JP2009526043A5 - - Google Patents
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- Publication number
- JP2009526043A5 JP2009526043A5 JP2008554186A JP2008554186A JP2009526043A5 JP 2009526043 A5 JP2009526043 A5 JP 2009526043A5 JP 2008554186 A JP2008554186 A JP 2008554186A JP 2008554186 A JP2008554186 A JP 2008554186A JP 2009526043 A5 JP2009526043 A5 JP 2009526043A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- chronic
- signs
- symptoms
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000002193 Pain Diseases 0.000 claims 8
- 230000001684 chronic effect Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010065390 Inflammatory pain Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 (4R) -1 ′-[(2E) -3- (3,4-Dichlorophenyl) prop-2-en-1-yl] -2H, 5H-spiro [imidazolidine-4,3′-indole] -2 , 2 ′, 5 (1′H) -trione compound Chemical class 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
- 208000008035 Back Pain Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 208000036494 Gastrooesophagitis Diseases 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010021639 Incontinence Diseases 0.000 claims 1
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000000450 Pelvic Pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000020629 overactive bladder Diseases 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- VCZILNWKBJBQGN-UHFFFAOYSA-N spiro[1h-indole-3,5'-imidazolidine]-2,2',4'-trione Chemical compound N1C(=O)NC(=O)C21C1=CC=CC=C1NC2=O VCZILNWKBJBQGN-UHFFFAOYSA-N 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77111906P | 2006-02-07 | 2006-02-07 | |
| PCT/SE2007/000107 WO2007091947A2 (en) | 2006-02-07 | 2007-02-06 | Novel spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-triones for treatment of conditions associated with vanilloid receptor 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526043A JP2009526043A (ja) | 2009-07-16 |
| JP2009526043A5 true JP2009526043A5 (enExample) | 2010-03-11 |
Family
ID=38345567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554186A Pending JP2009526043A (ja) | 2006-02-07 | 2007-02-06 | バニロイド受容体１に関連する状態を治療するための新規のスピロ［イミダゾリジン−４，３’−インドール］−２，２”，５’（ｉｈ）−トリオン |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20070185179A1 (enExample) |
| EP (1) | EP2013215A4 (enExample) |
| JP (1) | JP2009526043A (enExample) |
| KR (1) | KR20080094906A (enExample) |
| CN (1) | CN101415711A (enExample) |
| AR (1) | AR059265A1 (enExample) |
| AU (1) | AU2007212786B2 (enExample) |
| BR (1) | BRPI0707423A2 (enExample) |
| CA (1) | CA2641632A1 (enExample) |
| CL (1) | CL2009000523A1 (enExample) |
| IL (1) | IL192890A0 (enExample) |
| NO (1) | NO20083547L (enExample) |
| NZ (1) | NZ571070A (enExample) |
| RU (1) | RU2421457C2 (enExample) |
| SA (1) | SA07280027B1 (enExample) |
| SG (1) | SG169387A1 (enExample) |
| TW (1) | TW200801011A (enExample) |
| UA (1) | UA93226C2 (enExample) |
| UY (1) | UY30132A1 (enExample) |
| WO (1) | WO2007091947A2 (enExample) |
| ZA (1) | ZA200806407B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013057944A1 (ja) * | 2011-10-19 | 2013-04-25 | 興和株式会社 | 新規なスピロインドリン化合物、及びそれを含有する医薬 |
| TWI586668B (zh) * | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| CN108409746B (zh) * | 2018-05-15 | 2021-08-24 | 中山大学 | 一种含吡咯或吲哚并氮杂环烷结构的手性氧代螺环吲哚类化合物及其消旋体和制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490381A (en) | 1979-11-13 | 1984-12-25 | Imperial Chemical Industries Plc | 1'-Substituted spiro[imidazolidine-4,3'-indoline]2,2',5-triones |
| ZA806623B (en) * | 1979-11-13 | 1981-12-30 | Ici Ltd | Substituted indoline-2-one derivatives |
| IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
| GB8331194D0 (en) | 1982-12-20 | 1983-12-29 | Ici Plc | Chemical process |
| US4611062A (en) * | 1984-03-26 | 1986-09-09 | Imperial Chemical Industries Plc | Process for resolving certain spiro compounds |
| WO1992007830A2 (en) | 1990-10-29 | 1992-05-14 | Pfizer Inc. | Oxindole peptide antagonists |
| JP2003505388A (ja) * | 1999-07-21 | 2003-02-12 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| US7248802B2 (en) | 2002-11-27 | 2007-07-24 | Nokia Corporation | Distribution of a synchronization signal in an optical communication system |
| TW200508197A (en) | 2003-03-31 | 2005-03-01 | Ucb Sa | Indolone-acetamide derivatives, processes for preparing them and their uses |
| SE0301446D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
| CA2526387A1 (en) | 2003-06-12 | 2004-12-23 | Astellas Pharma Inc. | Benzamide derivative or salt thereof |
| GB0326633D0 (en) * | 2003-11-14 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006007851A2 (en) | 2004-07-19 | 2006-01-26 | Novo Nordisk A/S | Capsaicin inhibitors for treating obesity and-related disorders |
| WO2007091948A2 (en) | 2006-02-07 | 2007-08-16 | Astrazeneca Ab | Novel spiro [imidazolidine-4, 3´-indole] 2, 2´,5´(1h) triones for treatment of conditions associated with vanilloid receptor 1 |
-
2007
- 2007-01-31 TW TW096103591A patent/TW200801011A/zh unknown
- 2007-01-31 AR ARP070100412A patent/AR059265A1/es not_active Application Discontinuation
- 2007-02-05 US US11/671,153 patent/US20070185179A1/en not_active Abandoned
- 2007-02-06 SG SG201100854-7A patent/SG169387A1/en unknown
- 2007-02-06 CA CA002641632A patent/CA2641632A1/en not_active Abandoned
- 2007-02-06 EP EP07709323A patent/EP2013215A4/en not_active Withdrawn
- 2007-02-06 CN CNA2007800125819A patent/CN101415711A/zh active Pending
- 2007-02-06 AU AU2007212786A patent/AU2007212786B2/en not_active Ceased
- 2007-02-06 BR BRPI0707423-9A patent/BRPI0707423A2/pt not_active IP Right Cessation
- 2007-02-06 JP JP2008554186A patent/JP2009526043A/ja active Pending
- 2007-02-06 RU RU2008131905/04A patent/RU2421457C2/ru not_active IP Right Cessation
- 2007-02-06 KR KR1020087019272A patent/KR20080094906A/ko not_active Withdrawn
- 2007-02-06 UY UY30132A patent/UY30132A1/es not_active Application Discontinuation
- 2007-02-06 SA SA07280027A patent/SA07280027B1/ar unknown
- 2007-02-06 WO PCT/SE2007/000107 patent/WO2007091947A2/en not_active Ceased
- 2007-02-06 NZ NZ571070A patent/NZ571070A/en unknown
- 2007-06-02 UA UAA200809311A patent/UA93226C2/ru unknown
-
2008
- 2008-07-17 IL IL192890A patent/IL192890A0/en unknown
- 2008-07-23 ZA ZA200806407A patent/ZA200806407B/xx unknown
- 2008-08-14 NO NO20083547A patent/NO20083547L/no not_active Application Discontinuation
- 2008-11-20 US US12/274,837 patent/US7868181B2/en not_active Expired - Fee Related
-
2009
- 2009-03-05 CL CL2009000523A patent/CL2009000523A1/es unknown
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