JP2009527474A5 - - Google Patents
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- Publication number
- JP2009527474A5 JP2009527474A5 JP2008555298A JP2008555298A JP2009527474A5 JP 2009527474 A5 JP2009527474 A5 JP 2009527474A5 JP 2008555298 A JP2008555298 A JP 2008555298A JP 2008555298 A JP2008555298 A JP 2008555298A JP 2009527474 A5 JP2009527474 A5 JP 2009527474A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
- compound according
- pharmaceutically acceptable
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 9
- 150000003254 radicals Chemical class 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 6
- 239000007800 oxidant agent Substances 0.000 claims 6
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims 4
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 claims 4
- 150000002978 peroxides Chemical class 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000001590 oxidative effect Effects 0.000 claims 3
- 206010073306 Exposure to radiation Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 239000013522 chelant Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- -1 glycol thioester compound Chemical class 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002000 scavenging effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77287406P | 2006-02-14 | 2006-02-14 | |
| US60/772,874 | 2006-02-14 | ||
| PCT/US2007/003682 WO2007095178A2 (en) | 2006-02-14 | 2007-02-14 | Methoxypolyethylene glycol thioester chelate and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177877A Division JP2012031173A (ja) | 2006-02-14 | 2011-08-16 | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009527474A JP2009527474A (ja) | 2009-07-30 |
| JP2009527474A5 true JP2009527474A5 (enExample) | 2011-09-15 |
| JP5138612B2 JP5138612B2 (ja) | 2013-02-06 |
Family
ID=38372058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555298A Expired - Fee Related JP5138612B2 (ja) | 2006-02-14 | 2007-02-14 | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
| JP2011177877A Pending JP2012031173A (ja) | 2006-02-14 | 2011-08-16 | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011177877A Pending JP2012031173A (ja) | 2006-02-14 | 2011-08-16 | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8008347B2 (enExample) |
| EP (2) | EP2428234A1 (enExample) |
| JP (2) | JP5138612B2 (enExample) |
| CN (1) | CN101394844A (enExample) |
| AT (1) | ATE552833T1 (enExample) |
| AU (1) | AU2007215211B2 (enExample) |
| CA (1) | CA2642453A1 (enExample) |
| WO (1) | WO2007095178A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5138612B2 (ja) * | 2006-02-14 | 2013-02-06 | イースタン バージニア メディカル スクール | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
| JP2010100615A (ja) * | 2008-09-25 | 2010-05-06 | Santen Pharmaceut Co Ltd | ポリアルキレングリコールを有効成分として含有する網膜疾患の予防又は治療剤 |
| TWI568453B (zh) * | 2011-11-22 | 2017-02-01 | 原創生醫股份有限公司 | 具有螯合型複合微胞之藥物載體及其應用 |
| JP6086576B2 (ja) * | 2012-04-24 | 2017-03-01 | 公立大学法人首都大学東京 | 抗酸化剤 |
| WO2018236221A2 (en) * | 2017-06-03 | 2018-12-27 | Can Holding B.V. | Neurodegenerative peptide deposit dissolution |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
| JP2722250B2 (ja) | 1989-05-30 | 1998-03-04 | 興和株式会社 | 新規なジアミン化合物及びこれを含有する脳機能障害改善剤 |
| JPH0680964A (ja) * | 1991-12-27 | 1994-03-22 | Sogo Yatsukou Kk | 活性酸素消去剤 |
| EP0955044B1 (en) * | 1995-06-26 | 2005-11-16 | Chelator LLC | Method of inhibiting bacterial or fungal growth using a complexing agent |
| AU7454796A (en) | 1995-10-20 | 1997-05-07 | Eastern Virginia Medical School | Chelate derivatives as protectors against tissue injury |
| US6020373A (en) * | 1995-10-20 | 2000-02-01 | Eastern Virginia Medical School | Chelate derivatives as protectors against tissue injury |
| WO2004058289A1 (en) * | 2002-12-20 | 2004-07-15 | Chakshu Research, Inc. | Ophthalmic formulation for the prevention and treatment of ocular conditions |
| JP5138612B2 (ja) * | 2006-02-14 | 2013-02-06 | イースタン バージニア メディカル スクール | メトキシポリエチレングリコールチオエステルキレートおよびその使用 |
-
2007
- 2007-02-14 JP JP2008555298A patent/JP5138612B2/ja not_active Expired - Fee Related
- 2007-02-14 AU AU2007215211A patent/AU2007215211B2/en not_active Ceased
- 2007-02-14 CN CNA200780007327XA patent/CN101394844A/zh active Pending
- 2007-02-14 US US12/279,521 patent/US8008347B2/en not_active Expired - Fee Related
- 2007-02-14 EP EP11181006A patent/EP2428234A1/en not_active Withdrawn
- 2007-02-14 EP EP07750513A patent/EP1986631B1/en not_active Not-in-force
- 2007-02-14 CA CA002642453A patent/CA2642453A1/en not_active Abandoned
- 2007-02-14 WO PCT/US2007/003682 patent/WO2007095178A2/en not_active Ceased
- 2007-02-14 AT AT07750513T patent/ATE552833T1/de active
- 2007-02-14 US US11/705,759 patent/US7388028B2/en not_active Expired - Fee Related
-
2011
- 2011-07-22 US US13/188,914 patent/US8796336B2/en not_active Expired - Fee Related
- 2011-08-16 JP JP2011177877A patent/JP2012031173A/ja active Pending