontium Inorganic materials 0.000 claims 1
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims 1
• 239000000243 solution Substances 0.000 description 9
• 230000010261 cell growth Effects 0.000 description 5
• 239000003795 chemical substances by application Substances 0.000 description 4
• 206010052428 Wound Diseases 0.000 description 3
• 208000027418 Wounds and injury Diseases 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 239000003814 drug Substances 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 229910001427 strontium ion Inorganic materials 0.000 description 3
• 229940124597 therapeutic agent Drugs 0.000 description 3
• 230000017423 tissue regeneration Effects 0.000 description 3
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 229910001422 barium ion Inorganic materials 0.000 description 2
• 229910001424 calcium ion Inorganic materials 0.000 description 2
• 239000002158 endotoxin Substances 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 235000013355 food flavoring agent Nutrition 0.000 description 2
• 239000003205 fragrance Substances 0.000 description 2
• 235000013376 functional food Nutrition 0.000 description 2
• 239000003102 growth factor Substances 0.000 description 2
• 230000007935 neutral effect Effects 0.000 description 2
• 230000003204 osmotic effect Effects 0.000 description 2
• 239000002245 particle Substances 0.000 description 2
• 230000001737 promoting effect Effects 0.000 description 2
• 238000011084 recovery Methods 0.000 description 2
• 238000013268 sustained release Methods 0.000 description 2
• 239000012730 sustained-release form Substances 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• 239000004604 Blowing Agent Substances 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 239000000853 adhesive Substances 0.000 description 1
• 230000000181 anti-adherent effect Effects 0.000 description 1
• 229910052788 barium Inorganic materials 0.000 description 1
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 229920001222 biopolymer Polymers 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 230000021164 cell adhesion Effects 0.000 description 1
• 239000006143 cell culture medium Substances 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 238000007598 dipping method Methods 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 229940005740 hexametaphosphate Drugs 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 230000005764 inhibitory process Effects 0.000 description 1
• 239000001509 sodium citrate Substances 0.000 description 1
• NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
• 159000000008 strontium salts Chemical class 0.000 description 1
• UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1