JP2009526519A - 生物学的システム応答の予測方法 - Google Patents

生物学的システム応答の予測方法 Download PDF

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JP2009526519A
JP2009526519A JP2008550465A JP2008550465A JP2009526519A JP 2009526519 A JP2009526519 A JP 2009526519A JP 2008550465 A JP2008550465 A JP 2008550465A JP 2008550465 A JP2008550465 A JP 2008550465A JP 2009526519 A JP2009526519 A JP 2009526519A
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cell
cells
group
response
cellular
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ジュリアーノ,ケネス
ゴフ,アルバート
ジョンストン,パトリシア
テイラー,ディー.ランシング
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セルーメン、インコーポレイテッド
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Biotechnology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2008550465A 2006-01-17 2007-01-17 生物学的システム応答の予測方法 Withdrawn JP2009526519A (ja)

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US75947606P 2006-01-17 2006-01-17
US84600606P 2006-09-20 2006-09-20
PCT/US2007/001217 WO2008018905A2 (en) 2006-01-17 2007-01-17 Method for predicting biological systems responses

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JP2009526519A true JP2009526519A (ja) 2009-07-23
JP2009526519A5 JP2009526519A5 (https=) 2010-03-04

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US (1) US20090170091A1 (https=)
EP (1) EP1984737A2 (https=)
JP (1) JP2009526519A (https=)
WO (1) WO2008018905A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019537102A (ja) * 2016-09-30 2019-12-19 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 最適候補化合物を検出するためのコンピュータ装置およびその方法
WO2020071484A1 (ja) * 2018-10-05 2020-04-09 国立大学法人名古屋大学 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090131270A1 (en) * 2004-08-02 2009-05-21 Cellumen, Inc.A Corporation Methods for the detection of molecular interactions within cells
CN101484806A (zh) * 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
US20100009352A1 (en) * 2006-05-24 2010-01-14 Gough Albert H Method for Modeling a Disease
WO2008060483A2 (en) * 2006-11-10 2008-05-22 Cellumen, Inc. Protein-protein interaction biosensors and methods of use thereof
GB0907079D0 (en) 2009-04-24 2009-06-03 Ge Healthcare Uk Ltd Method and apparatus for multi-parameter data analysis
US9043249B2 (en) * 2009-11-22 2015-05-26 Azure Vault Ltd. Automatic chemical assay classification using a space enhancing proximity
EP2681551A1 (en) 2011-02-28 2014-01-08 Cellomics, Inc Predicting toxicity of a compound over a range of concentrations
ES2739623T3 (es) 2011-03-17 2020-02-03 Cernostics Inc Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos
CA2832031C (en) 2011-04-06 2019-09-17 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
CN105378475A (zh) * 2013-07-01 2016-03-02 伊克斯塞拉公司 治疗的系统生物学方法
CA3006356C (en) 2015-11-25 2024-07-02 Cernostics, Inc. METHODS FOR PREDICTING ENDOBRACHYOESOPHAGE PROGRESSION
US10453551B2 (en) 2016-06-08 2019-10-22 X Development Llc Simulating living cell in silico
US11619634B2 (en) 2017-08-21 2023-04-04 Savicell Diagnostic Ltd. Methods of diagnosing and treating lung cancer
US20230352149A1 (en) * 2020-05-14 2023-11-02 Universität Heidelberg Single-cell morphology analysis for disease profiling and drug discovery

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047321A (en) * 1988-06-15 1991-09-10 Becton Dickinson & Co. Method for analysis of cellular components of a fluid
US5733721A (en) * 1992-11-20 1998-03-31 The Board Of Regents Of The University Of Oklahoma Cell analysis method using quantitative fluorescence image analysis
FI101829B1 (fi) * 1995-03-07 1998-08-31 Erkki Juhani Soini Biospesifinen määritysmenetelmä
CA2232727C (en) * 1995-09-22 2002-03-26 Novo Nordisk A/S Novel variants of green fluorescent protein, gfp
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE69638321D1 (de) * 1995-10-11 2011-03-03 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US20060141539A1 (en) * 1996-05-30 2006-06-29 Taylor D L Miniaturized cell array methods and apparatus for cell-based screening
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
DE19634873A1 (de) * 1996-08-29 1998-03-12 Boehringer Mannheim Gmbh System zur Unterscheidung fluoreszierender Molekülgruppen durch zeitaufgelöste Fluoreszenzmessung
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US6897017B1 (en) * 1997-01-31 2005-05-24 Odyssey Thera Inc. Vivo library-versus-library selection of optimized protein-protein interactions
US7306914B2 (en) * 1997-01-31 2007-12-11 Odyssey Thera Inc. Protein fragment complementation assays in whole animals applications to drug efficacy, ADME, cancer biology, immunology, infectious disease and gene therapy
US6294330B1 (en) * 1997-01-31 2001-09-25 Odyssey Pharmaceuticals Inc. Protein fragment complementation assays for the detection of biological or drug interactions
CA2196496A1 (en) * 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
US5885840A (en) * 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens
US6759206B1 (en) * 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US7117098B1 (en) * 1997-02-27 2006-10-03 Cellomics, Inc. Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm
US6756207B1 (en) * 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
US7853411B2 (en) * 1997-02-27 2010-12-14 Cellomics, Inc. System for cell-based screening
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
WO1998038490A1 (en) * 1997-02-27 1998-09-03 Cellomics, Inc. A system for cell-based screening
US6727071B1 (en) * 1997-02-27 2004-04-27 Cellomics, Inc. System for cell-based screening
US6342345B1 (en) * 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
DE69837118T2 (de) * 1997-04-07 2007-12-27 Fisher Biolmage Aps Ein Verfahren zum Screenen von Substanzen hinsichtlich ihres Effekts auf cAMP Spiegel basierend auf intrazellulärer Translokation von PKA
US6259807B1 (en) * 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6548263B1 (en) * 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US7160687B1 (en) * 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
AU1582799A (en) * 1997-11-07 1999-05-31 Iconix Pharmaceuticals, Inc. Surrogate genetics target characterization method
US7166424B2 (en) * 1998-02-02 2007-01-23 Odyssey Thera Inc. Fragments of fluorescent proteins for protein fragment complementation assays
US7282350B2 (en) * 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
US6242205B1 (en) * 1998-04-24 2001-06-05 Yale University Method of detecting drug-receptor and protein-protein interactions
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6324479B1 (en) * 1998-05-08 2001-11-27 Rosetta Impharmatics, Inc. Methods of determining protein activity levels using gene expression profiles
US6218122B1 (en) * 1998-06-19 2001-04-17 Rosetta Inpharmatics, Inc. Methods of monitoring disease states and therapies using gene expression profiles
US6146830A (en) * 1998-09-23 2000-11-14 Rosetta Inpharmatics, Inc. Method for determining the presence of a number of primary targets of a drug
US6950752B1 (en) * 1998-10-27 2005-09-27 Rosetta Inpharmatics Llc Methods for removing artifact from biological profiles
US6203987B1 (en) * 1998-10-27 2001-03-20 Rosetta Inpharmatics, Inc. Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns
DK1131471T3 (da) * 1998-10-30 2002-12-30 Cellomics Inc Et system til cellebaseret screening
US6453241B1 (en) * 1998-12-23 2002-09-17 Rosetta Inpharmatics, Inc. Method and system for analyzing biological response signal data
US6801859B1 (en) * 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6222093B1 (en) * 1998-12-28 2001-04-24 Rosetta Inpharmatics, Inc. Methods for determining therapeutic index from gene expression profiles
US6370478B1 (en) * 1998-12-28 2002-04-09 Rosetta Inpharmatics, Inc. Methods for drug interaction prediction using biological response profiles
US6986993B1 (en) * 1999-08-05 2006-01-17 Cellomics, Inc. System for cell-based screening
US6312956B1 (en) * 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer
AU2073801A (en) * 1999-12-09 2001-06-18 Cellomics, Inc. A system for cell-based screening
JP4798921B2 (ja) * 2000-03-06 2011-10-19 バイオシーク インコーポレーティッド 機能相同性スクリーニング
US7266458B2 (en) * 2000-03-06 2007-09-04 Bioseek, Inc. BioMAP analysis
US6763307B2 (en) * 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
EP1283846A4 (en) * 2000-05-12 2005-06-01 Univ Yale METHODS FOR DETECTING INTERACTIONS BETWEEN PROTEINS, PEPTIDES OR THEIR LIBRARIES USING FUSION PROTEINS
CA2414626A1 (en) * 2000-07-04 2002-01-10 Bioimage A/S A method for extracting quantitative information relating to interactions between cellular components
AU2001294872A1 (en) * 2000-09-28 2002-04-08 Cellomics, Inc. Methods and reagents for live-cell gene expression quantification
WO2002031704A1 (en) * 2000-10-12 2002-04-18 Iconix Pharmaceuticals, Inc. Interactive correlation of compound information and genomic information
US6956961B2 (en) * 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
EP1368653B1 (en) * 2001-03-12 2013-01-23 Cellomics, Inc. Methods to increase the capacity of high content cell-based screening assays
WO2002077903A2 (en) * 2001-03-26 2002-10-03 Cellomics, Inc. Methods for determining the organization of a cellular component of interest
US7219016B2 (en) * 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
WO2002093129A2 (en) * 2001-05-15 2002-11-21 University Of Medicine & Dentistry Of New Jersey Methods for analyzing interactions between proteins in live and intact cells
US8000949B2 (en) * 2001-06-18 2011-08-16 Genego, Inc. Methods for identification of novel protein drug targets and biomarkers utilizing functional networks
CA2453528C (en) * 2001-08-01 2011-07-26 Cellomics, Inc. Novel fusion proteins and assays for molecular binding
US20040043436A1 (en) * 2001-09-21 2004-03-04 Antonia Vlahou Biomarkers of transitional cell carcinoma of the bladder
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US7274809B2 (en) * 2002-08-29 2007-09-25 Perceptronix Medical, Inc. And British Columbia Cancer Agency Computerized methods and systems related to the detection of malignancy-associated changes (MAC) to detect cancer
US7865534B2 (en) * 2002-09-30 2011-01-04 Genstruct, Inc. System, method and apparatus for assembling and mining life science data
US7691580B2 (en) * 2003-01-29 2010-04-06 Corning Incorporated Reverse protein delivery into cells on coded microparticles
EP1620722A4 (en) * 2003-04-23 2008-01-30 Bioseek Inc METHODS FOR CHARACTERIZING SIGNALING PATHWAYS AND COMPOUNDS INTERACTING THEREWITH
US7235353B2 (en) * 2003-07-18 2007-06-26 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US7461048B2 (en) * 2003-07-21 2008-12-02 Aureon Laboratories, Inc. Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition
WO2005023987A2 (en) * 2003-09-03 2005-03-17 Bioseek, Inc. Cell-based assays for determining drug action
US7269517B2 (en) * 2003-09-05 2007-09-11 Rosetta Inpharmatics Llc Computer systems and methods for analyzing experiment design
US20050136509A1 (en) * 2003-09-10 2005-06-23 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
US20050136549A1 (en) * 2003-10-30 2005-06-23 Bioimagene, Inc. Method and system for automatically determining diagnostic saliency of digital images
US7760927B2 (en) * 2003-09-10 2010-07-20 Bioimagene, Inc. Method and system for digital image based tissue independent simultaneous nucleus cytoplasm and membrane quantitation
EP1692506A4 (en) * 2003-11-17 2008-01-09 Janssen Pharmaceutica Nv MODELING A SYSTEMIC INFLAMMATORY RESPONSE TO INFECTION
AU2004296023A1 (en) * 2003-11-26 2005-06-16 Genstruct, Inc. System, method and apparatus for causal implication analysis in biological networks
US20050154535A1 (en) * 2004-01-09 2005-07-14 Genstruct, Inc. Method, system and apparatus for assembling and using biological knowledge
US7666583B2 (en) * 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
US8019551B2 (en) * 2004-02-27 2011-09-13 Bioseek Llc Biological dataset profiling of asthma and atopy
ES2527426T3 (es) * 2004-05-07 2015-01-23 Cepheid Detección combinada de agentes biológicos
US20090131270A1 (en) * 2004-08-02 2009-05-21 Cellumen, Inc.A Corporation Methods for the detection of molecular interactions within cells
US20070019854A1 (en) * 2005-05-10 2007-01-25 Bioimagene, Inc. Method and system for automated digital image analysis of prostrate neoplasms using morphologic patterns
US7410763B2 (en) * 2005-09-01 2008-08-12 Intel Corporation Multiplex data collection and analysis in bioanalyte detection
CA2624086A1 (en) * 2005-09-28 2007-04-05 H. Lee Moffitt Cancer Center Individualized cancer treatments
EP2363711A1 (en) * 2006-01-27 2011-09-07 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US7790463B2 (en) * 2006-02-02 2010-09-07 Yale University Methods of determining whether a pregnant woman is at risk of developing preeclampsia
CN101484806A (zh) * 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
US7709222B2 (en) * 2006-07-13 2010-05-04 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
US7706591B2 (en) * 2006-07-13 2010-04-27 Cellomics, Inc. Neuronal profiling
US7811778B2 (en) * 2006-09-06 2010-10-12 Vanderbilt University Methods of screening for gastrointestinal cancer

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019537102A (ja) * 2016-09-30 2019-12-19 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 最適候補化合物を検出するためのコンピュータ装置およびその方法
JP7130630B2 (ja) 2016-09-30 2022-09-05 モレキュラー デバイシーズ, エルエルシー 最適候補化合物を検出するためのコンピュータ装置およびその方法
US11636924B2 (en) 2016-09-30 2023-04-25 Molecular Devices, Llc Computer device for detecting an optimal candidate compound and methods thereof
US12308096B2 (en) 2016-09-30 2025-05-20 Molecular Devices, Llc Computer device for detecting an optimal candidate compound and methods thereof
WO2020071484A1 (ja) * 2018-10-05 2020-04-09 国立大学法人名古屋大学 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置
JPWO2020071484A1 (ja) * 2018-10-05 2021-09-02 国立大学法人東海国立大学機構 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置
JP7405373B2 (ja) 2018-10-05 2023-12-26 国立大学法人東海国立大学機構 化学物質のスクリーニング方法、プログラム、制御装置、及び培養観察装置

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Publication number Publication date
WO2008018905A2 (en) 2008-02-14
EP1984737A2 (en) 2008-10-29
US20090170091A1 (en) 2009-07-02
WO2008018905A3 (en) 2008-05-22
WO2008018905A8 (en) 2009-07-09

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