BRPI0708422A2 - Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca - Google Patents
Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca Download PDFInfo
- Publication number
- BRPI0708422A2 BRPI0708422A2 BRPI0708422-6A BRPI0708422A BRPI0708422A2 BR PI0708422 A2 BRPI0708422 A2 BR PI0708422A2 BR PI0708422 A BRPI0708422 A BR PI0708422A BR PI0708422 A2 BRPI0708422 A2 BR PI0708422A2
- Authority
- BR
- Brazil
- Prior art keywords
- foam
- composite
- gel
- alginate
- polysaccharide
- Prior art date
Links
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Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
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- Cell Biology (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Colloid Chemistry (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77786906P | 2006-03-01 | 2006-03-01 | |
| US60/777869 | 2006-03-01 | ||
| US87284406P | 2006-12-05 | 2006-12-05 | |
| US60/872844 | 2006-12-05 | ||
| US87417406P | 2006-12-11 | 2006-12-11 | |
| US60/874174 | 2006-12-11 | ||
| PCT/US2007/005436 WO2007103209A2 (en) | 2006-03-01 | 2007-03-01 | Gelled composite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0708422A2 true BRPI0708422A2 (pt) | 2011-05-31 |
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| BRPI0708422-6A BRPI0708422A2 (pt) | 2006-03-01 | 2007-03-01 | Método para formar um compósito, compósito, métodos para promover a proliferação celular no compósito, para inibir a proliferação celular e para recuperar células do compósito, uso de um compósito, e , métodos para fixar um compósito a um tecido, para remover o crescimento celular, para induzir a geleificação in situ dentro dos poros de uma espuma de alginato, para prevenir a adesão de tecido a tecido adjacene e para formar uma espuma absorvente seca |
| BRPI0708429-3A BRPI0708429A2 (pt) | 2006-03-01 | 2007-03-01 | método para formar uma espuma absorvente seca, espuma absorvente seca, compósito, uso de uma espuma ou de um compósito, e, métodos para inibir a proliferação celular, para fixar um compósito ao tecido e para evitar a adesão de tecido a tecido adjacente |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0708429-3A BRPI0708429A2 (pt) | 2006-03-01 | 2007-03-01 | método para formar uma espuma absorvente seca, espuma absorvente seca, compósito, uso de uma espuma ou de um compósito, e, métodos para inibir a proliferação celular, para fixar um compósito ao tecido e para evitar a adesão de tecido a tecido adjacente |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20070254016A1 (enExample) |
| EP (2) | EP1988937A2 (enExample) |
| JP (2) | JP2009528437A (enExample) |
| AT (1) | ATE517645T1 (enExample) |
| AU (2) | AU2007224138B2 (enExample) |
| BR (2) | BRPI0708422A2 (enExample) |
| CA (2) | CA2643084C (enExample) |
| IL (2) | IL193621A (enExample) |
| NO (2) | NO20083696L (enExample) |
| WO (2) | WO2007103208A2 (enExample) |
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| US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
| US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
| US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
| US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
| US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
| GB0508531D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
| EP2109409B1 (en) | 2006-12-12 | 2018-09-05 | C.R.Bard, Inc. | Multiple imaging mode tissue marker |
| WO2008157318A2 (en) * | 2007-06-13 | 2008-12-24 | Fmc Corporation | Alginate coated, polysaccharide gel-containing foam composite, preparative methods, and uses thereof |
| DE102007037051A1 (de) * | 2007-07-24 | 2009-01-29 | Aesculap Ag | Flächiges Implantat |
| EP2200674A2 (en) * | 2007-09-10 | 2010-06-30 | Boston Scientific Scimed, Inc. | Medical devices with triggerable bioadhesive material |
| EP2185637B1 (en) | 2007-09-19 | 2013-04-03 | SurModics, Inc. | Biocompatible foams, systems, and methods |
| DE102007051059B4 (de) * | 2007-10-18 | 2014-04-03 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen |
| US8673354B2 (en) | 2007-11-05 | 2014-03-18 | Technion Research And Development Foundation Ltd. | Adhesives and methods of applying the same |
| GB0722820D0 (en) | 2007-11-21 | 2008-01-02 | Smith & Nephew | Vacuum assisted wound dressing |
| WO2009067711A2 (en) | 2007-11-21 | 2009-05-28 | T.J. Smith & Nephew, Limited | Suction device and dressing |
| EP3354243A1 (en) | 2007-11-21 | 2018-08-01 | Smith & Nephew PLC | Wound dressing |
| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| GB0723875D0 (en) | 2007-12-06 | 2008-01-16 | Smith & Nephew | Wound management |
| GB0803564D0 (en) | 2008-02-27 | 2008-04-02 | Smith & Nephew | Fluid collection |
| US9327061B2 (en) * | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
| GB0902816D0 (en) | 2009-02-19 | 2009-04-08 | Smith & Nephew | Fluid communication path |
| EP2416741B1 (en) | 2009-04-06 | 2015-03-11 | Bender Analytical Holding B.V. | In situ gelling alginate systems |
| CN102497890B (zh) | 2009-06-01 | 2014-08-27 | 特克尼雍技术研究与发展基金会有限公司 | 密封材料、其制造和施加其方法 |
| WO2011017633A2 (en) * | 2009-08-07 | 2011-02-10 | Fmc Corporation | Toothpaste composition |
| EP2473201B1 (en) * | 2009-09-01 | 2016-08-10 | Medovent GmbH | Chitosan tissue dressing |
| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| US9315772B2 (en) * | 2010-06-22 | 2016-04-19 | Universite De Rouen | Crosslinked hyaluronan hydrogels for 3D cell culture |
| GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
| EP2624874A4 (en) | 2010-10-08 | 2014-04-02 | Univ Texas | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
| GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
| BR112013012785A2 (pt) | 2010-11-25 | 2020-10-20 | Bluestar Silicones France Sas | composição i - ii e produtos e usos das mesmas |
| WO2012127224A1 (en) * | 2011-03-21 | 2012-09-27 | University Of Reading | Transport of cells in hydrogels |
| EP3009445B1 (en) * | 2011-04-29 | 2017-11-01 | KCI Licensing, Inc. | Aptamer-modified polymeric materials for binding of therapeutic factors in wounds |
| RU2471824C1 (ru) * | 2011-07-26 | 2013-01-10 | Учреждение Российской академии наук Институт высокомолекулярных соединений РАН | Биосовместимый биодеградируемый пористый композиционный материал и способ его получения |
| US20150159066A1 (en) | 2011-11-25 | 2015-06-11 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| US20130288932A1 (en) * | 2012-04-27 | 2013-10-31 | Halliburton Energy Services, Inc. | Methods of cryodesiccating a broth comprising a biopolymer of an exopolysaccharide |
| EP2892950B1 (en) * | 2012-09-07 | 2017-03-08 | 3M Innovative Properties Company | Silicone compositions and related methods |
| ES2804534T3 (es) | 2012-12-07 | 2021-02-08 | Baxter Int | Espuma hemostática |
| CN104981259B (zh) * | 2012-12-11 | 2017-03-08 | 得克萨斯系统大学评议会 | 包含防粘连的水凝胶膜的试剂盒 |
| US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
| US20140242676A1 (en) * | 2013-02-01 | 2014-08-28 | Los Alamos National Security, Llc | Artificial leaf-like microphotobioreactor and methods for making the same |
| EP2968647B1 (en) | 2013-03-15 | 2022-06-29 | Smith & Nephew plc | Wound dressing sealant and use thereof |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| CA2913875A1 (en) * | 2013-05-29 | 2014-12-04 | Otsuka Pharmaceutical Factory, Inc. | Adhesion preventing material |
| FR3039555B1 (fr) | 2015-07-30 | 2017-08-18 | Univ Toulouse Iii - Paul Sabatier | Procede de preparation de matrices poreuses polymeres biocompatibles et biodegradables trimensionnelles et applications |
| JP6719182B2 (ja) * | 2015-08-05 | 2020-07-08 | 株式会社武蔵野化学研究所 | エンドトキシンの測定用試料の前処理方法 |
| US20170157283A1 (en) | 2015-12-08 | 2017-06-08 | Medtronic Xomed, Inc. | Dissolvable nasal sinus sponge |
| CA3015172A1 (en) | 2016-02-18 | 2017-08-24 | Privo Technologies, Inc. | Two-stage microparticle-based therapeutic delivery system and method |
| JP7065769B2 (ja) | 2016-07-13 | 2022-05-12 | 持田製薬株式会社 | 癒着防止用組成物 |
| WO2018117548A1 (ko) * | 2016-12-23 | 2018-06-28 | 주식회사 엘지화학 | 다공성 고흡수성 수지의 제조 방법 및 다공성 고흡수성 수지 |
| WO2018151849A1 (en) * | 2017-02-17 | 2018-08-23 | Privo Technologies, Inc. | Particle-based multi-layer therapeutic delivery device and method |
| US10478403B1 (en) | 2017-05-03 | 2019-11-19 | Privo Technologies, Inc. | Intraoperative topically-applied non-implantable rapid release patch |
| FR3068039B1 (fr) | 2017-06-22 | 2020-07-10 | Jellynov | Composition auto-moussante en milieu acide et procede de preparation |
| US10980913B2 (en) | 2018-03-05 | 2021-04-20 | Ethicon Llc | Sealant foam compositions for lung applications |
| JP7627214B2 (ja) | 2018-11-02 | 2025-02-05 | コバロン テクノロジーズ インコーポレイテッド | 発泡体組成物、発泡体マトリックスおよび方法 |
| FR3089224B1 (fr) | 2018-12-04 | 2020-12-11 | Jellynov | Composition auto-moussante en milieu acide et procédé de préparation |
| IL285436B2 (en) * | 2019-02-07 | 2024-02-01 | Biorez Inc | Composite scaffold for repair, restoration and regeneration of soft tissues |
| CA3129747A1 (en) | 2019-02-15 | 2020-08-20 | Johnson & Johnson Consumer Inc. | Moldable gel cleanser |
| NL2022788B1 (en) * | 2019-03-22 | 2020-09-28 | No Ceuticals B V | Chitosan nitrate for use as a nitric oxide donor (NO donor) |
| US20220289999A1 (en) * | 2019-07-11 | 2022-09-15 | StenCo, LLC | Biodegradable material |
| CN110960722A (zh) * | 2019-12-14 | 2020-04-07 | 广东泰宝医疗科技股份有限公司 | 一种抗菌藻酸盐创口贴及其制备方法 |
| CN111888524A (zh) * | 2020-08-04 | 2020-11-06 | 宁波迪创医疗科技有限公司 | 一种组织填充材料及其制备方法、组织工程支架和应用 |
| US11771122B2 (en) | 2020-09-29 | 2023-10-03 | Nitto Denko Corporation | Foam body and method for manufacturing the same |
| WO2023060076A1 (en) * | 2021-10-04 | 2023-04-13 | Cruz Foam, Inc. | Biodegradable foam with alginate |
| WO2023064540A1 (en) * | 2021-10-14 | 2023-04-20 | Kimberly-Clark Worldwide, Inc. | Microporous superabsorbent material with enhanced surface area |
| CN114403240B (zh) * | 2022-01-07 | 2023-07-21 | 华南农业大学 | 一种新型米糠蛋白基起酥油替代物及其在烘焙食品中的应用 |
| EP4417243A1 (de) * | 2023-02-15 | 2024-08-21 | Heraeus Medical GmbH | Implantat zur verzögerten wirkstofffreisetzung |
Family Cites Families (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2128551A (en) | 1934-01-11 | 1938-08-30 | Algin Corp Of America | Method of treating seaweed |
| US2036934A (en) | 1934-04-21 | 1936-04-07 | Kelco Co | Process for making alginic acid and product |
| US2246125A (en) * | 1941-04-01 | 1941-06-17 | Gen Electric | Electric discharge device |
| US2426125A (en) | 1944-04-03 | 1947-08-19 | Kelco Co | Manufacture of glycol alginates |
| US3772266A (en) | 1972-10-19 | 1973-11-13 | Kelco Co | Process for the preparation of propylene glycol alginate from partially neutralized alginic acid |
| CA1019326A (en) | 1974-07-16 | 1977-10-18 | Uniroyal Ltd. | Process for the production of alkylene glycol alginates |
| US3929678A (en) | 1974-08-01 | 1975-12-30 | Procter & Gamble | Detergent composition having enhanced particulate soil removal performance |
| GB1570485A (en) | 1975-11-18 | 1980-07-02 | Robinson & Sons Ltd | Absorbent material for aqueous fluids |
| US4292972A (en) | 1980-07-09 | 1981-10-06 | E. R. Squibb & Sons, Inc. | Lyophilized hydrocolloio foam |
| US5735902A (en) | 1987-07-20 | 1998-04-07 | Regen Biologics, Inc. | Hand implant device |
| DE3832643A1 (de) * | 1988-09-26 | 1990-03-29 | Patent Treuhand Ges Fuer Elektrische Gluehlampen Mbh | Verfahren zur herstellung einer reflexionsbeschichtung bei hochdruckentladungslampen |
| US4948575A (en) | 1989-01-24 | 1990-08-14 | Minnesota Mining And Manufacturing Company | Alginate hydrogel foam wound dressing |
| US5260345A (en) * | 1991-08-12 | 1993-11-09 | The Procter & Gamble Company | Absorbent foam materials for aqueous body fluids and absorbent articles containing such materials |
| CA2080035A1 (en) | 1991-10-15 | 1993-04-16 | George Colegrove | Gelled foams |
| US5840777A (en) * | 1992-06-19 | 1998-11-24 | Albany International Corp. | Method of producing polysaccharide foams |
| US5851461A (en) | 1992-06-19 | 1998-12-22 | Albany International Research Co. | Method of producing polysaccharide foams |
| JP2644626B2 (ja) * | 1992-06-19 | 1997-08-25 | アルバニー インターナショナル コーポレイション | 多糖フォームの製造方法 |
| IL104441A (en) * | 1993-01-19 | 2001-01-28 | Yossi Res Dev Company Of The H | Sponges from hydrocolloids and method for their production |
| US20030224022A1 (en) * | 1993-01-19 | 2003-12-04 | Amos Nussinovitch | Hydrocolloid cellular solid matrices |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| TW369414B (en) | 1994-09-30 | 1999-09-11 | Yamanouchi Pharma Co Ltd | Bone formation transplant |
| US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
| US5709934A (en) * | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
| NO953115L (no) * | 1995-06-07 | 1996-12-09 | Albany Int Research | Fremgangsmåte for fremstilling av polysakkaridskum |
| JP2822174B2 (ja) * | 1996-03-01 | 1998-11-11 | オーミケンシ株式会社 | キチンキトサン繊維及び構造体の製造法 |
| GB9608222D0 (en) | 1996-04-20 | 1996-06-26 | Innovative Tech Ltd | Dehydrated hydrogels |
| IL118376A0 (en) | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| US6054142A (en) * | 1996-08-01 | 2000-04-25 | Cyto Therapeutics, Inc. | Biocompatible devices with foam scaffolds |
| JP4335316B2 (ja) * | 1996-09-19 | 2009-09-30 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン | アルギネートまたは修飾アルギネートのようなポリサッカライドを含むポリマー |
| GB2318577B (en) | 1996-10-28 | 2000-02-02 | Johnson & Johnson Medical | Solvent dried polysaccharide sponges |
| GB9704749D0 (en) * | 1997-03-07 | 1997-04-23 | Univ London | Tissue Implant |
| JP4085341B2 (ja) | 1997-03-31 | 2008-05-14 | ザ、リージエンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | 開いたポアの生分解性マトリックス |
| WO1999020318A2 (en) | 1997-10-17 | 1999-04-29 | Advanced Medical Solutions Limited | Foam materials |
| IL124957A0 (en) | 1998-06-16 | 1999-01-26 | Univ Ben Gurion | Active ingredient delivery systems and devices based on porous matrices |
| KR100298846B1 (ko) | 1998-09-24 | 2003-10-22 | 한국원자력연구소 | 중화키토산스폰지또는중화키토산/콜라겐혼합스폰지를이용한인공진피 |
| US7128929B1 (en) * | 1999-04-29 | 2006-10-31 | Scherr George H | Alginate foam compositions |
| DE60014400T2 (de) * | 1999-07-28 | 2005-10-06 | United States Surgical Corp., Norwalk | Antiadhäsionsschicht aus hyaluronsäure |
| JP4044291B2 (ja) | 2000-01-24 | 2008-02-06 | クラレメディカル株式会社 | 水膨潤性高分子ゲルおよびその製造法 |
| AU2001234623A1 (en) * | 2000-01-28 | 2001-08-07 | Orthogene, Inc. | Gel-infused sponges for tissue repair and augmentation |
| US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
| IT1320163B1 (it) | 2000-02-15 | 2003-11-18 | Novamont Spa | Foglia e prodotti formati a base di amido espanso. |
| CA2401869A1 (en) | 2000-03-03 | 2001-09-07 | Syntacoll Ag | Agent for the treatment of wounds |
| US6565960B2 (en) * | 2000-06-01 | 2003-05-20 | Shriners Hospital Of Children | Polymer composite compositions |
| JP4493826B2 (ja) | 2000-09-29 | 2010-06-30 | 株式会社クラレ | 多糖類スポンジの製造法及び多糖類スポンジ |
| FR2816847B1 (fr) * | 2000-11-22 | 2006-07-14 | Assist Publ Hopitaux De Paris | Biomateriaux polymeriques poreux, procede de preparation et utilisations |
| US7041868B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
| US20060004314A1 (en) | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| BR0210406A (pt) | 2001-06-14 | 2006-04-04 | Providence Health Sys Oregon | curativo de ferimento, e, métodos de controle de sangramento severo, e de produção de um curativo de ferimento capaz de controlar o sangramento severo |
| US20050147656A1 (en) * | 2001-06-14 | 2005-07-07 | Hemcon, Inc. | Tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| US7371403B2 (en) | 2002-06-14 | 2008-05-13 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US6696077B2 (en) | 2001-07-26 | 2004-02-24 | George H. Scherr | Silver alginate foam compositions |
| US20030180242A1 (en) | 2001-11-01 | 2003-09-25 | The Procter & Gamble Company | Personal care compositions containing a water-disintegratable polymeric foam |
| US20030186826A1 (en) | 2001-11-01 | 2003-10-02 | The Procter & Gamble Company | Method of using personal care compositions containing a high density, water disintegratable, polymeric foam |
| AU2003234159A1 (en) | 2002-04-22 | 2003-11-03 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
| US20050137512A1 (en) | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
| US7993922B2 (en) * | 2002-10-18 | 2011-08-09 | Reliance Life Sciences Pvt. Ltd. | Three-dimensional tissue equivalent using macromass culture |
| US20040082063A1 (en) | 2002-10-18 | 2004-04-29 | Reliance Life Sciences Pvt. Ltd. | Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells, and the method of macromass culture |
| KR100984184B1 (ko) | 2003-03-18 | 2010-09-28 | 에스케이케미칼주식회사 | 알긴산 스폰지 및 그의 제조방법 |
| EP1663326B1 (en) | 2003-09-08 | 2010-03-03 | FMC Biopolymer AS | Gelled biopolymer based foam |
| CN1897890B (zh) * | 2003-12-23 | 2012-01-25 | Fmc生物聚合物联合股份有限公司 | 用藻酸盐基质控制细胞生长 |
| GB0329773D0 (en) * | 2003-12-23 | 2004-01-28 | Perry Forbes G D | Torque equalisation in toric transmissions |
| US20050148963A1 (en) * | 2004-01-05 | 2005-07-07 | Brennan H. G. | Bioabsorbable surgical sponge |
| CN1297600C (zh) | 2004-07-30 | 2007-01-31 | 胡靖� | 环保防伪型全生物降解塑料发泡及流延成型方法 |
| AU2005295927B2 (en) * | 2004-10-12 | 2012-02-02 | Fmc Biopolymer As | Self-gelling alginate systems and uses thereof |
| US7700355B2 (en) * | 2005-01-07 | 2010-04-20 | Industrial Technology Research Institute | Methods of producing a porous matrix for culturing and recovering cells |
| JP2007068879A (ja) * | 2005-09-09 | 2007-03-22 | National Cardiovascular Center | 生体埋込部材及び人工組織 |
| JP2007143833A (ja) * | 2005-11-28 | 2007-06-14 | National Cardiovascular Center | 生体埋込部材及び人工組織 |
| DK2347775T3 (da) | 2005-12-13 | 2020-07-13 | Harvard College | Skabeloner til celletransplantation |
| US20070249044A1 (en) * | 2006-01-30 | 2007-10-25 | University Of Illinois At Chicago | Microstructures in three dimensional gel suspensions for growth of cells |
| CN100415304C (zh) | 2006-03-13 | 2008-09-03 | 西北大学 | 一种可生物降解止血海绵材料及其制备方法 |
| US20070240080A1 (en) * | 2006-04-11 | 2007-10-11 | Invensys Systems, Inc. | Strategy editor for process control supporting drag and drop connections to declarations |
-
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| US9028872B2 (en) | 2015-05-12 |
| EP1988942B1 (en) | 2011-07-27 |
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| US20070254016A1 (en) | 2007-11-01 |
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