JP2009529601A5 - - Google Patents
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- Publication number
- JP2009529601A5 JP2009529601A5 JP2008558884A JP2008558884A JP2009529601A5 JP 2009529601 A5 JP2009529601 A5 JP 2009529601A5 JP 2008558884 A JP2008558884 A JP 2008558884A JP 2008558884 A JP2008558884 A JP 2008558884A JP 2009529601 A5 JP2009529601 A5 JP 2009529601A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- polymer
- pendant side
- groups
- sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000642 polymer Polymers 0.000 claims 30
- 238000000034 method Methods 0.000 claims 20
- 235000000346 sugar Nutrition 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002355 alkine group Chemical group 0.000 claims 6
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 125000000524 functional group Chemical group 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003999 initiator Substances 0.000 claims 3
- 229920001515 polyalkylene glycol Polymers 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 238000003821 enantio-separation Methods 0.000 claims 2
- 238000002372 labelling Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000010526 radical polymerization reaction Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 150000008163 sugars Chemical class 0.000 claims 2
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 1
- 238000012644 addition polymerization Methods 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 238000010560 atom transfer radical polymerization reaction Methods 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 230000015861 cell surface binding Effects 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 229960002442 glucosamine Drugs 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- BQINXKOTJQCISL-GRCPKETISA-N keto-neuraminic acid Chemical compound OC(=O)C(=O)C[C@H](O)[C@@H](N)[C@@H](O)[C@H](O)[C@H](O)CO BQINXKOTJQCISL-GRCPKETISA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0604911A GB0604911D0 (en) | 2006-03-10 | 2006-03-10 | Polymers |
| GB0604911.8 | 2006-03-10 | ||
| US80958806P | 2006-05-31 | 2006-05-31 | |
| US60/809,588 | 2006-05-31 | ||
| GB0617918.8 | 2006-09-11 | ||
| GB0617918A GB0617918D0 (en) | 2006-09-11 | 2006-09-11 | Polymers |
| PCT/GB2007/000840 WO2007104948A2 (en) | 2006-03-10 | 2007-03-12 | Polymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161143A Division JP5584337B2 (ja) | 2006-03-10 | 2013-08-02 | ポリマー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009529601A JP2009529601A (ja) | 2009-08-20 |
| JP2009529601A5 true JP2009529601A5 (enExample) | 2010-04-15 |
| JP5394074B2 JP5394074B2 (ja) | 2014-01-22 |
Family
ID=38048016
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008558884A Expired - Fee Related JP5394074B2 (ja) | 2006-03-10 | 2007-03-12 | ポリマー |
| JP2013161143A Expired - Fee Related JP5584337B2 (ja) | 2006-03-10 | 2013-08-02 | ポリマー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013161143A Expired - Fee Related JP5584337B2 (ja) | 2006-03-10 | 2013-08-02 | ポリマー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8197847B2 (enExample) |
| EP (1) | EP1996629A2 (enExample) |
| JP (2) | JP5394074B2 (enExample) |
| AU (1) | AU2007226348A1 (enExample) |
| CA (1) | CA2642819C (enExample) |
| IL (1) | IL193978A (enExample) |
| MX (1) | MX2008011584A (enExample) |
| WO (1) | WO2007104948A2 (enExample) |
| ZA (1) | ZA200808637B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5564249B2 (ja) | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| US8034396B2 (en) * | 2008-04-01 | 2011-10-11 | Tyco Healthcare Group Lp | Bioadhesive composition formed using click chemistry |
| FR2930252B1 (fr) * | 2008-04-18 | 2010-08-20 | Centre Nat Rech Scient | Polymeres thermo-reticulables par reaction de huisgen : application a la preparation des materiaux a proprietes electro-optiques stables |
| US8153729B2 (en) * | 2008-05-29 | 2012-04-10 | The Regents Of The University Of California | Highly efficient agents for dispersion of nanoparticles in matrix materials |
| AU2009321508B2 (en) | 2008-11-03 | 2015-03-12 | Adc Therapeutics Sa | Antibodies that specifically block the biological activity of a tumor antigen |
| WO2010091142A1 (en) * | 2009-02-04 | 2010-08-12 | President And Fellows Of Harvard College | Compositions and methods for labeling and imaging phospholipids |
| EP2398519A2 (en) | 2009-02-21 | 2011-12-28 | Sofradim Production | Compounds and medical devices activated with solvophobic linkers |
| US8535477B2 (en) | 2009-02-21 | 2013-09-17 | Sofradim Production | Medical devices incorporating functional adhesives |
| AU2010215194A1 (en) | 2009-02-21 | 2011-10-13 | Sofradim Production | Apparatus and method of reacting polymers passing through metal ion chelated resin matrix to produce injectable medical devices |
| US9375699B2 (en) | 2009-02-21 | 2016-06-28 | Sofradim Production | Apparatus and method of reacting polymers by exposure to UV radiation to produce injectable medical devices |
| WO2010096649A1 (en) | 2009-02-21 | 2010-08-26 | Tyco Healthcare Group Lp | Medical devices having activated surfaces |
| US8968818B2 (en) | 2009-02-21 | 2015-03-03 | Covidien Lp | Medical devices having activated surfaces |
| US8663689B2 (en) * | 2009-02-21 | 2014-03-04 | Sofradim Production | Functionalized adhesive medical gel |
| US8877170B2 (en) * | 2009-02-21 | 2014-11-04 | Sofradim Production | Medical device with inflammatory response-reducing coating |
| US9273191B2 (en) | 2009-02-21 | 2016-03-01 | Sofradim Production | Medical devices with an activated coating |
| EP2398941B1 (en) | 2009-02-21 | 2016-07-13 | Sofradim Production | Crosslinked fibers and method of making same by extrusion |
| US8512728B2 (en) | 2009-02-21 | 2013-08-20 | Sofradim Production | Method of forming a medical device on biological tissue |
| AU2010215202A1 (en) | 2009-02-21 | 2011-10-13 | Covidien Lp | Crosslinked fibers and method of making same using UV radiation |
| US8968733B2 (en) * | 2009-02-21 | 2015-03-03 | Sofradim Production | Functionalized surgical adhesives |
| EP2398845B1 (en) | 2009-02-21 | 2017-12-13 | Sofradim Production | Amphiphilic compounds and self-assembling compositions made therefrom |
| GB0912160D0 (en) | 2009-07-13 | 2009-08-26 | Warwick Effect Polymers Ltd | Polymer modified macromolecules |
| EP2550031B1 (en) | 2010-03-25 | 2015-08-19 | Sofradim Production | Medical devices incorporating functional adhesives |
| AU2011231246B2 (en) | 2010-03-25 | 2015-05-21 | Sofradim Production | Surgical fasteners and methods for sealing wounds |
| CN101824127B (zh) * | 2010-04-01 | 2011-10-19 | 江西科技师范学院 | 一种利用活性自由基无皂乳液聚合制备可交联嵌段共聚物的方法及其制备的化合物 |
| AU2011276443A1 (en) | 2010-06-29 | 2013-01-31 | Covidien Lp | Microwave-powered reactor and method for in situ forming implants |
| WO2012001532A2 (en) | 2010-07-01 | 2012-01-05 | Sofradim Production | Medical device with predefined activated cellular integration |
| AU2011284449B2 (en) | 2010-07-27 | 2015-07-23 | Sofradim Production | Polymeric fibers having tissue reactive members |
| CN102399352B (zh) * | 2010-09-15 | 2013-05-22 | 南开大学 | 一种含能热塑性弹性体及其合成方法 |
| JP5890324B2 (ja) * | 2011-01-27 | 2016-03-22 | 東亞合成株式会社 | カルボキシル基含有重合体の製造方法 |
| CN106146664B (zh) | 2011-03-31 | 2021-09-07 | Adc治疗股份有限公司 | 针对肾相关抗原1的抗体及其抗原结合片段 |
| CA3115623A1 (en) | 2012-01-09 | 2013-07-18 | Adc Therapeutics Sa | Method for treating breast cancer |
| US9775928B2 (en) | 2013-06-18 | 2017-10-03 | Covidien Lp | Adhesive barbed filament |
| EP2944955A1 (en) * | 2014-05-13 | 2015-11-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Benchmark for LC-MS systems |
| CN114805710B (zh) | 2014-10-31 | 2023-11-17 | 伊鲁米纳剑桥有限公司 | 聚合物以及dna共聚物涂层 |
| CN105001376A (zh) * | 2015-06-23 | 2015-10-28 | 天津大学 | 原子转移自由基聚合制备高容量蛋白质层析介质的方法 |
| GB201611849D0 (en) * | 2016-07-07 | 2016-08-24 | Univ Of Nottingham The | Sulfated glycopolymers |
| WO2018180547A1 (ja) * | 2017-03-30 | 2018-10-04 | Ｓｄｐグローバル株式会社 | ラジカル重合用分子量制御剤、それを用いた重合体の製造方法及び重合体 |
| JP2019112533A (ja) * | 2017-12-24 | 2019-07-11 | 国立大学法人千葉大学 | 貴金属分離回収可能なコポリマー及びそのコポリマーを用いた貴金属回収方法 |
| US12534562B2 (en) * | 2020-04-30 | 2026-01-27 | Dow Global Technologies Llc | Process for preparing olefin-acrylate block copolymers by ATRP |
| US20240400740A1 (en) * | 2021-10-15 | 2024-12-05 | Denka Company Limited | Compound and method of producing the compound |
| CN115124658B (zh) * | 2022-07-01 | 2023-07-11 | 苏州大学 | 主链型“半氟”交替共聚物的接枝共聚物的“一锅”法合成 |
| JP2026031534A (ja) * | 2024-08-09 | 2026-02-24 | デンカ株式会社 | トリアゾール骨格含有重合体の製造方法、トリアゾール骨格含有重合体及び組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2375248C (en) * | 1999-06-17 | 2009-11-24 | Wisconsin Alumni Research Foundation | Methods and reagents making multivalent arrays and combinatorial libraries of multivalent arrays |
| JP2004526691A (ja) * | 2001-01-12 | 2004-09-02 | エモリー ユニバーシティ | 糖ポリマーおよびフリーラジカル重合方法 |
| WO2004055160A2 (en) * | 2002-12-13 | 2004-07-01 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
| SG176455A1 (en) | 2003-10-09 | 2011-12-29 | Ambrx Inc | Polymer derivatives |
| US7795355B2 (en) | 2004-03-05 | 2010-09-14 | Carnegie Mellon University | Preparation of functional polymers |
| CA2558767A1 (en) * | 2004-07-06 | 2006-01-12 | Warwick Effect Polymers Limited | Living radical polymerization initiator comprising a functional group capable of reacting with polyeptides or the like, comb polymer obtained therewith, polypeptide conjugates anddrugs obtained therefrom |
-
2007
- 2007-03-12 AU AU2007226348A patent/AU2007226348A1/en not_active Abandoned
- 2007-03-12 EP EP07712880A patent/EP1996629A2/en not_active Withdrawn
- 2007-03-12 MX MX2008011584A patent/MX2008011584A/es unknown
- 2007-03-12 WO PCT/GB2007/000840 patent/WO2007104948A2/en not_active Ceased
- 2007-03-12 JP JP2008558884A patent/JP5394074B2/ja not_active Expired - Fee Related
- 2007-03-12 CA CA2642819A patent/CA2642819C/en not_active Expired - Fee Related
-
2008
- 2008-09-05 US US12/205,056 patent/US8197847B2/en not_active Expired - Fee Related
- 2008-09-09 IL IL193978A patent/IL193978A/en not_active IP Right Cessation
- 2008-10-09 ZA ZA2008/08637A patent/ZA200808637B/en unknown
-
2013
- 2013-08-02 JP JP2013161143A patent/JP5584337B2/ja not_active Expired - Fee Related
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