JP2009528517A5 - - Google Patents
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- Publication number
- JP2009528517A5 JP2009528517A5 JP2008556622A JP2008556622A JP2009528517A5 JP 2009528517 A5 JP2009528517 A5 JP 2009528517A5 JP 2008556622 A JP2008556622 A JP 2008556622A JP 2008556622 A JP2008556622 A JP 2008556622A JP 2009528517 A5 JP2009528517 A5 JP 2009528517A5
- Authority
- JP
- Japan
- Prior art keywords
- sample
- patient
- alzheimer
- disease
- dementia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 31
- 208000024827 Alzheimer disease Diseases 0.000 claims 22
- 239000002207 metabolite Substances 0.000 claims 21
- 239000000523 sample Substances 0.000 claims 20
- 208000028698 Cognitive impairment Diseases 0.000 claims 14
- 206010012289 Dementia Diseases 0.000 claims 14
- 208000010877 cognitive disease Diseases 0.000 claims 14
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 12
- 238000002560 therapeutic procedure Methods 0.000 claims 7
- 229940114079 arachidonic acid Drugs 0.000 claims 6
- 235000021342 arachidonic acid Nutrition 0.000 claims 6
- 230000036541 health Effects 0.000 claims 5
- 238000011002 quantification Methods 0.000 claims 5
- 230000007704 transition Effects 0.000 claims 5
- JZNWSCPGTDBMEW-RXMQYKEDSA-N 2-ammonioethyl (2R)-2,3-dihydroxypropyl phosphate zwitterion Chemical compound NCCOP(O)(=O)OC[C@H](O)CO JZNWSCPGTDBMEW-RXMQYKEDSA-N 0.000 claims 4
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 4
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 4
- 230000008859 change Effects 0.000 claims 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 4
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 4
- 230000007935 neutral effect Effects 0.000 claims 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 2
- 230000007792 alzheimer disease pathology Effects 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 2
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 2
- 230000003862 health status Effects 0.000 claims 2
- 238000004896 high resolution mass spectrometry Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 230000009467 reduction Effects 0.000 claims 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 239000013074 reference sample Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77729006P | 2006-02-28 | 2006-02-28 | |
| US60/777,290 | 2006-02-28 | ||
| US80477906P | 2006-06-14 | 2006-06-14 | |
| US60/804,779 | 2006-06-14 | ||
| US88888307P | 2007-02-08 | 2007-02-08 | |
| US60/888,883 | 2007-02-08 | ||
| PCT/CA2007/000313 WO2007098585A1 (en) | 2006-02-28 | 2007-02-28 | Methods for the diagnosis of dementia and other neurological disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012169181A Division JP2012255793A (ja) | 2006-02-28 | 2012-07-31 | 認知症及び他の神経障害の診断方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528517A JP2009528517A (ja) | 2009-08-06 |
| JP2009528517A5 true JP2009528517A5 (https=) | 2010-04-15 |
| JP5496513B2 JP5496513B2 (ja) | 2014-05-21 |
Family
ID=38458611
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556622A Active JP5496513B2 (ja) | 2006-02-28 | 2007-02-28 | 認知症及び他の神経障害の診断方法 |
| JP2012169181A Pending JP2012255793A (ja) | 2006-02-28 | 2012-07-31 | 認知症及び他の神経障害の診断方法 |
| JP2014131876A Pending JP2014197018A (ja) | 2006-02-28 | 2014-06-26 | 認知症及び他の神経障害の診断方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012169181A Pending JP2012255793A (ja) | 2006-02-28 | 2012-07-31 | 認知症及び他の神経障害の診断方法 |
| JP2014131876A Pending JP2014197018A (ja) | 2006-02-28 | 2014-06-26 | 認知症及び他の神経障害の診断方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8304246B2 (https=) |
| EP (3) | EP2851369A3 (https=) |
| JP (3) | JP5496513B2 (https=) |
| KR (1) | KR20080104350A (https=) |
| AT (1) | ATE535535T1 (https=) |
| AU (1) | AU2007219666A1 (https=) |
| CA (2) | CA2689848A1 (https=) |
| HK (1) | HK1208467A1 (https=) |
| IL (1) | IL193426A0 (https=) |
| NZ (1) | NZ570413A (https=) |
| WO (1) | WO2007098585A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2117527B1 (en) | 2007-02-08 | 2020-06-17 | Med-Life Discoveries LP | Compounds for use in the treatment of senile dementia of the alzheimer's type |
| CA2680748C (en) * | 2007-04-13 | 2012-08-28 | Phenomenome Discoveries Inc. | Methods for the diagnosis and risk assessment of plasmalogen deficiency mediated diseases of aging |
| JP5306345B2 (ja) * | 2007-07-26 | 2013-10-02 | フェノメノーム ディスカバリーズ インク | 自閉症スペクトラム障害の診断、リスク評価、及びモニタリングを行うための方法 |
| MX340916B (es) | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| US20140365895A1 (en) | 2008-05-13 | 2014-12-11 | Apple Inc. | Device and method for generating user interfaces from a template |
| US9121844B1 (en) * | 2008-09-09 | 2015-09-01 | Sociedad Europea de Analisis Diferencial de Movilidad | Method to analyze and classify persons and organisms based on odor patterns from released vapors |
| TWI475989B (zh) | 2008-12-22 | 2015-03-11 | Phenomenome Discoveries Inc | 縮醛磷脂類化合物，含彼之醫藥組成物以及治療老化疾病的方法 |
| EP3124980A1 (en) | 2009-10-01 | 2017-02-01 | Phenomenome Discoveries Inc. | Mass spectrophotometric method to diagnose pancreatic cancer |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| EP2596132A4 (en) | 2010-07-23 | 2013-12-18 | Harvard College | METHOD FOR DETECTING SIGNS FOR ILLNESS OR SUFFERING IN BODY FLUIDS |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| TW201209171A (en) | 2010-07-23 | 2012-03-01 | Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| WO2012090625A1 (ja) * | 2010-12-28 | 2012-07-05 | 医療法人社団ブックス | 認知症を血液サンプルで判定するための検査方法 |
| AU2012321071B2 (en) * | 2011-11-17 | 2015-02-26 | Med-Life Discoveries Lp | Methods for the synthesis of 13C labeled plasmalogen |
| WO2013119651A1 (en) * | 2012-02-08 | 2013-08-15 | Nestec Sa | Methods for diagnosing cognitive impairment |
| US20150031572A1 (en) * | 2012-02-15 | 2015-01-29 | Basf Se | Means and methods for assessing neuronal toxicity |
| CN104246781B (zh) * | 2012-03-29 | 2019-06-14 | 皇家飞利浦有限公司 | 用于改进神经科医师的关于阿尔茨海默氏病的工作流程的系统与方法 |
| MX2014015434A (es) | 2012-06-15 | 2015-07-14 | Harry Stylli | Metodos para detectar enfermedades o condiciones utilizando celulas enfermas en circulacion. |
| JP2015522260A (ja) | 2012-06-15 | 2015-08-06 | ハリー スティリ， | 疾患または状態を検出する方法 |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| DE202014004560U1 (de) * | 2013-06-08 | 2014-09-12 | Apple Inc. | Vorrichtung und grafische Benutzerschnittstelle zum Synchronisieren zweier oder mehrerer Anzeigen |
| CA2926592A1 (en) * | 2013-11-14 | 2015-05-21 | Nestec S.A. | Lipid biomarkers of healthy ageing |
| WO2015138879A1 (en) * | 2014-03-13 | 2015-09-17 | Massachusetts Institute Of Technology | Compositions containing pufa, uridine and choline and methods of use thereof |
| US10626464B2 (en) | 2014-09-11 | 2020-04-21 | Cell Mdx, Llc | Methods of detecting prostate cancer |
| US10006925B2 (en) | 2016-05-30 | 2018-06-26 | Universal Diagnostics, S. L. | Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous polyps |
| GB201611596D0 (en) * | 2016-07-04 | 2016-08-17 | British American Tobacco Investments Ltd | Apparatus and method for classifying a tobacco sample into one of a predefined set of taste categories |
| US20200241011A1 (en) * | 2017-02-24 | 2020-07-30 | Mattias ARNOLD | Compositions and methods related to sex- specific metabolic drivers in alzheimers disease |
| WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
| US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
| US12280219B2 (en) | 2017-12-31 | 2025-04-22 | NeuroLight, Inc. | Method and apparatus for neuroenhancement to enhance emotional response |
| US11478603B2 (en) | 2017-12-31 | 2022-10-25 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to enhance emotional response |
| US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
| US20190385711A1 (en) | 2018-06-19 | 2019-12-19 | Ellipsis Health, Inc. | Systems and methods for mental health assessment |
| JP7608171B2 (ja) | 2018-06-19 | 2025-01-06 | エリプシス・ヘルス・インコーポレイテッド | 精神的健康評価のためのシステム及び方法 |
| JP7389421B2 (ja) * | 2018-07-13 | 2023-11-30 | Ｐｓｔ株式会社 | 精神・神経系疾患を推定する装置 |
| US11452839B2 (en) | 2018-09-14 | 2022-09-27 | Neuroenhancement Lab, LLC | System and method of improving sleep |
| US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
| WO2022263927A2 (en) * | 2021-06-17 | 2022-12-22 | Phoska Biopharma Pte. Ltd. | Plasmalogen derivatives and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994009371A1 (en) * | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Antemortem diagnostic test for alzheimer's disease |
| US5731354A (en) | 1996-05-06 | 1998-03-24 | Clarion Pharmaceuticals Inc. | Treatment for the inhibition of neuro-degenerative disease states |
| US6177476B1 (en) | 1998-08-27 | 2001-01-23 | Clarion Pharmaceuticals Inc. | Nutritional supplements for replenishing plasmalogens |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US20020009740A1 (en) | 2000-04-14 | 2002-01-24 | Rima Kaddurah-Daouk | Methods for drug discovery, disease treatment, and diagnosis using metabolomics |
| AU2001286059A1 (en) * | 2000-09-08 | 2002-03-22 | Oxford Glycosciences (Uk) Ltd. | Automated identification of peptides |
| WO2002082075A2 (de) | 2001-04-06 | 2002-10-17 | Biovision Ag | Verfahren zum nachweis chronisch-demenzieller erkrankungen, zugehörige peptide und nachweisreagenzien |
| CA2446666A1 (en) * | 2001-05-09 | 2002-11-14 | Biovision Ag | Method for detecting progredient chronic dementia, and associated peptides and detection reagents |
| CA2745998C (en) * | 2002-08-23 | 2013-11-26 | Bayer Schering Pharma Aktiengesellschaft | Biomarkers for diagnosing alzheimer's disease |
| US7794948B2 (en) | 2003-11-07 | 2010-09-14 | Vermilllion, Inc. | Biomarkers for alzheimer's disease |
| WO2005085838A2 (en) * | 2004-03-02 | 2005-09-15 | Vanderbilt University | Computational analysis of mass spectroscopic lipid data |
| WO2005116659A2 (en) * | 2004-05-18 | 2005-12-08 | Neurodx, Llc | Compositions and methods relating to alzheimer’s disease |
| JP4176749B2 (ja) * | 2005-07-29 | 2008-11-05 | 学校法人帝京大学 | 疾病検査法 |
| US8026099B2 (en) * | 2007-07-26 | 2011-09-27 | Washington University | Lipid profile as a biomarker for early detection of neurological disorders |
-
2007
- 2007-02-28 CA CA2689848A patent/CA2689848A1/en not_active Abandoned
- 2007-02-28 EP EP14187832.2A patent/EP2851369A3/en not_active Withdrawn
- 2007-02-28 WO PCT/CA2007/000313 patent/WO2007098585A1/en not_active Ceased
- 2007-02-28 US US12/280,920 patent/US8304246B2/en active Active
- 2007-02-28 JP JP2008556622A patent/JP5496513B2/ja active Active
- 2007-02-28 EP EP10195818A patent/EP2322531A3/en not_active Ceased
- 2007-02-28 CA CA2640748A patent/CA2640748C/en active Active
- 2007-02-28 KR KR1020087023687A patent/KR20080104350A/ko not_active Withdrawn
- 2007-02-28 EP EP07710657A patent/EP1922325B1/en active Active
- 2007-02-28 AT AT07710657T patent/ATE535535T1/de active
- 2007-02-28 AU AU2007219666A patent/AU2007219666A1/en not_active Abandoned
- 2007-02-28 NZ NZ570413A patent/NZ570413A/en unknown
-
2008
- 2008-08-08 HK HK15109254.5A patent/HK1208467A1/en unknown
- 2008-08-13 IL IL193426A patent/IL193426A0/en unknown
-
2012
- 2012-07-31 JP JP2012169181A patent/JP2012255793A/ja active Pending
- 2012-09-25 US US13/626,703 patent/US20130110408A1/en not_active Abandoned
-
2014
- 2014-06-26 JP JP2014131876A patent/JP2014197018A/ja active Pending
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