JP2009528318A - シグマ受容体化合物 - Google Patents
シグマ受容体化合物 Download PDFInfo
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- JP2009528318A JP2009528318A JP2008556726A JP2008556726A JP2009528318A JP 2009528318 A JP2009528318 A JP 2009528318A JP 2008556726 A JP2008556726 A JP 2008556726A JP 2008556726 A JP2008556726 A JP 2008556726A JP 2009528318 A JP2009528318 A JP 2009528318A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
- C07D231/24—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms having sulfone or sulfonic acid radicals in the molecule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Psychiatry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06004288A EP1829873A1 (en) | 2006-03-02 | 2006-03-02 | Pyrrazole derivatives as sigma receptors antagonists |
| PCT/EP2007/001827 WO2007098964A2 (en) | 2006-03-02 | 2007-03-02 | Pyrrazole derivatives as sigma receptors antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009528318A true JP2009528318A (ja) | 2009-08-06 |
| JP2009528318A5 JP2009528318A5 (enExample) | 2010-04-15 |
Family
ID=36440951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556726A Pending JP2009528318A (ja) | 2006-03-02 | 2007-03-02 | シグマ受容体化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8138186B2 (enExample) |
| EP (2) | EP1829873A1 (enExample) |
| JP (1) | JP2009528318A (enExample) |
| CN (1) | CN101395152B (enExample) |
| CA (1) | CA2640754A1 (enExample) |
| ES (1) | ES2572985T3 (enExample) |
| MX (1) | MX2008011019A (enExample) |
| WO (1) | WO2007098964A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2395003A1 (en) | 2010-05-27 | 2011-12-14 | Laboratorios Del. Dr. Esteve, S.A. | Pyrazole compounds as sigma receptor inhibitors |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| SG11201604480PA (en) | 2013-12-17 | 2016-07-28 | Esteve Labor Dr | SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITORS (SNRIs) AND SIGMA RECEPTOR LIGANDS COMBINATIONS |
| EP2929883A1 (en) * | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
| CN104829541B (zh) * | 2015-05-05 | 2017-06-30 | 江苏豪森药业集团有限公司 | 高选择性及高纯度制备吗啉硝唑的方法 |
| AU2020345766A1 (en) | 2019-09-10 | 2022-03-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for increasing level of phosphorylated AMPK protein |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07196622A (ja) * | 1993-12-08 | 1995-08-01 | Kali Chem Pharma Gmbh | ３−（フェニルアルキルアミノアルキルオキシ）−５−フェニルピラゾール−化合物、その製造のための方法及び中間体、及びこれを含有する心臓循環作用薬剤 |
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| DD118636A1 (enExample) * | 1975-04-10 | 1976-03-12 | ||
| DD118637A1 (enExample) * | 1975-04-10 | 1976-03-12 | ||
| IL112764A0 (en) * | 1994-03-18 | 1995-05-26 | Ferrer Int | New chromene derivatives |
| US6514977B1 (en) * | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| GB9824310D0 (en) * | 1998-11-05 | 1998-12-30 | Univ London | Activators of soluble guanylate cyclase |
| KR101352012B1 (ko) * | 2004-08-27 | 2014-01-15 | 라보라토리오스 델 드라. 에스테브.에스.에이. | 시그마 수용체 저해제 |
| EP1634872A1 (en) * | 2004-08-27 | 2006-03-15 | Laboratorios Del Dr. Esteve, S.A. | Pyrazole derivatives as sigma receptor inhibitors |
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2006
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2007
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- 2007-03-02 CA CA002640754A patent/CA2640754A1/en not_active Abandoned
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- 2007-03-02 JP JP2008556726A patent/JP2009528318A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07196622A (ja) * | 1993-12-08 | 1995-08-01 | Kali Chem Pharma Gmbh | ３−（フェニルアルキルアミノアルキルオキシ）−５−フェニルピラゾール−化合物、その製造のための方法及び中間体、及びこれを含有する心臓循環作用薬剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8138186B2 (en) | 2012-03-20 |
| CN101395152A (zh) | 2009-03-25 |
| EP1829873A1 (en) | 2007-09-05 |
| MX2008011019A (es) | 2008-09-08 |
| US20090227589A1 (en) | 2009-09-10 |
| WO2007098964A3 (en) | 2007-11-29 |
| WO2007098964A2 (en) | 2007-09-07 |
| ES2572985T3 (es) | 2016-06-03 |
| CN101395152B (zh) | 2012-05-23 |
| CA2640754A1 (en) | 2007-09-07 |
| EP1996580A2 (en) | 2008-12-03 |
| EP1996580B1 (en) | 2016-03-02 |
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